Acta neurologica Belgica最新文献

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Neurological impairments in Duchenne muscular dystrophy: A comprehensive review. 杜氏肌营养不良症的神经损伤:综合综述。
IF 2.1 4区 医学
Acta neurologica Belgica Pub Date : 2025-09-04 DOI: 10.1007/s13760-025-02880-2
Xiao-Fang Zhang, Wenguang Hu, Jie Hu
{"title":"Neurological impairments in Duchenne muscular dystrophy: A comprehensive review.","authors":"Xiao-Fang Zhang, Wenguang Hu, Jie Hu","doi":"10.1007/s13760-025-02880-2","DOIUrl":"https://doi.org/10.1007/s13760-025-02880-2","url":null,"abstract":"<p><p>Duchenne muscular dystrophy, the most prevalent form of muscular dystrophy, is characterized by neurological complications including cognitive impairment, neuropsychiatric disorders, and epilepsy. Neuroimaging investigations have demonstrated structural brain alterations, hemodynamic disturbances, and metabolic dysregulation in individuals with Duchenne muscular dystrophy. These neurological impairments are primarily attributed to cerebral dystrophin deficiency and subsequent downstream molecular/cellular abnormalities, including altered excitation-inhibition balance, blood-brain barrier disruption, calcium dysregulation, and neuroinflammation. Current therapeutic strategies focus on two main methods: (1) enhancing brain expression of truncated dystrophin; (2) addressing downstream consequences of dystrophin loss. This review synthesizes recent literature on the neurological manifestations of Duchenne muscular dystrophy, providing a theoretical framework to inform clinical management strategies.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fear of falling, gait capacity, and dual task performance in multiple sclerosis patients with and without neurogenic overactive bladder. 有或无神经源性膀胱过动症的多发性硬化症患者的跌倒恐惧、步态能力和双重任务表现。
IF 2.1 4区 医学
Acta neurologica Belgica Pub Date : 2025-09-04 DOI: 10.1007/s13760-025-02889-7
Humeyra Kiloatar, Cimen Olcay Demir, Aylin Aydogdu Delibay, Dursun Ceylan, Emine Saygin Uysal
{"title":"Fear of falling, gait capacity, and dual task performance in multiple sclerosis patients with and without neurogenic overactive bladder.","authors":"Humeyra Kiloatar, Cimen Olcay Demir, Aylin Aydogdu Delibay, Dursun Ceylan, Emine Saygin Uysal","doi":"10.1007/s13760-025-02889-7","DOIUrl":"https://doi.org/10.1007/s13760-025-02889-7","url":null,"abstract":"<p><strong>Background: </strong>Overactive bladder (OAB) symptoms significantly affect the independence and quality of life in patient with multiple sclerosis (PwMS) by limiting daily activities. This study aimed to explore differences in fear of falling (FoF), gait, dual-task performance, and self-perceived impact of disease among PwMS with and without OAB.</p><p><strong>Method: </strong>Participants were divided into two groups based on their Overactive Bladder Questionnaire (OAB-V8) scores: OAB (score ≥ 8) and non-OAB (score < 8). Assessments included the Falls Efficacy Scale-International (FES-I) for FoF, the 2-Minute Walk Test (2MWT) for gait capacity, the Dual-Task Questionnaire (DTQ) for dual-task performance, and the Multiple Sclerosis Impact Scale-29 (MSIS-29) for self-perceived impact of disease.</p><p><strong>Results: </strong>The study included 78 PwMS. Significant differences were found between groups in fall history, number of falls, and all outcome measures (OAB-V8, FES-I, DTQ, 2MWT, MSIS-29; p < 0.001). OAB-V8 scores positively correlated with FES-I, DTQ, and MSIS-29 (r = 0.71-0.78, p < 0.001) and negatively with 2MWT (r = -0.38, p < 0.001). Similar patterns were observed between FES-I, DTQ, and MSIS-29, which showed strong positive correlations, while both negatively correlated with 2MWT.</p><p><strong>Conclusion: </strong>PwMS with OAB exhibit higher FoF, poorer gait, and impaired dual-task performance compared to those without OAB. These findings highlight the significant impact of OAB on functional and disease-related outcomes.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Late Adulthood Onset POLG Disease Presenting as Spastic Paraplegia: A Pathophysiological Continuum? 成年晚期发病的POLG疾病表现为痉挛性截瘫:病理生理连续体?
IF 2.1 4区 医学
Acta neurologica Belgica Pub Date : 2025-09-04 DOI: 10.1007/s13760-025-02878-w
Shreyashi Jha, Mandar Jog
{"title":"Late Adulthood Onset POLG Disease Presenting as Spastic Paraplegia: A Pathophysiological Continuum?","authors":"Shreyashi Jha, Mandar Jog","doi":"10.1007/s13760-025-02878-w","DOIUrl":"https://doi.org/10.1007/s13760-025-02878-w","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rapid progression of cerebral amyloid angiopathy following coil embolization for vertebral artery dissection: A case report. 椎动脉夹层线圈栓塞后脑淀粉样血管病的快速进展:1例报告。
IF 2.1 4区 医学
Acta neurologica Belgica Pub Date : 2025-09-02 DOI: 10.1007/s13760-025-02885-x
Yuya Kobayashi, Minori Kurashina, Tetsuo Sasaki, Tsuneaki Yoshinaga, Yoshiki Sekijima
{"title":"Rapid progression of cerebral amyloid angiopathy following coil embolization for vertebral artery dissection: A case report.","authors":"Yuya Kobayashi, Minori Kurashina, Tetsuo Sasaki, Tsuneaki Yoshinaga, Yoshiki Sekijima","doi":"10.1007/s13760-025-02885-x","DOIUrl":"https://doi.org/10.1007/s13760-025-02885-x","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disulfiram-Ethanol reaction mimicking posterior circulation stroke: A case report. 双硫仑-乙醇反应模拟后循环卒中1例报告。
IF 2.1 4区 医学
Acta neurologica Belgica Pub Date : 2025-09-01 DOI: 10.1007/s13760-025-02879-9
Alessandro Trebbastoni, Fabrizio Sallustio
{"title":"Disulfiram-Ethanol reaction mimicking posterior circulation stroke: A case report.","authors":"Alessandro Trebbastoni, Fabrizio Sallustio","doi":"10.1007/s13760-025-02879-9","DOIUrl":"https://doi.org/10.1007/s13760-025-02879-9","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pneumocephalus in pneumococcal meningitis. 肺炎球菌性脑膜炎中的气脑。
IF 2.1 4区 医学
Acta neurologica Belgica Pub Date : 2025-09-01 DOI: 10.1007/s13760-025-02882-0
L Van Avermaet, S Proost, G Vangrinsven, P G Jorens, L Yperzeele
{"title":"Pneumocephalus in pneumococcal meningitis.","authors":"L Van Avermaet, S Proost, G Vangrinsven, P G Jorens, L Yperzeele","doi":"10.1007/s13760-025-02882-0","DOIUrl":"https://doi.org/10.1007/s13760-025-02882-0","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful treatment of Charles Bonnet syndrome after cerebellar stroke in a patient with binocular macular degeneration with low dose brexpiprazole: a case report. 小剂量布雷哌唑成功治疗双目黄斑变性小脑卒中后Charles Bonnet综合征1例。
IF 2.1 4区 医学
Acta neurologica Belgica Pub Date : 2025-08-31 DOI: 10.1007/s13760-025-02886-w
Okan Ekinci
{"title":"Successful treatment of Charles Bonnet syndrome after cerebellar stroke in a patient with binocular macular degeneration with low dose brexpiprazole: a case report.","authors":"Okan Ekinci","doi":"10.1007/s13760-025-02886-w","DOIUrl":"https://doi.org/10.1007/s13760-025-02886-w","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The prevalence of restless legs syndrome among university students: a single-centre study. 不宁腿综合征在大学生中的流行:一项单中心研究。
IF 2.1 4区 医学
Acta neurologica Belgica Pub Date : 2025-08-27 DOI: 10.1007/s13760-025-02875-z
Burhanettin Çiğdem, Şeyda Figül Gökçe
{"title":"The prevalence of restless legs syndrome among university students: a single-centre study.","authors":"Burhanettin Çiğdem, Şeyda Figül Gökçe","doi":"10.1007/s13760-025-02875-z","DOIUrl":"https://doi.org/10.1007/s13760-025-02875-z","url":null,"abstract":"<p><strong>Introduction: </strong>Restless legs syndrome (RLS) is a relatively common movement disorder. Epidemiological data on RLS in young adults remain lacking. The objective of the present study was to determine the prevalence of primer RLS among university students comprising young adults.</p><p><strong>Methods: </strong>The study was performed by two neurologists using the face-to-face survey method. A total of 3,047 students were included in the study. First, secondary causes of RLS were excluded by anamnesis. Then, eligible participants were asked to provide demographic data and answer five questions from the 2014 revised international restless legs syndrome study group (IRLSSG) diagnostic criteria; students who answered \"yes\" to the five questions were considered to have RLS and were invited to the hospital to further exclude secondary causes of RLS using medical data system, neurological examination, and blood tests. The IRLSSG severity scale was applied to measure the severity of the disease.</p><p><strong>Results: </strong>Primary RLS was detected in 78 students comprising 44 females and 34 males, with a prevalence rate of 2.6%. Sleep disorders were more common in individuals with RLS (p = 0.005), and included difficulty falling asleep and waking up frequently (p = 0.001). Of the 78 students with RLS, 32 had first-degree relatives with RLS (41.02%).</p><p><strong>Conclusion: </strong>When the secondary causes of RLS, which adversely affects the quality of life, is excluded, the prevalence of primary RLS in among included university students was 2.6%.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What causes loss of muscle mass in primary sarcopenia: A MUNIX analysis and correlation with plasma biomarkers. 原发性肌肉减少症患者肌肉质量减少的原因:一项MUNIX分析及其与血浆生物标志物的相关性
IF 2.1 4区 医学
Acta neurologica Belgica Pub Date : 2025-08-27 DOI: 10.1007/s13760-025-02873-1
Aysegul Akkan Suzan, Seyda Bilgin, Pelin Degirmenci, Nurten Uzun Adatepe, Alper Doventas, Aysegul Gunduz
{"title":"What causes loss of muscle mass in primary sarcopenia: A MUNIX analysis and correlation with plasma biomarkers.","authors":"Aysegul Akkan Suzan, Seyda Bilgin, Pelin Degirmenci, Nurten Uzun Adatepe, Alper Doventas, Aysegul Gunduz","doi":"10.1007/s13760-025-02873-1","DOIUrl":"https://doi.org/10.1007/s13760-025-02873-1","url":null,"abstract":"<p><strong>Introduction: </strong>To determine if the loss of muscle mass in primary sarcopenia is secondary to motor neuron loss or directly related to muscle fiber loss using electrophysiological methods.</p><p><strong>Methods: </strong>We recruited individuals with primary sarcopenia and non-sarcopenic individuals of similar age and gender for the study. After a detailed evaluation of geriatric syndromes and neurological disorders through systemic, neurological, and electrophysiological examinations, we recorded the motor unit number index (MUNIX) and motor unit size index (MUSIX) of the first dorsal interosseus (FDI) and tibialis anterior (TA) muscles in all participants.</p><p><strong>Results: </strong>Individuals with sarcopenia exhibited reduced FDI MUNIX and lower TA CMAP amplitude and MUNIX values. The FDI MUNIX showed an inverse correlation with ferritin levels.</p><p><strong>Discussion: </strong>Primary sarcopenia is characterized by motor unit loss without significant reinnervation. Motor unit loss in individuals with sarcopenia can be demonstrated in both the upper and lower extremities using the MUNIX method, and functional iron deficiency contributes to the etiology of primary sarcopenia.</p><p><strong>Conclusion: </strong>Demonstration of motor unit loss in primary sarcopenia supports the hypothesis that the disease has a neuromuscular origin.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cervical intradural dirofilariasis mimicking a subdural tumour - case report. 模拟硬膜下肿瘤的宫颈硬膜内双丝虫病1例报告。
IF 2.1 4区 医学
Acta neurologica Belgica Pub Date : 2025-08-26 DOI: 10.1007/s13760-025-02877-x
Ioana Miron, Dan M Visarion, Carmen M Crețu, Sorin Duțulescu, Viorel M Prună
{"title":"Cervical intradural dirofilariasis mimicking a subdural tumour - case report.","authors":"Ioana Miron, Dan M Visarion, Carmen M Crețu, Sorin Duțulescu, Viorel M Prună","doi":"10.1007/s13760-025-02877-x","DOIUrl":"https://doi.org/10.1007/s13760-025-02877-x","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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