Allergy最新文献

{"title":"Secretion of Peanut Protein With IgE Crosslinking Capacity in Human Milk.","authors":"Amy D Burris,Nichole Diaz,Jon B Meddings,Bijoya Karmakar,Tarun Keswani,Sarita U Patil,Antti E Seppo,Kirsi M Järvinen","doi":"10.1111/all.70066","DOIUrl":"https://doi.org/10.1111/all.70066","url":null,"abstract":"BACKGROUNDHuman milk provides an infant one of the first routes of exposure to dietary antigens. A better understanding of the levels and functional capacity of maternal dietary proteins in human milk (HM) and their impact on infant food allergy (FA) is needed.OBJECTIVETo measure the quantity and biologic activity of maternal dietary proteins in HM and determine factors associated with their presence.METHODSHM samples from mothers of infants with or without FA were collected before and serially after consumption of a meal with prespecified amounts of peanut, egg, and cow's milk protein. Ara h 2 from peanut, egg ovalbumin, and bovine β-lactoglobulin in HM was detected using ELISA. IgE-crosslinking capacity of Ara h 2 was assessed by the basophil activation test (BAT). Maternal intestinal permeability was measured with the lactulose/mannitol test.RESULTSThirty-nine mothers were included and 69% had measurable Ara h 2 in HM. Secretion of food allergens was variable between different mothers and across allergens, but did not correlate with intestinal permeability. Atopic mothers' milk had a higher peak Ara h 2 concentration (median 246 pg/mL, range 2.0-1634) than nonatopic mothers (median 0 pg/mL, range 0-135, p = 0.017). In samples with the most BAT reactivity, there was a significant correlation between BAT reactivity and Ara h 2 level (R = 0.72, p = 2 × 10-8). Multiple monoclonal antibodies directed at different epitopes detected Ara h 2 at similar levels.CONCLUSIONAra h 2 is secreted in HM as intact protein or significant parts of it that are capable of IgE-crosslinking, found in higher levels in atopic mothers. HM levels of peanut lack correlation with other dietary proteins, which suggests antigen specificity of the secretion of dietary protein into HM.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"9 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular Vesicle miRNAs as Biomarkers of Asthma Severity.","authors":"Chandrashekhar Prasad,Rachel Griffard,Dong Pei,Steven Haworth,Navneet K Dhillon,Mario Castro,Isaac Kirubakaran Sundar","doi":"10.1111/all.70079","DOIUrl":"https://doi.org/10.1111/all.70079","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"103 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-Induced Periocular and Ocular Surface Disorders: An EAACI Position Paper.","authors":"Andrea Leonardi,Banu Bozkurt,Diana Silva,Charlotte G Mortz,Christophe Baudouin,Marina Atanaskovic-Markovic,Vibha Sharma,Serge Doan,Shweta Agarwal,Daniel Pérez-Formigo,Maria Joao Vasconcelos,Francoise-Brignole Baudouin,Gonzalo Chorzepa,Jean-Luc Fauquert,Virginia Calder,Pascal Demoly,Luis Delgado","doi":"10.1111/all.70074","DOIUrl":"https://doi.org/10.1111/all.70074","url":null,"abstract":"Various systemic and topical medications can induce ocular and periocular cutaneous adverse effects (AEs), ranging from mild to severe. These AEs may lead to ocular surface (OS) damage and, in some cases, life-threatening complications. Drug-induced ocular adverse reactions are generally classified into two primary categories: toxic reactions and/or allergic hypersensitivity reactions, which can be IgE or non-IgE-mediated. Systemic antibiotics, antivirals, and anticonvulsants can trigger adverse reactions that may involve the OS. Drugs like antihistamines, beta-blockers, antipsychotics, antidepressants, and isotretinoin are linked to dry eye disease. Topical treatments-including antibiotics, antiglaucoma medications, preservatives, contact lens solutions, and cosmetics-may elicit allergic or toxic ocular diseases. Recent evidence implicates ocular surface AEs in patients undergoing biological treatments for oncological diseases and atopic dermatitis. Epidermal growth factor receptor inhibitors, used in the treatment of several cancers, have been associated with conjunctivitis, meibomitis, dry eye, periocular skin changes, and trichomegaly. Similarly, dupilumab, the first biologic approved for treating moderate-to-severe atopic dermatitis, has also been linked to OS disease with blepharoconjunctivitis. This position paper provides a comprehensive overview of the clinical presentations, diagnostic approaches, and treatment strategies for drug-induced ocular AEs, integrating the latest literature and clinical guidelines.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"75 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-Related Increase in Anaphylaxis Severity Is Associated With Enhanced Sensitivity to Allergic Mediators.","authors":"Daniel Brigger,Melanie Steinmann,Nadine Roos,Pascal Guntern,Oliver M Würgler,Lukas Michaja Balsiger,Alexander Eggel","doi":"10.1111/all.70082","DOIUrl":"https://doi.org/10.1111/all.70082","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"20 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small Intestinal Dilation Is Associated With Severe Abdominal Symptoms of Food-Protein-Induced Enterocolitis Syndrome in Adults.","authors":"Sho Watanabe,Ayako Sato,Keitaro Shibuya,Rina Kusuda,Tsunehito Yauchi,Tatsuki Fukuie,Kiwako Yamamoto-Hanada,Yukihiro Ohya,Ichiro Nomura","doi":"10.1111/all.70081","DOIUrl":"https://doi.org/10.1111/all.70081","url":null,"abstract":"BACKGROUNDFood-Protein-Induced Enterocolitis Syndrome (FPIES) is a non-IgE-mediated food allergy that causes gastrointestinal symptoms, though its anatomical origin and pathogenesis remain unclear. Abdominal distention is common in adult FPIES, but symptoms vary among patients. This study aimed to establish objective criteria for assessing abdominal distention and to clarify the pathophysiology and anatomical origin of FPIES.METHODSThis study targeted 26 adult FPIES patients. Abdominal distention was broken down into eight factors, and an evaluation algorithm was developed based on items with high positivity rates. Clinical characteristics, blood, and imaging analyses were performed before and after OFC (oral food challenge) to investigate the pathophysiology.RESULTSAmong 14 adult FPIES patients who underwent OFC, seven showed positive results. The latency period was 1.5 h, with the most frequent symptoms being abdominal distention (100%), abdominal pain, and nausea (71.4%). All patients received treatment with intravenous extracellular fluid infusion and ondansetron, which resulted in reduced symptom duration. In an evaluation of blood test data, there were no specific serological markers of FPIES, except in the severe case. Image analysis with computed tomography revealed significant dilation and edema of the small intestine during the FPIES event, suggesting that dilation of the small intestine is associated with adult FPIES.CONCLUSIONThese results are expected to aid in the early and appropriate diagnosis of FPIES based on medical interviews, blood test data, and imaging findings when adult patients present to medical institutions with severe acute gastroenteritis symptoms.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"100 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145182762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining Atopic Dermatitis Through the One Health Concept Lens.","authors":"Dijana Minić-Pantić,Bernadette Abela,Jenni Lehtimäki,Alexander Zink,Erika Jensen-Jarolim,Antonia Fettelschoss-Gabriel,Claudia Traidl-Hoffmann,Johannes Ring,Peter Schmid-Grendelmeir,Pascal Prélaud,Alain Taïeb","doi":"10.1111/all.70080","DOIUrl":"https://doi.org/10.1111/all.70080","url":null,"abstract":"This paper explores the application of the One Health framework to atopic dermatitis (AD), a complex, chronic skin disease, emphasizing interdisciplinary approaches to prevention and management. One Health integrates human, animal, environmental, and plant health, addressing challenges such as antimicrobial resistance, infectious diseases, and neglected tropical diseases (NTDs). In the context of AD, One Health principles are applied to explore etiological factors like urbanization, climate change, biodiversity loss, and environmental pollution. Key findings include the interplay between lifestyle and environmental exposures, as evidenced by studies on human-dog microbiota sharing, which reveal that rural environments confer protective effects against allergic conditions for both species. Historical observations of the \"old farm effect\" highlight the protective role of traditional rural living, including raw milk consumption, in preventing atopic diseases. However, modern urbanization and industrial farming have eroded these benefits. Climate change intensifies AD symptoms through extreme weather, proliferation of more and higher allergenic pollen, likely also of house dust mites, allergen proliferation, and pollution. Rising CO2 levels exacerbate pollen allergenicity, prolong pollen seasons, and amplify allergic responses. The skin's microbiome and immune barrier are sensitive to pollutants like black carbon and traffic-related emissions, further influencing AD prevalence and severity. Innovative approaches to prevention, such as veterinary vaccination strategies targeting allergens or immunopathological key cytokines, illustrate cross-species solutions. Web data mining demonstrates potential for analyzing public interest and seasonal trends in AD, correlating search data with real-time monitored environmental factors and highlighting gaps in awareness and access to modern treatments. This integrative One Health lens provides a framework for reimagining AD prevention and management, emphasizing a return to environmental and lifestyle diversity, climate action, and leveraging digital and biomedical tools for personalized, sustainable care.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"62 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145153528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tezepelumab Targeting Thymic Stromal Lymphopoietin Enhances Steroid Sensitivity in Patients With Severe Asthma.","authors":"Keita Hirai,Sekiko Uehara,Toshihiro Shirai,Taisuke Akamatsu,Kunihiko Itoh","doi":"10.1111/all.70083","DOIUrl":"https://doi.org/10.1111/all.70083","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"42 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145153531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Allergic Rhinitis Treatments on Patient Satisfaction: A MASK-air and EAACI Methodological Committee Report.","authors":"Bernardo Sousa-Pinto,Rafael José Vieira,Antonio Bognanni,Matteo Martini,Michal Ordak,Giovanni Paoletti,Sara Gil-Mata,Rita Amaral,Anna Bedbrook,Patrizia Bonadonna,Luisa Brussino,G Walter Canonica,João Coutinho-Almeida,Álvaro A Cruz,Wienczyslawa Czarlewski,Mark Dykewicz,Mattia Giovannini,Bilun Gemicioglu,Juan Carlos Ivancevich,Ludger Klimek,Violeta Kvedariene,Desiree E Larenas-Linnemann,Manuel Marques-Cruz,André Moreira,Marek Niedoszytko,Ana Margarida Pereira,Nikolaos G Papadopoulos,Nhan Pham-Thi,Frederico S Regateiro,Sanna K Toppila-Salmi,Boleslaw Samolinski,Joaquin Sastre,Luís Taborda-Barata,Tuuli Thomander,Ilgım Vardaloğlu Koyuncu,Arunas Valiulis,Leticia de Las Vecillas,Maria Teresa Ventura,Jolanta Walusiak-Skorupa,Yi-Kui Xiang,Oliver Pfaar,João A Fonseca,Torsten Zuberbier,Holger J Schünemann,Danilo di Bona,Jean Bousquet","doi":"10.1111/all.70055","DOIUrl":"https://doi.org/10.1111/all.70055","url":null,"abstract":"INTRODUCTIONSatisfaction with treatments may affect medication adherence and use patterns, including the use of co-medication. We aimed to compare different medications for allergic rhinitis (AR) on (i) patients' satisfaction and (ii) co-medication use frequency.METHODSWe assessed data from the mHealth app MASK-air. We evaluated days on which users with self-reported AR had used-alone or in co-medication-intranasal corticosteroids (INCS), intranasal antihistamines (INAH), fixed combinations of INAH+INCS, or oral antihistamines (OAH). We built multivariable regression models to compare these different AR medication classes (as well as individual medications) on their (i) treatment satisfaction levels (measured using a specific daily visual analogue scale ['VAS satisfaction']) and (ii) odds of being used in co-medication.RESULTSWe assessed 28,177 days reported by 1691 MASK-air users. For all medication classes, co-medication usage was associated with lower treatment satisfaction. When used in monotherapy, OAH were associated with lower VAS satisfaction than INCS (-1.7 points; 95% CI = -2.7; -0.7) or INAH+INCS (-2.1 points; 95% CI = -3.5; -0.7). INCS displayed higher odds of being used in co-medication than OAH (OR = 1.3; 95% CI = 1.0; 1.6) or INAH+INCS (OR = 1.3; 95% CI = 0.8; 1.8). When comparing individual intranasal medications, fluticasone furoate and fluticasone propionate tended to be more frequently used in co-medication. Among individual OAH, desloratadine and rupatadine were associated with higher satisfaction, while fexofenadine was more frequently used in co-medication.CONCLUSIONUsing patient-reported data, we evaluated different medication classes and treatments in terms of satisfaction and co-medication frequency. These results provide key insights into the acceptability of AR treatments and will contribute to future treatment guidelines.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"18 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Analysis of Self-Administration of Biologic Treatments for Severe Asthma and Chronic Urticaria.","authors":"Hazal Kayıkçı,Ebru Damadoglu,Melek Cihanbeylerden,Çise Tüccar,Ayşegül Pehlivanlar Ustaoğlu,Gül Karakaya,Ali Fuat Kalyoncu","doi":"10.1111/all.70078","DOIUrl":"https://doi.org/10.1111/all.70078","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"89 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145140485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-Life Clinical Experience With SQ Grass, Tree, Ragweed, and House Dust Mite Sublingual Immunotherapy Tablets: A Review of Evidence From Non-Interventional Studies.","authors":"Oliver Pfaar,Christer Janson,Andreas Horn,André C Knulst,Pascal Demoly","doi":"10.1111/all.70039","DOIUrl":"https://doi.org/10.1111/all.70039","url":null,"abstract":"This review evaluates data from > 12,000 children, adolescents and adults (≥ 4 years) in non-interventional studies to assess the real-life effectiveness and safety of SQ sublingual immunotherapy (SLIT)-tablets for allergic rhinitis (AR). Non-interventional studies of SQ grass, tree, ragweed, and house dust mite (HDM) SLIT tablets were identified from PubMed (1 January 2006 to 11 February 2025) and supplemented by manual searches. Effectiveness was captured as patient-reported change in AR symptoms; AR and/or asthma medication use, safety and treatment satisfaction were also evaluated. In total, 12,136 participants were enrolled across 22 SQ SLIT tablet studies (grass: n = 6744; HDM: n = 4323; tree: n = 1069; ragweed: n = 102). Across studies, a high proportion of participants reported improvements from baseline or the previous season across nasal (up to 87%), ocular (up to 81%), and bronchial symptoms (up to 78%) with SQ SLIT tablets. Compared to baseline, a lower proportion of patients reported use of symptom-relieving medication, consistent across key drug classes including oral antihistamine, intranasal corticosteroids, short-acting beta-agonist, and inhaled corticosteroids. Discontinuations due to adverse events were low (0%-14.5%). Among studies reporting treatment satisfaction, 73%-96% of participants were found to be 'satisfied' or 'very satisfied' with this treatment. SQ SLIT tablets showed consistent effectiveness for AR, were well-tolerated, and were associated with a high degree of patient satisfaction. These real-life data from clinical practice are a valuable and important source of complementary evidence to the well established efficacy and safety from randomised clinical trials.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"77 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145153545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}