Acta neurologica Belgica最新文献

{"title":"Efficacy and safety of tradipitant in motion sickness: a systematic review and meta-analysis.","authors":"Mohammed Raed Elsaadouni, Norah Hani Aldekhail, Abdulla Taher Ahmed Alhawamdeh, Raghad Mohamed Eljoujou, Yousef Maher Al Mashhrawi, Faisal Hossain, Karam Fadi Alhaddad, Deema Alsouleman, Lujain Ali Ghabib Alghamdi, Talal Saad Alburaik, Alanoud Theyab Alotaibi, Rana Sameer Alsagga, Sara Khaled Abdelfattah, Rehan Ishaque","doi":"10.1007/s13760-026-03161-2","DOIUrl":"10.1007/s13760-026-03161-2","url":null,"abstract":"<p><strong>Background: </strong>Motion sickness affects up to 30% of the general population, yet the three pharmacological agents currently approved in the United States, dimenhydrinate, meclizine, and scopolamine carry significant sedative and cognitive liabilities and offer incomplete protection against vomiting. Tradipitant, a selective neurokinin-1 receptor antagonist, has been evaluated across three randomized controlled trials for motion sickness prevention, but no pooled quantitative synthesis of this evidence exists. This study aimed to evaluate the efficacy and safety of tradipitant versus placebo in adults with a documented history of motion sickness.</p><p><strong>Methods: </strong>PubMed, Cochrane CENTRAL, Web of Science, and ClinicalTrials.gov were searched from inception through March 25, 2026, following PRISMA guidelines (PROSPERO: CRD420261332049). Eligible studies were RCTs enrolling adults aged 18 years or older with documented motion sickness history. Binary outcomes were pooled as RRs using the Mantel-Haenszel method; continuous outcomes as MDs. Random-effects and fixed-effect models were applied to all outcomes.</p><p><strong>Results: </strong>Three RCTs enrolling 808 participants were included, with two trials rated low risk of bias and one receiving some concerns. For vomiting incidence (primary outcome; 3 RCTs, n = 807), tradipitant significantly reduced vomiting risk versus placebo (RR 0.42, 95% CI 0.33 to 0.53; p-value < 0.0001; I² = 0%), with consistent dose-stratified estimates at 170 mg (n = 466; RR 0.38, 95% CI 0.28 to 0.53; p-value < 0.0001; I² = 0%) and 85 mg (n = 341; RR 0.46, 95% CI 0.32 to 0.65; p-value < 0.0001; I² = 0%), and a rough sea conditions pooled RR of 0.39 (95% CI 0.29 to 0.54). Nausea severity (3 RCTs, n = 491) showed no significant difference (SMD - 0.05, 95% CI - 0.24 to 0.13; p = 0.5846; I² = 0%; GRADE: Low). MSAQ total score (n = 488) was MD 1.43 (95% CI - 5.89 to 8.75; p = 0.4896; I² = 0%), MSAQ-GI subscale (n = 488) was MD - 3.14 (95% CI - 7.94 to 1.66; p = 0.1063; I² = 0%), and PGI-S score (n = 490) was MD - 0.18 (95% CI - 0.37 to 0.02; p = 0.0603; I² = 0%), none reaching significance. Any TEAE (n = 807) was significantly higher with tradipitant (RR 1.94, 95% CI 1.20 to 3.13; p = 0.0185; I² = 4.8%). However, individual adverse events did not reach significance: headache RR 1.45 (95% CI 0.85 to 2.50; p = 0.1283; I² = 0%), fatigue RR 2.23 (95% CI 0.78 to 6.36; p = 0.0940; I² = 0%), and somnolence RR 1.69 (95% CI 0.68 to 4.22; p = 0.1839; I² = 20.5%).</p><p><strong>Conclusion: </strong>Tradipitant significantly reduced vomiting incidence at both doses and across sea conditions, with negligible heterogeneity and stable sensitivity analyses. Although no significant improvement was observed in nausea or broader symptom burden, tradipitant was associated with a higher overall treatment-emergent adverse event rate than placebo. These findings support characterizing tradipitant as a selective vomiting ","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148720668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The many faces of disulfiram-induced encephalopathy: diagnostic challenges in clinical practice.","authors":"Joline Michiels, Anton Adams, Wouter Stragier, Jo Leenders, Harald De Cauwer","doi":"10.1007/s13760-026-03154-1","DOIUrl":"10.1007/s13760-026-03154-1","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148719464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical artery dissection after upper respiratory infection: clinical features and prognosis.","authors":"Sara D B Rosa, Mafalda Soares, Ana Paiva Nunes, Liqi Shu, Eileen Wu, Nils Henninger, Jayachandra Muppa, Mirjam R Heldner, Kateryna Antonenko, Setareh Omran, Ahmad Nehme, Aaron Rothstein, Ossama Khazaal, Issa Metanis, Ronen R Leker, Malik Ghannam, Bastien Rioux, Michele Romoli, Marialuisa Zedde, Rosario Pascarella, Wayneho Kam, Brian Mac Grory, Faddi Velez, Mary Penckofer, James Siegler, Adeel S Zubair, João Pedro Marto, Danna Krupka, Marwa Elnazair, Shadi Yaghi, Diana Aguiar de Sousa","doi":"10.1007/s13760-026-03162-1","DOIUrl":"10.1007/s13760-026-03162-1","url":null,"abstract":"<p><strong>Background: </strong>Prior studies have suggested an association between cervical artery dissection (CAD) and upper respiratory tract infection, although evidence remains scarce. We aimed to compare the clinical features and outcomes of CAD with and without history of upper respiratory infection.</p><p><strong>Methods: </strong>We conducted a secondary analysis of a multicenter, international, retrospective study including adult patients diagnosed with spontaneous CAD between January 2015 and June 2022. History of recent upper respiratory tract infection (HURI) was defined as symptoms of cough, fever, sneezing and throat soreness (at least two) within the 30 days preceding CAD diagnosis, as documented in patient medical records. Baseline characteristics and outcomes were compared between patients with and without HURI.</p><p><strong>Results: </strong>Among 4,023 patients with CAD, 251 (6.2%) had HURI. Multi-vessel involvement was nearly twice as frequent in this group (19.1% vs. 10.5%, p < 0.001). In multivariable analyses, HURI was associated with lower rates of occlusive dissection (30.1% vs. 35.9%, adjusted OR [95% CI]: 0.76 [0.57-1.00]) and reduced odds of presenting with ischemic stroke symptoms (55.9% vs. 65.7%, aOR [95% CI]: 0.60 [0.46-0.79]) or hemorrhagic transformation (1.6% vs. 4.9%, p = 0.02). At day 90, patients with HURI were more likely to achieve favorable functional outcome (mRS ≤ 2 93.0% vs. 85.2%, aOR [95% CI]: 2.12 [1.10-4.11]). No significant differences were found in mortality or CAD recurrence between groups.</p><p><strong>Conclusions: </strong>Our findings suggest that CAD preceded by respiratory infection is associated with milder clinical presentation with better functional outcome, despite more frequent multivessel involvement.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of neuromuscular retraining and adjunctive electrical stimulation in Bell's palsy: a single-centre observational cohort study.","authors":"Sharodiya Das, Dilshod Tolibov, Dilfuza Mirzaeva, Djurayeva Zulfiya Baratovna, Dilorom Dinmukhammadieva","doi":"10.1007/s13760-026-03166-x","DOIUrl":"https://doi.org/10.1007/s13760-026-03166-x","url":null,"abstract":"<p><strong>Background: </strong>Bell's palsy is the most frequent reason for acute unilateral peripheral facial palsy. While some patients recover spontaneously, others experience incomplete recovery, asymmetry of face, synkinesis, disability, and decreased quality of life. The value of different rehabilitation paths in routine clinical practice is unknown.</p><p><strong>Purpose: </strong>To describe facial recovery outcomes across three routine clinical rehabilitation pathways in adults with Bell's palsy and to examine recovery patterns over 12 months.</p><p><strong>Methods: </strong>This single-center retrospective cohort study enrolled 500 adult patients with newly diagnosed Bell's palsy and was conducted according to one of the three routine clinical pathways: no rehabilitation, rehabilitation with facial neuromuscular training, and neuromuscular training along with electrostimulation. The clinical evaluations were carried out at the moment of the initial clinical evaluation and then at 1 month, 3 months, 6 months, and 12 months after the index clinical evaluation. The primary outcome was favorable recovery within 6 months, which is considered as House-Brackmann grade I-II.</p><p><strong>Results: </strong>The average age of participants was 45.3 years (SD 13.9 ) and 56.6% were female. Early application of corticosteroids within 72 h after illness onset was found in 65.4% of cases, but 45.8% of patients received antiviral therapy. By 6 months, favorable recovery rate was 63.0% among patients without rehabilitation, 83.4% among those receiving supervised neuromuscular retraining and 81.7% among patients who underwent a combination of neuromuscular retraining and electrical stimulation. Sunnybrook Facial Grading System scores increased over time in all groups. By 12 months, synkinesis was found less often in the supervised neuromuscular retraining group.</p><p><strong>Conclusion: </strong>In this single-center observational cohort study, structured rehabilitation pathways were associated with numerically higher observed proportions of favourable recovery than no formal rehabilitation. However, rehabilitation pathways were not randomly allocated and differed according to baseline severity and routine clinical factors. Therefore, these findings describe associations and cannot establish treatment effectiveness, causality, or superiority of one rehabilitation pathway over another.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148696756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kinetic and inhibitory profiling of serum MMP-9 in acute spinal cord injury: neurochemical links to injury severity and neuroinflammation.","authors":"Mustafa Alburhan, Omar Khalid Suhail, Alaa Haleem Imran, Mustafa Mohammed Fadhil","doi":"10.1007/s13760-026-03165-y","DOIUrl":"https://doi.org/10.1007/s13760-026-03165-y","url":null,"abstract":"<p><strong>Background: </strong>Spinal cord injury (SCI) is a devastating neurological condition characterized by pronounced neuroinflammation and progressive neurodegeneration. Matrix metalloproteinase-9 (MMP-9) has emerged as a crucial regulator of inflammatory cascades, yet its role as a predictive biomarker and enzyme kinetic behaviour persists ambiguous. MMP-9 has recently become a key and seemingly distinct contributor to brain physiology and pathology. The local and time-constrained nature of MMP-9 actions may be the reason why it is so specific, even when it is released into the brain by cells of different types, such as neurons, glia, and leukocytes.</p><p><strong>Objectives: </strong>The aims of the study were to examine the enzymatic kinetics of MMP-9 in acute spinal cord injury, determine how MMP-9-inhibitor-I inhibits MMP-9, and correlate MMP-9 levels with the severity of injury and neuroinflammatory indicators to explore the inhibitory response of MMP-9 inhibitor-I in vitro and evaluate the potential relevance of MMP-9 as a severity-associated biomarker and experimental inhibitory target in acute SCI.</p><p><strong>Methods: </strong>In this cross-sectional study, 160 patients with confirmed acute SCI were stratified according to the American Spinal Injury Association Impairment Scale into Mild/Moderate and severe groups. Serum concentrations of MMP-9, C-reactive protein (CRP), creatine kinase-BB (CK-BB), and routine biochemical markers were quantified. Multivariable regression analyses were performed to adjust for confounding variables, and receiver operating characteristic (ROC) curve analysis was used to assess the discriminatory performance of MMP-9.</p><p><strong>Results: </strong>MMP-9 levels were significantly elevated in patients with severe SCI compared with Mild/Moderate injury (p < 0.001) and showed a strong positive correlation with injury severity (r = 0.755, p < 0.001) and positive correlation with CK-BB levels (r = 0.223, p = 0.047). MMP-9 remained independently associated with SCI severity in the adjusted model. ROC analysis demonstrated excellent discriminatory performance (AUC = 0.942; 95% CI: 0.878-1.000). Enzymatic kinetic analysis suggested higher apparent catalytic activity in severe cases, Inhibition studies showed a kinetic pattern consistent with non-competitive inhibition by MMP-9 inhibitor-I.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148696836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thymoma-associated anti-AMPAR encephalitis presenting with hearing loss: a case report.","authors":"Xiangyue Tang, Lusen Ran, Bo Tang, Xiang Li, Wenfei Li","doi":"10.1007/s13760-026-03146-1","DOIUrl":"https://doi.org/10.1007/s13760-026-03146-1","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148696834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent ischemic strokes with normal inflammatory markers: when tests mislead.","authors":"Isabel Ros González, Daniel Pérez Gil, Leticia Martín Gil, María Alexandra Figueroa Arenas, Oscar Fontsere Paton, Cristina Hormigos Martín, Sara Torrico Hatami, Manuel De La Calle Cuevas","doi":"10.1007/s13760-026-03149-y","DOIUrl":"https://doi.org/10.1007/s13760-026-03149-y","url":null,"abstract":"<p><p>Giant cell arteritis (GCA) is an uncommon cause of ischemic stroke, and diagnosis may be particularly challenging when inflammatory markers remain normal. We describe a 67-year-old woman with recurrent ischemic strokes preceded by new-onset headache. Neuroimaging showed bilateral severe stenosis of the distal intracranial internal carotid arteries, while temporal artery ultrasound and biopsy confirmed GCA. Recurrent cerebrovascular events occurred despite glucocorticoids and tocilizumab, requiring rescue therapy with cyclophosphamide, which achieved disease stabilization. This case illustrates an aggressive intracranial phenotype of GCA in which diagnosis and treatment decisions relied on clinical and imaging findings rather than inflammatory markers alone.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148696822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability and convergent validity of the 6-minute pegboard and ring test in people with Parkinson's disease: a cross-sectional study.","authors":"Rüveyda Gürdal, Hakan Polat, Emel Taşvuran Horata, İbrahim Anıl Tuncer","doi":"10.1007/s13760-026-03159-w","DOIUrl":"https://doi.org/10.1007/s13760-026-03159-w","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the reliability and convergent validity of the 6-Minute Pegboard and Ring Test (6PBRT) in people with Parkinson's disease (PwPD).</p><p><strong>Methods: </strong>A total of 48 PwPD were included in this cross-sectional study (mean age: 67.0 ± 5.5 years). Upper extremity (UE) function was assessed using the 6PBRT, Nine-Hole Peg Test (9HPT), grip strength, shoulder muscle strength, Quick-DASH, and Fatigue Impact Scale (FIS). Intra-rater and inter-rater reliability were analyzed using the intraclass correlation coefficient (ICC [2,1]), standard error of measurement (SEM), and minimal detectable change (MDC). Agreement was evaluated using Bland-Altman analysis. Convergent validity was assessed using Spearman correlation analysis.</p><p><strong>Results: </strong>The 6PBRT demonstrated excellent intra-rater reliability (ICC = 0.995-0.996) and inter-rater reliability (ICC = 0.995), with low measurement error (SEM = 4.17-4.99 repetitions; MDC = 11.55-13.83 repetitions). Bland-Altman analysis revealed low bias and acceptable limits of agreement, indicating strong absolute reliability. The 6PBRT showed significant moderate-to-strong correlations with the 9HPT (dominant: rho = -0.878; non-dominant: rho = -0.848), shoulder flexor strength (rho = 0.756-0.760), shoulder abductor strength (rho = 0.775-0.787), FIS (rho = -0.657), and Quick-DASH (rho = -0.510) (all p < 0.001).</p><p><strong>Conclusion: </strong>The 6PBRT demonstrated high reliability and good convergent validity in PwPD. Its significant correlations with UE motor performance, muscle strength, and fatigue support its potential as a clinically relevant outcome measure in rehabilitation practice and research settings for Parkinson's disease. The results apply to early-to-mid stage Parkinson's disease and should not be extrapolated to more advanced stages.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148682938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NF186 mediated demyelinating polyneuropathy causing pseudo-dystonia and pseudo-athetosis.","authors":"Farsana Mustafa, Abhishek Mudda, Abu Suraih Sakhri, Ayush Agarwal, Achal Kumar Srivastava, Swati Mahajan, Divyani Garg","doi":"10.1007/s13760-026-03153-2","DOIUrl":"https://doi.org/10.1007/s13760-026-03153-2","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148676667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of neurosurgical patients during the COVID-19 pandemic: a systematic review and meta-analysis of global data.","authors":"Xuan Bai, Siyu Dong","doi":"10.1007/s13760-026-03156-z","DOIUrl":"https://doi.org/10.1007/s13760-026-03156-z","url":null,"abstract":"<p><strong>Background: </strong>COVID-19 pandemic has substantially affected neurosurgical care globally through service reorganizations, delayed presentation, alterations in case selection, and limited perioperative resources. However, overall impact of these changes on clinical outcomes in neurosurgical patients remains unclear. Hence, this review evaluated clinical outcomes of neurosurgical patients managed during COVID-19 era compared with pre-pandemic era.</p><p><strong>Methods: </strong>Systematic search of PubMed, Embase, Scopus, Web of Science was conducted from inception of database till March 2026. Pooled effect estimates were calculated using random-effects meta-analysis. Odds ratios (ORs) were used for dichotomous outcomes and weighted mean differences (WMDs) for continuous outcomes. Heterogeneity was assessed using I² statistic.</p><p><strong>Results: </strong>Twenty studies were included. In the primary pre-pandemic comparison, mortality was significantly higher during the COVID-19 era across 18 studies including 35,639 patients (OR = 1.49, 95%CI 1.20-1.85; I² = 44.7%). Postoperative complications were also increased across 13 studies including 12,174 patients (OR = 1.44, 95%CI 1.04-1.98; I² = 78.5%). No significant difference was observed for requirement of mechanical ventilation (OR = 1.20, 95%CI 0.81-1.76; I² = 0.0%), whereas length-of-stay findings were inconclusive because of high heterogeneity (WMD = -1.46 days, 95%CI -3.19 to 0.28; I² = 85.8%).</p><p><strong>Conclusions: </strong>Neurosurgical patients managed during the COVID-19 era had higher mortality and postoperative complication rates than those treated before the pandemic. These findings highlight the vulnerability of neurosurgical care systems to large-scale health-system disruption and underscore the need for resilient strategies to ensure timely and safer neurosurgical care during future disruptions.</p><p><strong>Clinical trial registration: </strong>Not applicable.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148676675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}