{"title":"Successful treatment of Charles Bonnet syndrome after cerebellar stroke in a patient with binocular macular degeneration with low dose brexpiprazole: a case report.","authors":"Okan Ekinci","doi":"10.1007/s13760-025-02886-w","DOIUrl":"https://doi.org/10.1007/s13760-025-02886-w","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The prevalence of restless legs syndrome among university students: a single-centre study.","authors":"Burhanettin Çiğdem, Şeyda Figül Gökçe","doi":"10.1007/s13760-025-02875-z","DOIUrl":"https://doi.org/10.1007/s13760-025-02875-z","url":null,"abstract":"<p><strong>Introduction: </strong>Restless legs syndrome (RLS) is a relatively common movement disorder. Epidemiological data on RLS in young adults remain lacking. The objective of the present study was to determine the prevalence of primer RLS among university students comprising young adults.</p><p><strong>Methods: </strong>The study was performed by two neurologists using the face-to-face survey method. A total of 3,047 students were included in the study. First, secondary causes of RLS were excluded by anamnesis. Then, eligible participants were asked to provide demographic data and answer five questions from the 2014 revised international restless legs syndrome study group (IRLSSG) diagnostic criteria; students who answered \"yes\" to the five questions were considered to have RLS and were invited to the hospital to further exclude secondary causes of RLS using medical data system, neurological examination, and blood tests. The IRLSSG severity scale was applied to measure the severity of the disease.</p><p><strong>Results: </strong>Primary RLS was detected in 78 students comprising 44 females and 34 males, with a prevalence rate of 2.6%. Sleep disorders were more common in individuals with RLS (p = 0.005), and included difficulty falling asleep and waking up frequently (p = 0.001). Of the 78 students with RLS, 32 had first-degree relatives with RLS (41.02%).</p><p><strong>Conclusion: </strong>When the secondary causes of RLS, which adversely affects the quality of life, is excluded, the prevalence of primary RLS in among included university students was 2.6%.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aysegul Akkan Suzan, Seyda Bilgin, Pelin Degirmenci, Nurten Uzun Adatepe, Alper Doventas, Aysegul Gunduz
{"title":"What causes loss of muscle mass in primary sarcopenia: A MUNIX analysis and correlation with plasma biomarkers.","authors":"Aysegul Akkan Suzan, Seyda Bilgin, Pelin Degirmenci, Nurten Uzun Adatepe, Alper Doventas, Aysegul Gunduz","doi":"10.1007/s13760-025-02873-1","DOIUrl":"https://doi.org/10.1007/s13760-025-02873-1","url":null,"abstract":"<p><strong>Introduction: </strong>To determine if the loss of muscle mass in primary sarcopenia is secondary to motor neuron loss or directly related to muscle fiber loss using electrophysiological methods.</p><p><strong>Methods: </strong>We recruited individuals with primary sarcopenia and non-sarcopenic individuals of similar age and gender for the study. After a detailed evaluation of geriatric syndromes and neurological disorders through systemic, neurological, and electrophysiological examinations, we recorded the motor unit number index (MUNIX) and motor unit size index (MUSIX) of the first dorsal interosseus (FDI) and tibialis anterior (TA) muscles in all participants.</p><p><strong>Results: </strong>Individuals with sarcopenia exhibited reduced FDI MUNIX and lower TA CMAP amplitude and MUNIX values. The FDI MUNIX showed an inverse correlation with ferritin levels.</p><p><strong>Discussion: </strong>Primary sarcopenia is characterized by motor unit loss without significant reinnervation. Motor unit loss in individuals with sarcopenia can be demonstrated in both the upper and lower extremities using the MUNIX method, and functional iron deficiency contributes to the etiology of primary sarcopenia.</p><p><strong>Conclusion: </strong>Demonstration of motor unit loss in primary sarcopenia supports the hypothesis that the disease has a neuromuscular origin.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hongdan Qi, Xin Wang, Bing Wu, Jing Chen, Gang Zhang
{"title":"The current status of Charcot-Marie-Tooth disease type 1 A treatment.","authors":"Hongdan Qi, Xin Wang, Bing Wu, Jing Chen, Gang Zhang","doi":"10.1007/s13760-025-02881-1","DOIUrl":"https://doi.org/10.1007/s13760-025-02881-1","url":null,"abstract":"<p><p>Charcot-Marie-Tooth disease type 1 A (CMT1A) is the major subtype of hereditary peripheral neuropathies and arises from a 1.5 megabase (Mb) tandem duplication in chromosome 17p11.2-p12 that contains the complete peripheral myelin protein 22 (PMP22) gene. Patients commonly present with progressive weakness and atrophy of the distal muscles, accompanied by hyperalgesia, decreased or absent tendon reflexes, and foot deformities. Current clinical management relies on multidisciplinary supportive care. Recent preclinical studies targeting potential therapeutic strategies for CMT1A have focused on correcting the gene-dose imbalance of PMP22. Notably, PXT3003 has shown phase III clinical efficacy in relieving symptoms and reducing neuropathy, and is expected to be the earliest CMT1A-targeted drug on the market. Gene editing approaches have also shown therapeutic promise in animal models, but off-target effects remain a concern. In addition, the rapid development of induced pluripotent stem cell (iPSC) technology has paved the way for stem cell therapies, which may be a promising therapeutic approach. This article reviews the existing literature on therapeutic strategies for CMT1A and aims to provide a valuable reference for the clinical treatment of CMT1A.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"P-Wave dispersion and atrial conduction abnormalities in migraine: implications for cardiovascular risk.","authors":"Cansu Sarıkaya, Fatma Özge Salkın, Caner Sarıkaya","doi":"10.1007/s13760-025-02876-y","DOIUrl":"https://doi.org/10.1007/s13760-025-02876-y","url":null,"abstract":"<p><strong>Introduction: </strong>Migraine is a common neurological disorder that is increasingly recognized for its systemic effects extending beyond the central nervous system. Emerging evidence suggests a potential association between migraine and cardiovascular dysfunction; however, the underlying pathophysiological mechanisms remain insufficiently elucidated. In this study we aimed to evaluate atrial electromechanical delay in patients with migraine and to test the hypothesis that migraine may be linked to subclinical cardiac alterations, particularly in atrial conduction.</p><p><strong>Methods: </strong>This cross-sectional study included 136 participants: 55 patients diagnosed with migraine and 81 age- and sex-matched healthy controls. All participants underwent standardized clinical, electrocardiographic, and echocardiographic evaluations at a tertiary care center.</p><p><strong>Results: </strong>Migraine patients demonstrated significantly prolonged P max and P dispersion values compared to controls (Pmax: 196 ± 44 vs. 131 ± 42 ms, p < 0.001; Pdisp: 133 ± 44 vs. 63 ± 23 ms, p < 0.001), indicating increased intra-atrial conduction heterogeneity. Although interatrial electromechanical delay did not differ significantly between groups, migraine patients exhibited prolonged lateral and medial atrial conduction times compared to controls (p < 0.05). These abnormalities were observed despite the absence of overt cardiovascular disease.</p><p><strong>Conclusions: </strong>This study supports the hypothesis that migraine is associated with subclinical atrial conduction disturbances, as evidenced by elevated P-wave dispersion and atrial electromechanical delay. These findings highlight the importance of cardiovascular monitoring in migraine patients, particularly those with aura or existing vascular risk factors. Further longitudinal investigations are necessary to determine whether these electrical changes have prognostic value in predicting future cardiovascular events.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ioana Miron, Dan M Visarion, Carmen M Crețu, Sorin Duțulescu, Viorel M Prună
{"title":"Cervical intradural dirofilariasis mimicking a subdural tumour - case report.","authors":"Ioana Miron, Dan M Visarion, Carmen M Crețu, Sorin Duțulescu, Viorel M Prună","doi":"10.1007/s13760-025-02877-x","DOIUrl":"https://doi.org/10.1007/s13760-025-02877-x","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Frequency of posterior interosseous nerve syndrome and its impact on clinical outcomes in patients with lateral epicondylitis: A prospective, controlled, electrophysiological study.","authors":"Çiğdem Çilingiroğlu, Meral Bilgilisoy Filiz, Şebnem Koldaş Doğan, Tuncay Çakır, Naciye Füsun Toraman, Gülşah Çelik","doi":"10.1007/s13760-025-02874-0","DOIUrl":"https://doi.org/10.1007/s13760-025-02874-0","url":null,"abstract":"<p><strong>Introduction: </strong>Lateral epicondylitis (LE) is a musculoskeletal disorder characterized by pain around the lateral epicondyle. Posterior interosseous nerve syndrome (PINS), a rare neuropathy caused by radial nerve compression, can mimic or coexist with LE, complicating diagnosis. This study aimed to evaluate the electrophysiological presence of PINS in LE and determine its impact on symptoms.</p><p><strong>Methods: </strong>This prospective study included 62 patients diagnosed with LE and 54 healthy controls. Electrophysiological examinations were performed on all patients in the LE group to investigate the presence of PINS. Subsequently, PINS-positive and PINS-negative patients within the LE group underwent a detailed clinical evaluation, including provocative tests, joint range of motion (ROM), hand grip strength, and symptom scoring using the Visual Analog Scale (VAS) and Patient-Rated Tennis Elbow Evaluation (PRTEE).</p><p><strong>Results: </strong>PINS was identified in 19.4% of LE patients and 1.9% of controls (p < 0.05). There were no significant differences between PINS-positive and PINS-negative patients in the LE group regarding provocative tests, joint ROM, grip strength, VAS, or PRTEE scores. The diagnosis of PINS was made solely based on electrophysiological findings.</p><p><strong>Discussion: </strong>This study highlights the importance of electrophysiological evaluation in the differential diagnosis of PINS and LE, especially in treatment-resistant cases. Although PINS did not significantly impact clinical parameters such as grip strength or symptom scores, its notable prevalence in LE patients underscores the need for its consideration in refractory LE cases. Further large-scale, controlled studies are needed to explore this relationship comprehensively.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical value of serum miR-451 in early diagnosis of multiple system atrophy from parkinson's disease and outcomes prediction.","authors":"Tingyan Shi, Zhongzheng Jia","doi":"10.1007/s13760-025-02870-4","DOIUrl":"https://doi.org/10.1007/s13760-025-02870-4","url":null,"abstract":"<p><strong>Background: </strong>The clinical diagnosis of multiple system atrophy (MSA) mainly depends on imaging examinations, and the misdiagnosis rate is high due to its similar symptoms to Parkinson's disease (PD).</p><p><strong>Objectives: </strong>This study aimed to identify a non-invasive indicator assisting in discriminating MSA and PD and predict the development of MSA.</p><p><strong>Materials and methods: </strong>This study enrolled 127 PD patients, 62 MSA patients, and 78 healthy individuals and collected their serum samples. The serum miR-451 levels were analyzed by PCR. The severity of MSA patients was assessed by the Unified Multiple System Atrophy Rating Scale-II (UMSARS-II). The outcomes of MSA patients were evaluated from the perspectives of cognitive function and motor symptoms.</p><p><strong>Results: </strong>Significant upregulation of miR-451 was observed in PD and MSA patients, and MSA patients showed higher serum miR-451 levels. Increasing serum miR-451 levels diagnosed PD and MSA patients from healthy individuals and could discriminate MSA patients from PD patients. miR-451 was positively correlated with UMSARS-II and SCOPA-AUT scores and showed a negative correlation with the MMSE score. MSA patients with motor symptoms and cognitive dysfunction showed higher serum miR-451 levels, and miR-451 was identified as a risk factor predicting the occurrence of cognitive dysfunction and motor symptoms.</p><p><strong>Conclusion: </strong>Serum miR-451 can serve as a biomarker for screening MSA and predicting disease development.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Naoki Nakano, Kouichiro Fujimoto, Masaharu Miyauchi, Jun C Takahashi
{"title":"Perampanel as first line monotherapy for seizure in japan. A single-centre real-world study.","authors":"Naoki Nakano, Kouichiro Fujimoto, Masaharu Miyauchi, Jun C Takahashi","doi":"10.1007/s13760-025-02865-1","DOIUrl":"https://doi.org/10.1007/s13760-025-02865-1","url":null,"abstract":"<p><strong>Aims: </strong>The aim of this study was to examine the efficacy of Perampanel (PER) monotherapy for patients with seizures in a single-centre in Japan. The National Health Insurance began covering PER monotherapy in Japan since January 2020, after which we began using PER as monotherapy for patients with epilepsy at our institute.</p><p><strong>Methods: </strong>All patients given PER between January 2020 and December 2022 were evaluated in this retrospective study. Treatment outcomes (including the seizure rate and seizure- free status) and patient sex, seizure type, and seizure aetiology were evaluated.</p><p><strong>Results: </strong>Sixty-three patients (29 females, 34 males) receiving PER monotherapy as the first-line antiseizure medication for epilepsy were evaluated. The age range was 12 to 88 years, with a mean age of 64.5 ± 18.8years. The follow-up period ranged from 194 days to 1004days, with a median of 576 days from PER initiation. A total of 49 patients (77.8%) were seizure free, while the other 14 patients had incomplete seizure control, including 2 patients (3.2%) who had a 75-99% reduction in seizures, 4 patients (6.3%) who had a 50-74% reduction in seizures,8 patients (12.7%) who had a 25-49% reduction in seizures, and no patients with a 0-24% reduction in seizures. The median PER dose was 2 mg (range; 2-8 mg). No patients discontinued PER monotherapy owing to adverse effects such as transient dizziness at initial administration.</p><p><strong>Conclusion: </strong>Perampanel monotherapy was effective for treating a wide spectrum of seizures, especially seizures related to lesions such as brain tumours, stroke and trauma. Seizure control could be achieved with a minimum dose of PER (2 mg/day).</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Viktor Procházka, Petr Skalický, Laura Banovčanová, Adéla Bubeníková, Vojtěch Novák, Róbert Leško, Vladimír Beneš IIIrd, Ondřej Bradáč
{"title":"Rethinking lumbar puncture safety: pathophysiology, diagnostic uncertainty, and research gaps in herniation risk.","authors":"Viktor Procházka, Petr Skalický, Laura Banovčanová, Adéla Bubeníková, Vojtěch Novák, Róbert Leško, Vladimír Beneš IIIrd, Ondřej Bradáč","doi":"10.1007/s13760-025-02866-0","DOIUrl":"https://doi.org/10.1007/s13760-025-02866-0","url":null,"abstract":"<p><strong>Background: </strong>Lumbar puncture (LP) is a key diagnostic and therapeutic tool, yet concerns persist about its potential to induce brain herniation, especially in patients with elevated intracranial pressure (ICP). Despite ongoing debate, precise risk factors and pathophysiological mechanisms remain unclear.</p><p><strong>Objective: </strong>This systematic review aims to examine the risk of cerebellar and paradoxical brain herniation following LP, evaluate the current evidence regarding its incidence, and discuss the implications for clinical practice as well as show the gaps in research.</p><p><strong>Methods: </strong>Following PRISMA guidelines, a systematic literature review was conducted using the PubMed (MEDLINE) database. Studies from 1990 to 2024 focusing on bacterial meningitis, idiopathic intracranial hypertension, post-surgical states, and other conditions associated with elevated ICP were included.</p><p><strong>Results: </strong>LP-related herniation was reported in diverse clinical settings, with cerebellar herniation primarily seen in bacterial meningitis and idiopathic intracranial hypertension. Herniation onset varied from minutes to days post-LP. While cranial CT is widely used for risk assessment, its predictive accuracy is debated.</p><p><strong>Conclusions: </strong>Although LP is relatively safe, herniation risk is highly context-dependent. Clinicians should integrate clinical, radiological, and pathophysiological factors in decision-making. Further research is needed to refine predictive models and establish evidence-based guidelines for high-risk patients.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144843971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}