{"title":"不宁腿综合症和桥本甲状腺炎。","authors":"Arif Tolga Sönmez, Hüseyin Demirci","doi":"10.1007/s13760-025-02871-3","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>It has been hypothesized that an imbalance between thyroid hormones and dopaminergic activity may contribute to the development of Restless legs syndrome (RLS). This study aimed to evaluate the incidence and severity of RLS in patients with Hashimoto's thyroiditis compared to healthy controls, with a focus on the potential impact of thyroid hormone replacement therapy.</p><p><strong>Methods: </strong>A total of 120 consecutive patients, 80 with Hashimoto's thyroiditis (40 untreated, 40 under treatment) and 40 healthy controls, were included in the study. RLS symptoms were assessed based on the International Restless Legs Syndrome Study Group (IRLSSG) diagnostic criteria. Symptom severity was evaluated using the Restless Legs Syndrome Severity Rating Scale (RLS-SRS).</p><p><strong>Results: </strong>RLS symptoms and RLS-SRS scores were significantly higher in patients with Hashimoto's thyroiditis compared to healthy controls (p < 0.01). The untreated group showed a significantly higher RLS incidence and symptom severity than both the treated group and controls (p < 0.001). No significant difference was observed between the treated Hashimoto's group and the control group. Additionally, RLS severity was associated with a longer duration of Hashimoto's disease (p = 0.03).</p><p><strong>Conclusion: </strong>The results of our study suggest that RLS is more prevalent and severe in patients with untreated Hashimoto's thyroiditis. Furthermore, thyroid hormone replacement therapy may have a protective role in reducing both the incidence and severity of RLS in this population.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Restless legs syndrome and hashimoto's thyroiditis.\",\"authors\":\"Arif Tolga Sönmez, Hüseyin Demirci\",\"doi\":\"10.1007/s13760-025-02871-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>It has been hypothesized that an imbalance between thyroid hormones and dopaminergic activity may contribute to the development of Restless legs syndrome (RLS). This study aimed to evaluate the incidence and severity of RLS in patients with Hashimoto's thyroiditis compared to healthy controls, with a focus on the potential impact of thyroid hormone replacement therapy.</p><p><strong>Methods: </strong>A total of 120 consecutive patients, 80 with Hashimoto's thyroiditis (40 untreated, 40 under treatment) and 40 healthy controls, were included in the study. RLS symptoms were assessed based on the International Restless Legs Syndrome Study Group (IRLSSG) diagnostic criteria. Symptom severity was evaluated using the Restless Legs Syndrome Severity Rating Scale (RLS-SRS).</p><p><strong>Results: </strong>RLS symptoms and RLS-SRS scores were significantly higher in patients with Hashimoto's thyroiditis compared to healthy controls (p < 0.01). The untreated group showed a significantly higher RLS incidence and symptom severity than both the treated group and controls (p < 0.001). No significant difference was observed between the treated Hashimoto's group and the control group. Additionally, RLS severity was associated with a longer duration of Hashimoto's disease (p = 0.03).</p><p><strong>Conclusion: </strong>The results of our study suggest that RLS is more prevalent and severe in patients with untreated Hashimoto's thyroiditis. Furthermore, thyroid hormone replacement therapy may have a protective role in reducing both the incidence and severity of RLS in this population.</p>\",\"PeriodicalId\":7042,\"journal\":{\"name\":\"Acta neurologica Belgica\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-08-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta neurologica Belgica\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s13760-025-02871-3\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta neurologica Belgica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s13760-025-02871-3","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Restless legs syndrome and hashimoto's thyroiditis.
Background: It has been hypothesized that an imbalance between thyroid hormones and dopaminergic activity may contribute to the development of Restless legs syndrome (RLS). This study aimed to evaluate the incidence and severity of RLS in patients with Hashimoto's thyroiditis compared to healthy controls, with a focus on the potential impact of thyroid hormone replacement therapy.
Methods: A total of 120 consecutive patients, 80 with Hashimoto's thyroiditis (40 untreated, 40 under treatment) and 40 healthy controls, were included in the study. RLS symptoms were assessed based on the International Restless Legs Syndrome Study Group (IRLSSG) diagnostic criteria. Symptom severity was evaluated using the Restless Legs Syndrome Severity Rating Scale (RLS-SRS).
Results: RLS symptoms and RLS-SRS scores were significantly higher in patients with Hashimoto's thyroiditis compared to healthy controls (p < 0.01). The untreated group showed a significantly higher RLS incidence and symptom severity than both the treated group and controls (p < 0.001). No significant difference was observed between the treated Hashimoto's group and the control group. Additionally, RLS severity was associated with a longer duration of Hashimoto's disease (p = 0.03).
Conclusion: The results of our study suggest that RLS is more prevalent and severe in patients with untreated Hashimoto's thyroiditis. Furthermore, thyroid hormone replacement therapy may have a protective role in reducing both the incidence and severity of RLS in this population.
期刊介绍:
Peer-reviewed and published quarterly, Acta Neurologica Belgicapresents original articles in the clinical and basic neurosciences, and also reports the proceedings and the abstracts of the scientific meetings of the different partner societies. The contents include commentaries, editorials, review articles, case reports, neuro-images of interest, book reviews and letters to the editor.
Acta Neurologica Belgica is the official journal of the following national societies:
Belgian Neurological Society
Belgian Society for Neuroscience
Belgian Society of Clinical Neurophysiology
Belgian Pediatric Neurology Society
Belgian Study Group of Multiple Sclerosis
Belgian Stroke Council
Belgian Headache Society
Belgian Study Group of Neuropathology