Allergy最新文献

{"title":"Efficacy and Safety of Biologics for Chronic Rhinosinusitis With Nasal Polyps: A Meta‐Analysis of Real‐World Evidence","authors":"Shiru Cai, Shenglong Xu, Yan Zhao, Luo Zhang","doi":"10.1111/all.16499","DOIUrl":"https://doi.org/10.1111/all.16499","url":null,"abstract":"Dupilumab, omalizumab, mepolizumab, and benralizumab have demonstrated good efficacy and safety in the treatment of severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP) in phase 3 randomised controlled trials (RCTs). With recent regulatory approvals, there has been a surge in real‐world studies (RWSs). This systematic review and meta‐analysis aimed to summarise the efficacy and safety of these four biologics in real‐world settings. Primary outcomes were nasal polyp score and sino‐nasal outcome test‐22 score. Secondary outcomes included smell identification test score, loss of smell score, nasal congestion score, overall nasal symptom score, treatment response, and adverse events (AEs) prompting discontinuation. Efficacy outcomes at 4, 6, 12, and over 12 months were summarised, and meta‐analyses of mean changes from baseline were conducted. Sixty‐four RWSs involving 3921 patients were included. Significant improvements in clinical outcomes were observed at most follow‐up time points, with dupilumab showing particularly notable effects. The efficacy observed in these RWSs was superior to that demonstrated in phase 3 RCTs. All biologics exhibited low discontinuation rates due to AEs. Overall, biologic treatments for CRSwNP in real‐world settings demonstrate strong efficacy and good safety. However, the limitations in current RWSs highlight the need for long‐term, high‐quality multicentre prospective studies and comprehensive healthcare database analyses.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"78 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discrepancies in Beta-Lactam Antibiotics Cross-Reactivity: Implications for Clinical Practice.","authors":"Evelien Maria Hutten, Maja Bulatović Ćalasan, Jason Anthony Trubiano, Rick Gert-Jan Pleijhuis, Ingrid Terreehorst","doi":"10.1111/all.16485","DOIUrl":"https://doi.org/10.1111/all.16485","url":null,"abstract":"<p><strong>Background: </strong>In patients with a beta-lactam antibiotic (BA) allergy label, avoidance of the whole group of BAs leads to displacement of first-line therapies potentially influencing patient outcomes and antimicrobial resistance. Studies previously published on BA cross-reactivity use different sets of BA and seem to contain conflicting recommendations on safe BA alternatives in case of (suspected) BA allergy.</p><p><strong>Methods: </strong>The objectives were (i) to identify discrepancies between studies regarding cross-allergy in BA and (ii) to identify research gaps. The tables and errata of 4 studies (Romano et al., Trubiano et al., Zagursky et al., SWAB-guideline by Wijnakker et al.) were evaluated and compared head-to-head.</p><p><strong>Results: </strong>A total of 51 antibiotics were covered by the four authors, theoretically leading to 2550 potential recommendations regarding alternatives in case of specific allergies. Internal discrepancies existed in 2 tables. Since none of the tables included all 51 BAs, in 356 situations data were lacking regarding specific alternatives. In 1104 situations, only one author gave advice about a specific alternative. Harmony and disharmony between authors could be evaluated in 1090 cases. The advice regarding alternative BAs was 696 times in harmony (482 safe, 214 unsafe), while discrepancies were found in 394 cases. This led to a different advice (safe vs. unsafe) in 272 cases or 69%.</p><p><strong>Conclusion: </strong>Disharmony between authors was identified in 36% of the cases. In 69%, this led to a clinically relevant, different advice. This indicates the need for synchronisation of cross-reactivity tables and answering remaining research gaps.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perinatal Photoperiod Associations With Allergic & Respiratory Disease in the UK Biobank Database.","authors":"Jonas P Wallraff, Achim Traub, Peter Morfeld, Martin Hellmich, Thomas C Erren, Philip Lewis","doi":"10.1111/all.16508","DOIUrl":"https://doi.org/10.1111/all.16508","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Point-of-Care Blood Eosinophils to Predict Preschool Wheeze Attacks.","authors":"Kushalinii Hillson, Sara Fontanella, Hernani Almeida, Barbara Pavlou, Katariina Lajunen, Samantha Irving, Ilaria Testa, Yvonne Bingham, Karina Mayoral Oritz, Shane Lacbay, Sophie Hay, Mindy Gore, Elizabeth Scotney, Emmanouil Paraskakis, Samatha Sonnappa, Louise Fleming, Andrew Bush, Sejal Saglani","doi":"10.1111/all.16500","DOIUrl":"https://doi.org/10.1111/all.16500","url":null,"abstract":"<p><strong>Background: </strong>Post hoc analysis of clinical trials shows blood eosinophil counts (BEC) predict future preschool wheeze attacks; however, prospective usefulness in a clinical setting is unreported. We assessed the feasibility of point-of-care (POC) eosinophil measurements in preschool wheezers and related BEC to symptoms, lung function, and utility in predicting attacks.</p><p><strong>Methods: </strong>Children aged 1-5 years with recurrent wheeze underwent finger-prick sampling during the outpatient clinic for POC eosinophils, forced oscillation technique (FOT) and/or spirometry, and symptom score (TRACK questionnaire). The utility of BEC and/or the other tests in predicting wheeze attacks in the subsequent 3 months was analysed by comparing those with and without an attack and using a predictive decision tree (DT) model.</p><p><strong>Results: </strong>Seventy-three children (median age 4.27 years) were recruited; BEC were higher in atopic children (median 0.5 × 10⁹/L vs. 0.3 × 10⁹/L non-atopic, p < 0.01). BEC moderately correlated with FOT reactance bronchodilator reversibility z-score changes (r = 0.495, p = 0.005), but no other lung function measures or TRACK score. 68/73 (93%) children were followed up at 3 months. 29/68 (43%) children had > 1 wheeze attack requiring unscheduled healthcare attendance. Absolute and %eosinophils at the baseline visit were higher in those who had an attack (median 0.5 × 10⁹/L vs. 0.3 × 10⁹/L, p = 0.03 and median 6% vs. 4%, p < 0.01). The DT model showed children with BEC ≥ 4% and TRACK score < 75 were more likely to have a future attack (probability 0.63).</p><p><strong>Conclusion: </strong>POC blood eosinophils were feasible in a clinical setting. Our preliminary data suggest elevated BEC with a low symptom score predicts a wheeze attack within 3 months.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual Inhibition of Mast Cells and Thymic Stromal Lymphopoietin Using a Novel Bispecific Antibody, CDX-622.","authors":"Michael B Murphy, Laura Vitale, Thomas O'Neill, Deena M Maurer, Linda Malenchek, Andrea Crocker, Colleen Patterson, Laura Mills-Chen, Virginia Saley, Nicole M Antczak, James M Boyer, Kelly M McManus, Noe Rico Montanari, Russell A Hammond, Joel Goldstein, Lawrence J Thomas, Tibor Keler, Diego Alvarado","doi":"10.1111/all.16509","DOIUrl":"https://doi.org/10.1111/all.16509","url":null,"abstract":"<p><strong>Background: </strong>Mast cells (MCs) respond to an array of allergens that drive allergic and inflammatory diseases. Stem cell factor (SCF), the ligand for the receptor KIT, is required for MC survival and function. Thymic stromal lymphopoietin (TSLP) is an alarmin that promotes Type 2 inflammation in asthma and other inflammatory diseases. We describe CDX-622, a bispecific antibody (bsAb), that targets both SCF and TSLP to neutralize these distinct cytokines.</p><p><strong>Methods: </strong>The bsAb CDX-622 was developed from novel antagonist monoclonal antibodies (mAbs) to SCF (SCF-12) and TSLP (1D10). CDX-622 encodes the full-length 1D10 mAb and the single-chain variable fragment of SCF-12, linked to the C-terminus of the 1D10 heavy chain. CDX-622 was modified to prevent Fcγ receptor interactions and enhance FcRn binding. CDX-622 was tested using in vitro assays of MC and dendritic cell (DC) activation, an ex vivo human skin model, and in vivo studies in nonhuman primates.</p><p><strong>Results: </strong>Novel SCF and TSLP mAbs with neutralizing activity were generated. The bsAb CDX-622 potently inhibited SCF-driven MC degranulation and TSLP-mediated CCL17 release by DCs. In human skin samples treated with SCF and TSLP, CDX-622 markedly reduced proinflammatory, MC, and DC-related RNA signatures. Additionally, CDX-622 and SCF-12 mAb administered to cynomolgus macaques (Macaca fascicularis) had a profound effect on MCs without any observed toxicity.</p><p><strong>Conclusions: </strong>CDX-622 is a potent inhibitor of MCs through the neutralization of SCF and effectively blocks Type 2 inflammatory responses driven by TSLP. Dual inhibition of these cytokines may lead to improved clinical outcomes in certain inflammatory disorders.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Oral Antihistamines on the Sweating Response During Heat Stress in Adults.","authors":"Douglas Newhouse, Taryn Klarner, Mario Nucci, Nicholas Ravanelli","doi":"10.1111/all.16507","DOIUrl":"https://doi.org/10.1111/all.16507","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence: Epithelial Barrier Dysfunction: Do Not Forget Functional Dyspepsia!","authors":"Jan Tack, Tim Vanuytsel, Florencia Carbone, Karen Van den Houte, Bert Broeders, Lukas Balsiger, Matthias Ceulemans, Cedric Van de Bruaene, Pauline Huyghe, Jara Lehoucq","doi":"10.1111/all.16505","DOIUrl":"https://doi.org/10.1111/all.16505","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Prevalence of Anemia and Asthma Severity","authors":"Mi‐So Kim, Hye‐Won Lee, Min Sik Choi, Hyun Seung Lee, Heung‐Woo Park, Kiyon Rhew","doi":"10.1111/all.16506","DOIUrl":"https://doi.org/10.1111/all.16506","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"4 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Direct and Indirect Role of IgE on Airway Epithelium in Asthma","authors":"Christian Domingo, William W. Busse, Nicola A. Hanania, Muyesser Ertugrul, Lauren A. Millette, Tina Maio‐Twofoot, Xavier Jaumont, Oscar Palomares","doi":"10.1111/all.16459","DOIUrl":"https://doi.org/10.1111/all.16459","url":null,"abstract":"Asthma is a chronic airway inflammatory disorder, affecting over 350 million people worldwide, with allergic asthma being the most common form of the disease. Allergic asthma is characterized by a type 2 (T2) inflammatory response triggered by numerous allergens beginning in the airway epithelium, which acts as a physical barrier to allergens as well as other external irritants including infectious agents, and atmospheric pollutants. T2 inflammation is propagated by several key cell types including T helper 2 (Th2) cells, eosinophils, mast cells, and B cells. Immunoglobulin E (IgE), produced by B cells, is a key molecule in allergic airway disease and plays an important role in T2 inflammation, as well as being central to remodeling processes within the airway epithelium. Blocking IgE with omalizumab has been shown to be efficacious in treating allergic asthma however, the role of IgE on airway epithelial cells is less communicated. Developing a deeper explanation of the complex network of interactions between IgE and the airway epithelium will facilitate an improved understanding of asthma pathophysiology. This review discusses the indirect and direct roles of IgE on airway epithelial cells, with a focus on allergic asthma disease.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"22 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Risks of Exposure to Acrylamide in Adult Asthma Clusters","authors":"Yuan‐Ting Hsu, Chao‐Chien Wu, Chin‐Chou Wang, Chau‐Chyun Sheu, Yi‐Hsin Yang, Ming‐Yen Cheng, Ruay‐Sheng Lai, Meng‐Hsuan Cheng, Huang‐Chi Chen, Chih‐Jen Yang, Chien‐Jen Wang, Huei‐Ju Liu, Hua‐Ling Chen, Chih‐Hsing Hung, Chon‐Lin Lee, Ming‐Shyan Huang, Shau‐Ku Huang","doi":"10.1111/all.16503","DOIUrl":"https://doi.org/10.1111/all.16503","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"23 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143417303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}