AllergyPub Date : 2024-12-11DOI: 10.1111/all.16424
Marta Kolacinska-Flont, Anna Elgalal, Maciej Kupczyk, Michał Panek, Katarzyna Jarmakowska, Joanna Molinska, Dorota Kierszniewska, Milena Sokolowska, Rafał Pawliczak, Tadeusz Pietras, Anna Zawodniak-Gschwend, Wojciech Piotrowski, Jerzy Marczak, Paweł Górski, Anna Zalewska-Janowska, Joanna Narbutt, Joanna Jerzynska, Joanna Makowska, Marcin Kurowski, Ilona Kurnatowska, Violetta Pietruszewska, Paweł Majak, Radoslaw Gawlik, Boleslaw Samolinski, Marek Kulus, Zbigniew Bartuzi, Anna Ben-Drissi, Piotr Kuna
{"title":"In Memory of Dr. Izabela Kuprys-Lipinska: A Pioneering Clinician, Scientist, and Beloved Friend.","authors":"Marta Kolacinska-Flont, Anna Elgalal, Maciej Kupczyk, Michał Panek, Katarzyna Jarmakowska, Joanna Molinska, Dorota Kierszniewska, Milena Sokolowska, Rafał Pawliczak, Tadeusz Pietras, Anna Zawodniak-Gschwend, Wojciech Piotrowski, Jerzy Marczak, Paweł Górski, Anna Zalewska-Janowska, Joanna Narbutt, Joanna Jerzynska, Joanna Makowska, Marcin Kurowski, Ilona Kurnatowska, Violetta Pietruszewska, Paweł Majak, Radoslaw Gawlik, Boleslaw Samolinski, Marek Kulus, Zbigniew Bartuzi, Anna Ben-Drissi, Piotr Kuna","doi":"10.1111/all.16424","DOIUrl":"https://doi.org/10.1111/all.16424","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AllergyPub Date : 2024-12-10DOI: 10.1111/all.16432
Michele Beaudoin, Ashna Mehra, Lydia Su Yin Wong, Marta Vazquez-Ortiz, Purificación González-Delgado, Anna Nowak-Wegrzyn
{"title":"An Algorithm for the Diagnosis and Treatment of Food Protein-Induced Enterocolitis Syndrome (FPIES), 2024 Update.","authors":"Michele Beaudoin, Ashna Mehra, Lydia Su Yin Wong, Marta Vazquez-Ortiz, Purificación González-Delgado, Anna Nowak-Wegrzyn","doi":"10.1111/all.16432","DOIUrl":"https://doi.org/10.1111/all.16432","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142798825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AllergyPub Date : 2024-12-09DOI: 10.1111/all.16426
Amy T. Hsu, Viktor Bugajev, Timothy A. Gottschalk, Livia Demkova, Lucie Potuckova, Lubica Draberova, Monika Bambouskova, Philipp Hagemann, Caitlin A. O'Brien, Martin Riecan, Ondrej Kuda, Evelyn Tsantikos, Petr Draber, Mark D. Wright, Annemiek B. van Spriel, Margaret L. Hibbs, Ivana Halova
{"title":"Tetraspanin CD53 Promotes Inflammation but Restrains Mucus Production in a Mouse Model of Allergic Airway Inflammation","authors":"Amy T. Hsu, Viktor Bugajev, Timothy A. Gottschalk, Livia Demkova, Lucie Potuckova, Lubica Draberova, Monika Bambouskova, Philipp Hagemann, Caitlin A. O'Brien, Martin Riecan, Ondrej Kuda, Evelyn Tsantikos, Petr Draber, Mark D. Wright, Annemiek B. van Spriel, Margaret L. Hibbs, Ivana Halova","doi":"10.1111/all.16426","DOIUrl":"https://doi.org/10.1111/all.16426","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"8 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142796883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AllergyPub Date : 2024-12-07DOI: 10.1111/all.16415
{"title":"Correction to Elucidating Allergic Reaction Mechanisms in Response to SARS‐CoV‐2 mRNA Vaccination in Adults","authors":"","doi":"10.1111/all.16415","DOIUrl":"https://doi.org/10.1111/all.16415","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"27 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142788635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AllergyPub Date : 2024-12-06DOI: 10.1111/all.16423
Leticia Martín-Cruz, Oscar Palomares
{"title":"Allergen-Specific Immunotherapy and Trained Immunity.","authors":"Leticia Martín-Cruz, Oscar Palomares","doi":"10.1111/all.16423","DOIUrl":"https://doi.org/10.1111/all.16423","url":null,"abstract":"<p><p>The high prevalence of allergic diseases reached over the last years is attributed to the complex interplay of genetic factors, lifestyle changes, and environmental exposome. Allergen-specific immunotherapy (AIT) is the single therapeutic strategy for allergic diseases with the potential capacity to modify the course of the disease. Our knowledge of the mechanisms involved in allergy and successful AIT has significantly improved. Recent findings indicate that long-term allergen tolerance upon AIT discontinuation not only relies on the generation of proper adaptive immune responses by the generation of allergen-specific regulatory T and B cells enabling the induction of different isotypes of blocking antibodies but also relies on the restoration of proper innate immune responses. Trained immunity (TRIM) is the process by which innate immune cells acquire memory by mechanisms depending on metabolic and epigenetic reprogramming, thus conferring the host with increased broad protection against infection. This concept was initially explored for infectious diseases, as well as for vaccination against infections, but compelling experimental evidence suggests that TRIM might also play a role in allergy and AIT. Hyperinflammatory innate immune responses in early life, likely due to TRIM maladaptations, lead to aberrant type 2 inflammation-enhancing allergy. However, exposure to farming environments and specific microbes prevents recurrent infections and allergy development, likely due to mechanisms partially depending on TRIM. TRIM-based vaccines and next-generation AIT vaccines inducing metabolic and epigenetic reprogramming in innate immune cells and their precursors have shown protective antiallergic effects. A better understanding of the factors involved in early-life TRIM mechanisms in the context of allergy and the identification and characterization of novel tolerance inducers might well enable the design of alternative TRIM-based allergen vaccines for allergic diseases.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AllergyPub Date : 2024-12-06DOI: 10.1111/all.16417
W J Fokkens, E de Corso, P W Hellings, R J Harvey, C Hopkins, S Reitsma
{"title":"Algorithm for the Management of Primary Diffuse Chronic Rhinosinusitis.","authors":"W J Fokkens, E de Corso, P W Hellings, R J Harvey, C Hopkins, S Reitsma","doi":"10.1111/all.16417","DOIUrl":"https://doi.org/10.1111/all.16417","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
AllergyPub Date : 2024-12-06DOI: 10.1111/all.16409
M Beatrice Bilò, Matteo Martini, Leonardo Antonicelli, Fausto de Michele, Adriano Vaghi, Antonino Musarra, Claudio Micheletto
{"title":"Real-World Finetuning of Biomarkers in Severe Asthma: Longitudinal Latent Class Analysis From the Italian Registry on Severe Asthma (IRSA).","authors":"M Beatrice Bilò, Matteo Martini, Leonardo Antonicelli, Fausto de Michele, Adriano Vaghi, Antonino Musarra, Claudio Micheletto","doi":"10.1111/all.16409","DOIUrl":"https://doi.org/10.1111/all.16409","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}