Allergy最新文献

{"title":"Transcriptomic Profiles of the Nasal Mucosa Following Birch Pollen Provocation Differ Between Birch Pollen-Allergic and Non-Allergic Individuals.","authors":"Srinidhi Sudharson, Julia Eckl-Dorna, Anastasia Meshcheryakova, José Basílio, Sophia Derdak, Tanja Kalic, Nina Lengger, Nina Schweitzer, Diana Mechtcheriakova, Heimo Breiteneder, Christine Hafner","doi":"10.1111/all.16448","DOIUrl":"https://doi.org/10.1111/all.16448","url":null,"abstract":"<p><strong>Background: </strong>Birch pollen (BP) interacts with airway epithelial cells to cause allergic sensitization and allergy in predisposed individuals. However, the basic mechanisms underlying the clinical effects are poorly understood. Changes in gene expression and cytokine secretion in nasal mucosal cells upon BP exposure were determined in BP-allergic and non-allergic individuals.</p><p><strong>Methods: </strong>BP-allergic (n = 11) and non-allergic individuals (n = 12) participated in nasal provocations with saline and aqueous BP solution. Nasal scrapings and secretions were obtained at baseline and after BP provocation. Bulk RNA sequencing of the nasal scrapings was performed, and cytokines in nasal secretions were quantified.</p><p><strong>Results: </strong>After BP challenge, we identified 160 differentially expressed genes (DEGs) in the nasal scrapings of allergic individuals and 44 in non-allergic individuals. DEGs encoding S100 proteins, keratins, small proline-rich repeat proteins, and cytokines were predominantly identified, with proinflammatory cytokine transcripts being upregulated only in the allergic cohort. The top canonical pathways in allergic individuals included granulocyte and agranulocyte adhesion and diapedesis, wound healing, IL-8 signaling, and IL-17-related pathways. Enriched pathways in allergic participants were associated with granulocyte chemotaxis, humoral cell responses, and IL-10, IL-4, and IL-13 signaling and were absent in non-allergic individuals. At baseline and after BP challenge, higher amounts of CCL17, CCL20, CCL26, IL-7, IL-16, and IL-33 were detected in nasal secretions of allergic compared to non-allergic individuals.</p><p><strong>Conclusion: </strong>Our results highlight the activation of important cellular signaling pathways specific to BP-allergic individuals after BP exposure offering new perspectives for studying key players in BP allergy.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Differentiated Epithelial Layer Graft Improves Fibrosis and Survival in Airway Stenosis via IL‐37","authors":"Roza Khalmuratova, Yi Sook Kim, Dae Woo Kim, Hyun‐Woo Shin","doi":"10.1111/all.16452","DOIUrl":"https://doi.org/10.1111/all.16452","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"17 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergen-Specific B Cell Responses Following Desensitisation and Natural Tolerance to Cow's Milk Allergy","authors":"Mohamed H. Shamji,&nbsp;Edwin H. Kim,&nbsp;Marta Vazquez-Ortiz,&nbsp;Paul J. Turner,&nbsp;Janice A. Layhadi","doi":"10.1111/all.16443","DOIUrl":"10.1111/all.16443","url":null,"abstract":"&lt;p&gt;Food allergy (FA) is a major public health concern, estimated to affect up to 10% of the global population [&lt;span&gt;1&lt;/span&gt;]. Cow's milk allergy (CMA) is the most common FA in younger children, with around 50% outgrowing the condition by the age of 5 (“natural tolerance”) [&lt;span&gt;2&lt;/span&gt;]. However, those who develop persisting CMA often have multiple allergic comorbidities and present with a more severe phenotype. As a result, in some countries, cow's milk is now the most common cause of fatal anaphylaxis in children and young people [&lt;span&gt;3&lt;/span&gt;]. In these patients, historical management has been the complete elimination of milk and milk-containing products from the diet. More recently, oral immunotherapy (OIT) has been used to induce desensitisation and remission to the sensitising allergen [&lt;span&gt;4&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;OIT involves a gradual introduction of small amounts of the allergenic food (i.e., milk, peanut and egg) into the affected person's diet over time, leading to a state of desensitisation, and ideally longer-term remission (previously named ‘sustained unresponsiveness’) allowing the patient to consume the food &lt;i&gt;ad libitum&lt;/i&gt;. This ultimately results in improved dietary flexibility and health-related quality of life. However, OIT is associated with significant challenges, including high rates of treatment-related adverse events including anaphylaxis, adherence issues as well as psychological and logistical implications and burden from the treatment. OIT for CMA appears to be a particular issue in terms of safety [&lt;span&gt;5&lt;/span&gt;]. In addition, outcomes from OIT vary considerably among individuals, with some achieving significant benefits whereas others showing limited or no improvement [&lt;span&gt;6&lt;/span&gt;]. Understanding the key immunological factors driving the response to OIT and identifying biomarkers that identify responders and non-responders and the induction of remission remains a key unmet need.&lt;/p&gt;&lt;p&gt;The recent article entitled “Allergen-specific B cell responses in oral immunotherapy-induced desensitisation, remission, and natural outgrowth in cow's milk allergy” by Satitsuksanoa et al. [&lt;span&gt;7&lt;/span&gt;] interrogated the trajectory profile of allergen-specific B cells during OIT (those who go on to reach desensitised or remission state) uniquely comparing these findings against the development of natural tolerance to the allergy. The study utilised time-course samples from children with CMA who received OIT, children who naturally outgrew CMA and healthy controls. In this seminal article, the authors revealed that albeit in small proportions, Bos 9-specific B cells are found in all patient groups investigated ruling out the common perception that allergen-specific cells are often confined to allergic individuals. Bos 9-specific B cells from healthy controls differ in that they are proficient in producing sIgG1 and sIgG4 but lack the ability to produce sIgE.&lt;/p&gt;&lt;p&gt;Using a single cell transcriptomic approach to fully elucidate ","PeriodicalId":122,"journal":{"name":"Allergy","volume":"80 1","pages":"12-13"},"PeriodicalIF":12.6,"publicationDate":"2024-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.16443","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142874614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncostatin‐M Is Produced by Human Eosinophils and Expression Is Increased in Uncontrolled Severe Asthma","authors":"Stephane Esnault, Ksenija Bernau, Heather L. Floerke, Arnaud Dendooven, Emeline Delaunay, Kimberly A. Dill‐McFarland, Matthew C. Altman, William W. Busse, Melissa A. Rosenkranz, Matthew C. Tattersall, Mats W. Johansson, Julien Labreuche, Delphine Beury, Shéhérazade Sebda, Frédéric Dezoteux, Baptiste Segard, Geoffrey Mortuaire, Delphine Staumont‐Sallé, Thomas Stoup, Cécile Chenivesse, Nathan Sandbo, Nizar N. Jarjour, Guillaume Lefèvre","doi":"10.1111/all.16453","DOIUrl":"https://doi.org/10.1111/all.16453","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"52 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary Metabolomic Signatures in Pediatric Eosinophilic Esophagitis","authors":"Girish Hiremath,&nbsp;Simona G. Codreanu,&nbsp;Stacy D. Sherrod,&nbsp;Regina Tyree,&nbsp;Hernan Correa,&nbsp;Yash Choksi,&nbsp;John A. McLean,&nbsp;Andrea Locke","doi":"10.1111/all.16450","DOIUrl":"10.1111/all.16450","url":null,"abstract":"&lt;p&gt;Little is known about metabolomic imbalances in eosinophilic esophagitis (EoE)—an allergen-mediated immunoinflammatory condition of the esophagus [&lt;span&gt;1&lt;/span&gt;]. To address this knowledge gap, we conducted global untargeted salivary metabolomics in children with EoE. We analyzed saliva as oral mucosa is the initial interface between the triggering allergens and the host mucosal immune system. Additionally, saliva is rich in metabolites and is uniquely suited for noninvasive sampling, especially in children [&lt;span&gt;2&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;In an institutional review board-approved study (#151341), unstimulated saliva samples were collected from 28 children (6–18 years) with known EoE and symptoms of esophageal dysfunction immediately before their esophagogastroduodenoscopy (EGD). Participants were &lt;i&gt;nil per os&lt;/i&gt; for &gt; 6 h prior to their EGD. Demographic, clinical, endoscopic, and histologic features were also analyzed (Table 1).&lt;/p&gt;&lt;p&gt;Per the current guidelines [&lt;span&gt;3&lt;/span&gt;], 19 (68%) had EoE (active EoE [aEoE] = 9 [47%], and inactive EoE [iEoE] = 10 [53%]), and 9 (32%) were non-EoE controls (controls). Liquid chromatography-high-resolution mass spectrometry was used to analyze saliva samples. Downstream analyses of confidence levels 1, 2, and 3a identified compounds matching searched libraries or databases were performed (see Supporting Information for details) [&lt;span&gt;4&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;In all, an abundance of 434 compounds was significantly different ([&lt;i&gt;p&lt;/i&gt; ≤ 0.05] with &gt; 2-fold change [FC]) between EoE and controls, and PLS-DA identified well-defined clustering of salivary metabolites classifying the two groups. Ten compounds from endogenous origins belonging to nucleosides, nucleotides, organic acid derivatives, and organoheterocyclic compounds robustly differentiated EoE from controls. Specifically, 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (FC = 6.85; &lt;i&gt;p&lt;/i&gt; = 0.003), and N-Heptanoylyglycine (FC = 3.62, &lt;i&gt;p&lt;/i&gt; = 0.02), were significantly increased in EoE compared to controls. While deoxyadenosine (FC = −4.0, &lt;i&gt;p&lt;/i&gt; = 0.01), deoxycytidine (FC = −3.42, &lt;i&gt;p&lt;/i&gt; = 0.01), and adenosine (FC = −3.55, &lt;i&gt;p&lt;/i&gt; = 0.02) were significantly lower in EoE than controls (Figure 1). Adenosine is known to have anti-inflammatory effects and is actively converted to inosine due to its long-term instability [&lt;span&gt;5&lt;/span&gt;]. We hypothesize that a decrease in adenosine and a corresponding increase in inosine (inosine-41N5) in EoE (compared to control; FC = 1.24; &lt;i&gt;p&lt;/i&gt; = 0.02) could be related to the underlying allergic inflammation. Next, 57 compounds differed between aEoE and iEoE. Of these, urea was significantly high (&lt;i&gt;p&lt;/i&gt; = 0.03), and serylarginine was significantly low (&lt;i&gt;p&lt;/i&gt; = 0.007) in aEoE compared to iEoE, suggesting that EoE activity can impact salivary metabolites (Figure 2b).&lt;/p&gt;&lt;p&gt;Finally, we found 102 compounds with negative FC and 207 with positive FC differentiated aEoE from controls. Of these, eight molecules had a","PeriodicalId":122,"journal":{"name":"Allergy","volume":"80 1","pages":"354-358"},"PeriodicalIF":12.6,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.16450","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Burden of Asthma and Atopic Dermatitis in 2021: A Systemic Analysis of the Global Burden of Disease Study 2021.","authors":"Hong Luo, Fuqiang Wen","doi":"10.1111/all.16449","DOIUrl":"https://doi.org/10.1111/all.16449","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IL-25 and Periostin Serum Concentrations May Be Associated With COVID-19 Severity and Recovery.","authors":"Anna Zaleska, Adrian Gajewski, Anna Dor-Wojnarowska, Anna Radlińska, Marta Rorat, Maciej Chałubiński","doi":"10.1111/all.16431","DOIUrl":"https://doi.org/10.1111/all.16431","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How FEV₁ Improvement Induced by Anti-IL-5 in Severe Type-2 Asthma Is Linked to Mucus Plugs Clearance.","authors":"Alain Michils, Maxime Hackx, Lucas Mlynarski, Amaryllis Haccuria, Silvia Perez-Bogerd, Andreï Malinovschi, Alain Van Muylem","doi":"10.1111/all.16441","DOIUrl":"https://doi.org/10.1111/all.16441","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating Nitrite in Severe Asthma: Just Another Biomarker or Novel Treatment Target?","authors":"Anna Freeman, Magdalena Minnion, Paul H Lee, Hans Michael Haitchi, Ramesh Kurukulaaratchy, Tom Wilkinson, Martin Feelisch","doi":"10.1111/all.16435","DOIUrl":"https://doi.org/10.1111/all.16435","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food Allergy Genetics and Epigenetics: A Review of Genome-Wide Association Studies","authors":"Aleix Arnau-Soler,&nbsp;Bénédicte L. Tremblay,&nbsp;Yidan Sun,&nbsp;Anne-Marie Madore,&nbsp;Mathieu Simard,&nbsp;Elin T. G. Kersten,&nbsp;Ahla Ghauri,&nbsp;Ingo Marenholz,&nbsp;Thomas Eiwegger,&nbsp;Elinor Simons,&nbsp;Edmond S. Chan,&nbsp;Kari Nadeau,&nbsp;Vanitha Sampath,&nbsp;Bruce D. Mazer,&nbsp;Susan Elliott,&nbsp;Christine Hampson,&nbsp;Lianne Soller,&nbsp;Andrew Sandford,&nbsp;Philippe Begin,&nbsp;Jennie Hui,&nbsp;Bethany F. Wilken,&nbsp;Jennifer Gerdts,&nbsp;Adrienn Bourkas,&nbsp;Anne K. Ellis,&nbsp;Denitsa Vasileva,&nbsp;Ann Clarke,&nbsp;Aida Eslami,&nbsp;Moshe Ben-Shoshan,&nbsp;David Martino,&nbsp;Denise Daley,&nbsp;Gerard H. Koppelman,&nbsp;Catherine Laprise,&nbsp;Young-Ae Lee,&nbsp;Yuka Asai","doi":"10.1111/all.16429","DOIUrl":"10.1111/all.16429","url":null,"abstract":"<p>In this review, we provide an overview of food allergy genetics and epigenetics aimed at clinicians and researchers. This includes a brief review of the current understanding of genetic and epigenetic mechanisms, inheritance of food allergy, as well as a discussion of advantages and limitations of the different types of studies in genetic research. We specifically focus on the results of genome-wide association studies in food allergy, which have identified 16 genetic variants that reach genome-wide significance, many of which overlap with other allergic diseases, including asthma, atopic dermatitis, and allergic rhinitis. Identified genes for food allergy are mainly involved in epithelial barrier function (e.g., <i>FLG</i>, <i>SERPINB7</i>) and immune function (e.g., <i>HLA</i>, <i>IL4</i>). Epigenome-wide significant findings at 32 loci are also summarized as well as 14 additional loci with significance at a false discovery of &lt; 1 × 10⁻⁴. Integration of epigenetic and genetic data is discussed in the context of disease mechanisms, many of which are shared with other allergic diseases. The potential utility of genetic and epigenetic discoveries is deliberated. In the future, genetic and epigenetic markers may offer ways to predict the presence or absence of clinical IgE-mediated food allergy among sensitized individuals, likelihood of development of natural tolerance, and response to immunotherapy.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":"80 1","pages":"106-131"},"PeriodicalIF":12.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11724255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}