Acta neurologica Belgica最新文献

{"title":"Age-stratified clinical characteristics and disability outcomes in neuromyelitis optica spectrum disorder: A cross-sectional study.","authors":"Omid Mirmosayyeb, Mehra Fekri, Mohammad Yazdan Panah, Mohammad Mohammadi, Saeed Vaheb, Vahid Shaygannejad","doi":"10.1007/s13760-026-03179-6","DOIUrl":"https://doi.org/10.1007/s13760-026-03179-6","url":null,"abstract":"<p><strong>Background: </strong>Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease of the central nervous system in individuals of any age group. Age-related differences may influence disease severity, treatment response, and long-term functional outcomes. However, age-related characteristics of pediatric-onset (PO-), early-onset (EO-), and late-onset (LO-) NMOSD remain incompletely understood. The purpose of this study was to compare these three groups in various features and to identify the relationship between age at initial disease presentation and disability profile in NMOSD.</p><p><strong>Methods: </strong>This study included 72 AQP4-positive NMOSD patients in Isfahan, Iran, between March and November 2024. Patients were categorized based on age at NMOSD diagnosis into PO (< 18 years), EO (18-49 years), and LO (≥ 50 years) groups. Logistic regression analysis was used to evaluate the associations between age at NMOSD diagnosis and disability.</p><p><strong>Results: </strong>Among 72 patients, 6 were classified as PO-NMOSD, 55 as EO-NMOSD, and 11 as LO-NMOSD. Age at NMOSD diagnosis was positively correlated with EDSS at disease diagnosis (r = 0.42, p < 0.001) and current EDSS (r = 0.37, p = 0.002). In multivariable analysis, older age at NMOSD diagnosis was significantly associated with both higher disability at diagnosis (OR = 1.14, p < 0.001) and current disability status (OR = 1.1, p < 0.001).</p><p><strong>Conclusion: </strong>Older age at NMOSD diagnosis may be associated with greater disability burden. Age at diagnosis may represent a relevant clinical factor when evaluating disability burden in NMOSD. Further prospective multicenter studies are warranted to better define longitudinal outcomes and prognostic factors in LO-NMOSD.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-invasive neuromodulation for LUTS in Parkinson's disease: a comprehensive systematic review and meta-analysis of tibial nerve stimulation with GRADE evaluation.","authors":"Mohamed F Abo-Elsoad, Ahmed W Abbas, Amr M Abou Elezz, Mohamed Abo Zaid, Alaa N Ahmed, Omar Hewezy, Ahmed Talkhan","doi":"10.1007/s13760-026-03163-0","DOIUrl":"https://doi.org/10.1007/s13760-026-03163-0","url":null,"abstract":"<p><strong>Background: </strong>Lower urinary tract symptoms (LUTS) are a common and burdensome part of Parkinson's disease (PD). Conventional treatments are inconsistently effective, making minimally invasive options like tibial nerve stimulation (TNS) promising. However, evidence for TNS in PD patients remains limited and varied.</p><p><strong>Purpose: </strong>To evaluate the efficacy of TNS (percutaneous and transcutaneous) for LUTS in patients with PD, focusing on both subjective symptom outcomes and objective urodynamic parameters through a systematic review and meta-analysis.</p><p><strong>Methods: </strong>A systematic search identified relevant randomized controlled trials (RCTs) and prospective single-arm studies on PTNS efficacy. Data were analyzed using RevMan Cochrane software (v5.4) and R (v4.3.2), with results pooled as mean difference (MD) or standardized mean difference (SMD) and 95% confidence intervals. Meta-regression assessed the influence of PD duration.</p><p><strong>Results: </strong>Seven studies (three RCTs and four prospective cohorts) were included in this review, with a total of 591 participants. TNS improved urodynamic outcomes, including first involuntary detrusor contraction volume (+ 107.49 mL, 95% CI 99.43 to 115.56), maximum cystometric capacity (+ 90 mL, 95% CI 83.14 to 96.84), and detrusor pressures (Pdetmax and PdetQmax reductions). In contrast, pooled evidence remained heterogeneous and inconsistent for patient-reported outcomes, including urgency, frequency, incontinence, and nocturia. Meta-regression analysis revealed no significant association between PD duration and treatment response.</p><p><strong>Conclusions: </strong>TNS improved urodynamic function in PD patients, but this objective improvement does not consistently translate to subjective symptom relief, highlighting the complexity of PD-related LUTS. Future adoption requires larger, standardized RCTs with extended follow-up to identify which patients benefit most.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postinfectious acute disseminated encephalomyelitis in a young adult: serial MRI documentation.","authors":"Francisco Peñaranda, Isaac Eli Martínez Safar, Catalina Wilches Vanegas, Ana M Rendón-Garavito","doi":"10.1007/s13760-026-03174-x","DOIUrl":"https://doi.org/10.1007/s13760-026-03174-x","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term efficacy and predictors of response to greater occipital nerve pulsed radiofrequency in migraine with prior preventive treatment failure.","authors":"Gulcin Babaoglu, Sukriye Dadali, Ulku Sabuncu, Ali Costu, Erkan Yavuz Akcaboy","doi":"10.1007/s13760-026-03178-7","DOIUrl":"https://doi.org/10.1007/s13760-026-03178-7","url":null,"abstract":"<p><strong>Background: </strong>Migraine with prior preventive treatment failure represents a significant clinical challenge. While Greater Occipital Nerve (GON) Pulsed Radiofrequency (PRF) is a promising intervention, data regarding its long-term efficacy are limited. This study aimed to evaluate the one-year efficacy of ultrasound-guided GON PRF in this patient population and to identify predictors of a sustained clinical response.</p><p><strong>Methods: </strong>This retrospective cohort study included 116 adults with migraine and prior preventive treatment failure. The primary endpoint was achievement of the Patient Acceptable Symptom State (PASS) at 12 months, which defined responders. Secondary endpoints included changes in monthly headache days (MHDs), visual analog scale (VAS) scores, patient-perceived improvement assessed using the 7-point Global Perceived Effect (GPE) scale, and treatment durability assessed by Kaplan-Meier analysis. Predictors of response were explored using multivariable logistic regression.</p><p><strong>Results: </strong>At 12 months, 70 of 116 patients (60.3%) achieved the PASS and were classified as responders. Significant reductions were achieved in mean MHDs (from 14.3 to 6.1, p < 0.001) and mean VAS scores (from 6.6 to 5.6, p < 0.05). Kaplan-Meier analysis estimated a 60.3% probability of sustained benefit at one year. Overall, 53.4% of patients reported > 75% improvement on the GPE scale. A strong clinical response at one month was significantly associated with one-year success. Higher baseline mean VAS score was the only independent predictor of long-term success (OR: 1.62).</p><p><strong>Conclusion: </strong>GON PRF provides significant and durable clinical benefits for patients with migraine and prior preventive treatment failure. This minimally invasive procedure may represent an effective long-term therapeutic option, and a positive early response may predict sustained clinical success.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intramedullary hemorrhage and early motor recovery as predictors of neurological recovery after acute cervical spinal cord injury.","authors":"Jile Xie, Zhidong Wang, Genlin Wang, Mao Li, Junjie Niu","doi":"10.1007/s13760-026-03132-7","DOIUrl":"https://doi.org/10.1007/s13760-026-03132-7","url":null,"abstract":"<p><strong>Objective: </strong>To investigate prognostic factors associated with neurological recovery in patients with acute cervical spinal cord injury (CSCI) with intramedullary hemorrhage and edema on magnetic resonance imaging (MRI).</p><p><strong>Methods: </strong>We retrospectively reviewed 93 patients with acute CSCI who showed intramedullary hemorrhage and edema on MRI and underwent surgery. Clinical and radiological data were collected, including intramedullary edema length (IEL), intramedullary hematoma length (IHL), maximum spinal cord compression (MSCC), preoperative American Spinal Injury Association (ASIA) motor score (AMS), and early postoperative AMS recovery rate. Neurological recovery was defined as improvement of at least 1 grade on the ASIA Impairment Scale (AIS) at 6 months. Univariate analysis and multivariate binary logistic regression were performed to identify independent predictors of neurological recovery.</p><p><strong>Results: </strong>Among the 93 patients, 67 (72.0%) showed neurological improvement at 6 months, whereas 26 (28.0%) did not. There were no significant differences between the recovery and non-recovery groups in age, sex, or injury mechanism. Univariate analysis showed that IEL, IHL, MSCC, postoperative AMS, and early AMS recovery rate were associated with neurological recovery. Multivariate logistic regression demonstrated that preoperative IHL was an independent negative predictor of neurological recovery (OR = 0.664, 95% CI 0.475-0.929), whereas early postoperative AMS recovery rate was an independent positive predictor (OR = 1.269, 95% CI 1.014-1.588). IEL and MSCC were not independently associated with recovery.</p><p><strong>Conclusion: </strong>In acute CSCI patients with intramedullary hemorrhage and edema, preoperative IHL and early postoperative AMS recovery rate are independent predictors of 6-month neurological recovery. Combining these indicators has prognostic value in assessing neurological recovery of CSCI patients.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroimaging biomarkers of the brain-heart axis in Takotsubo syndrome: regional convergence without directional consistency: a systematic review and biomarker qualification appraisal.","authors":"Abiya Ahad, Sultan Mujib Dabiry, Tanya Singh, Aakash Jain, Ghezal Dabiry","doi":"10.1007/s13760-026-03172-z","DOIUrl":"https://doi.org/10.1007/s13760-026-03172-z","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Takotsubo syndrome (TTS) is an acute stress-induced cardiomyopathy increasingly recognised as a disorder of the brain-heart axis. Neuroimaging studies have identified structural, functional and metabolic abnormalities within the central autonomic network, particularly the amygdala. Still, the role of amygdalar activity as a biomarker in TTS has not been systematically synthesised.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A systematic review was conducted according to PRISMA guidelines and registered in PROSPERO (CRD420251177487). PubMed, Web of Science, Cochrane Library, Google Scholar and ClinicalTrials.gov were searched through February 2025 for studies reporting neuroimaging findings in confirmed TTS. Data were extracted, narratively synthesised, and appraised against biomarker-qualification criteria. Directional consistency was additionally quantified by vote counting with exact binomial (sign) tests at the level of study-region-imaging domain, with Holm correction for multiplicity and sensitivity analyses excluding studies at high risk of bias.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The search identified 489 records, of which 29 underwent full-text assessment; 10 studies met the inclusion criteria. Multimodal neuroimaging consistently implicated the amygdala, insula, hippocampus, thalamus, anterior cingulate and prefrontal cortex, with reduced amygdalar and insular grey matter, altered limbic structural connectivity, and disrupted central autonomic and default mode network connectivity. Two ¹⁸F-FDG PET/CT cohorts, the only included studies in which imaging preceded the outcome, found raised amygdalar metabolic activity before TTS onset that independently predicted subsequent syndrome development; the remaining eight were cross-sectional and cannot separate predisposition from consequence. Convergent, though directionally inconsistent, evidence supports a working model of chronic limbic sensitisation and exaggerated sympathoadrenal activation contributing to myocardial stunning. Vote counting confirmed that an abnormality was reported by almost every study assessing the amygdala (8/9), insula (6/6), prefrontal cortex (6/6) and hippocampus (5/5), but no region survived correction for multiplicity, and only the prefrontal cortex approached directional consistency (5/5 reduced; p = 0.062); amygdalar findings were directionally split (4 increased versus 3 decreased; p = 1.00). Excluding the two studies at high risk of bias altered no conclusion.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Neuroimaging findings support TTS as a neurocardiac disorder characterised by dysfunction of limbic and autonomic brain networks. Amygdalar hyperactivity is the most frequently reported candidate marker of vulnerability, but none of these findings is clinically actionable, and the reasons are specific rather than generic: effect sizes are modest (Cohen's d = 0.37-0.53), the direction of abnormality is inconsistent for every region except the prefrontal c","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional normal-appearing white matter metabolic profiles and cognition in early relapsing-remitting multiple sclerosis: a multi-voxel proton magnetic resonance spectroscopy study.","authors":"Lorand Sakalaš, Vesna Suknjaja, Jasmina Boban","doi":"10.1007/s13760-026-03171-0","DOIUrl":"https://doi.org/10.1007/s13760-026-03171-0","url":null,"abstract":"<p><strong>Background: </strong>Cognitive impairment in multiple sclerosis (MS) is common but only weakly explained by conventional magnetic resonance imaging. Proton magnetic resonance spectroscopy (¹H-MRS) detects microstructural damage in normal-appearing white matter (NAWM). We examined whether regional NAWM metabolic profiles are spatially patterned in early relapsing-remitting MS (RRMS) and whether they relate to cognition.</p><p><strong>Methods: </strong>In this cross-sectional study, 52 patients with early RRMS (Expanded Disability Status Scale 0-3; 51 with usable spectroscopy) and 44 matched controls underwent multi-voxel three-dimensional ¹H-MRS at 3 tesla across six supracallosal NAWM regions. Group differences used Mann-Whitney tests with false discovery rate correction, and a group × region analysis tested for disease-related disruption. NAA/Cr-cognition associations used Spearman and partial correlations and multivariable models.</p><p><strong>Results: </strong>NAA/Cr differed between groups in four of six regions, and a group × region interaction (p < 0.001) indicated that the regional NAA/Cr pattern in RRMS was disrupted beyond the physiological anterior-posterior gradient seen in controls. Frontal NAA/Cr correlated with processing speed (ρ = 0.350, p = 0.012) and parietal NAA/Cr with verbal learning (ρ = 0.327, p = 0.019), but neither survived adjustment for age or parsimonious modelling, in which disability was the main independent correlate of processing speed.</p><p><strong>Conclusion: </strong>Early RRMS shows spatially organised NAWM metabolic disruption. Regional NAA/Cr-cognition associations are detectable but weak and not independent of age or disability, and frontal NAWM integrity relates more to physical function than cognition, supporting a network-disconnection model with limited cognitive specificity. These findings are preliminary and need longitudinal confirmation.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recognising and differentiating paroxysmal sympathetic hyperactivity after severe traumatic brain injury: a practical diagnostic approach.","authors":"Mohammed Waleed Abdullah","doi":"10.1007/s13760-026-03176-9","DOIUrl":"https://doi.org/10.1007/s13760-026-03176-9","url":null,"abstract":"<p><p>Paroxysmal sympathetic hyperactivity (PSH) is a syndrome seen in a subgroup of survivors of severe acquired brain injury, most often traumatic, in which episodic surges of sympathetic activity occur together with motor over-activity, typically dystonic posturing. It is associated with longer intensive care stays, more complications, and worse outcomes, yet remains under-recognised. The difficulty is twofold: its core features overlap with the common emergencies of the intensive care unit, so that sepsis, seizures, pulmonary embolism, and drug-related syndromes are reasonably considered first; and no biomarker or imaging finding confirms it. This review offers a practical two-part approach for the patient with severe traumatic brain injury: how to recognise the syndrome positively, using the consensus definition and the PSH Assessment Measure, and how to differentiate it from its mimics. The differential is extended beyond the conditions usually listed to include autonomic dysreflexia, iatrogenic and substance withdrawal, endocrine emergencies, non-convulsive status epilepticus, unrelieved pain, and drug-induced autonomic instability, and the limitations of the evidence are examined rather than assumed. Attention is given to the pitfalls that cause delay and to the frequent coexistence of PSH with conditions such as sepsis. The evidence is drawn into a stepwise framework which has not been prospectively validated and is offered as an educational aid rather than a clinical guideline. Throughout, the emphasis falls on serial reassessment and dynamic reasoning, since substantial diagnostic uncertainty commonly persists.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of combined virtual reality assisted gait training and proprioceptive neuromuscular facilitation on motor function in children with spastic cerebral palsy: a randomized controlled trial.","authors":"Jian Liang, Mengyuan Shu, Jiahe Liu, Lintao Wang, Yunrui Liu, Yiqian Li, Mingyi Ma, Guzalinur Yushan, Fang Li, Jinfeng Zhao","doi":"10.1007/s13760-026-03173-y","DOIUrl":"https://doi.org/10.1007/s13760-026-03173-y","url":null,"abstract":"<p><strong>Background: </strong>Spastic cerebral palsy (CP) is characterized by impaired motor function, particularly in the lower limbs. Although both virtual reality (VR)-assisted gait training and proprioceptive neuromuscular facilitation (PNF) have demonstrated beneficial effects, evidence regarding their combined application remains limited.</p><p><strong>Objective: </strong>This exploratory study aimed to explore the effects of combined VR-assisted gait training and PNF on lower-limb motor function in children with spastic CP.</p><p><strong>Methods: </strong>Thirty children with spastic CP were randomly assigned to a conventional rehabilitation group (CG), a VR training group, or a combined VR and PNF group (PNF + VR), with 10 participants in each group. All participants underwent a 12-week intervention program. The primary outcomes were Gross Motor Function Measure-88 (GMFM-88) dimensions D (GMFM-88D) and E (GMFM-88E); secondary outcomes included the Modified Ashworth Scale (MAS), Berg Balance Scale (BBS), lower-limb Fugl-Meyer Assessment (FMA), range of motion (ROM), and bone mineral density (BMD). A two-way mixed analysis of variance (ANOVA) was used to evaluate group-by-time interactions, with post hoc comparisons of change scores used as supportive analyses.</p><p><strong>Results: </strong>All groups showed improvements in functional outcomes after the intervention. Significant group × time interaction effects were observed for GMFM-88D, MAS, FMA, and ROM (p < 0.05), with the PNF + VR group demonstrating the greatest improvements. Although GMFM-88E improved significantly in the PNF + VR group, as indicated by change-score comparisons, the interaction effect was not statistically significant. No significant interaction effects were found for BBS or BMD (p > 0.05).</p><p><strong>Conclusion: </strong>The combination of VR-assisted gait training and PNF may provide additional benefits in improving lower-limb motor function in children with spastic CP compared with conventional rehabilitation or VR training alone.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-584-5p suppresses Aβ_1-42-induced apoptosis in Alzheimer's disease cell model via targeting of HDAC1.","authors":"Lingyan Cheng, Pingting Gong, Xiaofeng Su, Yika Fang, Tao Wang","doi":"10.1007/s13760-026-03170-1","DOIUrl":"https://doi.org/10.1007/s13760-026-03170-1","url":null,"abstract":"<p><strong>Background: </strong>Alzheimer's disease (AD) represents a profoundly detrimental neurodegenerative disorder, and early diagnosis coupled with effective treatment remains a major clinical challenge. MicroRNAs (miRNAs) have emerged as key regulators associated with pathological processes in AD.</p><p><strong>Aim: </strong>This study aimed to explore the expression pattern and the likely diagnostic value of miR-584-5p in AD, as well as its molecular mechanism of action in regulating β-amyloid (Aβ)-induced apoptosis.</p><p><strong>Methods: </strong>Peripheral blood samples from 90 AD patients and age- and sex-matched controls were examined using RT-qPCR. Correlation analyses of miR-584-5p expression with key AD biomarkers (Aβ₄₂, tTau, pTau) were performed in AD patients. Following exposure to 5 µM Aβ_1-42, SH-SY5Y cells were employed in subsequent functional experiments. Bioinformatics analysis, a dual-luciferase reporter assay, and negative correlation analysis of plasma samples were conducted to verify the target gene of miR-584-5p.</p><p><strong>Results: </strong>miR-584-5p was significantly downregulated in AD patients, and its expression correlated with Aβ₄₂ (r = 0.665), total tau (tTau, r = -0.642), phosphorylated tau (pTau, r = -0.576), and Mini-Mental State Examination (MMSE) scores (r = 0.618), yielding an AUC of 0.864 in this single-center cohort. miR-584-5p overexpression inhibited 5 µM Aβ_1-42-induced apoptosis in SH-SY5Y cells, an effect that was reversed by concurrent HDAC1 overexpression. Mechanistically, by targeting HDAC1, miR-584-5p modulates p53 acetylation and the Bcl-2/Bax pathway at the protein level.</p><p><strong>Conclusions: </strong>miR-584-5p exerted neuroprotective effects via the miR-584-5p/HDAC1 axis, offering new insights into AD pathogenesis and suggesting this axis as a candidate for further preclinical investigation.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}