Allergy最新文献 - Book学术

Association Between Long‐Term Exposure to Ambient Air Pollution and the Risk of Recurrent Asthma Hospitalizations

IF 12.4 1区医学

Allergy Pub Date : 2025-01-24 DOI: 10.1111/all.16476

Jin‐Lun Zhang, Chong‐Ye Zhao, Xiao‐Han Xu, Chen Shi, Hao‐Neng Huang, Yi‐Ming Tao, Li Li, Chun‐Quan Ou

引用次数: 0

A Silver (Birch) Bullet for Children With Tree Pollen Allergy: Single Allergen Immunotherapy With Birch Extract Protects Across the Birch Homologous Group Pollen Season.

IF 12.6 1区医学

Allergy Pub Date : 2025-01-23 DOI: 10.1111/all.16480

Eve Denton, Mark Hew, Robyn E O'Hehir

引用次数: 0

Effectiveness and Safety of Dupilumab for Prurigo Nodularis in China: A Multicentric and Observational Study. Dupilumab在中国治疗结节性痒疹的有效性和安全性：一项多中心观察性研究。

IF 12.4 1区医学

Allergy Pub Date : 2025-01-21 DOI: 10.1111/all.16478

Zuotao Zhao,Xiaoting Song,Yuanyuan Shang,Lijuan Liu,Rui Zheng,Jianxin Xia,Qiang Liu,Guodong Hao,Jie Li,Songmei Geng,Jingang An,Qiang Wang,Xiaoyan Liu,Jianping Tang,Yizhu Xiao,Litao Zhang

{"title":"Effectiveness and Safety of Dupilumab for Prurigo Nodularis in China: A Multicentric and Observational Study.","authors":"Zuotao Zhao,Xiaoting Song,Yuanyuan Shang,Lijuan Liu,Rui Zheng,Jianxin Xia,Qiang Liu,Guodong Hao,Jie Li,Songmei Geng,Jingang An,Qiang Wang,Xiaoyan Liu,Jianping Tang,Yizhu Xiao,Litao Zhang","doi":"10.1111/all.16478","DOIUrl":"https://doi.org/10.1111/all.16478","url":null,"abstract":"BACKGROUNDThe efficacy and safety of dupilumab in patients with refractory prurigo nodularis (PN) is well established in clinical trials, but there is a lack of multicenter data regarding its effectiveness and safety in real-world settings.METHODSPatients with moderate-to-severe PN who initiated dupilumab treatment between July 2023 and January 2024, with a follow-up period of at least 16 weeks at 10 hospitals in China were included. We used peak pruritus numeric rating scale (PP-NRS), investigator global assessment (IGA) for PN, and dermatology life quality index for adults or children (DLQI/CDLQI) to assess disease control status and quality of life impairment, and monitored adverse events to assess the safety.RESULTSA total of 73 PN patients (33 female, 40 male; mean age 45.9 ± 21.5 years) were included. A clinically meaningful improvement of ≥ 4 points in PP-NRS (PP-NRS4) was achieved in 84.9% of patients at Week 12. The percentage of patients achieving IGA 0/1 significantly increasing from 0% to 37.0% and 46.6% at Week 12 and 16, respectively. Patient-reported quality of life outcomes showed substantial improvement, with decreasing from 16.6 ± 6.8 at baseline to 7.2 ± 4.9 at Week 12, 6.4 ± 4.5 at Week 16. The safety profile of dupilumab was favorable, with one patient reporting dry eyes.CONCLUSIONDupilumab can effectively improve the pruritus, nodular lesions and quality of life for PN in real-world settings.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"74 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recombinant IgE-Reactive Functional Can f 5 Devoid of Cross-Reactive Carbohydrate Determinants. 缺乏交叉反应性碳水化合物决定因子的重组ige反应性功能Can - 5。

IF 12.4 1区医学

Allergy Pub Date : 2025-01-21 DOI: 10.1111/all.16465

Evgenii Kozlov,Daria Trifonova,Alexandra Dubovets,Anastasia Usanova,Inna Tulaeva,Pia Gattinger,Daria Fomina,Wolfgang Hemmer,Neonila Gorokhovets,Rudolf Valenta,Alexander Karaulov

引用次数: 0

Roles of Interleukin-24 in Epithelial Repair: Bridging Injury and Regeneration. 白细胞介素-24在上皮修复中的作用：桥接损伤和再生。

IF 12.4 1区医学

Allergy Pub Date : 2025-01-21 DOI: 10.1111/all.16479

Morgan Bryant,Piotr P Janas,Thibaut Sanchez

引用次数: 0

IL‐25 Enhances B Cell Responses in Type 2 Inflammation Through IL‐17RB Receptor IL - 25通过IL - 17RB受体增强2型炎症中的B细胞反应

IF 12.4 1区医学

Allergy Pub Date : 2025-01-20 DOI: 10.1111/all.16472

Semah Abdu, Jiao Xia, Huihui Yuan, Tiak Ju Tan, Janice A. Layhadi, Mohamed H. Shamji, Andrew N. J. McKenzie, Nora Haloob, Claire Hopkins, Grzegorz Woszczek, Stephen J. Till

{"title":"IL‐25 Enhances B Cell Responses in Type 2 Inflammation Through IL‐17RB Receptor","authors":"Semah Abdu, Jiao Xia, Huihui Yuan, Tiak Ju Tan, Janice A. Layhadi, Mohamed H. Shamji, Andrew N. J. McKenzie, Nora Haloob, Claire Hopkins, Grzegorz Woszczek, Stephen J. Till","doi":"10.1111/all.16472","DOIUrl":"https://doi.org/10.1111/all.16472","url":null,"abstract":"BackgroundAlarmin cytokine IL‐25 promotes type 2 inflammatory responses in disorders such as asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) and known targets include ILC2 and Th2 cells. However, other cellular targets for IL‐25 remain poorly defined.ObjectiveTo investigate induction and expression of IL‐25 receptor (IL‐17RB) by B cells and evaluate responsiveness of IL‐17RB‐expressing B cells to IL‐25 in vitro.MethodsIL‐17RB expression, regulation and function on B cells were evaluated in peripheral blood‐derived B cells by flow cytometry and RT‐PCR, including in response to IgE‐inducing stimuli (anti‐CD40 mAb and IL‐4). Single‐cell RNA sequencing was used to compare IL‐17RB+ and IL‐17RB‐activated peripheral blood‐derived B cells. To evaluate B cell IL‐17RB expression within type 2 inflamed tissue, B cells were compared from nasal polyps, control turbinate tissue and matched peripheral blood.ResultsActivation of B cells with anti‐CD40 and IL‐4 increased IL‐17RB expression at both protein and mRNA level, which was further upregulated by IL‐25. B cells induced to express IL‐17RB responded to IL‐25 with enhanced antibody production. Single‐cell RNA‐sequencing showed that IL17RB+ activated B cells expressed higher levels of IGHE, CCL17 and CCL22 compared to IL17RB‐ B cells. B cells from nasal polyp tissue expressed higher levels of surface IL‐17RB compared with control tissue, correlating with patient‐reported CRSwNP severity (SNOT‐22).ConclusionPeripheral blood B cells activated under IgE‐inducing conditions express surface IL‐17RB, and tissue IL‐17RB+ B cells are increased in type 2 inflammation. IL‐17RB+ cells have a distinct transcriptional profile and respond to IL‐25 with enhanced antibody production, highlighting the IL‐25/IL‐17RB pathway as a potential therapeutic target for CRSwNP and other type 2 inflammatory disorders.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"42 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stratum Corneum Interleukin-2 in Facial Eczema at 1-Month-Old Predicts Later Atopic Dermatitis. 1月龄面部湿疹患者角质层白细胞介素-2可预测日后的特应性皮炎。

IF 12.6 1区医学

Allergy Pub Date : 2025-01-15 DOI: 10.1111/all.16474

Eriko Maehara, Makiko Kido-Nakahara, Yasuyuki Fujita, Kiyoko Kato, Saki Kido, Ryo Yamasaki, Satoshi Nagata, Junji Kishimoto, Hiroko Watanabe, Eri Harada, Yumiko Nagashima, Eisuke Umeno, Gaku Tsuji, Hitokazu Esaki, Takeshi Nakahara

引用次数: 0

Allergic Reactivity and Memory Occur Independently of Sequential Switching Through IgG1. 过敏反应和记忆独立于IgG1的顺序转换。

IF 12.6 1区医学

Allergy Pub Date : 2025-01-13 DOI: 10.1111/all.16460

Joshua F E Koenig, Adam K Wade-Vallance, Rodrigo Jiménez-Saiz, Kelly Bruton, Siyon Gadkar, Emily Grydziuszko, Tina D Walker, Melissa E Gordon, Amy E Gillgrass, Justin J Taylor, Susan Waserman, Manel Jordana

{"title":"Allergic Reactivity and Memory Occur Independently of Sequential Switching Through IgG1.","authors":"Joshua F E Koenig, Adam K Wade-Vallance, Rodrigo Jiménez-Saiz, Kelly Bruton, Siyon Gadkar, Emily Grydziuszko, Tina D Walker, Melissa E Gordon, Amy E Gillgrass, Justin J Taylor, Susan Waserman, Manel Jordana","doi":"10.1111/all.16460","DOIUrl":"https://doi.org/10.1111/all.16460","url":null,"abstract":"Allergic reactions to foods are primarily driven by allergen-binding immunoglobulin (Ig)E antibodies. IgE-expressing cells can be generated through direct switching from IgM to IgE or a sequential class switching pathway where activated B cells first switch to an intermediary isotype, most frequently IgG1, and then to IgE. It has been proposed that sequential class switch recombination is involved in augmenting the severity of allergic reactions, generating high affinity IgE, differentiation of IgE plasma cells, and in holding the memory of IgE responses. We directly tested these possibilities by comparing the allergic immunity of wild-type and IgG1-deficient (hMT) mice. We found that sequential switching through IgG1 was not required to maintain the binding capacity of IgE nor for its ability to promote degranulation and elicit anaphylaxis against bona fide food allergens. Furthermore, the absence of sequential switching modestly impacted IgE affinity and clinical reactivity against hapten antigens, suggesting that the nature of the antigen impacts the requirement for sequential switching. At a cellular level, the capacity to undergo sequential switching through IgG1 provided no competitive advantage for subsequent IgE expression among germinal center B cells or plasma cells. Furthermore, the recall of allergic immunity at memory timepoints was preserved in the absence of sequential switching through IgG1, a finding that corresponded with intact type 2 memory B cell polarization. Together, these data demonstrate that sequential switching through IgG1 is redundant in sensitization, anaphylaxis, and the persistence of allergy, ultimately revealing that IgE derived from any switching source should be targeted by novel therapeutics seeking to ameliorate allergic diseases.","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142968774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Intestinal Permeability Using Serum Biomarkers in Learning Early About Peanut Allergy Trial. 早期花生过敏试验中使用血清生物标志物评价肠通透性。

IF 12.6 1区医学

Allergy Pub Date : 2025-01-13 DOI: 10.1111/all.16464

Ozge Nur Aktas, Allyson Mateja, Min Jenny Li, Lindsay Chatman, Megan C Grieco, Carolyn H Baloh, Michelle Huffaker, Lisa M Wheatley, George du Toit, Gideon Lack, Erica Brittain, Pamela A Frischmeyer-Guerrerio

{"title":"Evaluation of Intestinal Permeability Using Serum Biomarkers in Learning Early About Peanut Allergy Trial.","authors":"Ozge Nur Aktas, Allyson Mateja, Min Jenny Li, Lindsay Chatman, Megan C Grieco, Carolyn H Baloh, Michelle Huffaker, Lisa M Wheatley, George du Toit, Gideon Lack, Erica Brittain, Pamela A Frischmeyer-Guerrerio","doi":"10.1111/all.16464","DOIUrl":"https://doi.org/10.1111/all.16464","url":null,"abstract":"Background: Intestinal barrier dysfunction may lead to a break in tolerance and development of food allergy (FA). There is contradictory evidence on whether intestinal permeability (IP) is altered in IgE-mediated FA. Thus, we sought to determine whether IP differed between children with eczema who did (FA group) or did not (atopic controls, ACs) develop FA and whether peanut sensitization, allergy, and early introduction impacted IP using serum biomarkers zonulin, soluble CD14, and Intestinal Fatty Acid Binding Protein among randomly selected participants enrolled in the Learning Early About Peanut allergy trial.Methods: FA group was defined as having at least one FA at either baseline (4-11 months) or 60 months of age (V60). ACs had eczema at baseline and no FA at either visit. Serum IP markers (sIPMs) were measured by ELISA at baseline and V60, and their relationship with the clinical characteristics of participants was analyzed using parametric tests and linear regression models.Results: We evaluated 237 FA subjects and 76 ACs. sIPM levels were similar in FA subjects and ACs at baseline and V60. Age when the child first developed any FA (< 1 year vs. > 1 year), eczema severity, peanut sensitization, peanut allergy, and early peanut introduction were not statistically significantly associated with sIPM levels. Total IgE and eosinophil levels, peanut-specific IgE, IgG4, and IgG4/IgE ratio were not correlated with sIPM levels.Conclusions: No differences in sIPMs were detected to support altered IP in infants with FA compared to ACs or following early peanut introduction among peanut-sensitized children.","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142968777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Type 2 IgG Memory B Cells as Precursors of IgE Plasma Cells 2型IgG记忆B细胞作为IgE浆细胞的前体

IF 12.4 1区医学

Allergy Pub Date : 2025-01-11 DOI: 10.1111/all.16473

Larissa Nogueira de Almeida, Janina Petry, Christopher C. Udoye

引用次数: 0