Allergy最新文献

{"title":"Otitis Media With Effusion (OME) and Eustachian Tube Dysfunction: The Role of Allergy and Immunity-An EAACI Position Paper.","authors":"L Klimek,H A Brough,S Arasi,S Toppila-Salmi,C Bergmann,M Jutel,J Bousquet,V Hox,P Gevaert,P V Tomazic,C Rondón Segovia,C Cingi,M Cuevas,M Gröger,P Huber,S Reitsma,M Rudenko,J Maza-Solano,S Gane,A Karavelia,L van Gerven,M Schiappoli,B Bozkurt,S Becker,A Chaker,B Wollenberg,R Mösges,T Huppertz,J Hagemann,O Palomares,F Bärhold,O Pfaar,S Del Giacco,P Bonadonna,A Moreira,I Agache,C A Akdis,W Fokkens,J Walusiak-Skorupa,L de Las Vecillas,M Alvaro Lozano,M Giovannini,E Untersmayr,W Feleszko,A Cianferoni,U M Sahiner,I Eguiluz-Gracia,M Shamji,M J Torres Jaén","doi":"10.1111/all.16554","DOIUrl":"https://doi.org/10.1111/all.16554","url":null,"abstract":"IgE-mediated allergies play a significant role in respiratory diseases. Given the similar mucosal epithelium of the upper and lower respiratory tracts and their shared (patho)physiological immune responses, the \"unified airways\" concept views these tracts as a single system. Recently, this model has been extended to include the middle ear, with studies confirming that the Eustachian tube and middle ear are both anatomically and functionally part of the upper airways. However, the relationship between allergies and middle ear disorders remains controversial, with conflicting findings regarding pathogenesis and treatment. The increasing prevalence of allergies highlights the importance of further research. In Germany, the current sensitization rate to aeroallergens is 33.6%, with similar trends across Europe, where rates commonly range up to 30%. This widespread increase underscores the urgent need for a deeper understanding of the correlation between allergies and middle ear disorders across diverse European populations. Ineffective pharmacotherapy or possibly harmful medication for acute and chronic OME, such as systemic steroids, is most likely used globally in an uninformed way, due to a lack of evidence on the connection between allergic inflammation and eustachian tube dysfunction. Further research is essential to clarify the mechanisms linking IgE-mediated allergies to middle ear pathologies and to develop effective treatment strategies. Addressing these knowledge gaps is critical for improving patient outcomes and managing the rising burden of allergic diseases.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"7 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence to \"Omalizumab Reduces Anaphylactic Reactions and Allows Food Introduction in Food-Allergic in Children With Severe Asthma: An Observational Study\".","authors":"Angela Klain,Cristiana Indolfi,Carolina Grella,Simone Colosimo,Alessandra Perrotta,Michele Miraglia Del Giudice","doi":"10.1111/all.16560","DOIUrl":"https://doi.org/10.1111/all.16560","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"4590 5 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Correspondence: The Bronchodilator and Anti‐Inflammatory Effect of Long‐Acting Muscarinic Antagonists in Asthma: An EAACI Position Paper","authors":"I. Agache, I. M. Adcock, C. A. Akdis, M. Akdis, G. Bentabol‐Ramos, M. van den Berge, C. Boccabella, G. W. Canonica, C. Caruso, M. Couto, I. Davila, D. Drummond, J. Fonseca, A. Gherasim, S. del Giacco, D. J. Jackson, M. Jutel, A. Licari, S. Loukides, A. Moreira, M. Mukherjee, I. Ojanguren, O. Palomares, A. Papi, L. Perez de Llano, O. J. Price, M. Rukhazde, M. H. Shamji, D. Shaw, S. Sanchez‐Garcia, A. Testera‐Montes, M. J. Torres, Ibon Eguiluz‐Gracia","doi":"10.1111/all.16557","DOIUrl":"https://doi.org/10.1111/all.16557","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"60 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143822645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Faecalibacterium in the Gut Microbiota Predicts Tolerance Acquisition in Pediatric Hen's Egg Allergy","authors":"Shohei Akagawa, Shoji Tsuji, Yoko Nakai, Chika Urakami, Mitsuru Yamagishi, Yuko Akagawa, Kazunari Kaneko","doi":"10.1111/all.16556","DOIUrl":"https://doi.org/10.1111/all.16556","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"101 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143822561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Occupational Exposure and Sinus Surgery Outcomes in Chronic Rhinosinusitis: A Prospective Study","authors":"G. Vansteelant, D. A. E. Dietz de Loos, S. Ronsmans, M. Samaha, D. Langer, S. Keirsbilck, P. Rombaux, C. Huart, M. Jorissen, W. Fokkens, B. Nemery, P. W. Hellings, V. Hox","doi":"10.1111/all.16555","DOIUrl":"https://doi.org/10.1111/all.16555","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"20 3 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143819262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence to ‘Interleukin‐5 as a Pleiotropic Cytokine Orchestrating Airway Type 2 Inflammation: Effects on and Beyond Eosinophils’","authors":"Christopher McCrae, Maria L. Jison, Andrew Menzies‐Gow","doi":"10.1111/all.16545","DOIUrl":"https://doi.org/10.1111/all.16545","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"39 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143819263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccine-Induced Anti-IgE Antibodies Neutralize Free IgE but Fail to Bind and Activate Mast Cell-Displayed IgE.","authors":"Zahra Gharailoo, Monique Vogel, Paul Engeroff, Martin F Bachmann","doi":"10.1111/all.16530","DOIUrl":"https://doi.org/10.1111/all.16530","url":null,"abstract":"<p><strong>Background: </strong>In Type I hypersensitivity, IgE is the antibody that contributes to the onset of anaphylaxis through the activation of effector cells, causing the release of allergic mediators. Blocking IgE activity with anti-IgE autoantibodies induced by active immunization could potentially offer an efficient and cost-effective method to treat allergic disorders. We recently developed an effective and safe anti-IgE vaccine in mice, but the mechanisms by which the vaccine protects and the explanation for its safety remained largely unknown. Here, our objective was to better understand those mechanisms.</p><p><strong>Methods: </strong>CuMV_TT-Cε3-Cε4 is a virus-like particles (VLP)-based vaccine designed to target domains 3 and 4 of IgE. Here, we studied the role of FcγRIIb and CD23 in vaccine-mediated protection from allergy using FcγRIIb KO and CD23 KO mice. Moreover, vaccine-induced IgGs were purified for passive immunization studies and for in vitro experiments with murine bone marrow-derived mast cells (BMMCs).</p><p><strong>Results: </strong>Immunized mice generated high titers of IgG antibodies specific for IgE that conferred protection against allergic responses, independently of FcγRIIb and CD23. Sera of immunized mice blocked IgE binding to BMMC FcεRI and suppressed degranulation, independent of FcγRIIb. Purified anti-IgE antibodies did not provoke an anaphylactic response when transferred into allergic mice but protected against subsequent allergen challenge. Interestingly, the purified IgG antibodies were unable to recognize receptor-bound IgE in BMMCs, explained by the finding that recognition by these anti-IgEs depends on the same mannose moieties on IgE that are essential for FcεRI binding and thus hidden when receptor-bound.</p><p><strong>Conclusions: </strong>In conclusion, the CuMV_TT-Cε3-Cε4 vaccine induces high titers of anti-IgE IgGs that confer protection by neutralizing IgE through its glycan epitopes, without causing FcεRI cross-linking. Our results imply that an anti-IgE vaccine may represent a promising therapeutic strategy, offering effective protection while minimizing the risk of adverse reactions similar to the monoclonal antibody omalizumab.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Patients With Allergic Diseases in the Era of Biologics","authors":"Feng Lan, Cezmi A. Akdis, Luo Zhang","doi":"10.1111/all.16552","DOIUrl":"https://doi.org/10.1111/all.16552","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"108 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: D.J. Jackson, M.E. Wechsler, G. Brusselle, R. Buhl. Targeting the IL-5 pathway in eosinophilic asthma: A comparison of anti-IL-5 versus anti-IL-5 receptor agents. Allergy 2024;1-10. https://doi.org/10.1111/all.16346.","authors":"","doi":"10.1111/all.16541","DOIUrl":"https://doi.org/10.1111/all.16541","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flow Cytometry-Assisted Analyses of Individual Human Basophils, Mast Cells and T Cells in the Diagnosis of Immediate Drug Hypersensitivity: A Review.","authors":"Jessy Elst, Christel Mertens, Michel Van Houdt, Marie-Line M van der Poorten, Athina L Van Gasse, Alessandro Toscano, Michiel Beyens, Daniel Yerly, Margo M Hagendorens, Vito Sabato, Oliver Hausmann, Didier G Ebo","doi":"10.1111/all.16548","DOIUrl":"https://doi.org/10.1111/all.16548","url":null,"abstract":"<p><p>Immediate drug hypersensitivity reactions (IDHRs) pose significant diagnostic challenges, often requiring potentially hazardous drug challenge testing (DCT). Flow cytometry-based cellular tests including the basophil activation test (BAT), the mast cell activation test (MAT) and the T cell activation test (TAT) offer promising alternatives to reduce DCT reliance. While these tests are still in development, they demonstrate potential to compete with skin tests by providing superior diagnostic performance and improved patient safety by reducing the need for DCT. Furthermore, it is encouraging that these flow cytometry-based tests are also suitable for challenging populations, such as children. Despite requiring specialised infrastructure, these tests have the potential to be cost-effective when performed in reference centres and may offer unique mechanistic insights into immediate drug hypersensitivity reactions. However, further research is needed to validate their reliability, address pharmaceutical-specific testing considerations, and potentially integrate them into clinical guidelines.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}