Acta neurologica Belgica最新文献

{"title":"Egocentric mental rotation in individuals with multiple sclerosis: relationship with disability and cognitive parameters.","authors":"Merve Ünal, Ayla Fil Balkan, Nazire Pınar Acar Özen, Aslı Tuncer, Yeliz Salcı","doi":"10.1007/s13760-025-02827-7","DOIUrl":"https://doi.org/10.1007/s13760-025-02827-7","url":null,"abstract":"<p><strong>Background: </strong>This study aims to examine whether egocentric-based mental rotation is affected in individuals with Multiple Sclerosis (MS) and to analyze its relationship with disability, functional system scores (FSS), and cognitive parameters.</p><p><strong>Methods: </strong>The study involved 57 right-dominant individuals with MS and 40 right dominant healthy subjects. Disability was assessed using the Neurostatus-Expanded Disability Status Scale (Neurostatus-EDSS). Participants' performance on mental rotation tasks was evaluated with the Recognise Hand App™, Recognise Foot App™, measuring reaction times (seconds) and accuracy (%) for hand and foot stimuli. Cognitive functioning was assessed using the Brief International Cognitive Assessment for MS (BICAMS).</p><p><strong>Results: </strong>MS patients exhibited lower performance in right hand mental rotation reaction time (p = 0.042), right hand accuracy percentage (p < 0.001), right foot accuracy percentage (p = 0.035). Positive correlations were found between disease duration, EDSS total score, cerebellar FSS, bladder-bowel FSS, and ambulation scores with reaction times, while negative correlations were observed with accuracy percentages (p < 0.05). Additionally, a positive correlation was identified between accuracy percentages and BICAMS (p < 0.05).</p><p><strong>Conclusions: </strong>The study revealed substantial impairments in right-hand and right-foot performance in right dominant individuals with MS. Mental rotation abilities were found to be related to disease duration, higher EDSS and FSS scores, as well as cognitive functioning. Identifying the cognitive domains and functional systems associated with egocentric mental rotation will contribute to better understanding this underexplored area and developing potential treatment strategies to enhance functionality.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into diagnostics and management of spinal neuroschistosomiasis: A scoping review of 230 cases of a neglected disease.","authors":"Hossam Tharwat Ali, Ayat Ahmad Elsherbiny, Zainab Salah Elmellah, Bahy El-Din M Saied, Sara Abdelhameed Khalil, Manar Mahmoud AbouElhagag Mohamed","doi":"10.1007/s13760-025-02833-9","DOIUrl":"https://doi.org/10.1007/s13760-025-02833-9","url":null,"abstract":"<p><strong>Background: </strong>Schistosomiasis is a neglected tropical disease caused by parasitic worms from the genus Schistosoma. Spinal neuroschistosomiasis (SN) is a rare but serious complication that can result in significant morbidity and mortality, with only a few hundred cases documented in the literature.</p><p><strong>Methods: </strong>Following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA-ScR) statement, extension for scoping reviews, a systematic search of PubMed, Scopus, and Web of Science using relevant keywords, from inception until November 7th, 2024, was carried out followed by screening and extraction of only detailed cases.</p><p><strong>Results: </strong>Of 657 reports, 108 reports of 230 detailed cases were finally included. The included patients had a mean (standard deviation) age of 25.22 (14.65) years with most of them being males (79.6%). The majority of our patients (85.7%) got infected in endemic areas. As for clinical presentations, myelitis was the most common syndrome (48.3%) followed by myeloradicular syndrome (33.5%). The dorsal cord was the most frequently affected region, documented in 56.5% of cases. Imaging studies revealed pathological findings in 57.7% with magnetic resonance imaging (MRI) and 34.4% with computed tomography (CT). Cerebrospinal fluid (CSF) findings included elevated protein (47.4%), pleocytosis (26.5%), and eosinophilia (29.6%). Anti-parasitic use was reported in most cases (79.6%) while steroids were attempted in 70.5% of cases. A complete recovery was achieved in 18% of cases. Death was the outcome in 4% of the included patients.</p><p><strong>Conclusions: </strong>Due to delayed diagnosis and rarity, SN causes significant morbidity and mortality with diagnostic challenges and heterogeneity.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart rate variability in people with multiple sclerosis: A systematic review and meta-analysis.","authors":"Omid Mirmosayyeb, Mohammad Yazdan Panah, Mohammadreza Alinejadfard, Soroush Oraee, Saeed Vaheb, Vahid Shaygannejad","doi":"10.1007/s13760-025-02829-5","DOIUrl":"https://doi.org/10.1007/s13760-025-02829-5","url":null,"abstract":"<p><strong>Background: </strong>Multiple sclerosis (MS) is a neurodegenerative disease with diverse symptoms, including autonomic nervous system impairment. While autonomic dysfunction is well-documented in MS, debate continues over its extent and whether it primarily affects the sympathetic or parasympathetic divisions. This review aimed to investigate heart rate variability (HRV) as an indicator of cardiac autonomic function in people with MS (PwMS).\"</p><p><strong>Methods: </strong>PubMed/MEDLINE, Web of Science, Embase, and Scopus were systematically searched up to August 2024 to identify observational studies that assessed HRV in PwMS and healthy controls (HCs). The standard mean difference (SMD) of HRV parameters, along with its 95% confidence interval (CI), between PwMS and HCs was estimated utilizing R version 4.4.0 within the random-effects model.</p><p><strong>Results: </strong>This study combined data from 43 studies on 1518 PwMS and 1062 HCs. The meta-analysis revealed significant autonomic dysfunction in PwMS compared to HCs. Specifically, the time-domain measures such as root mean square of successive differences (RMSSD) (SMD = -0.81, p  <  0.01) and pNN50 (SMD = -0.63, p  <  0.001) showed significant reductions in PwMS, compared to HCs. Furthermore, among frequency domains, high frequency (HF) power (SMD = -0.51, p  <  0.01) and low frequency (LF) power were significantly lower in PwMS (SMD = -0.44, p  <  0.05) than HCs.</p><p><strong>Conclusion: </strong>This review revealed that PwMS exhibited different HRV than healthy individuals. Additionally, HRV findings demonstrated greater sympathetic dominance in PwMS compared to healthy individuals. Future studies are needed to explore HRV in PwMS across varying severity levels, subtypes, and treatments to understand autonomic dysfunction in this population better.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steroid therapy for severe cerebral venous thrombosis with rare manifestations of parkinsonism: a case report and literature review.","authors":"Wensi Hao, Yaqin Gu, Xunming Ji, Yuping Wang, Jiangang Duan","doi":"10.1007/s13760-025-02832-w","DOIUrl":"https://doi.org/10.1007/s13760-025-02832-w","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative assessment of endoscopic and microsurgery resection for intracranial ventricular tumors: a meta-analysis of 3059 patients.","authors":"Sandra Thair Al-Aish, Abbas F Abdul Hussein, Ahmed Sermed Al Sakini, Mohamed Rifai, Mustafa L Alshareefi, Mohammad Al Diab Al Azzawi, Khalid Sarhan, Hazim Alkousheh, Zineddine Belabaci, Arwa Jader, Santiago Pastrana-Brandes, Sameh Elmorsy Hassan","doi":"10.1007/s13760-025-02835-7","DOIUrl":"https://doi.org/10.1007/s13760-025-02835-7","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background and aim: &lt;/strong&gt;Surgical resection of ventricular brain tumors is traditionally performed via microsurgery, which requires open craniotomy and can result in significant complications. Endoscopic approaches have emerged as minimally invasive alternatives. There is a lack of consensus regarding the preferred surgical strategy for ventricular tumor resection; the technique with the optimal rates of recurrence, mortality, and complications is debatable.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;This article aims to evaluate the efficacy of endoscopic resection in comparison to microsurgical resection, focusing on identifying the approach with superior clinical outcomes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Method: &lt;/strong&gt;To determine surgical outcomes, we performed a meta-analysis of the existing original studies across PubMed, SCOPUS, Cochrane, and Web of Science medical databases from inception to 20 February 2024, per PRISMA guidelines that discussed microsurgery and endoscopic resection in ventricular tumors. Eligible studies (n = 47) were included, which contained data describing clinical outcomes, postoperative complications, and mortality rates that were extracted and analyzed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 47 studies, encompassing 3,059 patients (1,121 microsurgery, 1,938 endoscopy), were included. The mean age was 37.4 years (range 6-64), with 66.62% male (1,701/3,059). Colloid cysts were present in 67% (1,629/3,059), predominantly located in the third ventricle (55%, 715/1,301). Headache (96.15%, 2,700/2,808) was the most common symptom, followed by nausea/vomiting (12.5%, 351/2,808) and visual field deficits (11.26%, 316/2,808). The pooled gross-total resection (GTR) rate was 81.5% (95% CI, 75-88.1%; I²=66.66%), with endoscopic and microsurgery subgroups yielding GTR rates of 80% and 84.4%, respectively. Recurrence occurred in 4.7% (95% CI, 2.8-6.6%; I²=72.74%), with endoscopic and microsurgery rates of 3.9% and 6.6%. The mortality rate was 1.7% (95% CI, 0.9-2.5%; I²=29.1%), lower in endoscopic (0.6%) than microsurgery (5.2%). Postoperative hydrocephalus was noted in 4.8% (95% CI, 1.5-8.1%; I²=49.7%), cognitive deficits in 4.9% (95% CI, 3-6.9%; I²=33.57%), and cerebrospinal fluid leakage in 4.7% (95% CI, 1.8-7.6%; I²=53.81%). Seizures occurred in 3.6% (95% CI, 2-5.2%; I²=5.08%), neurological deficits in 5.5% (95% CI, 3-8%; I²=72.64%), visual field defects in 4.3% (95% CI, 2.6-6%; I²=35%), and wound infections in 2.5% (95% CI, 1-4%; I²=0%). Subgroup analyses generally showed lower complication rates for endoscopic surgery compared to microsurgery.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Endoscopic resection offers favorable trends in the management of ventricular tumors. These include improved neurological outcomes, postoperative complications such as visual field defects and seizure rates, and lower mortality rates. Despite the need for further research to fully elucidate its benefits, Endoscopic resection stands out as a valuable tech","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poor neurological outcome after treatment with photobiomodulation in a patient recovering from sequelae of vertebral artery dissection.","authors":"W J van Rooij, M Sluzewski","doi":"10.1007/s13760-025-02830-y","DOIUrl":"https://doi.org/10.1007/s13760-025-02830-y","url":null,"abstract":"<p><strong>Background: </strong>PhotBioModulation Therapy (PBMT) is regarded as a safe therapy for various disorders. We report a patient with a vertebral artery dissection treated with PBMT resulting in a poor neurological outcome.</p><p><strong>Case presentation: </strong>A 69-year-old patient with a PICA infarction after a vertebral artery dissection was treated with PhotoBioModulation Therapy using a helmet. This therapy induces strong vasodilatation in the area of application. Shortly after this treatment, she fell asleep and did not wake up the next morning. Clinically she was comatose and an MRI showed bithalamic and mesencephalic infarction as a result of thrombosis of the basilar artery tip. A causative relation between the PhotoBioModulation Therapy and the poor outcome is likely based on the time course, the immediate complaints after treatment, and the usually excellent prognosis after vertebral artery dissection.</p><p><strong>Conclusion: </strong>We advise the manufacturers of PBMT devices to add (recent) stroke to the list of contraindications.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding stigma in multiple sclerosis: workplace discrimination, social challenges and psychological impacts.","authors":"Nazlı Gamze Bülbül, Abdulkadir Tunç, Sena Destan Bünül, Serkan Demir, Meral Seferoğlu, Ali Özhan Sıvacı, Selma Aksoy, İpek Güngör Doğan, Ülgen Yalaz Tekan, Nefise Eda Arslanoğlu, Samet Öncel, Rıfat Erdem Toğrol, Hüsnü Efendi","doi":"10.1007/s13760-025-02826-8","DOIUrl":"https://doi.org/10.1007/s13760-025-02826-8","url":null,"abstract":"<p><strong>Background: </strong>Stigmatization in MS patients is an important problem that affects social interaction, work life and daily life. In this study, we investigated the prevalence, severity and especially the effects of stigmatization on work life in MS patients.</p><p><strong>Methods: </strong>A cross-sectional study of 420 people living with MS (PwMS) assessed stigma using the NeuroQoL Stigma Short Form and a direct stigma survey. Demographic, clinical, workplace, and social data were collected through an online survey. Statistical analyses were performed.</p><p><strong>Results: </strong>Stigma was prevalent, with 77% reporting stigma in direct surveys and 67.6% scoring > 8 on the NeuroQoL Stigma Short Form. Stigma was more severe in patients with progressive MS and higher EDSS scores. The most disturbing symptoms were fatigue (73.3%), imbalance (46.7%) and attention deficit 50.5%). The most prominent complaint affecting work life was fatigue (41.2%). Only 7.3% of the patients had sought psychological support for this issue. 57.4% of patients had disclosed their illness to their employer and 68.1% to their coworkers.</p><p><strong>Conclusions: </strong>Stigma in MS is pervasive, linked to clinical severity, workplace challenges, and social withdrawal. Interventions targeting stigma's psychological and social dimensions, along with workplace education and support are essential.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tackling paraneoplastic and non-paraneoplastic Lambert-Eaton myastenic syndromes: when timing is key. Comment on schőn et al. report.","authors":"Giuliana Galassi, Alessandra Ariatti, Marco Mazzoli, Alessandro Marchioni, Guido Ficarra","doi":"10.1007/s13760-025-02828-6","DOIUrl":"https://doi.org/10.1007/s13760-025-02828-6","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carotid web: identifying an often-overlooked cause of stroke during endovascular therapy.","authors":"Erik Elseviers, Thomas Jardinet, Caroline M J Loos","doi":"10.1007/s13760-025-02831-x","DOIUrl":"https://doi.org/10.1007/s13760-025-02831-x","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144367813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eyelid twitching in MuSK-myasthenia gravis.","authors":"Vasiliki Zouvelou, Dimitra Tzavella, Thomas Zambelis","doi":"10.1007/s13760-025-02811-1","DOIUrl":"https://doi.org/10.1007/s13760-025-02811-1","url":null,"abstract":"<p><p>A 22-year-old female suffering from MuSK-myasthenia gravis presented with fatigable eyelid ptosis, fluctuated bulbar symptoms and bilateral eyelid twichings which were greatly reinforced after tight closure of eyes and contraction of orbicularis oculi muscles. The patient never received acetylcholinesterase inhibitor treatment. Persistent twichings, irrespectively of clinical status, were signs of cholinergic hyperactivity. MuSK antibodies disrupt MuSK-collagen Q interaction with resultant deficient binding of acetylcholinesterase at synaptic cleft and impaired breakdown of acetylcholine. In myasthenia gravis, clinical signs of cholinergic hyperactivity may point to seropositivity of MuSK antibodies with therapeutic implications in clinical practice.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}