Allergy最新文献

{"title":"Initial OX40 – OX40L Signaling Promotes a Skin‐Resident Memory T‐Cell Reservoir in Atopic Dermatitis","authors":"Takayoshi Komatsu‐Fujii, Ryota Asahina, Tatsuya Hasegawa, Satoshi Nakamizo, Saeko Nakajima, Toshiaki Kogame, Kenji Kabashima","doi":"10.1111/all.70493","DOIUrl":"https://doi.org/10.1111/all.70493","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"381 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148809796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epithelial AhR-NKX3-1-Senescence Axis Drives Barrier Function and Inflammation in Allergic Rhinitis.","authors":"Xuan Yuan, Yixiang Zeng, Shaobing Xie, Wei Zhong, Wenjing Gu, Minxuan Hu, Hua Zhang, Angel Xu, Weihong Jiang, Zhihai Xie, Peisong Gao","doi":"10.1111/all.70489","DOIUrl":"https://doi.org/10.1111/all.70489","url":null,"abstract":"<p><strong>Background: </strong>Allergic rhinitis (AR) is a common airway disease characterized by epithelial barrier dysfunction and Type 2 inflammation. Although the aryl hydrocarbon receptor (AhR) regulates mucosal immunity and epithelial homeostasis, its role in epithelial pathology in AR remains poorly defined. We sought to determine the contribution of AhR signaling to AR pathogenesis and to identify downstream mechanisms linking barrier dysfunction to Type 2 inflammation.</p><p><strong>Methods: </strong>AhR expression and transcriptomic profiles were analyzed in nasal tissues from AR patients and controls. AhR-deficient (AhR^-/-) mice and CC10-CreER^TM; p16^f/f (p16^cKO) mice were used to assess the contributions of AhR signaling and p16-dependent epithelial senescence-associated programs to allergic inflammation and barrier integrity. Mechanistic pathways were interrogated using transcriptomic analysis, and pharmacologic modulation was evaluated by molecular docking and functional assays.</p><p><strong>Results: </strong>AhR expression was significantly increased in nasal epithelial cells from AR patients. AhR^-/- AR mice exhibited reduced Type 2 inflammation and preservation of epithelial barrier integrity. Transcriptomic analysis revealed enrichment of senescence-associated signatures in AR epithelium. AhR deficiency in primary epithelial cultures and AhR^-/- mice markedly attenuated epithelial senescence-associated programs. Consistently, p16^cKO AR mice showed reduced allergic inflammation and improved barrier function. Mechanistically, NKX3-1 was identified as an AhR-interacting regulator in cell-cycle arrest. Gain- and loss-of-function studies demonstrated that NKX3-1 contributes to allergen-induced epithelial senescence-associated programs. Finally, curcumin attenuated epithelial senescence-associated phenotypes with concomitant suppression of AhR and NKX3-1 expression.</p><p><strong>Conclusion: </strong>These findings support a context-dependent model in which AhR-NKX3-1-associated epithelial senescence programs contribute to barrier dysfunction and allergic inflammation in AR.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":11.3,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Placental Epigenetic Alterations and IL ‐10 Dysregulation Drive Early Persistent Food Allergy","authors":"Eom Ji Choi, Seung Hwa Lee, Si Hyeon Lee, Sung Ok Kwon, Da Kyeong Lee, Min Jee Park, Jisun Yoon, Song‐I Yang, Hyo‐Bin Kim, Jihyun Kim, Kyung Won Kim, Youn Ho Shin, Dong In Suh, Ji Soo Park, Sun Hee Choi, Hey‐Sung Baek, Suk‐Joo Choi, Soo‐Young Oh, Ja‐Young Kwon, Soo Hyun Kim, Jong Kwan Jun, Mi‐Young Lee, Hye‐Sung Won, So‐Yeon Lee, Kangmo Ahn, Soo‐Jong Hong","doi":"10.1111/all.70471","DOIUrl":"https://doi.org/10.1111/all.70471","url":null,"abstract":"Background The mechanisms underlying distinct food allergy (FA) trajectories in children remain unclear. This study aimed to classify FA trajectories and examine differences in placental DNA methylation and serum cytokine profiles. Methods A total of 1518 children from the COCOA (COhort for Childhood Origin of Asthma and Allergic Diseases) study, followed until age 7, were classified into FA trajectories using group‐based trajectory modeling. Serum cytokine levels were measured at ages 3 and 7 years. Placental methylation profiling was performed with Infinium MethylationEPIC BeadChip. Results Children were classified into four trajectories: no FA (87.3%), early remission (6.9%), early persistent (4.6%), and late remission (1.1%). At ages 3 and 7, the early persistent FA trajectory exhibited higher interleukin (IL)‐4, IL‐5, and IL‐6 levels than the no FA trajectory. At age 3, IL‐10 levels were lower in the early persistent trajectory than in the late remission trajectory. In DNA methylation analysis, the Ribosomal Protein S6 Kinase A2 (RPS6KA2) and Germinal Center Associated Signaling And Motility Like (GCSAML) genes were significantly hypermethylated in the early persistent FA trajectory compared to the no FA and early remission trajectory ( <jats:italic>p</jats:italic> &lt; 0.05). GCSAML methylation was positively correlated with total IgE, egg white–specific IgE, early‐life eosinophils, and IL‐5 at age 7 (all <jats:italic>p</jats:italic> &lt; 0.05). Conclusion Hypermethylation of RPS6KA2 and GCSAML, reduced IL‐10 levels, and elevated Th2 cytokines were associated with early persistent FA trajectory, potentially influencing its allergic inflammation and persistence.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"7 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148767499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Updated EAACI Statement on Drug Hypersensitivity Skin Testing: Methodology and Non‐Irritative Concentrations","authors":"Annick Barbaud, Lene Heise Garvey, Elizabeth Phillips, Michael Ardern‐Jones, Sevim Bavbek, Patrizia Bonadonna, Jean‐Christoph Caubet, Ana‐Maria Copaescu, Valentina Gueli, Jose Julio Laguna, Ricardo Madrigal‐Burgaleta, Francesca Mori, Vito Sabato, Maria J Torres, Knut Brockow","doi":"10.1111/all.70466","DOIUrl":"https://doi.org/10.1111/all.70466","url":null,"abstract":"These updated EAACI guidelines aim to standardize skin testing methodologies for both immediate and non‐immediate drug hypersensitivity reactions. For immediate reactions, the optimal testing window is 4–6 weeks post‐reaction; whereas beyond 6 months, false‐negative results increase. For chemotherapy‐related reactions, earlier testing (within 2 weeks) remains necessary due to treatment urgency. The previously published multicenter ENDA study established the international reference method for positive immediate intradermal test reading: injection of exactly 0.02 mL with a wheal at 20 min measuring ≥ initial wheal +3 mm, representing a major standardization achievement. For patch testing, exact active ingredient concentrations must be systematically documented. When tablets are crushed and diluted at 30% in petrolatum, significant variability in final concentrations has been observed. The guidelines present validated nonirritant concentrations for major drug classes including antibiotics, contrast media, anesthetics, proton pump inhibitors, chemotherapies, and biologicals. Specific recommendations are based on negative controls demonstrating specificity, while conditional recommendations are provided when few or no negative controls are available. Risk stratification algorithms now allow direct drug provocation testing for mild maculopapular exanthema, bypassing preliminary skin tests. However, more severe reactions such as anaphylaxis require skin testing before considering drug provocation tests. For DRESS/AGEP/SJS/TEN, skin tests are useful and safe for identifying culprit drugs. These harmonized methods enable safe drug allergy delabeling while preserving diagnostic accuracy and patient safety. Strict adherence to these standardized protocols is essential to ensure reproducible results and safe clinical practice in drug hypersensitivity evaluation.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"22 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148767500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors for Success and Failure of Allergen Immunotherapy ( AIT ) Trial Design in the Light of Evidence‐Based Medicine: Current Aspects 2026","authors":"Roy Gerth van Wijk, Vera Mahler, Melanie Albrecht, Danilo di Bona, Benjamin Hofner, Jasper Kappen, Susanne Kaul, Graham Roberts, Mohamed H. Shamji, Stefan Vieths, Oliver Pfaar","doi":"10.1111/all.70484","DOIUrl":"https://doi.org/10.1111/all.70484","url":null,"abstract":"Allergen immunotherapy (AIT) has been acknowledged as the only disease‐modifying treatment for respiratory diseases since its introduction in 1911. Although the efficacy and safety have convincingly been established in numerous randomized clinical trials (RCTs), the AIT study results may vary substantially. Several factors that may influence the outcome of RCTs will be addressed. First, the choice of the primary endpoint is essential. Lack of validated endpoints with proven clinical relevance may contribute to the variation in study results. Secondly, heterogeneity of the patient population affects the study outcome, thereby raising the question of whether current selection criteria should be further optimized to capture those patients who will benefit from immunotherapy. Thirdly, variability and particularly low allergen exposure may lead to unsuccessful AIT trials. Fourthly, unsuccessful trials may stem from large placebo effects. Furthermore, discrepancies between Phase II and III studies are asking for cautious interpretation of Phase II studies when planning Phase III studies. Flaws in trial design, inadequate reporting of the clinical trial protocol and data may hamper the interpretation of study results. In addition, this review addresses specific aspects of AIT trial design in children and asthmatic patients. To improve future AIT trials, innovative solutions are urgently needed, including the establishment of an internationally accepted minimal clinically important difference (MCID), the validation of primary endpoints, the integration of field studies and allergen exposure chamber studies, and the publication of negative study results.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"37 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148754443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Epithelium‐Derived Cystatin SN Inhibits House Dust Mite Protease Activity in Allergic Asthma”","authors":"","doi":"10.1111/all.70488","DOIUrl":"https://doi.org/10.1111/all.70488","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"5 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148767501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nomenclature on Immune‐Mediated Drug Reactions: An EAACI Position Paper","authors":"Maria J. Torres, Cristobalina Mayorga, Elizabeth J. Phillips, Adriana Ariza, Annick Barbaud, Patrizia Bonadonna, Mariana Castells, Gülfem Çelik, Knut Brockow, Lene H. Garvey, Inmaculada Doña, Jean C. Caubet, Francesca Mori, Jason Trubiano, Giorgia Marta, Antonino Romano, Ingrid Terreehorst, Asli Gelincik, Philip H. Li, Vito Sabato","doi":"10.1111/all.70480","DOIUrl":"https://doi.org/10.1111/all.70480","url":null,"abstract":"Over the past several decades, there have been significant advances in our understanding of both immunological and pharmacological mechanisms of adverse drug reactions (ADRs). Immune‐mediated drug reactions (IMDRs) represent a small proportion of ADRs and are caused by a pathological activation of the immune system or inflammatory pathways. Drugs can act as an antigen or may directly interact with the immune system or inflammatory pathways, making immune‐mediated drug reactions observed in contemporary practice not sufficiently explained by the Gell and Coombs (G&amp;C) framework. Moreover, the phenotype alone is neither pathognomonic nor sufficient to infer the endotype. The proposed nomenclature integrates chrono‐morphological phenotypes, mechanistic endotypes and characteristics of the involved drug. In this nomenclature, IMDRs are classified, according to the nature of interaction with the immune system, in: (i) drug allergy that encompasses antigen‐driven reactions—diagnosed by tests detecting sensitisation—and (ii) drug hypersensitivity that includes the heterogeneous broad group of drug‐directly‐driven reactions. This framework supports precision medicine, aligns terminology with mechanisms, and provides a common language for interdisciplinary communication, pharmacovigilance, and drug development. It accommodates emerging therapeutic classes and remains adaptable to future discoveries in immunopathogenesis and biomarker development.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"10 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148754444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nomenclature on Immune-Mediated Drug Reactions: An EAACI Position Paper.","authors":"Maria J Torres, Cristobalina Mayorga, Elizabeth J Phillips, Adriana Ariza, Annick Barbaud, Patrizia Bonadonna, Mariana Castells, Gülfem Çelik, Knut Brockow, Lene H Garvey, Inmaculada Doña, Jean C Caubet, Francesca Mori, Jason Trubiano, Giorgia Marta, Antonino Romano, Ingrid Terreehorst, Asli Gelincik, Philip H Li, Vito Sabato","doi":"10.1111/all.70480","DOIUrl":"https://doi.org/10.1111/all.70480","url":null,"abstract":"<p><p>Over the past several decades, there have been significant advances in our understanding of both immunological and pharmacological mechanisms of adverse drug reactions (ADRs). Immune-mediated drug reactions (IMDRs) represent a small proportion of ADRs and are caused by a pathological activation of the immune system or inflammatory pathways. Drugs can act as an antigen or may directly interact with the immune system or inflammatory pathways, making immune-mediated drug reactions observed in contemporary practice not sufficiently explained by the Gell and Coombs (G&C) framework. Moreover, the phenotype alone is neither pathognomonic nor sufficient to infer the endotype. The proposed nomenclature integrates chrono-morphological phenotypes, mechanistic endotypes and characteristics of the involved drug. In this nomenclature, IMDRs are classified, according to the nature of interaction with the immune system, in: (i) drug allergy that encompasses antigen-driven reactions-diagnosed by tests detecting sensitisation-and (ii) drug hypersensitivity that includes the heterogeneous broad group of drug-directly-driven reactions. This framework supports precision medicine, aligns terminology with mechanisms, and provides a common language for interdisciplinary communication, pharmacovigilance, and drug development. It accommodates emerging therapeutic classes and remains adaptable to future discoveries in immunopathogenesis and biomarker development.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":11.3,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental and Healthcare Professional Experiences of Food Allergen Introduction During Complementary Feeding: A Behavioural Theory–Informed Systematic Review","authors":"Karen Wright, Amelia Dennis, Luise V. Marino, Stephanie Easton, Samantha Hornsey, Sebastien Pollet, Misbah Primett, Goldie Putrym, Susan Dixon, Helen Reynolds, Anna Rattu, Miriam Santer, Ingrid Muller, Graham Roberts, Ben Ainsworth","doi":"10.1111/all.70451","DOIUrl":"https://doi.org/10.1111/all.70451","url":null,"abstract":"Background IgE‐mediated food allergy burdens individuals, families and healthcare systems. Randomised controlled trials indicate early introduction and regular consumption of common food allergens in infancy can reduce food allergy risk. Few studies have explored parental and healthcare professional experiences. This systematic review examines their perspectives applying a theory‐informed behavioural analysis identifying key barriers influencing food allergen introduction. Method A systematic search of seven databases was conducted in November 2025. All study designs and published primary research papers were included and screened against the inclusion/exclusion criteria. Quantitative findings were summarised narratively and analysed alongside qualitative data. All findings were synthesised concurrently using an integrated thematic synthesis following the Thomas and Harden approach. Quality appraisal was assessed. Results Twenty‐five studies were included. Four themes were identified: (1) Practical barriers to introducing the allergenic foods, (2) perceived risk and fear of allergic reactions and safety, (3) navigating and making sense of food allergy prevention information, particularly conflicting advice for parents and (4) food allergy prevention advice, guidance awareness, interpretation and implementation. Conclusion Effective food allergy prevention requires early, consistent support for parents from suitably trained healthcare professionals. Advice should be evidence‐based, simple, culturally relevant and accessible, promoting realistic and healthy infant and family foods and diets.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"11 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148754375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenic Airway Bacteria and Local Immune Responses During Early‐Life Asthma‐Like Episodes","authors":"Mathilde Bundgaard Svendsen, Tamo Sultan, Anton Kjellberg, Mathias Melgaard, Susanne Brix, Karen Krogfelt, Nilo Vahman, Ann‐Marie Malby Schoos, Jakob Stokholm, Bo Lund Chawes, Klaus Bønnelykke, Jonathan Thorsen, Julie Nyholm Kyvsgaard","doi":"10.1111/all.70481","DOIUrl":"https://doi.org/10.1111/all.70481","url":null,"abstract":"Background Respiratory tract colonization by the pathogenic airway bacteria <jats:styled-content style=\"fixed-case\"> <jats:italic>Haemophilus influenzae</jats:italic> </jats:styled-content> , <jats:styled-content style=\"fixed-case\"> <jats:italic>Streptococcus pneumoniae</jats:italic> </jats:styled-content> , and/or <jats:styled-content style=\"fixed-case\"> <jats:italic>Moraxella catarrhalis</jats:italic> </jats:styled-content> has been linked to the pathogenesis of childhood asthma and exacerbations, but the underlying mechanisms remain unclear. Objective To investigate the association of <jats:italic> <jats:styled-content style=\"fixed-case\">H. influenzae</jats:styled-content> , </jats:italic> <jats:styled-content style=\"fixed-case\"> <jats:italic>S. pneumoniae</jats:italic> </jats:styled-content> , and <jats:styled-content style=\"fixed-case\"> <jats:italic>M. catarrhalis</jats:italic> </jats:styled-content> with airway immune responses during acute early‐life asthma‐like episodes and examine how these responses differ between children with and without asthma. Methods The study included 476 asthma‐like episodes from 271 children aged 0 to 4 years from the COPSAC <jats:sub>2010</jats:sub> mother–child cohort. Levels of 17 immune mediators covering Type‐1, −2, and −17 and regulatory pathways were assessed in upper airway mucosal lining fluid while hypopharyngeal aspirates were collected for bacterial cultures and nasopharyngeal aspirates for viral PCR. Asthma was prospectively assessed until age 6 years. Results Detection of <jats:styled-content style=\"fixed-case\"> <jats:italic>H. influenzae</jats:italic> </jats:styled-content> during asthma‐like symptoms was associated with elevated IL‐1β, TNF‐α, and IL‐2, alongside decreased CXCL10 levels. Similar immune profiles were observed in children with and without asthma by age 3. Detection of <jats:styled-content style=\"fixed-case\"> <jats:italic>S. pneumoniae</jats:italic> </jats:styled-content> and <jats:styled-content style=\"fixed-case\"> <jats:italic>M. catarrhalis</jats:italic> </jats:styled-content> were not associated with significant changes in immune mediator levels; however, children with asthma by age 3 exhibited elevated IL‐1β levels during detection of <jats:styled-content style=\"fixed-case\"> <jats:italic>S. pneumoniae</jats:italic> </jats:styled-content> , a pattern not observed in children without asthma. No significant differences in mediator levels were observed in children with and without asthma at age 6. Conclusion Children with pathogenic bacterial detection in the airways during acute asthma‐like episodes exhibit an increased proinflammatory immune response marked by increased IL‐1β, IL‐2 and TNF‐α, which may promote chronic inflammation, possibly contributing to asthma development and exacerbations.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"5 3 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148754445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}