Allergy最新文献 - Book学术

IF 12.6 1区医学

Allergy Pub Date : 2025-07-15 DOI: 10.1111/all.16655

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Aging Increases the Severity of Anaphylaxis Through Changes in Mast Cell Numbers and Histamine Sensitivity. 衰老通过肥大细胞数量和组胺敏感性的变化增加过敏反应的严重程度。

IF 12.4 1区医学

Allergy Pub Date : 2025-07-14 DOI: 10.1111/all.16650

Jasper B J Kamphuis,Alexia Loste,William P M Worrall,Nadine Serhan,Thomas Villeneuve,Pol André Apoil,Benjamin Trouche-Estival, ,Laurent Guilleminault,Nicolas Gaudenzio,Laurent L Reber

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Mast Cells Are Intrinsically Primed for Degranulation in DOCK8 Deficiency. 在DOCK8缺乏的情况下，肥大细胞内在地引发脱颗粒。

IF 12.4 1区医学

Allergy Pub Date : 2025-07-14 DOI: 10.1111/all.16651

Nyssa B Samanas,Irina Miralda,Nate Camp,Josie Sachen,Victoria Puryear,Liyana Shah,Albert J Seo,Jake S Foronda,Madelyn Shapiro,Safa Baris,Ekrem Unal,Ahmet Eken,Shane D Morrison,Eric J Allenspach,Gail H Deutsch,Richard G James,Adrian M Piliponsky

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Multiomics Analysis of the Response to Ritlecitinib in Alopecia Areata Subtypes and Correlation With Efficacy. 利来替尼治疗斑秃亚型的多组学分析及疗效相关性研究。

IF 12.4 1区医学

Allergy Pub Date : 2025-07-14 DOI: 10.1111/all.16659

Li Xi,Elena Peeva,Yuji Yamaguchi,Zhan Ye,Alexandre Lejeune,Craig Hyde,Emma Guttman-Yassky

{"title":"Multiomics Analysis of the Response to Ritlecitinib in Alopecia Areata Subtypes and Correlation With Efficacy.","authors":"Li Xi,Elena Peeva,Yuji Yamaguchi,Zhan Ye,Alexandre Lejeune,Craig Hyde,Emma Guttman-Yassky","doi":"10.1111/all.16659","DOIUrl":"https://doi.org/10.1111/all.16659","url":null,"abstract":"BACKGROUNDAlopecia areata (AA) is an autoimmune disease characterized by hair loss. This study examined changes in molecular signatures in lesional scalp of patients with AA subtypes (patchy-type AA [AAP] or alopecia totalis/alopecia universalis [AT/AU]) in response to treatment with JAK3/TEC family kinase inhibitor ritlecitinib and evaluated correlations between potential biomarker levels/changes and scalp hair regrowth.METHODSThis was a post hoc analysis of a biopsy substudy from a phase 2a trial of ritlecitinib in patients with AA and ≥ 50% scalp hair loss. Transcriptomic expression profiles from scalp samples of patients with AAP or AT/AU were analyzed using microarray. Changes from baseline in transcriptional and serum protein expression were evaluated, as were correlations between both these changes and the baseline profile with clinical response (scalp hair regrowth).RESULTSFollowing 12 and 24 weeks of treatment, ritlecitinib downregulated key Type I (CCL5, CD8A, and GZMB) and Type II immunity-related genes (CCL13, CCL18, and IL13RA1), downregulated genes related to ritlecitinib's mechanism of action (ITK, JAK3, and BTK), and upregulated hair keratin genes in AAP and AT/AU lesions, with a lesser extent in AT/AU than AAP lesions. Baseline expression levels and changes from baseline to Weeks 12 and/or 24 in levels of genes and serum proteins related to Type I and II immunity, hair structure/function, and ritlecitinib's mechanism of action significantly correlated with clinical response at Weeks 12 and/or 24.CONCLUSIONThese results provide support that treatment with ritlecitinib improves the gene expression profile in AA lesional scalp and is correlated with subsequent hair regrowth response.TRIAL REGISTRATIONNCT02974868.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"13 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144622111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Biological Treatment of Chronic Rhinosinusitis With Polyps Increases Number of Nasal Ciliated Cells—Real‐Life Experience 慢性鼻窦炎伴息肉的生物治疗增加鼻纤毛细胞数量-真实生活经验

IF 12.4 1区医学

Allergy Pub Date : 2025-07-10 DOI: 10.1111/all.16636

Grażyna Stryjewska‐Makuch, Maria Humeniuk‐Arasiewicz, Magdalena Onyszczuk, Magdalena Kokoszka, Marcelina Niemiec‐Urbańczyk, Marta Michalak‐Kolarz, Wojciech Ścierski, Radosław Gawlik, Joanna Gluck

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Validation of the Skin Prick Automated Test (SPAT) Cut‐Off Value in Birch Pollen and House Dust Mite Allergic Rhinitis Patients 桦树花粉和屋尘螨变应性鼻炎患者皮肤点刺自动测试（SPAT）切断值的验证

IF 12.4 1区医学

Allergy Pub Date : 2025-07-09 DOI: 10.1111/all.16645

Sven F. Seys, Alina Gherasim, Florian Odul, Frank Dietsch, Zuzana Diamant, Philippe Gevaert, Peter W. Hellings, Dirk Loeckx, Senne Gorris, Frédéric de Blay

{"title":"Validation of the Skin Prick Automated Test (SPAT) Cut‐Off Value in Birch Pollen and House Dust Mite Allergic Rhinitis Patients","authors":"Sven F. Seys, Alina Gherasim, Florian Odul, Frank Dietsch, Zuzana Diamant, Philippe Gevaert, Peter W. Hellings, Dirk Loeckx, Senne Gorris, Frédéric de Blay","doi":"10.1111/all.16645","DOIUrl":"https://doi.org/10.1111/all.16645","url":null,"abstract":"IntroductionA novel device, Skin Prick Automated Test (SPAT), previously showed reduced variability and more consistent test results compared to conventional skin prick test (SPT) to identify allergic sensitisation. This study aimed to clinically validate the adjusted SPAT cut‐off in patients with confirmed birch or house dust mite (HDM) allergy.MethodsSeventy‐five adults were included: 25 non‐allergic subjects (confirmed by lack of allergy history and negative SPT), 25 birch and 25 HDM allergic rhinitis patients (both confirmed by positive SPT and nasal allergen challenge [NAC]). All subjects received a conventional SPT and an automated SPT for B ver, D pter, D far and control solutions.ResultsA cut‐off of 4.2 and 4.1 mm, respectively, resulted in the highest accuracy to detect birch or HDM allergy using SPAT. Referring to previous study results suggesting a reliable cut‐off value of 4.5 mm, it was decided to maintain 4.5 mm as SPAT cut‐off indicating allergic sensitisation. Accuracy did not significantly differ between SPAT (96% using 4.5 mm) and conventional SPT (98% using 3.0 mm) to detect HDM allergy or to detect birch pollen allergy (100% for SPAT and SPT). SPAT wheal measurements performed through a ruler on the forearm or through digital measurement on a composite image did not significantly differ for any of the patient groups analysed.ConclusionSPAT showed an equivalent accuracy to detect birch pollen or HDM allergy compared to conventional SPT, using the adjusted 4.5 mm SPAT cut‐off in patients with confirmed allergic rhinitis. The SPAT web viewer can be used easily and effectively for digital wheal measurement on a composite image.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"21 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Expression of IL‐4 Receptor Alpha in Ectopic Lymphoid Tissue in Chronic Rhinosinusitis IL - 4受体α在慢性鼻窦炎异位淋巴组织中的表达

IF 12.4 1区医学

Allergy Pub Date : 2025-07-09 DOI: 10.1111/all.16649

Kengo Kanai, Hiroyuki Kusano, Aiko Oka, Marie Yamada, Ryo Takagi, Isao Suzaki, Kojiro Hirano, Junqin Bai, Takayuki Shiomi, Mitsuhiro Okano

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Real‐World Effectiveness for Sublingual Allergen Immunotherapy Among School‐Aged Children and Adolescents 学龄儿童和青少年舌下过敏原免疫治疗的实际效果

IF 12.4 1区医学

Allergy Pub Date : 2025-07-09 DOI: 10.1111/all.16646

Yusuke Okubo, Yu Kuwabara, Sakura Sato, Masafumi Sakashita, Hideaki Morita

{"title":"Real‐World Effectiveness for Sublingual Allergen Immunotherapy Among School‐Aged Children and Adolescents","authors":"Yusuke Okubo, Yu Kuwabara, Sakura Sato, Masafumi Sakashita, Hideaki Morita","doi":"10.1111/all.16646","DOIUrl":"https://doi.org/10.1111/all.16646","url":null,"abstract":"BackgroundSublingual allergen immunotherapy (SLIT) is a safe and effective treatment of allergic rhinitis, and its use has been increasing in recent years. Although several randomized and observational studies showed the effectiveness of SLIT among adults and children aged > 12 years, its extent remains unclear in nationwide routine healthcare settings for school‐aged children.MethodsWe conducted a propensity score (PS)‐matched cohort study using a nationwide administrative database. Data from 13,449 individuals who received SLIT for house dust mites between 2015 and 2021 were extracted and matched with data from 1,732,961 individuals who did not. The PS‐matching procedure created 10,985 pairs and followed them for three years, totaling 812,795 person‐months. Then, we compared healthcare costs, resource use, and prescriptions between the SLIT and control groups over the three years.ResultsThe introduction of SLIT was associated with an 8.9% reduction in antibiotic use (95% CI, 12.0% to 34.7%) and a 65.2% reduction in hospitalizations (95% CI, 52.8% to 74.4%), as well as a 44.1% increase in health resource utilization (95% CI, 40.7% to 47.6%), with minimal impact on overall healthcare costs (+8.9% [95% CI, −12.0% to +34.7%]) over the three‐year follow‐up period. Similar findings were observed in event‐study design and intention‐to‐treat analyses, as well as in age‐stratified analyses (ages 5–10 years and 11–19 years).ConclusionsThe introduction of SLIT for house dust mites was associated with a reduction in antibiotic prescriptions and hospitalizations among children aged 5–19 years with minimal impact on healthcare costs, demonstrating sustained benefits over three years.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"21 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Langerhans Cell Modulation in Atopic Dermatitis Is TLR2/SOCS1‐Dependent and JAK Inhibitor‐Sensitive 朗格汉斯细胞在特应性皮炎中的调节是TLR2/SOCS1依赖性和JAK抑制剂敏感的

IF 12.4 1区医学

Allergy Pub Date : 2025-07-09 DOI: 10.1111/all.16641

Yuxuan Deng, Nicole Leib, Sylvia Schnautz, Said Benfadal, Johannes Oldenburg, Thomas Bieber, Nadine Herrmann

{"title":"Langerhans Cell Modulation in Atopic Dermatitis Is TLR2/SOCS1‐Dependent and JAK Inhibitor‐Sensitive","authors":"Yuxuan Deng, Nicole Leib, Sylvia Schnautz, Said Benfadal, Johannes Oldenburg, Thomas Bieber, Nadine Herrmann","doi":"10.1111/all.16641","DOIUrl":"https://doi.org/10.1111/all.16641","url":null,"abstract":"BackgroundLangerhans cells (LC) are epidermal dendritic cells building the skin's outermost immunological barrier and bridging innate and adaptive immune responses. Their sensing property of the microbiome via Toll‐like receptors (TLR) is impaired in atopic dermatitis (AD). We hypothesize a desensitization of LC because of persistent Staphylococcus aureus exposure in AD and underlying mechanisms being TLR2‐related.MethodsHuman LC generated from hematopoetic stem cells were desensitized via repetitive exposure to TLR2‐ligands (priming) and compared to unprimed cells for their TLR‐responsiveness. JAK inhibitors impact was evaluated. Maturation marker, migration marker and behavior, cytokine release, and downstream molecule regulation were addressed by flow cytometry, qPCR, and transwell and multiplex assays.ResultsPrimed LC mimicked the LC behavior in AD skin, exhibiting desensitization toward TLR2‐mediated activation monitored by impaired CD83/CD80/CD86 and MHCII expression as well as impaired regulation of chemokines CCR6 and CCR7, migration competence, and Th17‐driving cytokines. IL‐18 and IL‐1β were elevated under these conditions. Negative regulators of the TLR2 pathway, specifically SOCS1 and IRAKM, were significantly upregulated, whereas activating molecules were hardly affected. JAK inhibitors reduced SOCS1 expression in primed cells and restored activation markers CD83/80/86 and MHCII upon TLR2 engagement, but had no effect on IRAKM expression.ConclusionPrimed LC mimic the impaired LC‐responsiveness toward TLR2 in AD skin. Our findings unravel a new direct contribution of LC to AD‐associated IL‐1β and IL‐18 under these conditions and shed light on the mechanistical role of SOCS1 and the mode of action of JAK inhibitors.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"31 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Impact of Residential Greeness Exposure on the Development of Allergic Diseases and Asthma and on Asthma Control—A Systematic Review for the EAACI Guidelines of Environmental Science for Allergic Diseases and Asthma 住宅绿化暴露对变态反应性疾病和哮喘发展及哮喘控制的影响——EAACI变态反应性疾病和哮喘环境科学指南系统综述

IF 12.4 1区医学

Allergy Pub Date : 2025-07-09 DOI: 10.1111/all.16653

Ioana Agache, Graciela J. Balbin‐Ramon, Fiorella Karina Fernandez Saenz, Ivan Sola‐Arnau, Pablo Alonso‐Coello, Tari Haahtela, Claudia Traidl‐Hoffmann, Liam O'Mahony, Athanasios Damialis, Antti Lauerma, Kari C. Nadeau, Isabella Pali‐Schöll, Oscar Palomares, Harald Renz, Jurgen Schwarze, Donata Vercelli, Carlos Canelo‐Aybar, Marek Jutel, Cezmi A. Akdis

{"title":"Impact of Residential Greeness Exposure on the Development of Allergic Diseases and Asthma and on Asthma Control—A Systematic Review for the EAACI Guidelines of Environmental Science for Allergic Diseases and Asthma","authors":"Ioana Agache, Graciela J. Balbin‐Ramon, Fiorella Karina Fernandez Saenz, Ivan Sola‐Arnau, Pablo Alonso‐Coello, Tari Haahtela, Claudia Traidl‐Hoffmann, Liam O'Mahony, Athanasios Damialis, Antti Lauerma, Kari C. Nadeau, Isabella Pali‐Schöll, Oscar Palomares, Harald Renz, Jurgen Schwarze, Donata Vercelli, Carlos Canelo‐Aybar, Marek Jutel, Cezmi A. Akdis","doi":"10.1111/all.16653","DOIUrl":"https://doi.org/10.1111/all.16653","url":null,"abstract":"The role of residential greenness exposure (RGE) in prevention and control of allergic diseases remains controversial. This systematic review evaluated the association between RGE and the risk of developing asthma, allergic rhinitis (AR), food allergy, atopic dermatitis (AD), and asthma control. MEDLINE and EMBASE searches retrieved 17 cohort and case–control longitudinal studies (12 for asthma, 6 AR, 1 food allergy, 1 ad). Risk of bias was assessed with ROBINS‐E, and certainty of evidence with GRADE. Data were meta‐analyzed using adjusted odds ratios (aORs) with random‐effects models. For “ever asthma” and “ever AR” a non‐significant protective trend of RGE was observed (aOR 0.92, 95% CI 0.72–1.18; aOR 0.61; 95% CI 0.24–1.55). For “current asthma” RGE was associated with increased risk (aOR 1.17, 95% CI 1.04–1.33), with no clear association for “current AR” (aOR 1.03; 95% CI 0.80–1.32). Prenatal RGE reduced the risk of “ever asthma” (aOR 0.94, 95% CI 0.93–0.950) and AD (aOR 0.996, 95% CI 0.993–0.999). RGE increased the risk for peanut (aOR 1.78, 95% CI 1.13–2.82) and egg allergy (aOR 1.38, 95% CI [1.05–1.82]). Reduced RGE decreased asthma control (OR: 2.662, 95% CI [1.043–6.799]). Potential benefits or potential harms of RGE should be judged in a context‐specific manner.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"11 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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