Acta neurologica Belgica最新文献_第5页

Late Adulthood Onset POLG Disease Presenting as Spastic Paraplegia: A Pathophysiological Continuum? 成年晚期发病的POLG疾病表现为痉挛性截瘫：病理生理连续体？

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-09-04 DOI: 10.1007/s13760-025-02878-w

Shreyashi Jha, Mandar Jog

引用次数: 0

Rapid progression of cerebral amyloid angiopathy following coil embolization for vertebral artery dissection: A case report. 椎动脉夹层线圈栓塞后脑淀粉样血管病的快速进展：1例报告。

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-09-02 DOI: 10.1007/s13760-025-02885-x

Yuya Kobayashi, Minori Kurashina, Tetsuo Sasaki, Tsuneaki Yoshinaga, Yoshiki Sekijima

引用次数: 0

Zilucoplan in myasthenic crisis refractory to conventional treatment: a report of two cases. Zilucoplan治疗常规治疗难治性肌无力危象2例报告。

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-09-02 DOI: 10.1007/s13760-025-02860-6

Ari Maruani, Sophie Demeret, Mathilde Piljan, Nicolas Weiss, Clémence Marois

引用次数: 0

Risk of psychosis following mild traumatic brain injury: a systematic review and meta-analysis 轻度创伤性脑损伤后精神病的风险：一项系统回顾和荟萃分析。

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-09-02 DOI: 10.1007/s13760-025-02883-z

Akinwale Aguda, Ioannis Mavroudis

{"title":"Risk of psychosis following mild traumatic brain injury: a systematic review and meta-analysis","authors":"Akinwale Aguda, Ioannis Mavroudis","doi":"10.1007/s13760-025-02883-z","DOIUrl":"10.1007/s13760-025-02883-z","url":null,"abstract":"<div><h3>Background</h3>Mild traumatic brain injury (mTBI), commonly known as concussion, has historically been regarded as a transient and benign condition. However, recent studies suggest it may increase the risk of long-term psychiatric outcomes, including psychosis. This study aimed to systematically review and meta-analyze the association between mTBI and subsequent risk of psychosis.<h3>Methods</h3>A comprehensive search of PubMed, PsycINFO, and Google Scholar was conducted through June 2025. Studies were eligible if they included individuals with a history of mTBI, a non-TBI control group, and reported psychosis-related outcomes with estimable risk measures. Random-effects meta-analysis was performed using the metafor package in R. Risk of bias and publication bias were assessed, and meta-regression was conducted to explore moderators such as adjustment status and effect size type.<h3>Results</h3>Seven studies comprising pediatric and adult populations were included. The pooled risk ratio (RR) for psychosis following mTBI was 1.57 (95% CI: 1.28–1.91, p < 0.001), indicating a statistically significant association. The 95% prediction interval (1.03–2.38) suggests generalizability across future studies. No significant publication bias was detected (Egger’s test p = 0.10). Meta-regression found no difference between adjusted and unadjusted estimates (p = 0.802). Sensitivity analyses confirmed the robustness of the findings.<h3>Conclusions</h3>mTBI is associated with a moderate but statistically significant increase in the risk of psychosis. Given the prevalence of mTBI in the general population, these findings highlight the need for long-term psychiatric monitoring and preventive strategies, particularly in youth and high-risk individuals.</div>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":"125 5","pages":"1373 - 1383"},"PeriodicalIF":2.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disulfiram-Ethanol reaction mimicking posterior circulation stroke: A case report. 双硫仑-乙醇反应模拟后循环卒中1例报告。

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-09-01 DOI: 10.1007/s13760-025-02879-9

Alessandro Trebbastoni, Fabrizio Sallustio

引用次数: 0

Pneumocephalus in pneumococcal meningitis. 肺炎球菌性脑膜炎中的气脑。

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-09-01 DOI: 10.1007/s13760-025-02882-0

L Van Avermaet, S Proost, G Vangrinsven, P G Jorens, L Yperzeele

引用次数: 0

Successful treatment of Charles Bonnet syndrome after cerebellar stroke in a patient with binocular macular degeneration with low dose brexpiprazole: a case report. 小剂量布雷哌唑成功治疗双目黄斑变性小脑卒中后Charles Bonnet综合征1例。

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-08-31 DOI: 10.1007/s13760-025-02886-w

Okan Ekinci

引用次数: 0

The prevalence of restless legs syndrome among university students: a single-centre study. 不宁腿综合征在大学生中的流行：一项单中心研究。

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-08-27 DOI: 10.1007/s13760-025-02875-z

Burhanettin Çiğdem, Şeyda Figül Gökçe

{"title":"The prevalence of restless legs syndrome among university students: a single-centre study.","authors":"Burhanettin Çiğdem, Şeyda Figül Gökçe","doi":"10.1007/s13760-025-02875-z","DOIUrl":"https://doi.org/10.1007/s13760-025-02875-z","url":null,"abstract":"Introduction: Restless legs syndrome (RLS) is a relatively common movement disorder. Epidemiological data on RLS in young adults remain lacking. The objective of the present study was to determine the prevalence of primer RLS among university students comprising young adults.Methods: The study was performed by two neurologists using the face-to-face survey method. A total of 3,047 students were included in the study. First, secondary causes of RLS were excluded by anamnesis. Then, eligible participants were asked to provide demographic data and answer five questions from the 2014 revised international restless legs syndrome study group (IRLSSG) diagnostic criteria; students who answered \"yes\" to the five questions were considered to have RLS and were invited to the hospital to further exclude secondary causes of RLS using medical data system, neurological examination, and blood tests. The IRLSSG severity scale was applied to measure the severity of the disease.Results: Primary RLS was detected in 78 students comprising 44 females and 34 males, with a prevalence rate of 2.6%. Sleep disorders were more common in individuals with RLS (p = 0.005), and included difficulty falling asleep and waking up frequently (p = 0.001). Of the 78 students with RLS, 32 had first-degree relatives with RLS (41.02%).Conclusion: When the secondary causes of RLS, which adversely affects the quality of life, is excluded, the prevalence of primary RLS in among included university students was 2.6%.","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What causes loss of muscle mass in primary sarcopenia: A MUNIX analysis and correlation with plasma biomarkers. 原发性肌肉减少症患者肌肉质量减少的原因：一项MUNIX分析及其与血浆生物标志物的相关性

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-08-27 DOI: 10.1007/s13760-025-02873-1

Aysegul Akkan Suzan, Seyda Bilgin, Pelin Degirmenci, Nurten Uzun Adatepe, Alper Doventas, Aysegul Gunduz

{"title":"What causes loss of muscle mass in primary sarcopenia: A MUNIX analysis and correlation with plasma biomarkers.","authors":"Aysegul Akkan Suzan, Seyda Bilgin, Pelin Degirmenci, Nurten Uzun Adatepe, Alper Doventas, Aysegul Gunduz","doi":"10.1007/s13760-025-02873-1","DOIUrl":"https://doi.org/10.1007/s13760-025-02873-1","url":null,"abstract":"Introduction: To determine if the loss of muscle mass in primary sarcopenia is secondary to motor neuron loss or directly related to muscle fiber loss using electrophysiological methods.Methods: We recruited individuals with primary sarcopenia and non-sarcopenic individuals of similar age and gender for the study. After a detailed evaluation of geriatric syndromes and neurological disorders through systemic, neurological, and electrophysiological examinations, we recorded the motor unit number index (MUNIX) and motor unit size index (MUSIX) of the first dorsal interosseus (FDI) and tibialis anterior (TA) muscles in all participants.Results: Individuals with sarcopenia exhibited reduced FDI MUNIX and lower TA CMAP amplitude and MUNIX values. The FDI MUNIX showed an inverse correlation with ferritin levels.Discussion: Primary sarcopenia is characterized by motor unit loss without significant reinnervation. Motor unit loss in individuals with sarcopenia can be demonstrated in both the upper and lower extremities using the MUNIX method, and functional iron deficiency contributes to the etiology of primary sarcopenia.Conclusion: Demonstration of motor unit loss in primary sarcopenia supports the hypothesis that the disease has a neuromuscular origin.","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The current status of Charcot-Marie-Tooth disease type 1 A treatment. ①A型腓骨肌萎缩症的治疗现状。

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-08-27 DOI: 10.1007/s13760-025-02881-1

Hongdan Qi, Xin Wang, Bing Wu, Jing Chen, Gang Zhang

{"title":"The current status of Charcot-Marie-Tooth disease type 1 A treatment.","authors":"Hongdan Qi, Xin Wang, Bing Wu, Jing Chen, Gang Zhang","doi":"10.1007/s13760-025-02881-1","DOIUrl":"https://doi.org/10.1007/s13760-025-02881-1","url":null,"abstract":"Charcot-Marie-Tooth disease type 1 A (CMT1A) is the major subtype of hereditary peripheral neuropathies and arises from a 1.5 megabase (Mb) tandem duplication in chromosome 17p11.2-p12 that contains the complete peripheral myelin protein 22 (PMP22) gene. Patients commonly present with progressive weakness and atrophy of the distal muscles, accompanied by hyperalgesia, decreased or absent tendon reflexes, and foot deformities. Current clinical management relies on multidisciplinary supportive care. Recent preclinical studies targeting potential therapeutic strategies for CMT1A have focused on correcting the gene-dose imbalance of PMP22. Notably, PXT3003 has shown phase III clinical efficacy in relieving symptoms and reducing neuropathy, and is expected to be the earliest CMT1A-targeted drug on the market. Gene editing approaches have also shown therapeutic promise in animal models, but off-target effects remain a concern. In addition, the rapid development of induced pluripotent stem cell (iPSC) technology has paved the way for stem cell therapies, which may be a promising therapeutic approach. This article reviews the existing literature on therapeutic strategies for CMT1A and aims to provide a valuable reference for the clinical treatment of CMT1A.","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0