Aysegul Akkan Suzan, Seyda Bilgin, Pelin Degirmenci, Nurten Uzun Adatepe, Alper Doventas, Aysegul Gunduz
{"title":"What causes loss of muscle mass in primary sarcopenia: A MUNIX analysis and correlation with plasma biomarkers.","authors":"Aysegul Akkan Suzan, Seyda Bilgin, Pelin Degirmenci, Nurten Uzun Adatepe, Alper Doventas, Aysegul Gunduz","doi":"10.1007/s13760-025-02873-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>To determine if the loss of muscle mass in primary sarcopenia is secondary to motor neuron loss or directly related to muscle fiber loss using electrophysiological methods.</p><p><strong>Methods: </strong>We recruited individuals with primary sarcopenia and non-sarcopenic individuals of similar age and gender for the study. After a detailed evaluation of geriatric syndromes and neurological disorders through systemic, neurological, and electrophysiological examinations, we recorded the motor unit number index (MUNIX) and motor unit size index (MUSIX) of the first dorsal interosseus (FDI) and tibialis anterior (TA) muscles in all participants.</p><p><strong>Results: </strong>Individuals with sarcopenia exhibited reduced FDI MUNIX and lower TA CMAP amplitude and MUNIX values. The FDI MUNIX showed an inverse correlation with ferritin levels.</p><p><strong>Discussion: </strong>Primary sarcopenia is characterized by motor unit loss without significant reinnervation. Motor unit loss in individuals with sarcopenia can be demonstrated in both the upper and lower extremities using the MUNIX method, and functional iron deficiency contributes to the etiology of primary sarcopenia.</p><p><strong>Conclusion: </strong>Demonstration of motor unit loss in primary sarcopenia supports the hypothesis that the disease has a neuromuscular origin.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta neurologica Belgica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s13760-025-02873-1","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: To determine if the loss of muscle mass in primary sarcopenia is secondary to motor neuron loss or directly related to muscle fiber loss using electrophysiological methods.
Methods: We recruited individuals with primary sarcopenia and non-sarcopenic individuals of similar age and gender for the study. After a detailed evaluation of geriatric syndromes and neurological disorders through systemic, neurological, and electrophysiological examinations, we recorded the motor unit number index (MUNIX) and motor unit size index (MUSIX) of the first dorsal interosseus (FDI) and tibialis anterior (TA) muscles in all participants.
Results: Individuals with sarcopenia exhibited reduced FDI MUNIX and lower TA CMAP amplitude and MUNIX values. The FDI MUNIX showed an inverse correlation with ferritin levels.
Discussion: Primary sarcopenia is characterized by motor unit loss without significant reinnervation. Motor unit loss in individuals with sarcopenia can be demonstrated in both the upper and lower extremities using the MUNIX method, and functional iron deficiency contributes to the etiology of primary sarcopenia.
Conclusion: Demonstration of motor unit loss in primary sarcopenia supports the hypothesis that the disease has a neuromuscular origin.
期刊介绍:
Peer-reviewed and published quarterly, Acta Neurologica Belgicapresents original articles in the clinical and basic neurosciences, and also reports the proceedings and the abstracts of the scientific meetings of the different partner societies. The contents include commentaries, editorials, review articles, case reports, neuro-images of interest, book reviews and letters to the editor.
Acta Neurologica Belgica is the official journal of the following national societies:
Belgian Neurological Society
Belgian Society for Neuroscience
Belgian Society of Clinical Neurophysiology
Belgian Pediatric Neurology Society
Belgian Study Group of Multiple Sclerosis
Belgian Stroke Council
Belgian Headache Society
Belgian Study Group of Neuropathology