Assessment of serum glucagon-like peptide-1 and dipeptidyl peptidase-4 levels in patients with migraine.

IF 2.1 4区 医学 Q3 CLINICAL NEUROLOGY
Melis Gultekin, Fatih Davran, Nehir Yuksel, Ozge Beyazcicek, Serif Demir
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引用次数: 0

Abstract

Background: Migraine is a prevalent neurovascular disorder affecting over one billion people globally, imposing significant daily life limitations. Migraine headaches are linked to the activation of trigeminal nerve endings. Glucagon-like peptide-1 (GLP-1) is a hormone involved in insulin regulation and plays neuroprotective roles in the central nervous system (CNS). Dipeptidyl peptidase-4 (DPP-4) is a protease enzyme that degrades GLP-1, rendering it inactive, and modulates metabolic and neurological pathways. This study investigates the association between serum GLP-1 and DPP-4 levels and migraine pathophysiology to propose a novel therapeutic approach for migraine.

Methods: The study included 42 migraine patients and 42 healthy controls. After fasting for at least 8 h, blood samples were collected. Serum GLP-1 and DPP-4 levels were measured using ELISA, and statistical analyses were conducted with SPSS 24.0.

Results: Serum GLP-1 and DPP-4 levels were significantly lower in migraine patients compared to controls (p < 0.001). Patients with migraine with aura had significantly lower GLP-1 levels compared to those with migraine without aura (p = 0.016). A significant decrease in GLP-1 levels was observed in patients experiencing pain localized in the occipital lobe (p = 0.01).

Conclusions: Serum GLP-1 and DPP-4 levels were lower in migraine patients. Given the role of GLP-1 in the central nervous system, reduced GLP-1 may contribute to migraine pain. Similarly, low DPP-4, which metabolizes GLP-1, may be linked to these findings and could trigger attacks by increasing blood CGRP levels.

偏头痛患者血清胰高血糖素样肽-1和二肽基肽酶-4水平的评估。
背景:偏头痛是一种普遍的神经血管疾病,影响全球超过10亿人,对日常生活造成严重限制。偏头痛与三叉神经末梢的激活有关。胰高血糖素样肽-1 (Glucagon-like peptide-1, GLP-1)是一种参与胰岛素调节的激素,在中枢神经系统(CNS)中起神经保护作用。二肽基肽酶-4 (DPP-4)是一种蛋白酶,可降解GLP-1,使其失活,并调节代谢和神经通路。本研究探讨血清GLP-1和DPP-4水平与偏头痛病理生理的关系,提出一种新的治疗偏头痛的方法。方法:选取42例偏头痛患者和42例健康对照。禁食至少8小时后,采集血样。采用ELISA法测定血清GLP-1、DPP-4水平,并用SPSS 24.0软件进行统计学分析。结果:偏头痛患者血清GLP-1和DPP-4水平明显低于对照组(p结论:偏头痛患者血清GLP-1和DPP-4水平较低。考虑到GLP-1在中枢神经系统中的作用,GLP-1的减少可能导致偏头痛。同样,代谢GLP-1的低DPP-4可能与这些发现有关,并可能通过增加血液CGRP水平引发攻击。
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来源期刊
Acta neurologica Belgica
Acta neurologica Belgica 医学-临床神经学
CiteScore
4.20
自引率
3.70%
发文量
300
审稿时长
6-12 weeks
期刊介绍: Peer-reviewed and published quarterly, Acta Neurologica Belgicapresents original articles in the clinical and basic neurosciences, and also reports the proceedings and the abstracts of the scientific meetings of the different partner societies. The contents include commentaries, editorials, review articles, case reports, neuro-images of interest, book reviews and letters to the editor. Acta Neurologica Belgica is the official journal of the following national societies: Belgian Neurological Society Belgian Society for Neuroscience Belgian Society of Clinical Neurophysiology Belgian Pediatric Neurology Society Belgian Study Group of Multiple Sclerosis Belgian Stroke Council Belgian Headache Society Belgian Study Group of Neuropathology
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