Allergy最新文献

{"title":"Polymeric α-Hairpinin Allergens Induce a Functional Response via a Single Antibody.","authors":"Gage O Leighton, Taylor M Cosey, Emmanuel R De Diavoukana, Isabelle R Lytle, Alexander C Y Foo, Lars C Pedersen, Scott A Gabel, Robert M Petrovich, Min Shi, Venu Aruva, Paige Creeks, Joyce J W Wong, Jian Zhang, R Stokes Peebles, Derek Croote, Scott A Smith, Geoffrey A Mueller","doi":"10.1111/all.70201","DOIUrl":"10.1111/all.70201","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":"3725-3727"},"PeriodicalIF":11.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12758636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145877338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Pilot Study Measuring Transepidermal Water Loss (TEWL) in Children Suggests Trilipid Cream Is More Effective Than a Paraffin-Based Emollient\".","authors":"","doi":"10.1111/all.70319","DOIUrl":"10.1111/all.70319","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":"3766"},"PeriodicalIF":11.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147939492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tezepelumab Reverses TSLP-Driven Immunometabolic Rewiring in Human cDC2s Underlying Pathogenic Th2 and Dysfunctional Treg Responses.","authors":"Leticia Martín-Cruz, Andrés de la Rocha-Muñoz, Isabel María Peñalver-Fernández, Ángel Maldonado, Sofía Sirvent, Oscar Palomares","doi":"10.1111/all.70470","DOIUrl":"10.1111/all.70470","url":null,"abstract":"<p><strong>Background: </strong>Thymic stromal lymphopoietin (TSLP) is a key epithelial alarmin involved in the initiation and maintenance of type 2 inflammatory airway diseases. Although tezepelumab, the first approved anti-TSLP monoclonal antibody, has shown robust clinical efficacy in asthma and CRSwNP, the molecular mechanisms underlying its mode of action remain incompletely defined.</p><p><strong>Objective: </strong>To determine whether TSLP induces a pathogenic immunometabolic program in human type 2 conventional dendritic cells (cDC2s) and whether tezepelumab can directly reverse this process.</p><p><strong>Methods: </strong>Purified human circulating cDC2s from healthy non-atopic donors were stimulated with TSLP in the presence or absence of tezepelumab. cDC2 phenotype, function, metabolism, and T-cell polarization capacity were assessed. Pathogenic Th2 responses, Treg generation, suppressive function, and metabolic fitness were analyzed.</p><p><strong>Results: </strong>TSLP induced a metabolic rewiring in human cDC2s characterized by increased glycolysis and mitochondrial oxidative phosphorylation. This metabolic hyperactivation was associated with the acquisition of a pro-type 2 phenotype and required for the induction of pathogenic T-cell responses. TSLP-activated cDC2s generated pathogenic Th2 cells and FOXP3⁺ Tregs with impaired suppressive function and an altered metabolic profile. Tezepelumab effectively reversed TSLP-induced metabolic and functional reprogramming in cDC2s, thereby limiting pathogenic Th2 polarization while restoring the functional and metabolic properties of induced Tregs.</p><p><strong>Conclusions: </strong>We identify immunometabolic rewiring as a key mechanism of the TSLP-cDC2 axis and provide mechanistic insight into how tezepelumab reshapes pathogenic adaptive immune responses. These results support upstream epithelial alarmin blockade as a strategy to interfere with early disease-driving immune programs in type 2 inflammatory airway diseases.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":"3695-3706"},"PeriodicalIF":11.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148648029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Cysteinyl Leukotrienes in Food Allergy and Anaphylaxis: A Potential Therapeutic Target.","authors":"Adrienn Weingärtner, Thomas Eiwegger","doi":"10.1111/all.70393","DOIUrl":"10.1111/all.70393","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":"3763-3765"},"PeriodicalIF":11.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147947109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-Year Post-Treatment Outcomes Following Cessation of Peanut Oral Immunotherapy: Comparisons by Clinical Allergy Status and Treatment Group.","authors":"Paxton Loke, Xiaofang Wang, Sophie Rosser, Melanie Lloyd, Sarah E Ashley, Adriana C Lozinsky, Julie Burns, Patrick Quinn, Michael D O'Sullivan, Michael Gold, Francesca Orsini, Mimi L K Tang","doi":"10.1111/all.70400","DOIUrl":"10.1111/all.70400","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":"3746-3751"},"PeriodicalIF":11.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148547122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Abatacept Versus Placebo During Peanut Oral Immunotherapy for Adults With Severe Peanut Allergy","authors":"Marie‐Lee Simard, Camille Braun, Éloise Antony, Émilie Roy, Marie‐Ève Gingras, François Graham, Anne Des Roches, Louis Paradis, Kathryn Samaan, Florence Gingras‐Lessard, Roxane Labrosse, Thomas Eiwegger, Philippe Bégin","doi":"10.1111/all.70531","DOIUrl":"https://doi.org/10.1111/all.70531","url":null,"abstract":"Background Unmet needs remain for disease‐modifying interventions for the treatment of severe persistent food allergies. In mice models, abatacept, a cytotoxic T lymphocyte‐associated antigen‐4 (CTLA‐4) immunoglobulin fusion protein, promotes immune tolerance to food proteins, and suppresses the initial allergen‐related induction of specific immunoglobulin E (IgE) when used as an adjuvant to allergen immunotherapy. Methods In this Phase 2a placebo‐controlled clinical trial, 14 peanut‐allergic participants (14–50 years old) with specific IgE &gt; 50 kU/L were randomized 1:1 to adjuvant abatacept vs. placebo to peanut oral immunotherapy (OIT) for 24 weeks, followed by 12 weeks of OIT alone. With the hypothesis that abatacept suppresses the transient OIT‐induced increase in specific IgE, the primary outcome was the relative change from baseline of the peanut‐specific/total IgE ratio at 24 weeks. Sustained unresponsiveness was assessed as a secondary outcome with repeated oral food challenges (OFCs) following incremental periods of peanut avoidance. Results No significant difference in the relative change in peanut‐specific/total IgE ratio from baseline was observed between groups (placebo group 87.9% vs. abatacept group 48.2%, <jats:italic>p</jats:italic> ‐value 0.26). Median minimal reactive doses on repeated OFCs were similar in both groups (3000 mg) after 4 weeks of peanut avoidance. Lower adverse event rates including anaphylaxis were observed in the abatacept group (5.9 vs. 10 per participant, <jats:italic>p</jats:italic> ‐value 0.006). Conclusion Compared to placebo, abatacept did not suppress the allergen‐related induction of peanut‐specific IgE relative to their total at 24 weeks, but improved OIT tolerability in this severely allergic adult population. Independently of abatacept, most participants achieved sustained unresponsiveness with OIT.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"272 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Body Mass Index, Offspring Impaired Skin Barrier Function, Allergic Sensitization, and Bronchial Obstruction.","authors":"Eva Maria Rehbinder, Riyas Vettukattil, Corina Silvia Rueegg, Karin C Lødrup Carlsen, Christophe von Garnier, Berit Granum, Guttorm Haugen, Gunilla Hedlin, Christine Monceyron Jonassen, Björn Nordlund, Håvard O Skjerven, Knut Rudi, Anne Cathrine Staff, Cilla Söderhäll, Niki Ubags","doi":"10.1111/all.70408","DOIUrl":"10.1111/all.70408","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":"3756-3759"},"PeriodicalIF":11.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148256655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Efficacy of Dupilumab in Chinese Atopic Dermatitis Patients and Development of a Prediction Model.","authors":"Ruojun Wang, Bang Zheng, Jiahui Zhao, Shaomin Zhong, Zhihao Jiang, Yang Liu, Hang Li, Yang Wang","doi":"10.1111/all.70405","DOIUrl":"10.1111/all.70405","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":"3752-3755"},"PeriodicalIF":11.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148209523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to article: Structural Basis for Trivalent Cross-Linking of a Patient-Derived IgE Antibody by the Major Peanut Allergen Ara h 2.0201.","authors":"","doi":"10.1111/all.70529","DOIUrl":"https://doi.org/10.1111/all.70529","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":11.3,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-Sensitization, Reactivity and Severity: Three Distinct Layers of Vicilin-Based Diagnosis.","authors":"Bülent Enis Şekerel, Özge Soyer, Melike Ocak","doi":"10.1111/all.70527","DOIUrl":"https://doi.org/10.1111/all.70527","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":11.3,"publicationDate":"2026-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}