Acta neurologica Belgica最新文献_第6页

Gaze palsy in glycine receptor antibody-mediated autoimmune encephalitis: a case report. 甘氨酸受体抗体介导的自身免疫性脑炎中的凝视麻痹：病例报告。

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-06-01 Epub Date: 2024-11-08 DOI: 10.1007/s13760-024-02681-z

Wan Jiang, Chong Wang, Yun Xu, Qing Ye

引用次数: 0

Associations of plasma Neurofilament light chain with sarcopenia and physical capacity in patients with Alzheimer's diseases. 阿尔茨海默病患者血浆神经丝轻链与肌肉减少症和体能的关系

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-06-01 Epub Date: 2025-03-11 DOI: 10.1007/s13760-025-02759-2

Rizwan Qaisar, Asima Karim, M Shahid Iqbal, Shaea A Alkahtani, Firdos Ahmad

{"title":"Associations of plasma Neurofilament light chain with sarcopenia and physical capacity in patients with Alzheimer's diseases.","authors":"Rizwan Qaisar, Asima Karim, M Shahid Iqbal, Shaea A Alkahtani, Firdos Ahmad","doi":"10.1007/s13760-025-02759-2","DOIUrl":"10.1007/s13760-025-02759-2","url":null,"abstract":"Background: Despite the close association of Alzheimer's disease (AD) with muscle decline, the biomarkers of age-related muscle loss, termed sarcopenia, in AD remain elusive.Objectives: We investigated the plasma neurofilament light (NfL) chain levels as potential biomarkers of sarcopenia in AD patients. DESIGN SETTING, PARTICIPANTS, MEASUREMENTS: We conducted a cross-sectional, observational study on older adults, including controls and patients with AD (n = 38-44/group). We measured the frequency of sarcopenia, body composition, handgrip strength (HGS), gait speed, and short physical performance battery (SPPB) in the study participants. We also measured the plasma NfL levels as marker of neurodegeneration.Results: AD was associated with a higher frequency of sarcopenia and reduced HGS, gait speed, and SPPB scores (all p < 0.05). The higher plasma NfL levels in AD patients were correlated with lower HGS, gait speed, and SPPB scores (all p < 0.05). Plasma NfL exhibited moderate accuracy in diagnosing sarcopenia (area under the curve; AUC = 0.701, p < 0.001) and functional dependency (AUC = 0.772, p < 0.001). Among different subgroups of AD, moderate AD was associated with more advanced sarcopenia and functional dependency than early and mild AD. Patients with AD also exhibited heightened inflammation and oxidative stress.Conclusion: Altogether, plasma NfL may be a preliminary tool in diagnosing advanced sarcopenia and functional dependency in AD. The study is relevant to non-ambulant and/or comatose AD patients with sarcopenia.","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":"691-698"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tofacitinib as maintenance therapy for refractory Neurosarcoidosis. 托法替尼作为难治性神经肉芽肿病的维持疗法。

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-06-01 Epub Date: 2024-11-06 DOI: 10.1007/s13760-024-02680-0

Maria Ciravegna Fonseca de Melo Bandeira, Vincent Van Pesch, Valeria Onofrj, Tévi Morel Lawson, Halil Yildiz

引用次数: 0

Split syndrome with acute-onset hemichorea and contralateral progressive parkinsonism: a case report. 伴有急性发作性肢痛症和对侧进行性帕金森病的分裂综合征：病例报告。

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-06-01 Epub Date: 2024-12-20 DOI: 10.1007/s13760-024-02704-9

Francescantonio Cammarota, Cristina Tassorelli, Giuseppe Cosentino, Anna Pichiecchio, Massimiliano Todisco

引用次数: 0

A case of MOG antibody-positive unilateral optic neuritis following a pulmonary tuberculosis infection. 肺结核感染后单侧视神经炎MOG抗体阳性1例。

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-06-01 Epub Date: 2025-02-17 DOI: 10.1007/s13760-025-02745-8

Mi Xiong, Rui Gu, Yan Liu

引用次数: 0

Endocrine dysfunction post-traumatic brain injury: challenges and therapeutic approaches. 创伤性脑损伤后的内分泌功能障碍：挑战与治疗方法。

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-06-01 Epub Date: 2025-03-07 DOI: 10.1007/s13760-025-02755-6

Zahra Soltani, Masoud Nazari, Meisam Babaei, Habibesadat Shakeri, Sediqeh Jalali, Vahid Hajali, Zakieh Keshavarzi

{"title":"Endocrine dysfunction post-traumatic brain injury: challenges and therapeutic approaches.","authors":"Zahra Soltani, Masoud Nazari, Meisam Babaei, Habibesadat Shakeri, Sediqeh Jalali, Vahid Hajali, Zakieh Keshavarzi","doi":"10.1007/s13760-025-02755-6","DOIUrl":"10.1007/s13760-025-02755-6","url":null,"abstract":"Traumatic brain injury (TBI) is a widespread, serious public health concern with substantial lasting effects, such as impacting the endocrine system. Here, we review the complications and consequences of TBI on the hypothalamic-pituitary axis (HPA) and connected endocrine glands, which are essential for maintaining body balance. Endocrine dysfunctions caused by TBI, especially hypopituitarism, can result in hormonal imbalances that impact various physiological systems, such as growth, metabolism, reproduction, and stress responses. These dysfunctions can cause issues like adrenal insufficiency, hypothyroidism, and hypogonadism, greatly affecting the quality of life of survivors. In cases of moderate to severe TBI, up to 40% of individuals may suffer from post-TBI hypopituitarism, leading to extended morbidity. The introduced treatment methods concentrate on different therapeutic options, including hormone replacement therapies (HRTs) (corticosteroid, growth, thyroid, and sex hormones replacement therapies), emerging plant-based bioactive compounds, and other options to address particular deficiencies. Simultaneously, there is a growing interest in novel bioactive compounds derived from plants because of their neuroprotective and anti-inflammatory properties. In addition, certain populations, such as veterans and children, are more likely to develop endocrine dysfunction due to TBI. Comprehensive, cross-disciplinary care and individualized treatment plans are crucial to improve outcomes and long-term recovery for TBI patients. Further investigation is needed to enhance diagnostic instruments, explore novel therapies, and establish predictive biomarkers for early intervention in TBI-induced endocrine disorders.","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":"649-660"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of NLRP3, ASC, and Caspase-1 in serum and cerebrospinal fluid of traumatic brain injury patients: implications for short-term prognosis. 外伤性脑损伤患者血清和脑脊液中NLRP3、ASC和Caspase-1的检测：对短期预后的影响

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-06-01 Epub Date: 2025-03-11 DOI: 10.1007/s13760-025-02761-8

Adilijiang Aihemaitiniyazi, Kuo Ma, Jinhui Xu, Hua Chen, Xianglu Liu, Jilin Li

{"title":"Detection of NLRP3, ASC, and Caspase-1 in serum and cerebrospinal fluid of traumatic brain injury patients: implications for short-term prognosis.","authors":"Adilijiang Aihemaitiniyazi, Kuo Ma, Jinhui Xu, Hua Chen, Xianglu Liu, Jilin Li","doi":"10.1007/s13760-025-02761-8","DOIUrl":"10.1007/s13760-025-02761-8","url":null,"abstract":"Objectives: Traumatic brain injury (TBI) is a critical public health issue with high mortality and disability rates. Current diagnostic tools lack sensitivity and specificity, under-scoring the need for novel biomarkers. This study aimed to evaluate the clinical utility of NLRP3, ASC, and Caspase-1 as biomarkers for assessing TBI severity and prognosis.Methods: A prospective cohort of 89 patients with moderate-to-severe TBI was studied. Blood and cerebrospinal fluid (CSF) samples were collected for four consecutive days post-injury. Levels of NLRP3, ASC, and Caspase-1 were measured using enzyme-linked immunosorbent as-say (ELISA). Statistical analyses, including ROC curve analysis, were conducted to assess their predictive performance.Results: NLRP3, ASC, and Caspase-1 levels in both serum and CSF were significantly elevated in TBI patients, with higher levels correlating with greater injury severity. ROC analysis revealed that CSF biomarkers, particularly NLRP3, demonstrated superior predictive value. CSF NLRP3 levels on days 1, 2, and 4 had AUC values of 0.9871, 0.9466, and 0.8967, respectively. Dynamic changes in these biomarkers over time provided insights into disease progression and prognosis. Serum markers, while less predictive than CSF, were also effective for assessing injury severity.Conclusions: NLRP3, ASC, and Caspase-1 are promising biomarkers for evaluating TBI severity and predicting outcomes. Their dynamic monitoring may improve clinical management and in-form therapeutic strategies. Future research should validate these findings in larger cohorts and explore interventions targeting these inflammatory pathways.","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":"745-755"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reversible globus pallidus lesions secondary to severe anemia caused by acute myeloid leukemia. 急性髓性白血病引起的严重贫血继发的可逆性苍白球病变。

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-06-01 Epub Date: 2025-01-23 DOI: 10.1007/s13760-025-02722-1

Laura Castro, Bruno Niemeyer, Edson Marchiori

引用次数: 0

Septo-optic dysplasia with associated closed lip schizencephaly: "SOD-plus syndrome". 视隔发育不良伴闭唇裂脑畸形：“sod +综合征”。

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-06-01 Epub Date: 2025-01-24 DOI: 10.1007/s13760-025-02733-y

Aswen Sriranganathan, Rahul A Sharma

引用次数: 0

Microstructural alterations of cerebellar peduncles in multiple sclerosis: a diffusion tensor imaging study. 多发性硬化症小脑脚的微结构改变：弥散张量成像研究。

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-06-01 Epub Date: 2024-11-01 DOI: 10.1007/s13760-024-02675-x

Homa Seyedmirzaei, Alireza Soltani Khaboushan, Amirhussein Abdolalizadeh, Mohammad Hadi Aarabi

{"title":"Microstructural alterations of cerebellar peduncles in multiple sclerosis: a diffusion tensor imaging study.","authors":"Homa Seyedmirzaei, Alireza Soltani Khaboushan, Amirhussein Abdolalizadeh, Mohammad Hadi Aarabi","doi":"10.1007/s13760-024-02675-x","DOIUrl":"10.1007/s13760-024-02675-x","url":null,"abstract":"Background and purpose: Ataxia, tremors, dysarthria, and sometimes impaired cognition are the signs of cerebellum involvement in multiple sclerosis (MS). These symptoms affect up to 80% of patients and are usually hard to treat. To find the underlying involvement of the cerebellum in MS, we assessed the microstructural alterations with DTI in the cerebellar peduncles of the affected subjects.Materials and methods: We included 58 relapsing-remitting MS patients and 27 healthy controls. Patients were divided into 18 patients of relapsing-remitting MS with cerebellar impairment (RRMSc) and 40 without cerebellar impairment (RRMSnc). Using Diffusion Tensor Imaging (DTI), we calculated fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) metrics in all subjects. We also checked if there were associations between DTI metrics and clinical cerebellar measures (i.e., tremor severity and the scale for the assessment and rating of ataxia).Results: ANOVA and post-hoc results showed significant differences in DTI metrics between RRMSc and HC and between RRMSnc and HC subjects. Inferior peduncle RD remained the only metric with a significant difference across all pairwise comparisons. The general linear model assessing the effects of the three study groups on the association between DTI metrics and clinical cerebellar measures yielded no significant result.Conclusions: Our study showed that DTI can mainly reveal significant differences between different MS groups and HCs. Our results imply the role of cerebellar peduncles in the pathophysiology of MS and that this role does not necessarily reflect the severity of cerebellar signs of the patients.","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":"679-689"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142556880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0