Allergy最新文献

{"title":"Complement-Eosinophil Crosstalk Links Complement Activation to Fibrin Deposition in Eosinophilic Chronic Rhinosinusitis.","authors":"Ryo Hasegawa, Shigeharu Ueki, Misaki Arima, Shohei Nishiyama, Keinosuke Hizuka, Kohei Tatsumi, Ayako Sawai, Anna Shimizu, Yuki Sonoda, Eiichi Kato, Masanori Kidoguchi, Masafumi Sakashita, Yohei Sato, Atsushi Kato, Bruce K Tan, Robert C Kern, Robert P Schleimer, Shigeharu Fujieda, Yoshimasa Imoto","doi":"10.1111/all.70381","DOIUrl":"https://doi.org/10.1111/all.70381","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147830756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MAIT Cells Suppress IgE-Mediated Asthma via IFNγ-Dependent B Cell Regulation.","authors":"Angela M Cannata, Jaclyn W McAlees, Julie M Hargis, Archana Shankar, Shouxiong Huang, Senad Divanovic, Ian P Lewkowich","doi":"10.1111/all.70384","DOIUrl":"https://doi.org/10.1111/all.70384","url":null,"abstract":"<p><strong>Background: </strong>Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes enriched in mucosal tissues, but their role in allergic asthma pathogenesis remains poorly defined. In this study, we sought to elucidate the role of MAIT cells in a T cell-dominant model of allergic asthma.</p><p><strong>Methods: </strong>We used a murine model of house dust mite-induced asthma and a selective MAIT cell antagonist (Acetyl-6-formylpterin, A6FP) to inhibit MAIT cell activation in vivo. Airway hyperresponsiveness, lung inflammation, serum IgE, and cytokine profiles were assessed. In vitro co-culture experiments evaluated the direct impact of MAIT cells on B cell IgE production.</p><p><strong>Results: </strong>Pharmacologic inhibition of MAIT cells exacerbated airway hyperresponsiveness and elevated circulating IgE without altering airway eosinophilia or T helper type 2/type 17 cytokine production. MAIT cell antagonism failed to increase AHR in IgE-deficient mice. In vitro, activated MAIT cells directly suppressed B cell IgE production through IFNγ signaling. IL-4 was sufficient to enhance IFNγ production by MAIT cells, suggesting that allergic inflammation may induce a counter-regulatory response from MAIT cells to limit IgE-mediated pathology.</p><p><strong>Conclusion: </strong>MAIT cells limit airway hyperresponsiveness by suppressing IgE production through IFNγ-dependent B cell regulation. These findings define a previously unrecognized immunoregulatory function of MAIT cells in allergic asthma and suggest that enhancing MAIT cell activity may represent a therapeutic strategy for IgE-mediated diseases.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silica Aggravates Steroid Hyporesponsiveness via STING Activation in House Dust Mite Lung Inflammation.","authors":"Bushra Mdkhana, Narjes Saheb Sharif-Askari, Mariam Wed Eladham, Shirin Hafezi, Baraa Khalid Salah Al-Sheakly, Sarra B Shakartalla, Hala Halwani, Fatemeh Saheb Sharif-Askari, Ibrahim Yaseen Hachim, Qutayba Hamid, Rabih Halwani","doi":"10.1111/all.70350","DOIUrl":"https://doi.org/10.1111/all.70350","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.0,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-Effectiveness of Allergen Immunotherapy for Allergic Rhinitis: A Systematic Review.","authors":"Joshua Jacob, Andrew Fong, Caroline Joyce, Melanie Lloyd, Adrian Lowe, Constance Katelaris","doi":"10.1111/all.70382","DOIUrl":"https://doi.org/10.1111/all.70382","url":null,"abstract":"<p><p>Allergic rhinitis imposes a substantial clinical and socioeconomic burden globally. While symptomatic pharmacotherapy such as oral antihistamines and intranasal corticosteroids offers temporary relief, allergen immunotherapy provides disease-modifying benefits but requires higher upfront costs. This systematic review synthesises cost-effectiveness evaluations of subcutaneous (SCIT) and sublingual immunotherapy (SLIT) compared to symptomatic pharmacotherapy (SP). A systematic search of electronic databases was undertaken, identifying 35 eligible economic evaluations. Due to methodological heterogeneity, a narrative synthesis was performed. Thirty-two evaluations (91%) concluded that allergen immunotherapy represents a cost-effective intervention, with incremental cost-effectiveness ratios predominantly falling below jurisdictional willingness-to-pay thresholds. Both SCIT and SLIT demonstrated economic value, particularly in patients with co-morbid asthma and when models incorporated sustained post-treatment benefits. Future clinical research should prioritise endpoints that facilitate direct estimation of health utility. Despite diverse healthcare settings and modelling approaches, the evidence supports allergen immunotherapy (AIT) as an economically rational investment. Policymakers should utilise these findings to inform reimbursement decisions. Trial Registration: PROSPERO registration number: CRD42024530911.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.0,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-Processed Food Consumption and Childhood Allergic Diseases: Increased Risk of Asthma Onset in the SENDO Project.","authors":"O Galindo, M J Goikoetxea, L Moreno-Galarraga, L Argiz, J M Moreno-Villares, Victor de la O, N Martín-Calvo","doi":"10.1111/all.70378","DOIUrl":"https://doi.org/10.1111/all.70378","url":null,"abstract":"<p><strong>Background: </strong>While the role of genetic predisposition in asthma and other allergic conditions is well established, the contribution of nutritional patterns is heterogeneous and has been demonstrated in cross-sectional studies but not in prospective cohorts.</p><p><strong>Methods: </strong>We analyzed data from 1546 participants enrolled in the SENDO cohort between January 2015 and June 2024. Children aged 4-5 years were prospectively recruited. UPF consumption was assessed at baseline and updated at the 3-year follow-up. Information on asthma and allergic diseases was collected at baseline and updated annually during the follow-up. A final sample of 691 participants was classified into tertiles (T1, T2, T3) according to UPF consumption. Prevalent cases were excluded from the analysis to ensure that incident cases were included during the follow-up. In the main analyses, we calculated the adjusted hazard ratios (HRs) and 95% CI with survival analyses.</p><p><strong>Results: </strong>After a mean follow-up of 3.4 years, the adjusted risk for asthma in each tertile (T1, T2, T3) of UPF consumption was 2.6%, 9.9%, and 7.6% respectively (p for trend: 0.03). In the fully adjusted model of the survival analysis, children with greater UPF consumption (T2 + T3) showed a significantly higher risk of asthma (HR 3.76; 95% CI 1.15-11.51, p = 0.02) but not of AA, nor other allergic outcomes compared with their peers in the lowest tertile (T1) of UPF consumption.</p><p><strong>Conclusion: </strong>Higher UPF consumption may be associated with an increased risk of developing asthma in school-age children.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.0,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lupus Panniculitis Immunoprofiling Reveals a Cytotoxic, Type 1-Skewed T-Cell Response With Signs of Metabolic Alteration.","authors":"Milad Ameri, Reihane Ziadlou, Stephan Traidl, Milena Sokolowska, Emmanuel Contassot, Nick Li, Maija Kiuru, Isabel Kolm, Werner Kempf, Emanual Maverakis, Cezmi Akdis, Marie-Charlotte Brüggen","doi":"10.1111/all.70377","DOIUrl":"https://doi.org/10.1111/all.70377","url":null,"abstract":"<p><p>Lupus panniculitis (LP) is a neglected, often treatment-refractory subtype of cutaneous lupus erythematosus. It is characterized by inflammation of subcutaneous adipose tissue, and the pathomechanisms are poorly understood. We sought to explore the cellular and molecular signatures of LP and their relationship to systemic lupus erythematosus. We performed imaging mass cytometry (IMC; LP n = 8, Healthy Control (HC) n = 6) and targeted transcript profiling by NanoString nCounter (Human Immunology Panel, 579 genes; LP n = 9, HC n = 9). LP lesions showed extensive septal leukocyte infiltration. The infiltrate consisted predominantly of T cells (48%), followed by B cells (14%) and antigen-presenting cells (APCs). T cells exhibited a cytotoxic (CD8⁺, GranzymeB⁺) and skin-homing (CLA⁺) phenotype, with upregulation of Th1 markers. They closely interacted with M1 macrophages. B cells displayed strong spatial interactions with naïve T cells. NanoString analyses revealed upregulation of T- and B-cell receptor signaling pathway genes, antigen presentation-related genes (MHC-I/II), and Th1 associated programs (STAT1/IRF1), together with activation of innate immune, complement, and pattern-recognition receptor pathways. This was paralleled by strong upregulation of IDO1, a key enzyme in tryptophan metabolism, and inversely correlated, reduced AHR expression. Our data provide new pathomechanistic insights into LP, highlighting overlaps with systemic lupus, but also LP-specific features. This may pave the way for adopting more targeted treatment approaches for LP.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.0,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kinetics of Antibody Responses and Effector Cell Sensitivity After High Dose Birch Extract Nasal Challenge.","authors":"N J Campion, S Villazala-Merino, C Morgenstern, L Nemec, V Stanek, A Tu, M Zghaebi, J Toth, R Fröschl, T Perkmann, M Bastl, K Gangl, S Schneider, H Breiteneder, R Ristl, M Focke-Tejkl, R Valenta, V Niederberger-Leppin, J Eckl-Dorna","doi":"10.1111/all.70365","DOIUrl":"https://doi.org/10.1111/all.70365","url":null,"abstract":"<p><strong>Background: </strong>In allergic rhinitis (AR), effector cell activation via allergen-specific (s) IgE cross-linking is well established, yet the in vivo kinetics of allergen-specific antibody responses and their modulation of effector cell reactivity after nasal allergen exposure warrant further investigation. We therefore set out to characterize the sequence and timing of systemic and local antibody responses and basophil/mast cell sensitivity after nasal allergen challenge, and their influence on subsequent seasonal responses.</p><p><strong>Methods: </strong>In this randomized, double-blind, placebo-controlled trial, birch pollen-allergic adults received three daily nasal challenges with birch pollen extract (n = 20) or placebo (n = 10) in autumn. sIgE, sIgG, sIgG1, sIgG4 and sIgA levels, basophil activation (BAT), and titrated skin prick test (tSPT) responses were measured biweekly in nasal mucosal lining fluid (nMLF), blood and skin for 3 months, and before, during, and after seasonal exposure.</p><p><strong>Results: </strong>Allergen but not placebo challenge induced sequential sIgE rises, first in serum, then nMLF, mirrored by sIgG responses. Basophil sensitivity peaked with serum sIgE at 4 weeks, followed by maximal mast cell sensitivity in tSPT at 8 weeks. Allergen-specific antibodies remained elevated through the pre-seasonal and seasonal periods. Allergen-challenged subjects showed reduced sIgE rise and lower effector cell sensitivity during the following pollen season.</p><p><strong>Conclusion: </strong>Out-of-season high-dose nasal allergen exposure enhances sIgE levels and effector cell sensitivity as well as sIgG and nasal sIgA responses. The latter appear to later attenuate seasonal amplification of allergic responses.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov ID: NCT03644680.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.0,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147808882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pollen-Pharmacotherapy Interaction Impacts Symptom Control in Seasonal Allergic Rhinitis.","authors":"Zengxiao Zhang, Menglin Wang, Xiaomo Wang, Jingyun Li, Yunbo Gao, Xian Li, Bing Yan, Chengshuo Wang, Luo Zhang, Yuan Zhang","doi":"10.1111/all.70371","DOIUrl":"https://doi.org/10.1111/all.70371","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.0,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147808868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Algorithms in Allergy: Elevated IgE in Pediatric Patients.","authors":"Burcu Kolukisa, Asena Pinar Sefer Arinc, Cevdet Ozdemir, Elif Karakoc-Aydiner","doi":"10.1111/all.70376","DOIUrl":"https://doi.org/10.1111/all.70376","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.0,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147830807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trace Elements in Allergy: Narrative Review.","authors":"Michal Ordak, Magdalena Zemelka-Wiacek, Anna Kosowska, Marek Jutel, Kielczynska Anna, Majewski Michal, Piwar Hubert, Jan Pawlasek, Ewa Bulska, Anna Ruszczynska, Pawel Konieczynski, Marek Wesolowski, Alina Plenis, Bernardo Sousa-Pinto, Antonio Bognanni, Matteo Martini, Giovanni Paoletti, Danilo di Bona, Giorgio Walter Canonica, Jean Bousquet, Wojciech Feleszko, Maja Cieslik, Christy Wing Man Leung, Ting Fan Leung, Andrzej Eljaszewicz","doi":"10.1111/all.70383","DOIUrl":"https://doi.org/10.1111/all.70383","url":null,"abstract":"<p><p>Allergic diseases are increasing worldwide and reflect a complex interplay between genetic susceptibility and environmental exposures. Among environmental determinants, trace elements contribute to epithelial barrier dysfunction, tissue remodeling, redox homeostasis, and immune regulation and may influence the development and severity of allergic diseases. This narrative review summarizes current mechanistic, epidemiological, and clinical evidence on the role of essential and non-essential trace elements in allergy. We discuss essential elements, including iron, zinc, selenium, copper, manganese, iodine, molybdenum, and boron, which support antioxidant defense, epithelial integrity, and immune homeostasis. We also review sensitizing and potentially toxic elements such as nickel, chromium, cobalt, silicon, and fluoride, which may promote allergic sensitization and inflammation through hapten-driven immune responses, oxidative stress, and adjuvant-like effects. Evidence across asthma, allergic rhinitis, atopic dermatitis, and food allergy indicates that trace elements may contribute to the development and heterogeneity of allergic disease. However, reported associations between elemental status and allergic diseases remain heterogeneous across studies. This variability likely reflects both underlying biological differences and methodological heterogeneity, including variation in study design, biological matrices, exposure assessment, and analytical techniques. Better methodological harmonization will be essential to elucidate the roles of trace elements in allergy development and to strengthen future translational and preventive research efforts. At present, available evidence does not support routine assessment of trace element status or generalized supplementation in the prevention or management of allergic diseases, except in cases of documented deficiency or clearly defined clinical indications.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.0,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}