Acta neurologica Belgica最新文献

{"title":"CLCN2-related leukoencephalopathy with a mild presentation and prominent facial pain: diagnostic value of MRI pattern recognition.","authors":"Evangelos Ntais, Gkirai Chamko, Anastasia K Zikou, Spiridon Konitsiotis","doi":"10.1007/s13760-026-03072-2","DOIUrl":"https://doi.org/10.1007/s13760-026-03072-2","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LINC00926 promotes microglial M1 polarization and neuroinflammation by sponging miR-383-3p in Alzheimer's disease: a potential diagnostic and therapeutic target.","authors":"Gang Liu, Bo Xie, Jingjiao Zhao, Lianlian Lv","doi":"10.1007/s13760-026-03065-1","DOIUrl":"https://doi.org/10.1007/s13760-026-03065-1","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated eyelid ptosis as a manifestation of recurrent painful ophthalmoplegic neuropathy in a young adult.","authors":"Najwa Al-Bustani, Bisher Tulimat, Zulfiqar Hussein, Mahmoud Shaqfeh","doi":"10.1007/s13760-026-03073-1","DOIUrl":"https://doi.org/10.1007/s13760-026-03073-1","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stage-dependent associations of plasma clusterin with reduced brain volume, tau pathology, and cognitive impairment across the Alzheimer's disease spectrum.","authors":"Qamar Abuhassan, Mustafa T Ardah, Soumya V Menon, Laxmidhar Maharana, L Inbathamizh, Gunjan Mukherjee, Aashna Sinha, Sevginoz Khodzhiyeva","doi":"10.1007/s13760-026-03070-4","DOIUrl":"https://doi.org/10.1007/s13760-026-03070-4","url":null,"abstract":"<p><p>Clusterin, a multifunctional glycoprotein involved in proteostasis, amyloid-β clearance, and neuroinflammation, has been proposed as a biomarker in Alzheimer's disease (AD), but its stage-specific links to brain structure, tau pathology, and cognition remain unclear. This study evaluated plasma clusterin across the AD spectrum, its associations with brain volumes and CSF tau/p-tau, and whether structural brain measures mediate its cognitive effects. Data from 333 participants (CN = 38, MCI = 207, AD = 88) were analyzed using FDR-corrected regression, Pearson correlations, and mediation analyses, adjusting for demographic factors and APOE ɛ4 status. Results showed that plasma clusterin was highest in mild cognitive impairment (MCI) compared to cognitively normal (CN) and AD, suggesting a peak during early neurodegeneration. In CN participants, higher clusterin was associated with lower whole-brain volume, but it was not significantly related to hippocampal volumes or tau/p-tau. In MCI, clusterin was modestly associated with reduced whole-brain volume and elevated CSF tau, while associations with hippocampal volumes and p-tau were nonsignificant. In AD, higher clusterin was significantly associated with smaller left and right hippocampal volumes, with a trend toward lower whole-brain volume; no significant associations with tau or p-tau were observed. Based on the mediation analysis, in CN participants, no significant mediation effects of brain volumes were observed between plasma clusterin and cognitive function. In the MCI group, higher plasma clusterin was associated with lower whole-brain volume, and this volumetric measure showed significant indirect effects linking plasma clusterin to cognitive performance, consistent with indirect-only (full mediation) patterns. This suggests an indirect association whereby higher clusterin may be linked to poorer cognitive function through its association with reduced global brain volume. Likewise, in the AD group, higher clusterin levels were associated with lower whole-brain and right hippocampal volumes. Both measures significantly mediated the relationship between clusterin and cognitive performance, indicating that higher clusterin may be linked to poorer cognitive function through its association with reductions in global and region-specific brain volumes. Future studies should clarify the temporal and mechanistic pathways linking clusterin to neurodegeneration to determine its value as a biomarker and therapeutic target.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147728046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: 'Association between obesity and subsequent risk of myasthenia gravis: a nationwide population-based cohort study'.","authors":"Okan Sökmen","doi":"10.1007/s13760-026-03069-x","DOIUrl":"https://doi.org/10.1007/s13760-026-03069-x","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147715532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical neuroleptic malignant syndrome without hyperthermia or rigidity in the ıntensive care unit: a diagnostic challenge.","authors":"Nuray Can Usta, Almina Aydın, Zübeyir Sivrikaya, Ahmet Akyol","doi":"10.1007/s13760-026-03068-y","DOIUrl":"https://doi.org/10.1007/s13760-026-03068-y","url":null,"abstract":"<p><p>Neuroleptic malignant syndrome (NMS) is a potentially life-threatening condition associated with dopamine antagonist medications. Although the classical presentation includes hyperthermia, generalized rigidity, autonomic instability, and altered mental status, atypical forms lacking these features may occur and complicate diagnosis. We report a case most consistent with atypical NMS in a 76-year-old patient who developed acute delirium and intermittent paratonia without fever or sustained rigidity following antipsychotic exposure. The clinical course was characterized by marked autonomic instability and a transient elevation of creatine kinase, peaking early and subsequently normalizing. A temporal relationship between antipsychotic exposure, symptom onset, and laboratory findings supported the diagnostic consideration. Although clinical improvement was observed following dopaminergic therapy, this finding was interpreted cautiously given potential confounding factors. This case highlights that NMS may occur without fulfilling classical diagnostic criteria and underscores the importance of integrating clinical, laboratory, and temporal features, particularly in critically ill patients.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147715530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recovering vision function after post-traumatic bilateral occipital infarction.","authors":"Sara Lima, Carolina Azoia, Pedro Guimarães, Cristina Ramos, Luís Rocha","doi":"10.1007/s13760-026-03046-4","DOIUrl":"https://doi.org/10.1007/s13760-026-03046-4","url":null,"abstract":"<p><p>Visual impairment may occur in severe traumatic brain injury due to ischemia in the territory of the posterior cerebral arteries, usually secondary to the compressive effect of expanding collections. The resulting functional defect tends to be permanent; however, through mechanisms yet to be clarified, some patients recover aspects of visual function, with blindsight suggested as a potential mechanism. We present a peculiar case of gradual visual recovery after cortical blindness in a victim of a car accident, which resulted in bilateral occipital infarcts. We aim to raise awareness of this rare phenomenon and contribute to the recognition that visual loss can, in some cases and to a certain extent, be transient.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147715573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatigue rather than cognitive reserve is associated with self-management in low-disability multiple sclerosis.","authors":"Simge Karadeniz, Bengu Altunan, Aysun Ünal, Filiz Dilek, Tuba Karakoyun Alpay","doi":"10.1007/s13760-026-03061-5","DOIUrl":"https://doi.org/10.1007/s13760-026-03061-5","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paroxysmal dyspnea in multiple system atrophy: a case of severe floppy arytenoid.","authors":"Ryo Murakami, Yuki Murata, Yuki Kobayashi, Akira Machida","doi":"10.1007/s13760-026-03062-4","DOIUrl":"https://doi.org/10.1007/s13760-026-03062-4","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroclinical predictors for drug-resistant epilepsy and outcome in tuberous sclerosis complex: a single center pediatric cohort.","authors":"Meltem Orbay, Hepsen Mine Serin, Seda Kanmaz, Erdem Simsek, Esra Isik, Tahir Atik, Ozgur Cogulu, Ferda Ozkinay, Sanem Yilmaz, Hasan Tekgul","doi":"10.1007/s13760-026-03067-z","DOIUrl":"https://doi.org/10.1007/s13760-026-03067-z","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}