Allergy最新文献

{"title":"Redefining tryptase norms in the pediatric population reveals sex-based differences: Clinical implications.","authors":"Mathilde Puel,Julien Rossignol,Clotilde Devin,Marine Madrange,Antoine Diep,Pascale Nicaise Roland,Sylvie Chollet-Martin,Julien Husson,Olivier Hermine,Christine Bodemer,Chantal Brouzes,Luc De Chaisemartin,Laura Polivka,","doi":"10.1111/all.16365","DOIUrl":"https://doi.org/10.1111/all.16365","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"31 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic evidence for T cell-fibroblast-keratinocyte axis via IL-13-periostin-integrin in atopic dermatitis","authors":"Nguyen Quoc Vuong Tran, Yoshiaki Kobayashi, Yuki Nakamura, Kayoko Ishimaru, Kenji Izuhara, Atsuhito Nakao","doi":"10.1111/all.16352","DOIUrl":"10.1111/all.16352","url":null,"abstract":"<p>Increasing evidence suggests that <i>POSTN</i> encoding periostin plays important roles in atopic dermatitis (AD). For instance, serum periostin levels were positively correlated with the severity of AD.<span><sup>1</sup></span> In a mouse model of AD, Th2 cell-producing IL-4/IL-13 stimulated fibroblasts to produce periostin, which interacted with integrin receptors on keratinocytes, inducing proinflammatory cytokines, which then accelerated Th2-type responses.<span><sup>2, 3</sup></span> However, human evidence supporting the hypothesis that periostin links Th2-type responses to keratinocyte activation in AD remains largely lacking.</p><p>This study aimed to validate the hypothesis by applying cell–cell interaction analysis to single-cell RNA sequencing (scRNA-seq) datasets from AD. We combined scRNA-seq data from skin biopsy samples of healthy controls, patients with AD, and patients with psoriasis from four published datasets (GSE222840, GSE147424, GSE173706, and GSE221648). After quality control, a total of 221,014 cells from 20 healthy, 9 AD, and 22 psoriasis patients are available (Table S1).</p><p>We identified 17 clusters of major cell types in human skin (Figure 1A,B). Comparing the proportion of each cell type, proliferating and suprabasal keratinocytes were high in AD and psoriasis compared to healthy skin (Figure 1C, Table S2). In addition, T cells, proliferating T cells, dendritic cells (DCs), and macrophages were high in AD compared to psoriasis and healthy skin (Figure 1C, Table S2). These findings based on 4 combined scRNA-seq datasets confirmed previous reports.<span><sup>4</sup></span></p><p>We then examined the expression of <i>POSTN</i> and its receptors consisting of an alpha integrin (<i>ITGAV</i>) and a beta integrin (<i>ITGB3</i> or <i>ITGB5</i>)<span><sup>5</sup></span> among the identified cell types. In line with previous research, <i>POSTN</i> and its receptors were predominantly expressed in keratinocytes and fibroblast (Figure 1D). In healthy skin or psoriasis, <i>POSTN</i> expression was highest in basal keratinocytes or fibroblasts, respectively. In AD, all subpopulations of keratinocytes and fibroblasts expressed higher <i>POSTN</i> than those in healthy skin and psoriasis (Figure 1E, Table S3). Fibroblast subpopulation analysis revealed that a subset of <i>POSTN</i><sup>+</sup> fibroblasts expressed <i>COL6A5</i>, which was specific for AD (Figure 1F, Figure S1).<span><sup>6</sup></span> The expressions of <i>ITGAV</i> and <i>ITGB5</i> were comparable in keratinocytes and fibroblasts among normal skin, AD, and psoriasis, but <i>ITGB3</i> was undetected (Figure 1E).</p><p>We performed cell–cell communication analysis (Appendix S1) focusing on periostin and other signalings that could be upstream of periostin including IL-4/IL-13 and TGF-β, and also IL-17 due to its specificity for psoriasis (Table S4). The communication probability via periostin was significantly higher in AD and psoriasis fibroblasts (total co","PeriodicalId":122,"journal":{"name":"Allergy","volume":"79 12","pages":"3521-3525"},"PeriodicalIF":12.6,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.16352","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142448248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epithelial barrier dysfunction and associated diseases in companion animals: Differences and similarities between humans and animals and research needs","authors":"Sena Ardicli,&nbsp;Ozge Ardicli,&nbsp;Duygu Yazici,&nbsp;Yagiz Pat,&nbsp;Huseyn Babayev,&nbsp;Peng Xiong,&nbsp;Can Zeyneloglu,&nbsp;Asuncion Garcia-Sanchez,&nbsp;Li-Li Shi,&nbsp;Oliva Giannelli Viscardi,&nbsp;Stephen Skolnick,&nbsp;Ismail Ogulur,&nbsp;Raja Dhir,&nbsp;Marek Jutel,&nbsp;Ioana Agache,&nbsp;Jozef Janda,&nbsp;Isabella Pali-Schöll,&nbsp;Kari C. Nadeau,&nbsp;Mubeccel Akdis,&nbsp;Cezmi A. Akdis","doi":"10.1111/all.16343","DOIUrl":"10.1111/all.16343","url":null,"abstract":"<p>Since the 1960s, more than 350,000 new chemicals have been introduced into the lives of humans and domestic animals. Many of them have become part of modern life and some are affecting nature as pollutants. Yet, our comprehension of their potential health risks for both humans and animals remains partial. The “epithelial barrier theory” suggests that genetic predisposition and exposure to diverse factors damaging the epithelial barriers contribute to the emergence of allergic and autoimmune conditions. Impaired epithelial barriers, microbial dysbiosis, and tissue inflammation have been observed in a high number of mucosal inflammatory, autoimmune and neuropsychiatric diseases, many of which showed increased prevalence in the last decades. Pets, especially cats and dogs, share living spaces with humans and are exposed to household cleaners, personal care products, air pollutants, and microplastics. The utilisation of cosmetic products and food additives for pets is on the rise, unfortunately, accompanied by less rigorous safety regulations than those governing human products. In this review, we explore the implications of disruptions in epithelial barriers on the well-being of companion animals, drawing comparisons with humans, and endeavour to elucidate the spectrum of diseases that afflict them. In addition, future research areas with the interconnectedness of human, animal, and environmental well-being are highlighted in line with the “One Health” concept.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":"79 12","pages":"3238-3268"},"PeriodicalIF":12.6,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.16343","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142447996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The IL‐4–IL‐4Rα axis modulates olfactory neuroimmune signaling to induce loss of smell","authors":"Yannis Hara, Mithilesh Kumar Jha, Jeremy Y. Huang, Yingnan Han, Ingeborg M. Langohr, Giorgio Gaglia, Cheng Zhu, Peter Piepenhagen, Kaitlyn Gayvert, Wei Keat Lim, Seblewongel Asrat, Scott Nash, Juby A. Jacob‐Nara, Jamie M. Orengo, Dinesh S. Bangari, Emanuele de Rinaldis, Hamid Mattoo, Alexandra Hicks","doi":"10.1111/all.16338","DOIUrl":"https://doi.org/10.1111/all.16338","url":null,"abstract":"BackgroundLoss of smell is a part of the diagnostic criteria for CRSwNP. Although the mechanistic understanding is poor, inhibition of IL‐4Rα and IL‐4/IL‐13 signaling improves loss of smell in CRSwNP patients. In the present study, we compare the effects of IL‐4, IL‐13, and IL‐4Rα blockade on murine olfaction and identify the underlying pathophysiological mechanisms of loss of smell.MethodsTo evaluate the effects of IL‐4 and IL‐13 on olfactory function, we administered these cytokines intranasally to BALB/c mice for 5 consecutive days and assessed their latency to find hidden food. Calcium uptake assays were conducted to measure olfactory neuronal activity in vitro and ex vivo. We also performed histological analyses, proteomics, bulk RNA sequencing, and single‐cell RNA sequencing to assess the impact of IL‐4, IL‐13, and IL‐4Rα blockade on the olfactory epithelium and to identify potential molecular or cellular correlations with smell loss in human CRSwNP patients.ResultsHere, we provide evidence for non‐redundant effects of IL‐4 and IL‐13 in olfaction, with loss of smell in mice evoked by intranasal administration of IL‐4, not IL‐13. We demonstrate that an IL‐4–IL‐4Rα axis has a direct functional impact on murine olfactory sensory neurons and evokes inflammatory cell infiltration and pathophysiologic modulation of unique molecular signatures in olfactory epithelium without compromising structural integrity. Furthermore, single‐cell analysis of olfactory epithelium reveals that IL‐4–IL‐4Rα signaling modulates neuronal crosstalk with mast cells, macrophages, and NK cells, suggesting a functional link between olfactory impairment and neuroinflammation.ConclusionCollectively, this study suggests that an IL‐4–IL‐4Rα signaling axis plays a unique pathophysiological role in olfactory dysfunction via direct effect on neurons and modulation of neuroimmune interactions.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"1 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142448211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D in early life and risk of daily registered childhood infection episodes.","authors":"Nicklas Brustad,Julie Nyholm Kyvsgaard,Casper-Emil Tingskov Pedersen,Laura Marie Hesselberg,Anders U Eliasen,Signe Kjeldgaard Jensen,Luo Yang,Nilofar Vahman,Jakob Stokholm,Klaus Bønnelykke,Bo L Chawes","doi":"10.1111/all.16354","DOIUrl":"https://doi.org/10.1111/all.16354","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"74 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142443724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of patient satisfaction with dupilumab for chronic rhinosinusitis with nasal polyps.","authors":"Aiko Oka,Kengo Kanai,Shoji Matsune,Kei Hosoya,Taro Komachi,Ryosuke Murakami,Kimihiro Okubo,Kojiro Hirano,Isao Suzaki,Tomotaka Shimura,Takatoshi Tokudome,Sho Kanzaki,Ken-Ichiro Wakabayashi,Hiroyuki Ozawa,Yasuhide Okamoto,Kenji Kondo,Hironobu Nishijima,Ami Nishijima,Mitsuhiro Okano","doi":"10.1111/all.16355","DOIUrl":"https://doi.org/10.1111/all.16355","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"124 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142443753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A fungal spore calendar for England: Analysis of 13 years of daily concentrations.","authors":"Fiona A Symon,Samuel Anees-Hill,Jack Satchwell,Abbie Fairs,Richard Edwards,Andrew J Wardlaw,Leah Cuthbertson,Anna L Hansell,Catherine H Pashley","doi":"10.1111/all.16356","DOIUrl":"https://doi.org/10.1111/all.16356","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"11 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142443723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical algorithm: Diagnosis and treatment of drug hypersensitivity reactions to biologicals, 2024 update.","authors":"Barbara Carolyn Yang,Mariana Castells","doi":"10.1111/all.16353","DOIUrl":"https://doi.org/10.1111/all.16353","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"56 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142435979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Farm-dust mediated protection of childhood asthma: Mass cytometry reveals novel cellular regulation","authors":"Claudia Carina Beerweiler,&nbsp;Michael Salvermoser,&nbsp;Johanna Theodorou,&nbsp;Andreas Böck,&nbsp;Franziska Sattler,&nbsp;Paulina Kulig,&nbsp;Vinko Tosevski,&nbsp;Bianca Schaub","doi":"10.1111/all.16347","DOIUrl":"10.1111/all.16347","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Farm-dust mediated asthma protection in childhood was replicated in numerous epidemiological studies. Central immune mechanisms are not fully understood. This exploratory study aimed to disentangle underlying immunological regulation of farm-dust mediated protection in peripheral blood on a single-cell level.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Single-cell protein expression of in vitro farm-dust stimulated and unstimulated cells from allergic asthmatics and healthy controls were measured using mass cytometry. Analysis of innate and adaptive cellular proportions (linear regression) and T-cell proliferation was performed. Functional marker intensity was investigated using Earth Mover's Distance and the Monte Carlo permutation test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Farm-dust stimulation induced cell type-specific regulation: Key-features of farm-dust stimulation comprised opposing regulation of immune-cell frequencies (downregulated innate cell populations (monocytes/DCs (<i>p</i> &lt; .001), NK-cells (<i>p</i> &lt; .05)) and upregulated adaptive populations (B-cells, CD4⁺ T-cells (both <i>p</i> &lt; .05)), reduced CD4⁺ CD25⁻ T-cell proliferation, and differential cell type-specific functional marker expression. Following stimulation, functional marker analysis revealed induced activation (CD25) in T-cells and NK-T-cells in both phenotypes even after correction for multiple testing. Cytotoxicity (GZMB) and inflammation (pERK1/2, pp38) related markers were reduced in T-cells exclusively in asthmatic children. Asthma-associated markers (Gata3, RORγ, and HLA-DR) were reduced in T- and innate- cell populations of asthmatics following stimulation. B-cells displayed a phenotypically independent increase of diverse functional markers upon farm-dust stimulation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study mimicking in vivo environmental exposure identified a novel profile of immune-regulatory markers using mass cytometry demonstrating decreased asthma-associated markers following farm-dust stimulation. These findings may be key for further studies on asthma prevention in childhood.</p>\u0000 </section>\u0000 </div>","PeriodicalId":122,"journal":{"name":"Allergy","volume":"79 11","pages":"3022-3035"},"PeriodicalIF":12.6,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.16347","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142436127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting the IL-5 pathway in eosinophilic asthma: A comparison of anti-IL-5 versus anti-IL-5 receptor agents","authors":"David J. Jackson,&nbsp;Michael E. Wechsler,&nbsp;Guy Brusselle,&nbsp;Roland Buhl","doi":"10.1111/all.16346","DOIUrl":"10.1111/all.16346","url":null,"abstract":"<p>Eosinophilic asthma is characterized by frequent exacerbations, poor symptom control and accelerated lung function decline. It is now recognized that the immune response underlying eosinophilic asthma involves a complex network of interconnected pathways from both the adaptive and innate immune systems. Within this response, interleukin-5 (IL-5) plays a central role in eosinophil differentiation, activation and survival and has emerged as a key target for therapies treating severe asthma. The monoclonal antibodies mepolizumab and reslizumab target the ligand IL-5, preventing its interaction with eosinophils; in contrast, benralizumab binds to the IL-5 receptor (IL-5R), preventing IL-5 from binding and leading to substantially greater eosinophil reduction by enhanced antibody-dependent cell-mediated cytotoxicity. Although no direct head-to-head clinical trials of asthma have been published to formally evaluate the clinical significance of these different therapeutic approaches, the potential benefits of partial versus complete eosinophil depletion continue to remain an important area of study and debate. Here, we review the existing real-world and clinical study data of anti-IL-5/anti-IL-5R therapies in severe eosinophilic asthma.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":"79 11","pages":"2943-2952"},"PeriodicalIF":12.6,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.16346","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142431116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}