Acta neurologica Belgica最新文献_第2页

The nature of fatigue in amyotrophic lateral sclerosis: a systematic review and meta-analysis. 肌萎缩性侧索硬化症患者疲劳的性质：一项系统回顾和荟萃分析。

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-09-09 DOI: 10.1007/s13760-025-02890-0

Mansur A Kutlubaev, Ekaterina V Pervushina, Matthew C Kiernan

{"title":"The nature of fatigue in amyotrophic lateral sclerosis: a systematic review and meta-analysis.","authors":"Mansur A Kutlubaev, Ekaterina V Pervushina, Matthew C Kiernan","doi":"10.1007/s13760-025-02890-0","DOIUrl":"https://doi.org/10.1007/s13760-025-02890-0","url":null,"abstract":"Objectives: Patients diagnosed with amyotrophic lateral sclerosis (ALS) typically describe symptoms of fatigue. Despite this frequency, the underlying mechanisms of fatigue are poorly understood, and are likely multifactorial. To help clarify mechanisms, the present systematic review was undertaken to determine the risk factors related to fatigue in ALS.Methods: A systematic review was conducted using PubMed and Google Scholar databases using key words. From a total of 40,014 articles, 18 articles were included in the final review, following PRISMA guidelines. Meta-regression and subgroup analyses were conducted to study the relationship between fatigue in ALS and different covariates.Results: Eighteen studies were included in the analysis. A number of factors were investigated, including age, sex, disease severity and duration, site of disease onset, neurophysiological parameters, and respiratory symptoms, depression and anxiety, sleep disorders, and pain. Combined analyses established that participants with ALS who reported fatigue had more severe disease, as confirmed by lower functional rating scores, than those who did not report fatigue. The remaining factors including depression, anxiety and pain, were not found to be related to the onset of fatigue in ALS. Overall, fatigue worsened quality of life in patients diagnosed with ALS.Discussion: Fatigue in ALS appears to be particularly associated with progressive neurological deficit and disability, linked to both central and peripheral neuromuscular mechanisms.","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A study of the responsiveness of the Six-Spot Step Test in people with multiple sclerosis. 多发性硬化症患者6点步测试反应性的研究。

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-09-04 DOI: 10.1007/s13760-025-02887-9

Esben Køhler, Jacob Callsen, John Kodal Brincks

{"title":"A study of the responsiveness of the Six-Spot Step Test in people with multiple sclerosis.","authors":"Esben Køhler, Jacob Callsen, John Kodal Brincks","doi":"10.1007/s13760-025-02887-9","DOIUrl":"https://doi.org/10.1007/s13760-025-02887-9","url":null,"abstract":"Aims: This study aimed to evaluate the responsiveness of the Six-Spot Step Test (SSST) in people with multiple sclerosis to assess its capability as a measure for detecting changes in gait and balance capacity following a 10-week training intervention.Methods: The SSST, Timed 25-Foot Walk, and mini-BESTest were administered to 71 individuals with MS, ranging from mild to severe disability, before and after a 10-week program of progressive resistance and balance training. However, 16 patients were lost to follow-up. This study adhered to the COSMIN framework for reporting and evaluating the psychometric properties of health-related outcome measures.Results: Spearman's analyses revealed a moderate negative correlation between changes in the SSST and the mini-BESTest (rs = -0.33, p = 0.02) and changes in the SSST and the Timed 25-Foot Walk (rs = -0.37, p = 0.01). Significant median (min;max) changes and corresponding effect sizes (ES) were observed in the SSST (-1.4 (-11.4;4.7), p < 0.001, ES = -0.84), the Mini-BESTest (3 (-3;13), p < 0.001, ES = 0.89), and the Timed 25-Foot Walk (0.09 (-0.21;0.54), p < 0.001, ES = 0.71).Conclusion: The SSST serves as a sensitive measure for changes in gait and balance capacity. Furthermore, the consistently large effect sizes observed across all three gait and balance assessments following the exercise intervention suggest that these measures reflect a shared underlying construct-functional mobility-which is essential for independent community living.","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurological impairments in Duchenne muscular dystrophy: A comprehensive review. 杜氏肌营养不良症的神经损伤：综合综述。

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-09-04 DOI: 10.1007/s13760-025-02880-2

Xiao-Fang Zhang, Wenguang Hu, Jie Hu

引用次数: 0

Fear of falling, gait capacity, and dual task performance in multiple sclerosis patients with and without neurogenic overactive bladder. 有或无神经源性膀胱过动症的多发性硬化症患者的跌倒恐惧、步态能力和双重任务表现。

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-09-04 DOI: 10.1007/s13760-025-02889-7

Humeyra Kiloatar, Cimen Olcay Demir, Aylin Aydogdu Delibay, Dursun Ceylan, Emine Saygin Uysal

{"title":"Fear of falling, gait capacity, and dual task performance in multiple sclerosis patients with and without neurogenic overactive bladder.","authors":"Humeyra Kiloatar, Cimen Olcay Demir, Aylin Aydogdu Delibay, Dursun Ceylan, Emine Saygin Uysal","doi":"10.1007/s13760-025-02889-7","DOIUrl":"https://doi.org/10.1007/s13760-025-02889-7","url":null,"abstract":"Background: Overactive bladder (OAB) symptoms significantly affect the independence and quality of life in patient with multiple sclerosis (PwMS) by limiting daily activities. This study aimed to explore differences in fear of falling (FoF), gait, dual-task performance, and self-perceived impact of disease among PwMS with and without OAB.Method: Participants were divided into two groups based on their Overactive Bladder Questionnaire (OAB-V8) scores: OAB (score ≥ 8) and non-OAB (score < 8). Assessments included the Falls Efficacy Scale-International (FES-I) for FoF, the 2-Minute Walk Test (2MWT) for gait capacity, the Dual-Task Questionnaire (DTQ) for dual-task performance, and the Multiple Sclerosis Impact Scale-29 (MSIS-29) for self-perceived impact of disease.Results: The study included 78 PwMS. Significant differences were found between groups in fall history, number of falls, and all outcome measures (OAB-V8, FES-I, DTQ, 2MWT, MSIS-29; p < 0.001). OAB-V8 scores positively correlated with FES-I, DTQ, and MSIS-29 (r = 0.71-0.78, p < 0.001) and negatively with 2MWT (r = -0.38, p < 0.001). Similar patterns were observed between FES-I, DTQ, and MSIS-29, which showed strong positive correlations, while both negatively correlated with 2MWT.Conclusion: PwMS with OAB exhibit higher FoF, poorer gait, and impaired dual-task performance compared to those without OAB. These findings highlight the significant impact of OAB on functional and disease-related outcomes.","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Late Adulthood Onset POLG Disease Presenting as Spastic Paraplegia: A Pathophysiological Continuum? 成年晚期发病的POLG疾病表现为痉挛性截瘫：病理生理连续体？

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-09-04 DOI: 10.1007/s13760-025-02878-w

Shreyashi Jha, Mandar Jog

引用次数: 0

Rapid progression of cerebral amyloid angiopathy following coil embolization for vertebral artery dissection: A case report. 椎动脉夹层线圈栓塞后脑淀粉样血管病的快速进展：1例报告。

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-09-02 DOI: 10.1007/s13760-025-02885-x

Yuya Kobayashi, Minori Kurashina, Tetsuo Sasaki, Tsuneaki Yoshinaga, Yoshiki Sekijima

引用次数: 0

Zilucoplan in myasthenic crisis refractory to conventional treatment: a report of two cases. Zilucoplan治疗常规治疗难治性肌无力危象2例报告。

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-09-02 DOI: 10.1007/s13760-025-02860-6

Ari Maruani, Sophie Demeret, Mathilde Piljan, Nicolas Weiss, Clémence Marois

引用次数: 0

Risk of psychosis following mild traumatic brain injury: a systematic review and meta-analysis. 轻度创伤性脑损伤后精神病的风险：一项系统回顾和荟萃分析。

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-09-02 DOI: 10.1007/s13760-025-02883-z

Akinwale Aguda, Ioannis Mavroudis

{"title":"Risk of psychosis following mild traumatic brain injury: a systematic review and meta-analysis.","authors":"Akinwale Aguda, Ioannis Mavroudis","doi":"10.1007/s13760-025-02883-z","DOIUrl":"https://doi.org/10.1007/s13760-025-02883-z","url":null,"abstract":"Background: Mild traumatic brain injury (mTBI), commonly known as concussion, has historically been regarded as a transient and benign condition. However, recent studies suggest it may increase the risk of long-term psychiatric outcomes, including psychosis. This study aimed to systematically review and meta-analyze the association between mTBI and subsequent risk of psychosis.Methods: A comprehensive search of PubMed, PsycINFO, and Google Scholar was conducted through June 2025. Studies were eligible if they included individuals with a history of mTBI, a non-TBI control group, and reported psychosis-related outcomes with estimable risk measures. Random-effects meta-analysis was performed using the metafor package in R. Risk of bias and publication bias were assessed, and meta-regression was conducted to explore moderators such as adjustment status and effect size type.Results: Seven studies comprising pediatric and adult populations were included. The pooled risk ratio (RR) for psychosis following mTBI was 1.57 (95% CI: 1.28-1.91, p < 0.001), indicating a statistically significant association. The 95% prediction interval (1.03-2.38) suggests generalizability across future studies. No significant publication bias was detected (Egger's test p = 0.10). Meta-regression found no difference between adjusted and unadjusted estimates (p = 0.802). Sensitivity analyses confirmed the robustness of the findings.Conclusions: mTBI is associated with a moderate but statistically significant increase in the risk of psychosis. Given the prevalence of mTBI in the general population, these findings highlight the need for long-term psychiatric monitoring and preventive strategies, particularly in youth and high-risk individuals.","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disulfiram-Ethanol reaction mimicking posterior circulation stroke: A case report. 双硫仑-乙醇反应模拟后循环卒中1例报告。

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-09-01 DOI: 10.1007/s13760-025-02879-9

Alessandro Trebbastoni, Fabrizio Sallustio

引用次数: 0

Pneumocephalus in pneumococcal meningitis. 肺炎球菌性脑膜炎中的气脑。

IF 2.1 4区医学

Acta neurologica Belgica Pub Date : 2025-09-01 DOI: 10.1007/s13760-025-02882-0

L Van Avermaet, S Proost, G Vangrinsven, P G Jorens, L Yperzeele

引用次数: 0