Acta neurologica Belgica最新文献_第2页

Charlevoix-Saguenay spastic ataxia: a novel mutation in the SACS gene. Charlevoix-Saguenay痉挛性共济失调：SACS基因的新突变。

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-06-05 DOI: 10.1007/s13760-025-02813-z

Lan Li, Xiuhua Tian, Junfeng Chen, Xiaoyan Guo

引用次数: 0

Correlation between elevated blood and cerebrospinal fluid glucose levels and the severity and short-term prognosis of Guillain-Barré syndrome. 血液和脑脊液葡萄糖水平升高与格林-巴-罗综合征严重程度和短期预后的关系

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-06-05 DOI: 10.1007/s13760-025-02816-w

Prashant Bhatele, Aparna R Pai

{"title":"Correlation between elevated blood and cerebrospinal fluid glucose levels and the severity and short-term prognosis of Guillain-Barré syndrome.","authors":"Prashant Bhatele, Aparna R Pai","doi":"10.1007/s13760-025-02816-w","DOIUrl":"https://doi.org/10.1007/s13760-025-02816-w","url":null,"abstract":"Objective: This study aimed to explore the relationships between diabetes mellitus and Guillain-Barré syndrome (GBS) progression and short-term prognosis.Materials and methods: This retrospective cohort analysis included 330 patients with GBS. The study was performed at the Department of Neurology, Kasturba Medical College, Manipal, from January 2016 to December 2023. Diabetes mellitus was present in 31.8% of the 330 GBS patients. The degree of disability was assessed according to the GBS Disability Scale (GDS).Results: Compared with patients with normal glycosylated hemoglobin A1c (HbA1c) and cerebrospinal fluid (CSF) glucose levels, patients in the high HbA1c and high CSF glucose groups were characterized by severe disability (GDS ≥ 3) at admission (52.4 vs. 75.2, P = 0.001; 80 vs. 53.4, P = 0.001), at nadir (63.1 vs. 83.8, P = 0.02; 84.5 vs. 60.6, P = 0.03), and at discharge (52.4 vs. 31.1, P = 0.04; 57.8 vs. 27.8, P = 0.03). Older age, gastrointestinal tract infection, and axonal subtype were significantly associated with severe disability at admission, at nadir, and at discharge. Elevated blood levels of HbA1c were significantly correlated with worse disability at admission (OR = 0.64) and at nadir (OR = 0.74) but not at discharge. Elevated CSF glucose levels were significantly correlated with severe disability at admission (OR = 0.68), at nadir (OR = 0.62), and at discharge (OR = 0.72).Conclusion: The present study revealed that elevated glucose levels in the blood and CSF were correlated with disease severity at admission, nadir and discharge and might predict the short-term prognosis of GBS patients.","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum ferritin levels linked to cognitive decline and biomarker profiles in dementia with lewy bodies. 血清铁蛋白水平与路易体痴呆患者认知能力下降和生物标志物相关。

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-06-04 DOI: 10.1007/s13760-025-02804-0

Zhihong Ren, Hui Chen, Hao Wu, Ling-Yun Ma, Jinghuan Gan, Shuai Liu, Feng Zhou, Guili Zhang, Yong Ji

{"title":"Serum ferritin levels linked to cognitive decline and biomarker profiles in dementia with lewy bodies.","authors":"Zhihong Ren, Hui Chen, Hao Wu, Ling-Yun Ma, Jinghuan Gan, Shuai Liu, Feng Zhou, Guili Zhang, Yong Ji","doi":"10.1007/s13760-025-02804-0","DOIUrl":"https://doi.org/10.1007/s13760-025-02804-0","url":null,"abstract":"Objective: Elevated serum ferritin levels have been associated with neurodegenerative diseases, yet their specific role in dementia with Lewy bodies (DLB) remains insufficiently explored.Method: A total of 434 participants were enrolled, including 217 controls, 217 Alzheimer's disease (AD) patients, and 89 DLB patients. Demographic and clinical characteristics, cognitive performance, and neurobehavioral symptoms were evaluated. Serum ferritin levels were stratified into quartiles, and logistic regression models were used to examine the association between ferritin levels and the risk of DLB. Additionally, biomarker profiles of Aβ42, Aβ40, t-tau, and p-tau were analyzed across ferritin quartiles in DLB patients.Results: DLB patients exhibited the most severe neurobehavioral symptoms (NPI: 11.09 ± 1.24) and significant cognitive impairment (MMSE: 14.16 ± 6.81; MoCA: 9.77 ± 6.20) compared to controls. Higher serum ferritin levels were significantly associated with increased DLB risk, with the highest quartile showing an adjusted odds ratio of 7.58 (95% CI: 2.52-22.81). In DLB patients, ferritin levels were significantly associated with Aβ42 (p < 0.001), with Aβ42 concentrations following a U-shaped distribution across quartiles, suggesting a complex interplay between ferritin and amyloid pathology. Aβ40, t-tau, and p-tau showed weaker or non-significant associations.Conclusion: Elevated serum ferritin levels are strongly associated with an increased risk of DLB and may modulate amyloid pathology, particularly Aβ42. These findings underscore the relevance of iron metabolism in the pathophysiology of DLB and suggest ferritin as a potential biomarker for diagnosis and disease monitoring.","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A unique case of epileptic foreign Language auditory verbal hallucination. 癫痫性外语听觉言语幻觉一例。

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-06-04 DOI: 10.1007/s13760-025-02791-2

Ashique Hamza, Janu Santhosh Kumar, P Gilna, V P Tushar, Sachin Sureshbabu

引用次数: 0

Correction to: Alteration in the expression of long non‑coding RNAs in the circulation of migraineurs. 更正：长链非编码rna在偏头痛循环中的表达改变。

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-06-04 DOI: 10.1007/s13760-025-02807-x

Mohammad Taheri, Reyhaneh Eghtedarian, Solat Eslami, Bashdar Mahmud Hussen, Soudeh Ghafouri-Fard, Seyed Abdulmajid Ayatollahi

引用次数: 0

Developmental venous anomalies: benign in nature, potentially debilitating for life. 发育性静脉异常：本质上是良性的，但可能使人终生衰弱。

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-06-02 DOI: 10.1007/s13760-025-02786-z

L Maes, T van der Zijden, C M J Loos

引用次数: 0

A rare cause of persistent hiccups: familial cerebral cavernous malformations associated with mutation of the KRIT1 gene. 持续性打嗝的罕见原因：家族性脑海绵状血管瘤与KRIT1基因突变相关。

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-06-02 DOI: 10.1007/s13760-025-02817-9

Mert Altıntaş, Göksel Vatansever, Seda Kaynak Şahap, İrem Hartuç Çevik, Miraç Yıldırım

引用次数: 0

Reliability and validity of the Turkish version of the core lower urinary tract symptom score in multiple sclerosis. 土耳其版多发性硬化症核心下尿路症状评分的信度和效度。

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-06-01 Epub Date: 2025-03-26 DOI: 10.1007/s13760-025-02769-0

Humeyra Kiloatar, Aylin Aydogdu Delibay, Cimen Olçay Demir, Dursun Ceylan, Niyazi Uysal

{"title":"Reliability and validity of the Turkish version of the core lower urinary tract symptom score in multiple sclerosis.","authors":"Humeyra Kiloatar, Aylin Aydogdu Delibay, Cimen Olçay Demir, Dursun Ceylan, Niyazi Uysal","doi":"10.1007/s13760-025-02769-0","DOIUrl":"10.1007/s13760-025-02769-0","url":null,"abstract":"Background: In multiple sclerosis, lower urinary tract symptoms are frequently observed depending on the site of involvement. A comprehensive assessment of these symptoms is crucial for their effective management.Objective: This research was designed to evaluate the validity and reliability of the Turkish adaptation of the Core Lower Urinary Tract Symptom Scale (CLSS) in patients with multiple sclerosis (PwMS).Methods: 71 PwMS who had an Expanded Disability Status Scale score of 6.5 or below was included. Data collection involved demographic information as well as responses to the CLSS, Overactive Bladder Questionnaire, Interstitial Cystitis Symptom Index, Interstitial Cystitis Problem Index, and International Prostate Symptom Score. To evaluate test-retest reliability, the CLSS was administered again under identical conditions after a 7-day interval.Results: The internal consistency of the questionnaire was assessed, resulting in a Cronbach's alpha coefficient of 0.79. Test-retest reliability for the CLSS sub-items ranged from 0.593 to 0.950. No statistically significant differences were found between the sub-items scores of the test and retest administrations. (p > 0.05). Moreover, the subscales showed significant correlations with the other questionnaires, with correlation coefficients varying between 0.109 and 0.770. Straining, feeling incomplete emptying, and pain in the bladder sub-items did not show a significant correlation with the corresponding sub-items of other questionnaires (r = 0.109, 0.270, and 0.195, respectively).Conclusion: The Turkish adaptation of the CLSS questionnaire has been proven to be a reliable and valid instrument for evaluating lower urinary tract symptoms in PwMS.Clinicaltrials: Gov Number: NCT06599866.","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":"811-817"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

It is not so easy to objectively detect cognitive fluctuations in dementia with Lewy bodies. 客观地检测路易体痴呆患者的认知波动并不容易。

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-06-01 Epub Date: 2025-02-08 DOI: 10.1007/s13760-025-02737-8

Yasuhiro Nagahama, Shinya Yuki, Hiroko Suga, Sotaro Hieda

引用次数: 0

Survival outcomes among hospitalized patients with dementia: a propensity score matching analysis. 住院痴呆患者的生存结局：倾向评分匹配分析

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-06-01 Epub Date: 2025-03-15 DOI: 10.1007/s13760-025-02746-7

Henry Oliveros Rodríguez, Natalia Diaz-Dussan, Yahira Guzmán-Sabogal, Juliana Proaños, Eduardo Tuta-Quintero

{"title":"Survival outcomes among hospitalized patients with dementia: a propensity score matching analysis.","authors":"Henry Oliveros Rodríguez, Natalia Diaz-Dussan, Yahira Guzmán-Sabogal, Juliana Proaños, Eduardo Tuta-Quintero","doi":"10.1007/s13760-025-02746-7","DOIUrl":"10.1007/s13760-025-02746-7","url":null,"abstract":"Background: Hospitalized patients with dementia exhibit high mortality rates, underscoring the importance of investigating variables associated with reduced survival. This study aims to determine the incidence of dementia among hospitalized patients and survival rates at 1 and 3 years post-hospitalization.Methods: A retrospective cohort study was conducted using administrative databases from the Ministry of Health of Colombia. One- and three-year survival rates, along with adjusted hazard ratios for survival accounting for comorbidities included in the Charlson Index, were assessed using a Cox proportional hazards model. This analysis was performed for patients with dementia versus a control group without dementia. Additionally, findings were compared with those from an inverse propensity score weighting model.Results: 6.769 (1.04%) patients were diagnosed with dementia, and 5798 (85.65%) were over 65 years of age. The unadjusted HR, the HR adjusted using the proportional hazards Cox model, and the HR obtained through propensity score matching (PSM) were 10.32 (95% CI 9.82 to 10.84), 1.69 (95% CI 1.60 to 1.78), and 1.32 (95% CI 1.02 to 1.71), respectively. The 1-year adjusted mortality rates for patients with dementia and those without were 12.5% and 1.31%, respectively, while the corresponding 3-year adjusted mortality rates were 21.25% and 2.76%. Through PSM, we determined that the mean survival time for patients with dementia, in comparison to those without, was - 0.98 months (95% CI: -0.65 to -1.94; p < 0.001).Conclusions: Dementia significantly reduces survival rates of hospitalized patients, regardless of other comorbidities. Specifically, our research revealed that dementia was associated with a decrease in 3-year survival by an average of 0.98 months.","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":"771-781"},"PeriodicalIF":2.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0