Allergy最新文献

{"title":"Correspondence: Cellular Rhinitis-A Key Yet Overlooked Factor in the Management of Otitis Media With Effusion (OME) and Eustachian Tube Dysfunction (ETD).","authors":"Matteo Gelardi","doi":"10.1111/all.16609","DOIUrl":"https://doi.org/10.1111/all.16609","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"35 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144146137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-KIT Barzolvolimab for Chronic Spontaneous Urticaria.","authors":"Marcus Maurer,Martin Metz,John Anderson,Neetu Talreja,Diane Young,Elizabeth Crowley,Margo Heath-Chiozzi,Rick Ma,Elsa Paradise,Thomas Hawthorne,Diego Alvarado,Jonathan A Bernstein","doi":"10.1111/all.16598","DOIUrl":"https://doi.org/10.1111/all.16598","url":null,"abstract":"BACKGROUNDChronic spontaneous urticaria (CSU) is characterized by mast cell (MC)-mediated wheals and/or angioedema without identifiable triggers and is driven by MC activation. Barzolvolimab-a monoclonal anti-KIT antibody-depletes MCs by inhibiting activation of KIT by stem cell factor. We evaluated multiple ascending doses in patients with CSU.METHODSPhase 1b double-blind placebo-controlled trial (NCT04538794) in adults with moderate-to-severe (urticaria activity score over 7 days [UAS7] ≥ 16) antihistamine-refractory CSU treated with intravenous barzolvolimab for 12 weeks with a 12-week follow-up in four sequentially enrolled cohorts (randomized 4:1 barzolvolimab:placebo): 0.5 mg/kg, Q4W (n = 9); 1.5 mg/kg, Q4W (n = 8); 3 mg/kg, Q8W (n = 9); and 4.5 mg/kg, Q8W (n = 9). Primary and secondary objectives were safety and disease activity (UAS7 and urticaria control test [UCT]). Pharmacokinetics and pharmacodynamics were assessed.RESULTSPatients had high mean (range) baseline CSU activity, with UAS7 = 29.6 (16.3-42.0) for barzolvolimab-treated, UAS7 = 35.8 (19.0-42.0) for placebo-treated, and 44% prior omalizumab use. Multiple doses of barzolvolimab were well tolerated. Hair color change was the commonest adverse event in barzolvolimab-treated patients. Across barzolvolimab doses, rapid symptom reduction within 1 week was observed and sustained during 12 weeks; 71% of patients achieved a well-controlled (UAS7 ≤ 6) response and 57% a complete response (UAS7 = 0). Additionally, 77% of barzolvolimab-treated patients achieved a well-controlled response (UCT ≥ 12) and 43% a complete response (UCT = 16) by Week 12. The kinetics of disease activity paralleled tryptase suppression, indicative of MC inhibition. Patients with and without prior omalizumab treatment responded similarly.CONCLUSIONSThis study supports barzolvolimab as a promising treatment for CSU.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"12 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations in Gut Microbiota Composition Are Related to Disease Severity and Systemic Inflammation in Patients With Chronic Urticaria.","authors":"Han-Ki Park,Young Her,Doo Young Choi,Tansol Park,Jae-Woo Kwon","doi":"10.1111/all.16601","DOIUrl":"https://doi.org/10.1111/all.16601","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"172 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144122095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 2 Immunity Promotes Neonatal Lung Progenitor Developmental Activity Through the STAT6 Signaling Axis","authors":"Chien‐Chia Liao, Chiao‐Juno Chiu, Bor‐Luen Chiang","doi":"10.1111/all.16604","DOIUrl":"https://doi.org/10.1111/all.16604","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"27 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linking Exosomal MicroRNA Signatures in Sputum and Peripheral Blood to Inflammatory Endotypes in Severe Asthma.","authors":"D Sanz-Rubio,E Vera,J Rodríguez-Sanz,J Cubero,R Langarita,M Aguado,L Pastor,L Martín,M Marín-Oto,A R Remacha,M Ruiz,V Gil,J A Domingo,J A Carretero,J M Marín","doi":"10.1111/all.16578","DOIUrl":"https://doi.org/10.1111/all.16578","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"25 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Legends of Allergy and Immunology: Werner Pichler.","authors":"Lukas Joerg,Arthur Helbling,Oliver Hausmann,Daniel Yerly","doi":"10.1111/all.16597","DOIUrl":"https://doi.org/10.1111/all.16597","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"132 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering the Connection Between Atopic Dermatitis and Cardiovascular Diseases: Analysis of Clinical Associations and Cardiometabolic Proteins.","authors":"Danielle Fehr,Van Hung Huynh-Tran,Laura Maintz,David Niederseer,Milad Ameri,Anita Dreher,Cezmi A Akdis,Roger Lauener,Claudio Rhyner,Claudia Traidl-Hoffmann,Peter Schmid-Grendelmeier,Thomas Bieber,Marie-Charlotte Brüggen","doi":"10.1111/all.16588","DOIUrl":"https://doi.org/10.1111/all.16588","url":null,"abstract":"BACKGROUNDThere are conflicting data on a potential association between atopic dermatitis (AD) and cardiovascular diseases (CVD). The aim of this study was to further explore this connection and whether there are biomarkers indicating the risk for CVD in AD patients.METHODSWe included 677 AD patients and 79 nonatopic controls from an observational multicenter case-control study (ProRaD: Prospective longitudinal study investigating the remission phase in patients with atopic dermatitis and other allergy-associated diseases). AD severity and atopic, metabolic, and cardiovascular conditions as well as risk factors were assessed. Serum samples were analyzed with targeted proteomics (cardiometabolics panel, Olink).RESULTSWe did not find an overall association between AD and CVD. However, AD patients without atopic comorbidities (pure AD) showed a significantly higher CVD prevalence than AD patients with atopic comorbidities (ADAC) (28.2% [37/131] vs. 14.7% [80/546], p < 0.001). Yet, this association could not be confirmed when controlling for cardiovascular risk factors. In pure AD, patients with CVD showed a more severe AD than those without CVD (median EASI [Eczema Area and Severity Index] 12.9 vs. 4.0, p < 0.001). In this subgroup of patients, EASI remained a significant predictor of CVD even in the adjusted model (adjusted odds ratio [aOR] = 1.05, p = 0.040). Forty serum cardiometabolic proteins were upregulated in AD patients compared with nonatopic controls. CC-chemokine ligand 18 (CCL18) was upregulated in both AD (p < 0.001) and CVD (p < 0.001) and its increase correlated with AD severity.CONCLUSIONSOur study does not suggest an overall association between AD and CVD, but a more complex relation between the two conditions. Disease severity may be a risk factor for CVD in pure AD patients, but not in those with atopic comorbidities. CCL18 may be a biomarker for CVD.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"10 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IFNγ Signaling Impairs Regulatory B Cell Function Resulting in Worse Control of Esophageal Food Allergy.","authors":"Rachel L Clement,Julie Dilollo,Eric M Rodríguez-López,Cleandre M Guerrier,David A Hill","doi":"10.1111/all.16594","DOIUrl":"https://doi.org/10.1111/all.16594","url":null,"abstract":"BACKGROUNDEosinophilic Esophagitis (EoE) is a chronic food allergy that causes esophageal inflammation and fibrosis and manifests with symptoms of reflux, chest pain, swallowing difficulty, and food impactions. Though the prevalence of EoE is increasing by ~15% each year, our understanding of EoE immunopathology is limited. A noted feature of EoE is the presence of food-specific IgG4 antibodies in the circulation and esophageal tissue. Production of IgG4 is confined to IL-10+ B cells (Bregs) in other allergic diseases, suggesting Bregs may be present in EoE.METHODSWe examined circulating Bregs in patients with EoE milk allergy. In parallel, we performed mechanistic investigations of the role of Bregs in a murine model of food-antigen-dependent EoE. Flow cytometry and histologic analyses were used to assess esophageal and draining lymph node immune cells, and in vitro assays were used to evaluate Breg functional capacity.RESULTSBreg frequency was reduced in both EoE milk allergic subjects and an EoE disease model. Murine Breg suppressive capacity was impaired during EoE-like inflammation. Inducible deletion of Breg-derived IL-10 worsened EoE-like inflammation, while adoptive transfer of IL-10 sufficient Bregs suppressed DC activation and improved esophageal eosinophilia. IFNγ was sufficient to suppress Breg expansion and IL-10 production in vitro and contributed to Breg dysfunction and esophageal inflammation in vivo.CONCLUSIONBregs play an immunoregulatory role during EoE by controlling esophageal eosinophilia but are functionally impaired due to IFNγ-mediated signaling. These findings have important implications for understanding EoE's etiology and implementing future therapies that target IFNγ.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"41 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-Based Objective Severity Assessment of Atopic Dermatitis Using Patient Photos in a Real-World Setting: A Digital Biomarker Approach.","authors":"Utako Okata-Karigane,Masakazu Hirota,Chiaki Takahashi,Akihiro Miyagawa,Ryotaro Ako,Saeko Nakajima,Masaki Futamura,Satoru Yonekura,Yasushi Ogawa,Takenori Inomata,Tetsuo Ishikawa,Yoshihiro Ito,Katsunori Masaki,Sakura Sato,Norito Katoh,Hideaki Morita,Takeya Adachi","doi":"10.1111/all.16586","DOIUrl":"https://doi.org/10.1111/all.16586","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"80 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144097795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct Single-Dose Drug-Provocation Test Is Safe for Delabelling Penicillin Low-Risk Reactions in Adults.","authors":"Marina Labella,Julia Rodriguez de Guzmán,Patricia Diez-Echave,María Salas,Rubén Fernández-Santamaría,Cristobalina Mayorga,Inmaculada Doña,María José Torres","doi":"10.1111/all.16567","DOIUrl":"https://doi.org/10.1111/all.16567","url":null,"abstract":"BACKGROUNDPenicillins (PENs) are the most frequent drug-allergic reactions trigger. However, diagnostic work-up is complex and time-consuming: it requires skin testing (ST) and drug-provocation test (DPT), needing faster delabelling strategies. Although direct DPT without previous STs has shown to be safe, most of the studies are performed in children or in North American, Asian, or Oceanian adults, with few studies in the European adult population. We explored its safety in European adult patients with low-risk PEN allergy history and, additionally, analysed ST role and T-cell involvement by lymphocyte transformation test (LTT).METHODSWe prospectively evaluated > 16 years of PEN-allergic labelled patients referred to Málaga Regional University Hospital during 2023. They reported non-immediate reactions without alarm signs and unknown reactions. Direct-single-dose DPT was performed in all patients. If positive, ST and LTT were carried out after reaction resolution.RESULTSWe included 269 patients with the culprits being an unidentified PEN (36%), amoxicillin (AX) (32%), and AX-clavulanic acid (AX-CLV) (31%); and the symptoms maculopapular exanthema (MPE) (34%) and unknown reaction during childhood (23%). Only 16 (5.9%) had positive DPT, being 56% for AX and 44% for AX-CLV, 81% developing MPE, none severe. Most DPT-reacting patients reported cutaneous non-immediate reactions in the index reaction, and only one had an unknown childhood reaction. The mean day interval between drug administration and symptom development was lower (p = 0.002) in positive DPT than in the index reaction (2 vs 5 days). Moreover, ST was positive in only 19% and LTTs in 86.7% of positive DPT patients.CONCLUSIONSDirect-single-dose DPT is safe for delabelling PEN allergy in non-immediate reactions without alarm signs and unknown reactions. ST had a poor diagnostic value and LTT had a high one, confirming a T-cell involvement.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"4 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}