解读特应性皮炎与心血管疾病之间的联系：临床关联和心脏代谢蛋白分析。

IF 12.6 1区医学 Q1 ALLERGY

Allergy Pub Date : 2025-05-19 DOI:10.1111/all.16588

Danielle Fehr,Van Hung Huynh-Tran,Laura Maintz,David Niederseer,Milad Ameri,Anita Dreher,Cezmi A Akdis,Roger Lauener,Claudio Rhyner,Claudia Traidl-Hoffmann,Peter Schmid-Grendelmeier,Thomas Bieber,Marie-Charlotte Brüggen

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引用次数: 0

摘要

背景：关于特应性皮炎（AD）和心血管疾病（CVD）之间的潜在关联，存在相互矛盾的数据。本研究的目的是进一步探索这种联系，以及是否有生物标志物表明AD患者患CVD的风险。方法：我们从一项观察性多中心病例对照研究（proorad：调查特应性皮炎和其他过敏相关疾病患者缓解期的前瞻性纵向研究）中纳入677例AD患者和79例非特应性对照。评估了AD的严重程度、特应性、代谢和心血管状况以及危险因素。用靶向蛋白质组学（cardimetabolics panel, Olink）分析血清样本。结果我们没有发现AD和CVD之间的整体关联。然而，无特应性合并症（纯AD）的AD患者CVD患病率明显高于有特应性合并症（ADAC）的AD患者（28.2% [37/131]vs. 14.7% [80/546], p < 0.001）。然而，在控制心血管危险因素后，这种关联还不能得到证实。在单纯AD中，有CVD的患者比没有CVD的患者表现出更严重的AD （EASI[湿疹面积和严重程度指数]中位数为12.9比4.0,p < 0.001）。在该亚组患者中，即使在调整模型中，EASI仍然是CVD的重要预测因子（调整优势比[aOR] = 1.05, p = 0.040）。与非特应性对照组相比，AD患者的40种血清心脏代谢蛋白上调。cc -趋化因子配体18 （CCL18）在AD （p < 0.001）和CVD （p < 0.001）中均上调，其升高与AD严重程度相关。结论我们的研究并未表明AD和CVD之间存在全面的关联，两者之间存在更复杂的关系。在单纯AD患者中，疾病严重程度可能是CVD的危险因素，但在有特应性合并症的患者中则不是。CCL18可能是CVD的生物标志物。

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Deciphering the Connection Between Atopic Dermatitis and Cardiovascular Diseases: Analysis of Clinical Associations and Cardiometabolic Proteins.

BACKGROUND There are conflicting data on a potential association between atopic dermatitis (AD) and cardiovascular diseases (CVD). The aim of this study was to further explore this connection and whether there are biomarkers indicating the risk for CVD in AD patients. METHODS We included 677 AD patients and 79 nonatopic controls from an observational multicenter case-control study (ProRaD: Prospective longitudinal study investigating the remission phase in patients with atopic dermatitis and other allergy-associated diseases). AD severity and atopic, metabolic, and cardiovascular conditions as well as risk factors were assessed. Serum samples were analyzed with targeted proteomics (cardiometabolics panel, Olink). RESULTS We did not find an overall association between AD and CVD. However, AD patients without atopic comorbidities (pure AD) showed a significantly higher CVD prevalence than AD patients with atopic comorbidities (ADAC) (28.2% [37/131] vs. 14.7% [80/546], p < 0.001). Yet, this association could not be confirmed when controlling for cardiovascular risk factors. In pure AD, patients with CVD showed a more severe AD than those without CVD (median EASI [Eczema Area and Severity Index] 12.9 vs. 4.0, p < 0.001). In this subgroup of patients, EASI remained a significant predictor of CVD even in the adjusted model (adjusted odds ratio [aOR] = 1.05, p = 0.040). Forty serum cardiometabolic proteins were upregulated in AD patients compared with nonatopic controls. CC-chemokine ligand 18 (CCL18) was upregulated in both AD (p < 0.001) and CVD (p < 0.001) and its increase correlated with AD severity. CONCLUSIONS Our study does not suggest an overall association between AD and CVD, but a more complex relation between the two conditions. Disease severity may be a risk factor for CVD in pure AD patients, but not in those with atopic comorbidities. CCL18 may be a biomarker for CVD.

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来源期刊

Allergy 医学-过敏

CiteScore

26.10

自引率

9.70%

发文量

393

审稿时长

2 months

期刊介绍： Allergy is an international and multidisciplinary journal that aims to advance, impact, and communicate all aspects of the discipline of Allergy/Immunology. It publishes original articles, reviews, position papers, guidelines, editorials, news and commentaries, letters to the editors, and correspondences. The journal accepts articles based on their scientific merit and quality. Allergy seeks to maintain contact between basic and clinical Allergy/Immunology and encourages contributions from contributors and readers from all countries. In addition to its publication, Allergy also provides abstracting and indexing information. Some of the databases that include Allergy abstracts are Abstracts on Hygiene & Communicable Disease, Academic Search Alumni Edition, AgBiotech News & Information, AGRICOLA Database, Biological Abstracts, PubMed Dietary Supplement Subset, and Global Health, among others.