Allergy最新文献

{"title":"Preclinical Development of GR2002, a Novel Anti-TSLP Bispecific Antibody With Potent TSLP Inhibitory Effects","authors":"Xueping Zhang, Suya Luo, Xiaobo Hao, Yulan Liu, Junjie Hu, Jiaqian Yang, Hongtao Qin, Zhigang Liu","doi":"10.1111/all.16591","DOIUrl":"10.1111/all.16591","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"80 7","pages":"2077-2080"},"PeriodicalIF":12.6,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Biological Remission With Tezepelumab: The Real-World Response in Severe Uncontrolled Asthma","authors":"Jessica Gates,&nbsp;Faizan Haris,&nbsp;Francesca Cefaloni,&nbsp;Paniz Khooshemehri,&nbsp;Linda Green,&nbsp;Mariana Fernandes,&nbsp;Louise Thomson,&nbsp;Cris Roxas,&nbsp;Jodie Lam,&nbsp;Grainne d'Ancona,&nbsp;Alexandra M. Nanzer,&nbsp;Jaideep Dhariwal,&nbsp;David J. Jackson","doi":"10.1111/all.16590","DOIUrl":"10.1111/all.16590","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Tezepelumab is an anti-TSLP monoclonal antibody approved for the treatment of severe asthma. It has broad downstream anti-T2 effects, offering the prospect of biological remission. Real-world data on clinical remission rates with tezepelumab is lacking, and the relationship between clinical and biological remission is unclear. Finally, the effectiveness of tezepelumab in patients who have failed to respond to existing biologic therapies is unknown.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Clinical and biomarker data from adults with severe asthma treated with tezepelumab in a real-world setting was analyzed. Clinical outcome measures including clinical remission were recorded along with rates of biological remission (defined as blood eosinophil count &lt; 300 cells/mcL and FeNO &lt; 25 ppb).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>One hundred seventy-five patients were included. 98/175 (56%) had switched from another biologic. Following tezepelumab initiation, the exacerbation rate decreased from 3.1 (2.5) to 0.8 (1.4), with 59% of patients remaining exacerbation-free at 1 year. 54% achieved an ACQ score &lt; 1.5. Clinical remission at 1 year was observed in 36%, with a rate of 55% in T2-high patients versus 19% in T2 low patients. The clinical response in biologic-naïve and biologic switch patients was similar. FeNO declined from 41 ppb (24–76) to 24 ppb (16–38) and BEC fell from 300 cells/μL (60–610) to 180 cells/μL (105–320) (both <i>p</i> &lt; 0.001). 38% achieved biological remission. 15% attained both clinical and biological remission.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Tezepelumab led to substantial clinical improvements and clinical remission in up to 55% of T2-high patients with severe asthma. A disconnect between clinical and biological remission was observed. The long-term significance of residual T2 inflammation on tezepelumab is unknown.</p>\u0000 </section>\u0000 </div>","PeriodicalId":122,"journal":{"name":"Allergy","volume":"80 6","pages":"1669-1676"},"PeriodicalIF":12.6,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.16590","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Involvement of IL-13-Induced Dysregulation of BDNF-NTRK2 Pathway in Symptoms of Eosinophilic Esophagitis.","authors":"Kasumi Osonoi,Akinari Sawada,Yuki Maekawa,Mari Yamaguchi,Shingo Yamada,Kazuhiro Matsuyama,Mark Rochman,Marc E Rothenberg,Xiaobo Han,Naoki Matsuda,Ikuro Suzuki,Fumio Tanaka,Yasuhiro Fujiwara,Tetsuo Shoda","doi":"10.1111/all.16592","DOIUrl":"https://doi.org/10.1111/all.16592","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"60 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood Asthma and Allergy Are Related to Accelerated Epigenetic Aging","authors":"Miriam Leskien,&nbsp;Elisabeth Thiering,&nbsp;Zhebin Yu,&nbsp;Anke Huels,&nbsp;Yueli Yao,&nbsp;Simon Kebede Merid,&nbsp;Olena Gruzieva,&nbsp;Stephan Weidinger,&nbsp;Melanie Waldenberger,&nbsp;Annette Peters,&nbsp;Erik Melén,&nbsp;Marie Standl","doi":"10.1111/all.16583","DOIUrl":"10.1111/all.16583","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Few studies showed associations of childhood allergic diseases with epigenetic aging using traditional clocks trained mainly on adults. Tracking DNA methylation variation early in life has suggested poor performance of these clocks in children. Therefore, we aim to elucidate the association between allergic diseases and epigenetic age using a pediatric clock.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used data from the German LISA birth cohort study at six (<i>N</i> = 234) and ten (<i>N</i> = 227) years. DNA methylation was measured in blood using the Infinium Methylation EPIC BeadChip. We calculated epigenetic age using the pediatric clock developed by Wu et al. (Aging 2019) (median absolute error = 0.04 years, Spearman correlation with chronological age <i>r</i> = 0.75). Linear mixed models were used to examine longitudinal associations of epigenetic age acceleration with doctor-diagnosed asthma, rhinitis, and eczema, or a combination thereof (“any allergy”) as well as aeroallergen sensitization. Replication was performed in BAMSE at the 8-year follow-up (<i>N</i> = 625) using linear models. Additionally, epigenetic age in adults from KORA F4 was estimated using Horvath's clocks and associations with allergic diseases were tested applying linear models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Having any allergy was significantly associated with a mean epigenetic age acceleration of 0.34 years (95% CI = [0.06; 0.63]) using Wu's clock in LISA. Associations with consistent effect directions were found for allergic rhinitis, asthma, and eczema. No associations with aeroallergen sensitization were observed. In BAMSE, an inverse association of epigenetic age acceleration with eczema was found (−0.52 years, 95% CI = [−0.97; −0.07]). In KORA, hay fever was significantly associated with accelerated epigenetic age when using the Horvath pan-tissue clock (1.05 years, 95% CI = [0.21; 1.89]).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>We found an increase in epigenetic age in children with allergic diseases from LISA. Our results suggest that epigenetic age acceleration seems to be related to the persistent burden of allergic diseases, but not to non-symptomatic aeroallergen sensitization.</p>\u0000 </section>\u0000 </div>","PeriodicalId":122,"journal":{"name":"Allergy","volume":"80 7","pages":"1912-1922"},"PeriodicalIF":12.6,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.16583","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between a History of Stevens–Johnson Syndrome/Toxic Epidermal Necrolysis and the Risk of Systemic Autoimmune Rheumatic Diseases: A Nationwide, Population‐Based Case–Control Study","authors":"Yun‐Wen Chen, Tsai‐Hung Yen, Chung‐Mao Kao, Wen‐Cheng Chao, Der‐Yuan Chen, Hsin‐Hua Chen","doi":"10.1111/all.16584","DOIUrl":"https://doi.org/10.1111/all.16584","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"1 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients With Atopic Dermatitis Show Increased Clonal Hematopoiesis and Risk of Hematological Cancer","authors":"Verena Vogi, Emina Jukic, Robert Gruber, Andre Fiona, Deborah Minzaghi, Johannes Zschocke, Sandrine Dubrac","doi":"10.1111/all.16587","DOIUrl":"https://doi.org/10.1111/all.16587","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"118 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143930583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive αβ T-Cell Receptor Repertoire Analysis Reveals a Unique CD8+ TCR Landscape in DOCK8-Deficient Patients.","authors":"Ceren Bozkurt,Gökhan Cildir,Umran Aba,Rahmi Kutay Erdogan,Nicholas I Warnock,Chung Hoow Kok,Asena Pinar Sefer,Sule Haskologlu,Sidem Didar Tekeoglu,Gülşah Merve Kılınç,Canberk Ipsir,Tugba Arikoglu,Aylin Kont Ozhan,Saliha Esenboga,Ahmet Özen,Elif Karakoç-Aydiner,Sevgi Bilgiç Eltan,Çigdem Aydogmus,Candan Islamoglu,Kübra Baskın,Betul Karaatmaca,Ayse Metin,Deniz Çagdaş,Figen Dogu,Aydan Ikinciogullari,Safa Baris,Baran Erman","doi":"10.1111/all.16580","DOIUrl":"https://doi.org/10.1111/all.16580","url":null,"abstract":"BACKGROUNDDedicator of cytokinesis protein 8 (DOCK8) is a guanine nucleotide exchange factor highly expressed in, and critical for, the function of various innate and adaptive immune cells. DOCK8 deficiency leads to combined immunodeficiency characterized by susceptibility to infections, autoimmunity, and a severe Th2-type immune response. While dysfunction in various T cell subsets has been implicated in these phenotypes, a comprehensive analysis of the T-cell receptor (TCR) repertoire in these patients has not yet been documented. This study investigates the αβ TCR repertoire in DOCK8-deficient patients to identify features related to disease pathogenesis and explore the potential role of TCR repertoire alterations in disease development.METHODSWe compared immune repertoire profiles determined by high-throughput TCR sequencing of circulating CD4+ and CD8+ T cells from patients with DOCK8 deficiency (n = 10) to healthy controls (n = 7) and patients with ataxia-telangiectasia (AT) (n = 5).RESULTSDifferent diversity analyses revealed a restricted TRA and TRB repertoire in both CD4+ and CD8+ T cells from DOCK8-deficient patients, with the restriction being more pronounced in CD8+ T cells. Skewed usage of individual variable (V) and joining (J) genes and potentially self-reactive CD8+ T cell clones, as determined by hydrophobicity and cysteine indices, were identified in DOCK8-deficient patients.CONCLUSIONOur study represents the most comprehensive immune repertoire analysis in DOCK8 deficiency. The identification of a significantly restricted αβ TCR repertoire, along with the detection of potentially autoreactive clones, highlights the crucial role of immune repertoire profiling in elucidating the pathogenesis of DOCK8 deficiency.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"25 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143932586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endotypes in Immune Mediated Drug Reactions: Present and Future of Relevant Biomarkers. An EAACI Task Force Report","authors":"C. Mayorga,&nbsp;R. Fernandez-Santamaria,&nbsp;G. E. Çelik,&nbsp;M. Labella,&nbsp;G. Murdaca,&nbsp;M. Sokolowska,&nbsp;D. Naisbitt,&nbsp;V. Sabato","doi":"10.1111/all.16576","DOIUrl":"10.1111/all.16576","url":null,"abstract":"<p>Drug-induced immune reactions are an important burden for patients and health systems. They can be classified into immediate-drug hypersensitivity reactions (IDHRs) and delayed-DHRs (DDHRs) based on their phenotype. Drugs do not always behave as allergens and need to bind to proteins, forming adducts. Therefore, IDHRs can be classified as antigenic (IgE, and IgG mediated) and nonantigenic immune responses (complement activation-[CARPA], mas-related G-protein coupled receptor member X2 [MRGPRX2], cyclooxygenase [COX]-1 and cytokine release reactions [CRRs]). DDHRs are even more complex due to the different cell subsets and mechanisms involved, showing both antigenic and nonantigenic immune responses too. Since different endotypes result in similar phenotypes, the establishment of specific biomarkers is essential for an accurate diagnosis, with important relevance for the management of patients, as well as for risk stratification. The biomarkers of clinical utility are skin tests, specific IgE (sIgE), tryptase, and some HLA-DR genotyping. The diagnostic performance depends on the responsible drug. This review highlights that, unfortunately, most biomarkers have not gone beyond analytic or clinical validity. It is therefore important to set up multicentre translational studies to advance the validation process towards reaching a clinical utility phase.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":"80 7","pages":"1831-1847"},"PeriodicalIF":12.6,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.16576","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143915038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise Recommendations and Practical Considerations for Asthma Management—An EAACI Position Paper","authors":"Oliver J. Price,&nbsp;Nikolaos G. Papadopoulos,&nbsp;Darío Antolín Amérigo,&nbsp;Vibeke Backer,&nbsp;Valérie Bougault,&nbsp;Stefano Del Giacco,&nbsp;Radoslaw Gawlik,&nbsp;Ibon Eguiluz-Gracia,&nbsp;Enrico Heffler,&nbsp;Christer Janson,&nbsp;Vanessa M. McDonald,&nbsp;André Moreira,&nbsp;Andrew Simpson,&nbsp;Matteo Bonini","doi":"10.1111/all.16573","DOIUrl":"10.1111/all.16573","url":null,"abstract":"<p>Exercise is an important treatment for people with asthma and should be considered alongside pharmacological therapy when developing personalised asthma management plans. Despite this, there remains limited guidance concerning the practicalities of asthma-specific exercise prescription. This European Academy of Allergy and Clinical Immunology task force was therefore established to achieve three fundamental aims: first, to provide an up-to-date perspective concerning the role of exercise for asthma management (i.e., describe the disease modifying potential of exercise and associated impact on asthma-related extrapulmonary comorbidities); second, to develop pragmatic recommendations to facilitate safe and effective exercise prescription; and third, to identify key unmet needs and provide focused direction for future research. The position paper is structured as a practically focused document, with recommendations formulated according to best available scientific evidence and expert opinion, with an emphasis on providing healthcare providers with pragmatic advice that can be implemented during routine asthma review.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":"80 6","pages":"1572-1591"},"PeriodicalIF":12.6,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.16573","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143914847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CAR-T Cell Therapy in Autoimmune Setting: A New Appealing Approach Extendable to Allergy?","authors":"Federico Rossi,Rubén Fernandez Santamaria,Riccardo Castagnoli","doi":"10.1111/all.16585","DOIUrl":"https://doi.org/10.1111/all.16585","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"30 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143914833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}