Allergy最新文献

{"title":"Wildfires and Respiratory Allergy.","authors":"Gennaro D'Amato, Ioana Agache, Kari Nadeau, Vanitha Sampath, Cezmi Akdis, Isabella Annesi-Maesano","doi":"10.1111/all.16527","DOIUrl":"https://doi.org/10.1111/all.16527","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Safe and Efficient 7‐Week Immunotherapy Protocol With Aluminum Hydroxide Adsorbed Bee Venom","authors":"Lisa Arzt‐Gradwohl, Urban Čerpes, Eva Schadelbauer, Clemes Schöffl, Sereina Annik Herzog, Christoph Schrautzer, Danijela Bokanovic, Lukas Koch, Karin Laipold, Barbara Binder, Gunter Sturm","doi":"10.1111/all.16528","DOIUrl":"https://doi.org/10.1111/all.16528","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"183 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143631325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Omics Landscape of Long COVID—A Comprehensive Systematic Review to Advance Biomarker, Target and Drug Discovery","authors":"Nadia Baalbaki,&nbsp;Elise M. A. Slob,&nbsp;Samuel W. Kazer,&nbsp;Mahmoud I Abdel-Aziz,&nbsp;Harm Jan Bogaard,&nbsp;Korneliusz Golebski,&nbsp;Anke H. Maitland-van der Zee","doi":"10.1111/all.16526","DOIUrl":"10.1111/all.16526","url":null,"abstract":"<p>An estimated 10% of coronavirus disease (COVID-19) survivors suffer from persisting symptoms referred to as long COVID (LC), a condition for which approved treatment options are still lacking. This systematic review (PROSPERO: CRD42024499281) aimed to explore the pathophysiological mechanisms underlying LC and potential treatable traits across symptom-based phenotypes. We included studies with primary data, written in English, focusing on omics analyses of human samples from LC patients with persistent symptoms of at least 3 months. Our search in PubMed and Embase, conducted on January 8, 2024, identified 642 studies, of which 29 met the inclusion criteria after full-text assessment. The risk of bias was evaluated using the Joanna Briggs Institute appraisal tool. The synthesis of omics data, including genomics, transcriptomics, proteomics, metabolomics, and metagenomics, revealed common findings associated with fatigue, cardiovascular, pulmonary, neurological, and gastrointestinal phenotypes. Key findings included mitochondrial dysfunction, dysregulated microRNAs associated with pulmonary dysfunction, tissue impairment, blood–brain barrier disruption, coagulopathy, vascular dysfunction, microbiome disturbances, microbial-derived metabolite production and persistent inflammation. Limitations include cross-study heterogeneity and variability in sampling methods. Our review emphasizes the complexity of LC and the need for further longitudinal omics-integrated studies to advance the development of biomarkers and targeted treatments.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":"80 4","pages":"932-948"},"PeriodicalIF":12.6,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.16526","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D Model of Human Epidermis Exposed to Staphylococci Reveals Keratinocyte Responses Unique to Atopy-Associated S. aureus Challenge.","authors":"Piotr Brzoza, Michelle Camacho, Mariia Tyshchenko, Agnieszka Morytko, Mateusz Kwitniewski, Maciej Pastuszczak, Paulina Stepinska, Marcin Migaczewski, Joanna Cichy","doi":"10.1111/all.16524","DOIUrl":"https://doi.org/10.1111/all.16524","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Legends of Allergy and Immunology: Antonino Romano","authors":"María J. Torres,&nbsp;Patrizia Bonadonna,&nbsp;Jean-Louis Guéant","doi":"10.1111/all.16511","DOIUrl":"10.1111/all.16511","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"80 4","pages":"1180-1182"},"PeriodicalIF":12.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunophenotyping in Vernal Keratoconjunctivitis: Schirmer Test for Therapy Response Prediction.","authors":"Maria Teresa Bilotta, Paola Vacca, Mariacristina Esposito, Luca Buzzonetti, Giuseppe Bianco, Alessandro Giovanni Fiocchi, Lorenzo Moretta, Massimiliano Raponi, Maria Cristina Artesani, Nicola Tumino","doi":"10.1111/all.16525","DOIUrl":"https://doi.org/10.1111/all.16525","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence to “The Bronchodilator and Anti‐Inflammatory Effect of Long‐Acting Muscarinic Antagonists in Asthma: An EAACI Position Paper”","authors":"Umberto Semenzato, Daniele Previtero, Ylenia Padrin, Simonetta Baraldo, Mariaenrica Tinè","doi":"10.1111/all.16523","DOIUrl":"https://doi.org/10.1111/all.16523","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"68 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143599486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of an Allergen Exposure Chamber and Nasal Allergen Challenge Versus In-Field Symptom Assessment in Patients With Allergic Rhinitis Triggered by Timothy Grass Pollen.","authors":"Magdalena Zemelka-Wiacek, Anna Kosowska, Oliver Pfaar, Ioana Agache, Krzysztof Kujawa, Marek Jutel","doi":"10.1111/all.16518","DOIUrl":"https://doi.org/10.1111/all.16518","url":null,"abstract":"<p><strong>Background: </strong>An allergen exposure chamber (AEC) is a specialized medical facility designed to expose individuals to allergens at precise and consistent concentrations within a controlled environment. This study aimed to correlate the assessment of clinical endpoints in patients with allergic rhinitis sensitized to timothy grass pollen (Phleum pratense) by comparing three different methods: AEC, nasal allergen challenge (NAC), and symptoms during natural exposure during the grass pollen season.</p><p><strong>Methods: </strong>Fifteen allergic subjects and twelve healthy controls were evaluated in the ALLEC AEC; allergic symptoms were measured by subjective and objective methods, including total nasal symptom score (TNSS), acoustic rhinometry (AcR), peak nasal inspiratory flow (PNIF), and nasal discharge amount. For the in-field evaluation, a combined symptom medication score (EAACI-CSMS), as proposed by the European Academy of Allergy and Clinical Immunology (EAACI), was used, which was assessed for 14 days during the peak of the pollen season. The AcR, PNIF, and TNSS were used for the NAC assessment.</p><p><strong>Results: </strong>Both in the AEC and NAC, all allergic individuals developed symptoms at the optimal pollen/allergen concentration across all the measured endpoints. Using Spearman's rank correlation coefficient (p < 0.05), the analysis revealed significant correlations between symptoms assessed in AEC at 120 min of the challenge, as well as in NAC after 15 min with the EAACI-CSMS in-field. The correlations between in-field assessment and AEC were stronger than those with NAC, which showed weaker or no significant correlations. This indicates that the AEC challenge correlates better with in-field assessments than NAC.</p><p><strong>Conclusion: </strong>Clinical endpoints assessed to allergen exposure in the AEC and NAC significantly correspond to the efficacy analysis in-field (EAACI-CSMS during the peak of pollen exposure). The effect of NAC was not significant for all outcomes measured. Both methods might be considered to be an alternative to traditional assessment during natural exposure.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143583994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Asthma Control and Risk Factors for Poor Asthma Outcomes in Chinese Asthma Patients: Baseline Analysis of a Multi-Centre, Single-Arm Study (CARE4ALL).","authors":"Kewu Huang, Meishan Liu, Wenjun Wang, Honglei Shi, Chenxi Shi, Ying Wang, Eric D Bateman, Yanming Li, Xiaokai Feng, Huahao Shen, Chen Wang","doi":"10.1111/all.16522","DOIUrl":"https://doi.org/10.1111/all.16522","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143583993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Single Multiplex CytoBas Assay Incorporating Eight Major Components for Accurate Detection of Allergen Sensitization in Asthma and Allergic Rhinitis","authors":"Lin Hsin,&nbsp;Mark Hew,&nbsp;Pei Mun Aui,&nbsp;Kirsten Deckert,&nbsp;P. Mark Hogarth,&nbsp;Robyn E. O'Hehir,&nbsp;Menno C. van Zelm","doi":"10.1111/all.16513","DOIUrl":"10.1111/all.16513","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Allergic rhinitis and asthma can be triggered by a variety of aeroallergens, including house dust mites (HDM), tree and grass pollen, and household pets. Identification of the relevant allergen is critical for lifestyle changes and treatments, including allergen immunotherapy. We here assessed the diagnostic performance and clinical utility of a single flow cytometry staining of basophils with major aeroallergen components (AeroDiff CytoBas).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In 156 atopic patients with allergic rhinitis/asthma and 21 non-atopic individuals, allergen-specific IgE levels were determined by ImmunoCAP, and component-specific IgE by ELISA. PBMCs were analyzed by flow cytometry with basophil markers and eight fluorochrome-conjugated allergen component tetramers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Patients were stratified for sensitization to each of the four allergens. Allergen-component staining in a single multiplex CytoBas assay and component-specific IgE serology performed similarly for Der p 2, Lol p 1, Fel d 1, and Can f 1 (ROC AUC: 0.76–0.97 vs. 0.73–0.93). CytoBas had greater diagnostic accuracy than component-specific IgE serology (<i>p</i> &lt; 0.001) for HDM sensitization using Der f 1 or Der p 1, and grass pollen using Lol p 5 or Phl p 1. Furthermore, the combined evaluation of Der p 1 and Der p 2 with CytoBas was 96.3% sensitive and 90.7% specific for HDM sensitization. The combined evaluation of Lol p 1 and Lol p 5 achieved 95.4% sensitivity and 96.4% specificity for ryegrass pollen sensitization.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>AeroDiff CytoBas has similar to superior diagnostic accuracy compared to singleplex IgE serology, with the additional advantage of a single assay to evaluate multiple allergens. This enables precise and efficient component-resolved diagnosis of aeroallergen sensitization to guide personalized treatment for patients with allergic rhinitis and/or asthma.</p>\u0000 </section>\u0000 </div>","PeriodicalId":122,"journal":{"name":"Allergy","volume":"80 4","pages":"1047-1059"},"PeriodicalIF":12.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.16513","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}