Acta neurologica Belgica最新文献

{"title":"Relationship between lower extremity sensation, physical activity, cognition, body awareness, and fatigue in people with multiple sclerosis: a cross-sectional study.","authors":"Kader Eldemir, Cagla Ozkul, Muhammed Seref Yildirim, Sefa Eldemir, Fettah Saygili, Ceyla Irkec, Arzu Guclu-Gunduz","doi":"10.1007/s13760-025-02768-1","DOIUrl":"10.1007/s13760-025-02768-1","url":null,"abstract":"<p><strong>Background: </strong>Multiple sclerosis (MS) is a chronic autoimmune disease causing sensory and motor impairments due to central nervous system demyelination. Sensory feedback, essential for balance and gait, is often disrupted in people with MS (PwMS). However, its relationship with fatigue, physical activity, cognitive function, and body awareness remains unclear.</p><p><strong>Aim: </strong>To investigate the relationship between plantar sensation, knee position sense, and clinical factors in PwMS compared to healthy controls (HC).</p><p><strong>Methods: </strong>Thirty-three PwMS and 11 HC participated in this study. Foot sensations including light touch threshold, two-point discrimination, vibration duration, and knee position sense were assessed. In addition, physical activity level, cognitive function, body awareness, and fatigue were assessed as clinical factors.</p><p><strong>Results: </strong>No significant differences were found between PwMS and HC in most sensory measures, except for body awareness, which was higher in HC (p:0.029). In PwMS, light touch thresholds correlated with age (r = 0.454, p = 0.008), vibration duration with walking and physical activity levels (r = 0.392-0.396, p < 0.05), two-point discrimination with EDSS score (r = 0.474, p = 0.005), knee position sense with EDSS (r = 0.385, p = 0.027) and cognitive function (r = 0.382, p = 0.028). In HC, vibration duration correlated negatively with age (r=-0.834, p:0.001), and knee position sense correlated with body mass index (r = 0.764, p:0.006) and cognitive function (r = 0.609-0.736, p < 0.05).</p><p><strong>Conclusion: </strong>These findings highlight the relationship between sensory function and clinical factors in PwMS, emphasizing the importance of age, disability level, physical activity, and cognitive function in preserving the sensory functions of the lower extremity.</p><p><strong>Trial registration: </strong>NCT04548297.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":"801-810"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examination of the autonomic nervous system at the bedside.","authors":"Baikuntha Panigrahi, Achal Kumar Srivastava, Divyani Garg, Ashok Jaryal","doi":"10.1007/s13760-024-02654-2","DOIUrl":"10.1007/s13760-024-02654-2","url":null,"abstract":"<p><p>Autonomic function is an integral part of the assessment of neurological disorders. However, pragmatically, it is often the most neglected part of neurological examination and is often limited to testing for orthostatic hypotension. Testing the autonomic nervous system may aid in the early diagnosis of neurodegenerative disorders, thereby enabling the initiation of neuroprotective strategies and resulting in improved quality of life in this group of patients. It may also enable differentiation between certain atypical parkinsonisms, such as Multiple System Atrophy and Dementia with Lewy Bodies, in which autonomic dysfunction is early and usually profound compared to Parkinson's disease. Our review focusses on the \"first-line\" autonomic function tests which can be done at the bedside and require use of minimal equipment and provide insights into cardiovascular, pupillary and sudomotor function. The use of minimal equipment underscores the value of these tests in resource-constrained settings as a major unmet need, thereby saving resources and avoiding delays in diagnosis and treatment.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":"625-634"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of quality of life in patients with cervical dystonia and hemifacial spasm after botulinum toxin injections.","authors":"Haidy Elshebawy, Gihan M Ramzy, Mohammed Salama, Shaimaa El-Jaafary","doi":"10.1007/s13760-025-02742-x","DOIUrl":"10.1007/s13760-025-02742-x","url":null,"abstract":"<p><strong>Background: </strong>Botulinum toxin is now used to treat a variety of neurological and non-neurological disorders. Despite the fact that injections of botulinum neurotoxin may significantly reduce the involuntary muscular contractions associated with focal dystonia and hemifacial spasm (HFS), it is less certain whether the motor effect would result in an improvement in health-related quality of life (HR-QoL).Our goal was to evaluate how botulinum toxin affected individuals with cervical dystonia and hemifacial spasm in terms of their quality of life, self-esteem, pain, sleep, and depression.</p><p><strong>Methods: </strong>This is a prospective study that included 40 patients diagnosed with cervical dystonia or hemifacial spasm treated with Botulinum toxin. Quality of life, self-esteem, pain, sleep and depression were all assessed in the studied patients by self-reporting questionnaires to assess the impact of botulinum toxin on them.</p><p><strong>Results: </strong>The quality of life with its components (physical, physical role, emotional role, vitality, mental health, social functioning and pain) showed significant improvement at the end of follow up compared to baseline with p values ≤ 0.001. Also, there was a significant improvement of self-esteem score, depression score, at the end of follow up period compared to baseline assessment with p value 0.012, < 0.001 respectively. Moreover, there was a significant improvement of all pain scales and sleep quality scores with p values < 0.05 except the habitual sleep efficiency.</p><p><strong>Conclusion: </strong>botulinum toxin is an effective therapy for motor and non-motor manifestations associated with focal cervical dystonia and hemifacial spasm as well as the quality of life and to conclude that its effectiveness is dependent not only on the elimination of physical symptoms, but also on improving the patients' and their families' emotional and social status to help providing the drug to all eligible patients.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":"707-716"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Local recurrence of melanocytoma of the cervical spine.","authors":"Eleanor M Moncur, Selma Al-Ahmad, Maria Thom, Claudia L Craven, David Choi","doi":"10.1007/s13760-023-02459-9","DOIUrl":"10.1007/s13760-023-02459-9","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":"899-901"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139690950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-level laser therapy for intractable hiccups following stroke: a novel use case report.","authors":"Mingyue Liu, Shasha Jin, Liang Wu, Zhe Li, Jianghua Zhu","doi":"10.1007/s13760-025-02778-z","DOIUrl":"10.1007/s13760-025-02778-z","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":"891-893"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statins and the risk of dementia: a meta-analysis.","authors":"Xue Li, Yuzhen Liu, Tiantian Song, Xiaoxuan Wu, Ying Xing","doi":"10.1007/s13760-025-02758-3","DOIUrl":"10.1007/s13760-025-02758-3","url":null,"abstract":"<p><p>Clarify the relationship between the use of statins and the risk of dementia, and further guide the clinical application of statins. This paper uses computer search Chinese and foreign language databases Pubmed, Medline, Cochrane, Embase, Web of Science, Weipu, CBM, Wanfang, CNKI, etc., to include the literature that meets the standards from the establishment of the library to December 2020, and uses Revman 5.1 software and Stata15.0 software for meta-analysis. Of the 34 included observational studies, stratified subgroup analyses were performed based on the type of clinical trial, sex of participants, presence or absence of apolipoprotein E-4 (ApoEε4) allele, and duration of use. The conclusions showed that (1) the use of statins can significantly reduce the risk of dementia; (2) There is no significant sex difference in reducing the risk of dementia; (3) Continuous use of statins for ≥ 1 year can significantly reduce the risk of dementia compared with the time of taking the drug for < 1 year; (4) Compared with subjects with negative ApoEε4 allele, the use of statins has a more significant effect on reducing the risk of dementia in subjects carrying the ApoEε4 allele.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":"699-705"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuromodulation techniques in traumatic brain injury: a narrative review of the current state.","authors":"Mrinmoy Kundu, Vallabh Shet, Tariq Janjua, Luis Rafael Moscote","doi":"10.1007/s13760-024-02691-x","DOIUrl":"10.1007/s13760-024-02691-x","url":null,"abstract":"<p><p>Traumatic brain injury (TBI) is a leading cause of death and disability throughout the world. Despite significant advances in medical care, many TBI survivors continue to have cognitive, physical, and psychological deficits that have a significant impact on their quality of life. Neuromodulation techniques, which use electrical or magnetic stimulation to modulate brain activity, have shown promise in the treatment of TBI symptoms. The purpose of this narrative review is to provide an overview of the current state of neuromodulation techniques for TBI, such as transcranial magnetic stimulation, transcranial direct current stimulation, deep brain stimulation, and vagus nerve stimulation. This review summarizes the evidence for using these techniques, as well as their potential mechanisms of action and limitations. Additionally, the review discusses future research directions in this field, as well as the possibility of combining neuromodulation techniques with other interventions to improve outcomes for TBI patients.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":"635-644"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142798935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified zipper method in steroid-resistant ADEM: a case report.","authors":"Nihal Akçay, İlyas Bingöl, Hilal Merve Dolu, Behice Kaniye Yılmaz, Demet Tosun","doi":"10.1007/s13760-025-02788-x","DOIUrl":"10.1007/s13760-025-02788-x","url":null,"abstract":"<p><strong>Background: </strong>Acute disseminated encephalomyelitis (ADEM) is a rare, inflammatory, demyelinating central nervous system disorder typically responsive to corticosteroid therapy. However, some cases are resistant to steroids, requiring alternative treatment options.</p><p><strong>Case presentation: </strong>We present an 8-year-old male child with steroid-resistant ADEM who underwent treatment with the modified zipper technique, combining intravenous immunoglobulin (IVIG) and therapeutic plasma exchange (TPE). Despite initial high-dose intravenous methylprednisolone, which failed to improve his condition, the patient showed significant clinical and radiological improvement after five cycles of the modified zipper technique.</p><p><strong>Methods: </strong>The patient received alternating cycles of TPE and IVIG (0.4 g/kg/day) over five cycles, with a 48-hour interval between each TPE and IVIG session. TPE sessions used fresh frozen plasma, followed by IVIG to enhance antibody clearance and immunomodulation.</p><p><strong>Results: </strong>After two cycles of TPE, clinical improvement was observed. Follow-up MRI on day 15 showed marked regression of white matter lesions. The patient was discharged on day 20 with near-complete recovery. Follow-up at one, three, and six months showed no neurological deficits, and MRI lesions continued to regress.</p><p><strong>Conclusions: </strong>This case suggests the modified zipper technique as a promising alternative for steroid-resistant ADEM. The combination of TPE and IVIG may provide beneficial effects, but further controlled studies are needed to evaluate its efficacy and safety in broader populations.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":"895-897"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrence of Susac syndrome after 20 years of remission.","authors":"Adnane El Fahdi, Souraya El Sankari","doi":"10.1007/s13760-025-02772-5","DOIUrl":"10.1007/s13760-025-02772-5","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":"887-889"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing and expanding the neurological clinical spectrum of PHARC syndrome: a systematic review.","authors":"Vítor Mendes Ferreira, Marta Magriço, Bruna Meira, Paulo Bugalho, Raquel Barbosa","doi":"10.1007/s13760-025-02721-2","DOIUrl":"10.1007/s13760-025-02721-2","url":null,"abstract":"<p><p>PHARC syndrome is an autosomal recessive neurodegenerative disease caused by mutations in the ABHD12 gene and is characterized by five main clinical features: polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataracts. This systematic review aimed to characterize the neurological features of PHARC syndrome and identify potential new clinical features. A systematic search of studies reporting cases of PHARC syndrome was conducted using PubMed/MEDLINE and NLM databases, identifying 57 unique cases. The results showed that hearing loss was the most common initial symptom, with a complete syndrome observed in only 31.6% of reported cases. The mean diagnostic delay from the appearance of the first PHARC-related symptom to diagnosis was 20.5 years. Although pyramidal signs are not classically associated with PHARC syndrome, they were a prevalent feature when assessed. Patients with pyramidal signs were more likely to exhibit an ataxic phenotype (p-value 0.018), a complete syndrome (p-value 0.092), and cerebellar atrophy on MRI (p-value 0.001), compared to those without pyramidal signs. This review further supports the highly variable phenotype of PHARC syndrome and the lack of a clear genotype-phenotype correlation. Further research is needed to clarify the relevance of these findings within the clinical spectrum of PHARC syndrome.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":"737-743"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}