轻度创伤性脑损伤后精神病的风险:一项系统回顾和荟萃分析。

IF 2.1 4区 医学 Q3 CLINICAL NEUROLOGY
Akinwale Aguda, Ioannis Mavroudis
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引用次数: 0

摘要

背景:轻度创伤性脑损伤(mTBI),通常被称为脑震荡,历来被认为是一种短暂的良性疾病。然而,最近的研究表明,它可能会增加长期精神疾病的风险,包括精神病。本研究旨在系统回顾和荟萃分析mTBI与随后精神病风险之间的关系。方法:综合检索PubMed、PsycINFO和谷歌Scholar,检索时间截止到2025年6月。如果研究纳入有mTBI病史的个体,非tbi对照组,并报告了具有可估计风险措施的精神病相关结果,则研究符合条件。随机效应荟萃分析采用r中的meta软件包进行,评估偏倚风险和发表偏倚,并进行meta回归探讨调节状态和效应大小类型等调节因素。结果:包括儿童和成人人群的7项研究被纳入。mTBI后精神病的合并风险比(RR)为1.57 (95% CI: 1.28-1.91, p)。结论:mTBI与精神病风险的中度但有统计学意义的增加相关。鉴于mTBI在普通人群中的患病率,这些发现强调了长期精神监测和预防策略的必要性,特别是在年轻人和高危人群中。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Risk of psychosis following mild traumatic brain injury: a systematic review and meta-analysis.

Background: Mild traumatic brain injury (mTBI), commonly known as concussion, has historically been regarded as a transient and benign condition. However, recent studies suggest it may increase the risk of long-term psychiatric outcomes, including psychosis. This study aimed to systematically review and meta-analyze the association between mTBI and subsequent risk of psychosis.

Methods: A comprehensive search of PubMed, PsycINFO, and Google Scholar was conducted through June 2025. Studies were eligible if they included individuals with a history of mTBI, a non-TBI control group, and reported psychosis-related outcomes with estimable risk measures. Random-effects meta-analysis was performed using the metafor package in R. Risk of bias and publication bias were assessed, and meta-regression was conducted to explore moderators such as adjustment status and effect size type.

Results: Seven studies comprising pediatric and adult populations were included. The pooled risk ratio (RR) for psychosis following mTBI was 1.57 (95% CI: 1.28-1.91, p < 0.001), indicating a statistically significant association. The 95% prediction interval (1.03-2.38) suggests generalizability across future studies. No significant publication bias was detected (Egger's test p = 0.10). Meta-regression found no difference between adjusted and unadjusted estimates (p = 0.802). Sensitivity analyses confirmed the robustness of the findings.

Conclusions: mTBI is associated with a moderate but statistically significant increase in the risk of psychosis. Given the prevalence of mTBI in the general population, these findings highlight the need for long-term psychiatric monitoring and preventive strategies, particularly in youth and high-risk individuals.

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来源期刊
Acta neurologica Belgica
Acta neurologica Belgica 医学-临床神经学
CiteScore
4.20
自引率
3.70%
发文量
300
审稿时长
6-12 weeks
期刊介绍: Peer-reviewed and published quarterly, Acta Neurologica Belgicapresents original articles in the clinical and basic neurosciences, and also reports the proceedings and the abstracts of the scientific meetings of the different partner societies. The contents include commentaries, editorials, review articles, case reports, neuro-images of interest, book reviews and letters to the editor. Acta Neurologica Belgica is the official journal of the following national societies: Belgian Neurological Society Belgian Society for Neuroscience Belgian Society of Clinical Neurophysiology Belgian Pediatric Neurology Society Belgian Study Group of Multiple Sclerosis Belgian Stroke Council Belgian Headache Society Belgian Study Group of Neuropathology
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