Allergy最新文献

{"title":"Global Burden of Asthma and Atopic Dermatitis in 2021: A Systemic Analysis of the Global Burden of Disease Study 2021.","authors":"Hong Luo, Fuqiang Wen","doi":"10.1111/all.16449","DOIUrl":"https://doi.org/10.1111/all.16449","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IL-25 and Periostin Serum Concentrations May Be Associated With COVID-19 Severity and Recovery.","authors":"Anna Zaleska, Adrian Gajewski, Anna Dor-Wojnarowska, Anna Radlińska, Marta Rorat, Maciej Chałubiński","doi":"10.1111/all.16431","DOIUrl":"https://doi.org/10.1111/all.16431","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How FEV₁ Improvement Induced by Anti-IL-5 in Severe Type-2 Asthma Is Linked to Mucus Plugs Clearance.","authors":"Alain Michils, Maxime Hackx, Lucas Mlynarski, Amaryllis Haccuria, Silvia Perez-Bogerd, Andreï Malinovschi, Alain Van Muylem","doi":"10.1111/all.16441","DOIUrl":"https://doi.org/10.1111/all.16441","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating Nitrite in Severe Asthma: Just Another Biomarker or Novel Treatment Target?","authors":"Anna Freeman, Magdalena Minnion, Paul H Lee, Hans Michael Haitchi, Ramesh Kurukulaaratchy, Tom Wilkinson, Martin Feelisch","doi":"10.1111/all.16435","DOIUrl":"https://doi.org/10.1111/all.16435","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food Allergy Genetics and Epigenetics: A Review of Genome-Wide Association Studies.","authors":"Aleix Arnau-Soler, Bénédicte L Tremblay, Yidan Sun, Anne-Marie Madore, Mathieu Simard, Elin T G Kersten, Ahla Ghauri, Ingo Marenholz, Thomas Eiwegger, Elinor Simons, Edmond S Chan, Kari Nadeau, Vanitha Sampath, Bruce D Mazer, Susan Elliott, Christine Hampson, Lianne Soller, Andrew Sandford, Philippe Begin, Jennie Hui, Bethany F Wilken, Jennifer Gerdts, Adrienn Bourkas, Anne K Ellis, Denitsa Vasileva, Ann Clarke, Aida Eslami, Moshe Ben-Shoshan, David Martino, Denise Daley, Gerard H Koppelman, Catherine Laprise, Young-Ae Lee, Yuka Asai","doi":"10.1111/all.16429","DOIUrl":"https://doi.org/10.1111/all.16429","url":null,"abstract":"<p><p>In this review, we provide an overview of food allergy genetics and epigenetics aimed at clinicians and researchers. This includes a brief review of the current understanding of genetic and epigenetic mechanisms, inheritance of food allergy, as well as a discussion of advantages and limitations of the different types of studies in genetic research. We specifically focus on the results of genome-wide association studies in food allergy, which have identified 16 genetic variants that reach genome-wide significance, many of which overlap with other allergic diseases, including asthma, atopic dermatitis, and allergic rhinitis. Identified genes for food allergy are mainly involved in epithelial barrier function (e.g., FLG, SERPINB7) and immune function (e.g., HLA, IL4). Epigenome-wide significant findings at 32 loci are also summarized as well as 14 additional loci with significance at a false discovery of < 1 × 10^-4. Integration of epigenetic and genetic data is discussed in the context of disease mechanisms, many of which are shared with other allergic diseases. The potential utility of genetic and epigenetic discoveries is deliberated. In the future, genetic and epigenetic markers may offer ways to predict the presence or absence of clinical IgE-mediated food allergy among sensitized individuals, likelihood of development of natural tolerance, and response to immunotherapy.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IL‐1R2 Expression in Tfr Cells Controls Allergic Anaphylaxis by Regulating IgG Versus IgE Responses","authors":"Paul Engeroff, Aude Belbezier, Romain Vaineau, Gwladys Fourcade, Hugo D. Lujan, Bertrand Bellier, Stephanie Graff‐Dubois, David Klatzmann","doi":"10.1111/all.16437","DOIUrl":"https://doi.org/10.1111/all.16437","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"30 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142841019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering Dysfunctional Regulatory T Cells in Atopic Dermatitis","authors":"Seong‐Jun Kang, Jeong‐Ryeol Gong, Seon‐Pil Jin, Jin‐Mi Oh, Hyunjin Jin, Yuji Lee, Yewon Moon, Dongjun Kim, Hyo Jeong Nam, Hyun Seung Choi, Sanha Hwang, Yun Jung Huh, Kyung Yeon Han, Jihwan Moon, Jongsuk Chung, Woong‐Yang Park, Chung‐Gyu Park, Hyun Je Kim, Jeong Eun Kim","doi":"10.1111/all.16439","DOIUrl":"https://doi.org/10.1111/all.16439","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"23 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142841018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiomic Integration Analysis for Monitoring Severe Asthma Treated With Mepolizumab or Omalizumab","authors":"Nuria Contreras, Andrea Escolar‐Peña, María I. Delgado‐Dolset, Paloma Fernández, David Obeso, Elena Izquierdo, Heleia González Cuervo, José Ángel Cumplido, Victoria Múgica, Carolina Cisneros, Santiago Angulo‐Díaz‐Parreño, Coral Barbas, Carlos Blanco, Teresa Carrillo, Domingo Barber, Alma Villaseñor, María M. Escribese","doi":"10.1111/all.16434","DOIUrl":"https://doi.org/10.1111/all.16434","url":null,"abstract":"RationaleBiologics are becoming increasingly important in the management of severe asthma. However, little is known about the systemic immunometabolic consequences of Th2 response blockage.ObjectivesTo provide a better immunometabolic understanding of the effects of mepolizumab and omalizumab treatments by identifying potential biomarkers for monitoring.MethodsIn this exploratory longitudinal study severe asthmatic patients were followed for 18 months after initiating mepolizumab (<jats:italic>n</jats:italic> = 36) or Omalizumab (<jats:italic>n</jats:italic> = 20) treatment. Serum samples were collected before, 6, and 18 months after treatment. Targeted omic approaches were performed to analyze inflammatory metabolites (<jats:italic>n</jats:italic> = 35) and proteins (<jats:italic>n</jats:italic> = 45). Multiomic integration was performed individually for each treatment applying supervised analysis Data Integration Analysis for Biomarker discovery using Latent cOmponents (DIABLO) framework. Then, potential biomarkers were confirmed using multivariate ROC analyses and correlated with clinical variables along treatment.Measurements and Main ResultsMepolizumab and omalizumab were both effective (improved clinical variables) and showed different and specific metabolic and protein profiles in severe asthmatic patients during treatment. Multiomic integration and multivariate ROC analyses identified specific biomarkers, such as arachidonic acid, palmitoleic acid, oleic acid, propionylcarnitine, bilirubin, CCL11, and TNFSF10, which can explain the differences observed with Mepolizumab treatment over 18 months and significantly correlate with clinical improvement. However, no significant biomolecules and no discriminative multivariate ROC curves were found for Omalizumab treatment.ConclusionsOur results provide a comprehensive insight into the differential effects of mepolizumab and omalizumab on the immunometabolic kinetics of the inflammatory response in severe asthma. We identified a set of biomolecules with potential for monitoring mepolizumab treatment which could be useful for personalized medicine.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"54 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142841020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Algorithms in Allergy: Assessment of Rhinitis Using Allergen Exposure Chambers.","authors":"Marek Jutel, Magdalena Zemelka-Wiacek, Yoshitaka Okamoto, Oliver Pfaar","doi":"10.1111/all.16444","DOIUrl":"https://doi.org/10.1111/all.16444","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Bronchodilator and Anti-Inflammatory Effect of Long-Acting Muscarinic Antagonists in Asthma: An EAACI Position Paper.","authors":"I Agache, I M Adcock, C A Akdis, M Akdis, G Bentabol-Ramos, M van den Berge, C Boccabella, W G Canonica, C Caruso, M Couto, I Davila, D Drummond, J Fonseca, A Gherasim, S Del Giacco, D J Jackson, M Jutel, A Licari, S Loukides, A Moreira, M Mukherjee, I Ojanguren, O Palomares, A Papi, L Perez de Llano, O J Price, M Rukhazde, M H Shamji, D Shaw, S Sanchez-Garcia, A Testera-Montes, M J Torres, I Eguiluz-Gracia","doi":"10.1111/all.16436","DOIUrl":"https://doi.org/10.1111/all.16436","url":null,"abstract":"<p><p>As cholinergic innervation is a major contributor to increased vagal tone and mucus secretion, inhaled long-acting muscarinic antagonists (LAMA) are a pillar for the treatment of chronic obstructive pulmonary disease and asthma. By blocking the muscarinic receptors expressed in the lung, LAMA improve lung function and reduce exacerbations in asthma patients who remained poorly controlled despite treatment with inhaled corticosteroids and long-acting β2 agonists. Asthma guidelines recommend LAMA as a third controller to be added on before the initiation of biologicals. In addition to bronchodilation, LAMA also exert anti-inflammatory and anti-fibrotic effects by inhibiting muscarinic receptors present in neutrophils, macrophages, fibroblasts and airway smooth muscle cells. Thus, besides bronchodilation, LAMA might provide additional therapeutic effects, thereby supporting an endotype-driven approach to asthma management. The Position Paper, developed by the Asthma Section of the European Academy of Allergy and Clinical Immunology, discusses the main cholinergic pathways in the lung, reviews the findings of significant clinical trials and real-life studies on LAMA use in asthma, examines the placement of these drugs in asthma clinical guidelines, and considers the potential for personalised medicine with LAMA in both adult and paediatric asthma patients.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}