Acta neurologica Belgica最新文献

{"title":"Influencing factors and clinical value of anti-aquaporin-4 antibody in cerebrospinal fluid: a study of 82 patients with neuromyelitis optica spectrum disorder.","authors":"Jing Peng, Feifei Yu, Xiajun Zhou, Yifan Wu, Kan Wang, Jie Ding, Nan Zhao, Desheng Zhu, Yangtai Guan, Chong Xie","doi":"10.1007/s13760-025-02853-5","DOIUrl":"https://doi.org/10.1007/s13760-025-02853-5","url":null,"abstract":"<p><strong>Objective: </strong>Serum AQP4 antibody (AQP4-IgG) is the causative antibody of neuromyelitis optica spectrum disorder (NMOSD) but AQP4-IgG in cerebrospinal fluid (CSF) has been seldom studied. We aimed to explore the clinical value and influencing factors of CSF AQP4-IgG in NMOSD.</p><p><strong>Methods: </strong>In this study, we screened 137 patients with NMOSD diagnosed according to the 2015 International Consensus Diagnostic Criteria (IPND criteria). From this cohort, paired CSF and serum samples were simultaneously collected from 82 patients (including seropositive and seronegative subgroups) for antibody titer measurement. We explored the relationship between CSF AQP4-IgG and patient's clinical features. Their demographic, clinical, laboratory data and MRI images were collected and analyzed.</p><p><strong>Results: </strong>74 patients were seropositive for AQP4-IgG and 8 patients were seronegative. Among the 74 patients seropositive for AQP4-IgG, 46 were CSF-positive and 28 were CSF-negative, while none of the 8 seronegative patients were CSF-positive. CSF AQP4-IgG positive and negative patients showed significant differences in EDSS and relapse status. Out of the 82 patients, 67 patients were during relapse and only patients during relapse were included in the next analysis. Between the CSF-positive and CSF-negative patients, no significant differences were found in EDSS, relapse manifestation, CSF indicators, serum cytokine levels, lymphocyte subsets or MRI lesions. Responses to treatment during relapse and length of hospital stay showed no significant differences either. A positive correlation between the serum and CSF titers (rs: 0.64, p < 0.001) was found. Further binary logistic regression analysis revealed that CSF AQP4-IgG positivity was associated with serum AQP4-IgG titers and EDSS scores.</p><p><strong>Conclusions: </strong>CSF AQP4-IgG positivity primarily results from passive diffusion of serum antibodies across the blood-brain barrier, which is different from the CNS-restricted antibody production in MOG-IgG associated disorders (MOGAD). Limited prognostic value of CSF AQP4-IgG was revealed in this study.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating molecular background of multiple sclerosis through multi-omics: linking via psychoneuroimmunology.","authors":"Nadia Islam, Betül Akçeşme","doi":"10.1007/s13760-025-02859-z","DOIUrl":"https://doi.org/10.1007/s13760-025-02859-z","url":null,"abstract":"<p><p>This study performs a comprehensive in-silico multi-omic analysis to explore the genetic and molecular mechanisms of Multiple Sclerosis (MS), highlighting its psychoneuroimmunology link to stress-related pathways. High-throughput data from the Gene Expression Omnibus focused on corpus callosum gene expression, a key region in MS pathology. Using GEO2R, significant differentially expressed genes in MS were identified, followed by pathway analysis through KEGG databases to uncover implicated biological pathways. Functional enrichment and network analyses via DAVID and Cytoscape highlighted core biological processes, focusing on heat shock proteins and immune signalling pathways. Additionally, genome-wide association study (GWAS) data identified MS-associated genetic loci, aiding in building a robust multi-omic profile. A protein-protein interaction network using STRING emphasized key stress protein interactions: DNAJB1, HSPA6, HSPB1, and HSPH1. This integrative study provides a detailed framework linking psychoneuroimmunological pathways to MS pathology, identifying potential therapeutic targets and biomarkers, enhancing the understanding of MS's complex aetiology, and paving the way for novel interventions in stress-related neurological disorders.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of psychological resilience in adult patients with epilepsy: a cross-sectional study.","authors":"Qing Fu, Yue Huang, De-Feng Liu","doi":"10.1007/s13760-025-02856-2","DOIUrl":"https://doi.org/10.1007/s13760-025-02856-2","url":null,"abstract":"<p><strong>Background: </strong>Psychological resilience plays a crucial role in the quality of life and mental health of patients with epilepsy (PWE). However, there is limited research on the factors influencing psychological resilience in Chinese PWE. This study aimed to investigate the determinants of psychological resilience in PWE and explore the relationship between neurological health status and resilience.</p><p><strong>Methods: </strong>A cross-sectional study was conducted with 80 PWE recruited from a single center in China. Psychological resilience was assessed using the Connor-Davidson Resilience Scale (CD-RISC), and neurological health status was evaluated using the Neurological Health Status Scale (NHS3). Demographic and clinical data, including age, gender, education level, marital status, employment status, monthly household income, residential area, disease duration, seizure type, and seizure frequency, were collected. Multiple linear regression analysis was performed to identify factors associated with psychological resilience.</p><p><strong>Results: </strong>The mean CD-RISC score for PWE was 51.3 ± 11.12. Univariate analysis showed that male gender, higher education level, married status, urban residence, shorter disease duration (≤ 5 years), focal seizures, lower seizure frequency (1-3 times per month), and absence of status epilepticus history were associated with higher resilience scores. Multiple linear regression analysis identified gender (P = 0.012), education level (P = 0.013), disease duration (P = 0.001), seizure frequency (P = 0.001), and NHS3 score (P = 0.031) as significant predictors of psychological resilience. The model was statistically significant (F = 16.217, p < 0.001) and explained 67.6% of the variance (R²=0.676).</p><p><strong>Conclusion: </strong>This study highlights the key factors influencing psychological resilience in Chinese PWE, emphasizing the impact of gender, education level, disease duration, seizure frequency, and neurological health status. The findings suggest that targeted psychological interventions, educational support, and improved healthcare access are crucial for enhancing resilience in PWE. Additionally, addressing social stigma and promoting epilepsy awareness in China may further improve the psychological well-being of patients.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nervous system tumors as subject of multidisciplinary oncological consult.","authors":"Laurens Dobbels, Bernard Hanseeuw, Ludo Vanopdenbosch, Anne Sieben, Patrick Cras","doi":"10.1007/s13760-025-02847-3","DOIUrl":"https://doi.org/10.1007/s13760-025-02847-3","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endocrinopathy, dystonia, and tremor in a patient with homozygous MRPL49 mutation.","authors":"Mehri Salari, Mahdieh Afroozian, Kamran Rezaei, Masoud Etemadifar","doi":"10.1007/s13760-025-02850-8","DOIUrl":"https://doi.org/10.1007/s13760-025-02850-8","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insufficient awareness of the disease and reproductive health issues in persons with multiple sclerosis.","authors":"Olivera Tamas, Nevena Veljancic, Marija Kovacevic, Nikola Veselinovic, Maja Budimkic, Nikola Momcilovic, Marko Andabaka, Sarlota Mesaros","doi":"10.1007/s13760-025-02844-6","DOIUrl":"https://doi.org/10.1007/s13760-025-02844-6","url":null,"abstract":"<p><strong>Objective: </strong>Multiple sclerosis (MS) is a chronic immune-mediated demyelinating disease of the central nervous system that predominantly affects women of reproductive age. With ongoing therapeutic advances, ending common misconceptions related to the disease and pregnancy in MS is crucial for the adherence to MS treatment. The aim of our research was to assess the level of knowledge of MS as a disease in general, to estimate the awareness of reproductive issues in MS, and to evaluate the primary sources of information in persons with MS (PwMS) and persons without MS.</p><p><strong>Material and methods: </strong>The study included female PwMS aged 18-49 years and male PwMS aged 18-65 years, who were matched with persons without MS of the same age, gender, and education. After obtaining informed consent, participants filled out an online questionnaire distributed via electronic mail between November 1st, 2022 and November 1st, 2023. The questionnaire consisted of a different statements regarding the clinical aspects of MS, pregnancy and reproductive health, primary source of information and subjective assessment of the knowledge.</p><p><strong>Results: </strong>The study included 410 PwMS and 400 persons without MS. The survey has shown higher levels of knowledge related to the disease in the PwMS group. Seven in ten PwMS disagreed with the false statement that all PwMS at some point lose the ability to walk, while 39.2% of persons without MS agreed. On the other hand, the most common answer, for all study participants, related to reproductive issues in MS was \"I do not know\". Over two-thirds of PwMS did not have an answer to the question related to the benefits of breastfeeding. The primary source of information for the PwMS group were neurologists (82.7%) and for persons without MS the Internet (54.4%). Persons with MS additionally received information from MS nurses. Both PwMS and persons without MS subjectively evaluated their level of knowledge as an inadequate (49.3% vs. 77.5%).</p><p><strong>Conclusion: </strong>People with MS still have a low level of information concerning reproductive issues while a considerable number of respondents recognized a deficit of adequate information regarding MS. Availability and validity of information are key aspects to consider in the future. Improvements in access to verified information is needed with an emphasis on reproductive issues.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neck muscle hypertrophy in paramyotonia congenita caused by a missense variant in the SCN4A gene (p.Val445Met).","authors":"Farsana Mustafa, Divyani Garg, Ayush Agarwal, Achal Kumar Srivastava","doi":"10.1007/s13760-025-02849-1","DOIUrl":"https://doi.org/10.1007/s13760-025-02849-1","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Could serum IGF-1 and IGF-2 serve as potential biomarkers in idiopathic Parkinson’s disease? A correlation with disease stages","authors":"Ezgi Ayse Cakir,&nbsp;Ayşegül Özyılmaz,&nbsp;Merve Alpay,&nbsp;Sare Uyurca","doi":"10.1007/s13760-025-02839-3","DOIUrl":"10.1007/s13760-025-02839-3","url":null,"abstract":"<div><h3>Introduction</h3><p>Idiopathic Parkinson’s Disease (IPD) is a progressive neurodegenerative disorder characterized by tremor, rigidity, akinesia, and postural instability. Dysfunction in lysosomal autophagy, involving proteins like IGF-1(insulin like growth factor) and IGF-2, contributes to neuroinflammation and neuronal death. Reliable biomarkers for IPD diagnosis and monitoring remain elusive. This study investigates serum IGF-1 and IGF-2 levels to evaluate their biomarker potential.</p><h3>Methods</h3><p>Eighty-four individuals (43 IPD patients, 41 controls) aged 18–79 were included. Diagnoses followed the UK Brain Bank Criteria; disease severity was assessed with Hoehn &amp; Yahr (H&amp;Y) and UPDRS scales. Serum IGF-1 and IGF-2 levels were measured using ELISA. Statistical analyses were performed using SPSS v30.0. Normality was assessed via the Shapiro-Wilk test. Based on data distribution, Independent Samples t-test, Mann-Whitney U, Chi-square, Kruskal-Wallis, Spearman correlation, and ROC analysis were applied. A p-value &lt; 0.05 was considered statistically significant.</p><h3>Results</h3><p>Serum IGF-2 levels were significantly higher in patients compared to controls (<i>p</i> = 0.006), while IGF-1 levels showed no significant difference. Both IGF-1 and IGF-2 levels displayed negatively correlated with disease duration (<i>p</i> = 0.044 and <i>p</i> = 0.008). Although IGF-1 and IGF-2 levels appeared elevated at H&amp;Y stage 2, the differences were not statistically significant. No significant associations were observed between IGF levels and UPDRS scores or medication use.</p><h3>Conclusion</h3><p>Elevated serum IGF-2 levels indicate its potential as a biomarker for IPD. These findings contribute to a better understanding of the role of IGF-1 and IGF-2 in IPD pathophysiology, suggesting that further multicenter studies are needed to clarify their diagnostic and therapeutic potential.</p></div>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":"125 4","pages":"1083 - 1090"},"PeriodicalIF":2.1,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Achieving complete recanalization is the best predicting factor of good outcome for thrombectomy in the elderly. Results from a prospective monocentric study.","authors":"Manar Abomulay, Philippe Desfontaines, Carla Ciobanu, Denis Brisbois, Olivier Cornet, François Dister, François Delvoye","doi":"10.1007/s13760-025-02846-4","DOIUrl":"https://doi.org/10.1007/s13760-025-02846-4","url":null,"abstract":"<p><strong>Background and aims: </strong>Little is known about predicting factors for a good outcome (GO) after endovascular treatment (EVT) performed for acute ischemic stroke (AIS) related to large vessel occlusion (LVO) in the over-80s population. We evaluate demographic and procedural predictors of GO from our prospective registry of patients treated during the acute phase of an LVO-related AIS.</p><p><strong>Methods: </strong>GO was defined as a 3-month modified Rankin scale (mRS) [Formula: see text] 3 or equivalent to pre-stroke mRS. Univariate (UVA) and multivariate (MVA) analysis were performed to assess the factors' independent effect on the outcome. The magnitude of the between-group differences was assessed by calculating the standardized differences (StD). Variables with StD >0,2 were included in the MVA.</p><p><strong>Results: </strong>From 182 patients aged ≥ 80, 3-month GO was observed in 31.3% (57/182). The proportion of TICI ≥ 2c-3 was significantly lower in the poor outcome (PO) group compared to the GO group (52% versus 78.9%, StD = 0.591). In univariate logistic regression model, TICI ≥ 2c-3 is associated with a 277% increase in the chances of a GO (OR = 3.77, 95%CI 1.79-7.97, P < 0.001). This association remained significant in multivariate logistic regression model (aOR = 0.77, 95%CI 0.66-0.89, P = 0.000501) even when a hemorrhagic transformation (HT) occurs (p het = 0.57948).</p><p><strong>Conclusions: </strong>We show that achieving a TICI score of 2c-3 seems to be the best predictive factor for the outcome in the elderly population. In this group, every effort should be made to achieve excellent recanalization.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimated glucose disposal rate is correlated with decreased parkinson's disease: a population-based study.","authors":"Wenting Hu, Hai Liu, Ying Zhang, Huanxian Liu","doi":"10.1007/s13760-025-02845-5","DOIUrl":"https://doi.org/10.1007/s13760-025-02845-5","url":null,"abstract":"<p><strong>Background: </strong>Increasing evidence suggests that insulin resistance (IR) plays a key role in Parkinson's disease (PD). This study aimed to investigate the relationship between the estimated glucose disposal rate (eGDR), a practical and noninvasive measure for assessing IR, and PD prevalence.</p><p><strong>Methods: </strong>We conducted a population-based cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) 1999-2020. Weighted multivariable logistic regression was used to examine the association between eGDR and PD, adjusting for confounders. A restricted cubic spline (RCS) model was employed to examine the possible non-linear dose-response relationship. Subgroup analysis and sensitivity analysis were conducted to validate the robustness of the results.</p><p><strong>Results: </strong>A total of 37,951 adults aged 20 years or older were included in the study. A significant inverse association between eGDR and PD prevalence was observed. Each 1-unit increase in eGDR was associated with a 17% reduction in the likelihood of PD (OR = 0.73, 95% CI: 0.62, 0.85, P < 0.001). Participants with the higher eGDR (4-5.99, 6-7.99, and ≥ 8 mg/kg/min) had a significantly lower prevalence of PD compared to those with the lowest eGDR (< 4 mg/kg/min). The reductions in PD prevalence were 58% (OR = 0.42; 95% CI: 0.24, 0.74; P = 0.003), 56% (OR = 0.44; 95% CI: 0.25, 0.77; P = 0.004), and 79% (OR = 0.21; 95% CI: 0.06, 0.68; P = 0.010), respectively. RCS analysis indicated a linear inverse association between eGDR and PD prevalence. Subgroup and sensitivity analyses further confirmed the consistency of these findings.</p><p><strong>Conclusion: </strong>Higher eGDR, reflecting improved insulin sensitivity, is associated with a reduced prevalence of PD.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}