Acta neurologica Belgica最新文献_第3页

Atypical Rett syndrome with chorea: a case report. 非典型Rett综合征伴舞蹈病1例报告。

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-10-02 DOI: 10.1007/s13760-025-02901-0

M Erdogan, E Olinger, S Ferrao Santos

引用次数: 0

Opalski syndrome with ipsilateral upper motor neuron type facial palsy. Opalski综合征伴同侧上运动神经元型面瘫。

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-10-02 DOI: 10.1007/s13760-025-02908-7

Somarajan Anandan, Sajeesh S Rajendran, Alfia Najeem, Gopika Shaji Kuttickal

引用次数: 0

Metronidazole-induced encephalopathy: reversible but not to be missed. 甲硝唑诱导的脑病：可逆但不可错过。

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-10-02 DOI: 10.1007/s13760-025-02895-9

Vincent Leclercq, Audrey Cambier, Imene Chafai, Chiara Mabiglia, Gilles Naeije

引用次数: 0

Sudden neurological decline after trauma: cerebral fat embolism unveiled. 外伤后突然神经功能下降：脑脂肪栓塞。

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-10-02 DOI: 10.1007/s13760-025-02898-6

E Vergauwe, E Elseviers, C M J Loos

引用次数: 0

Posterior auricular neuropathy as a complication of facial nerve palsy in a patient with polyneuritis cranialis. 颅多神经炎患者面神经麻痹并发耳后神经病1例。

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-09-30 DOI: 10.1007/s13760-025-02907-8

Olivia Pype, Sofie Carrette

引用次数: 0

Elucidate biomarkers and the molecular pathways associated with genetic variants that contribute to the etiology of Parkinson's disease. 阐明与帕金森病病因的遗传变异相关的生物标志物和分子途径。

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-09-30 DOI: 10.1007/s13760-025-02897-7

Hai Duc Nguyen

{"title":"Elucidate biomarkers and the molecular pathways associated with genetic variants that contribute to the etiology of Parkinson's disease.","authors":"Hai Duc Nguyen","doi":"10.1007/s13760-025-02897-7","DOIUrl":"https://doi.org/10.1007/s13760-025-02897-7","url":null,"abstract":"Genetic variants can affect signaling pathways that are important in the pathophysiology of Parkinson's disease (PD). Comprehending their relationship is crucial for the development of diagnostic instruments and preventative drugs for PD. We thoroughly analyzed data from 68 genome-wide association studies to uncover significant genetic variations and clarify the molecular pathways underlying the etiology of Parkinson's disease (PD) resulting from genetic variants. Six common biomarkers linked to PD were found in all 68 investigations: SNCA, TMEM175, BST1, RIT2, LRRK2, and MCCC1. SNCA (↑rs5019538 and ↑rs356182), LRRK2 (↑rs34637584 and ↑rs76904798), and SH3GL2 (↑rs10756907 and ↓rs13294100) were the main biomarkers associated with PD. The clinical traits of PD, such as age at onset, cognitive progression, motor progression, composite progression, tremor dominant, and postural instability gait difficulty, have been found to be underpinned by additional biomarkers, including APOE, NTRK2, SLCO1B3, SLC28A3, AQP10, SNCAIP, ANO2, CADM1, PTPRD, GPR32, GPR321, SQOR, SULT1C2, GABRG2, CYP4Z1, CDH13, and FANCF. Significant evidence was found linking genetic variants linked to an increased risk of PD to reduced dopamine production, receptor recycling, oxidoreductase activity, and increased amyloid-beta accumulation. Considerable evidence links genetic variations with a lower risk of PD due to improved synaptic vesicle signaling, neuron projection development, controlled histone methylation, and excitatory postsynaptic potential. Additionally, we found MYT1L and hsa-miR-20a-5p, which are essential for understanding the genetic variations linked to PD. These findings provide a solid underpinning for future therapeutic approaches aimed at PD, with a focus on the genetic variants and processes connected to the illness.","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of migraine menstrual, migraine and risk factors in women of reproductive age; a multi-centre study. 育龄妇女月经期偏头痛、偏头痛患病率及危险因素多中心研究。

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-09-29 DOI: 10.1007/s13760-025-02893-x

Meryem Erdoğan Acar, Gonca Buran, Yasemin Özyer Güvener, Çiler Yeygel, Ayşegül Dönmez, Nurten Denizhan Kırcan

{"title":"Prevalence of migraine menstrual, migraine and risk factors in women of reproductive age; a multi-centre study.","authors":"Meryem Erdoğan Acar, Gonca Buran, Yasemin Özyer Güvener, Çiler Yeygel, Ayşegül Dönmez, Nurten Denizhan Kırcan","doi":"10.1007/s13760-025-02893-x","DOIUrl":"https://doi.org/10.1007/s13760-025-02893-x","url":null,"abstract":"Purpose: To determine the prevalence and risk factors associated with migraine and menstrual migraine in women of reproductive age.Method: This multicenter cross-sectional study included 2049 women who were successfully contacted between May and December 2023. The data were collected via an online interview method using the Individual Identification Form, which was created by the researchers and consists of three parts.Results: The mean age of the study participants was determined to be 24.19 ± 7.76 years. The prevalence of migraine was found to be 16.4%, while the prevalence of menstrual migraine was 56.4%. A statistically significant relationship was identified between migraine diagnosis and a number of variables, including marital status, educational status, employment status, social security status, income status, family type, smoking habits, alcohol consumption and coffee intake (p < 0.05). A statistically significant relationship was found between menstrual headache and marital status, working in a gainful job, presence of social security, income status, family type, smoking, alcohol use and coffee consumption (p < 0.05).Conclusion: Many sociodemographic characteristics and habits in women's daily lives are among the risk factors for migraine and menstrual migraine. It is advisable for health professionals to provide comprehensive counseling services to facilitate the adoption of healthy behaviors in relation to these risk factors.","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An atypical case of FA2H-related HSP35 with subtle neuroimaging findings and a novel variant in a young adult with spastic paraparesis. fa2h相关HSP35的非典型病例与微妙的神经影像学发现和一种新的变异在一个年轻的成人痉挛性截瘫。

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-09-26 DOI: 10.1007/s13760-025-02899-5

Subhajit Roy, Pooja Mailankody, Gautham Arunachal, Rohan R Mahale, Hansashree Padmanabha

引用次数: 0

Assessment of serum glucagon-like peptide-1 and dipeptidyl peptidase-4 levels in patients with migraine. 偏头痛患者血清胰高血糖素样肽-1和二肽基肽酶-4水平的评估。

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-09-26 DOI: 10.1007/s13760-025-02894-w

Melis Gultekin, Fatih Davran, Nehir Yuksel, Ozge Beyazcicek, Serif Demir

{"title":"Assessment of serum glucagon-like peptide-1 and dipeptidyl peptidase-4 levels in patients with migraine.","authors":"Melis Gultekin, Fatih Davran, Nehir Yuksel, Ozge Beyazcicek, Serif Demir","doi":"10.1007/s13760-025-02894-w","DOIUrl":"https://doi.org/10.1007/s13760-025-02894-w","url":null,"abstract":"Background: Migraine is a prevalent neurovascular disorder affecting over one billion people globally, imposing significant daily life limitations. Migraine headaches are linked to the activation of trigeminal nerve endings. Glucagon-like peptide-1 (GLP-1) is a hormone involved in insulin regulation and plays neuroprotective roles in the central nervous system (CNS). Dipeptidyl peptidase-4 (DPP-4) is a protease enzyme that degrades GLP-1, rendering it inactive, and modulates metabolic and neurological pathways. This study investigates the association between serum GLP-1 and DPP-4 levels and migraine pathophysiology to propose a novel therapeutic approach for migraine.Methods: The study included 42 migraine patients and 42 healthy controls. After fasting for at least 8 h, blood samples were collected. Serum GLP-1 and DPP-4 levels were measured using ELISA, and statistical analyses were conducted with SPSS 24.0.Results: Serum GLP-1 and DPP-4 levels were significantly lower in migraine patients compared to controls (p < 0.001). Patients with migraine with aura had significantly lower GLP-1 levels compared to those with migraine without aura (p = 0.016). A significant decrease in GLP-1 levels was observed in patients experiencing pain localized in the occipital lobe (p = 0.01).Conclusions: Serum GLP-1 and DPP-4 levels were lower in migraine patients. Given the role of GLP-1 in the central nervous system, reduced GLP-1 may contribute to migraine pain. Similarly, low DPP-4, which metabolizes GLP-1, may be linked to these findings and could trigger attacks by increasing blood CGRP levels.","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of patient education interventions on non-motor symptoms and disease outcomes in parkinson’s disease: a systematic review 患者教育干预对帕金森病非运动症状和疾病结局的影响：一项系统综述

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-09-26 DOI: 10.1007/s13760-025-02900-1

Lisa Van Doeselaer, Kaat Colman, David Crosiers, Femke Dijkstra

{"title":"Effect of patient education interventions on non-motor symptoms and disease outcomes in parkinson’s disease: a systematic review","authors":"Lisa Van Doeselaer, Kaat Colman, David Crosiers, Femke Dijkstra","doi":"10.1007/s13760-025-02900-1","DOIUrl":"10.1007/s13760-025-02900-1","url":null,"abstract":"<div>Parkinson’s disease is the second most common neurodegenerative disease, characterized by both motor symptoms (MS) and non-motor symptoms (NMS). While MS have traditionally been the primary focus of treatment and research, NMS significantly contribute to disease burden. However, knowledge regarding NMS in Parkinson’s patients seems particularly lacking. Educational interventions have previously shown a positive effect on health outcomes in chronic illnesses such as Alzheimer’s disease and diabetes, warranting investigation into their impact on NMS in Parkinson’s disease. We conducted a systematic review to evaluate whether education interventions on non-motor symptoms (NMS) in Parkinson’s disease (PD) patients contribute to better disease outcomes. Education interventions showed significant effects on various patient-reported and physician-reported outcomes, including quality of life, motor symptoms, depression, fatigue, adherence to treatment, acceptance of diagnosis, satisfaction with care, psychosocial adjustment, and independence in activities of daily living. Some effects were temporary, implying the need for booster sessions in future education interventions. There was limited focus on the direct impact of education interventions on NMS other than depression and anxiety. No studies directly compared different education interventions, preventing conclusions on which type of intervention leads to the best outcome. In conclusion, education interventions on NMS in PD have significant effects on disease outcomes. Future research should determine the optimal timing for booster sessions and further investigate their impact on NMS beyond depression and anxiety. Direct comparisons between different education interventions are needed to identify the most effective approach.</div>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":"125 5","pages":"1195 - 1208"},"PeriodicalIF":2.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0