Miriam Leskien, Elisabeth Thiering, Zhebin Yu, Anke Huels, Yueli Yao, Simon Kebede Merid, Olena Gruzieva, Stephan Weidinger, Melanie Waldenberger, Annette Peters, Erik Melén, Marie Standl
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We calculated epigenetic age using the pediatric clock developed by Wu et al. (Aging 2019) (median absolute error = 0.04 years, Spearman correlation with chronological age <i>r</i> = 0.75). Linear mixed models were used to examine longitudinal associations of epigenetic age acceleration with doctor-diagnosed asthma, rhinitis, and eczema, or a combination thereof (“any allergy”) as well as aeroallergen sensitization. Replication was performed in BAMSE at the 8-year follow-up (<i>N</i> = 625) using linear models. Additionally, epigenetic age in adults from KORA F4 was estimated using Horvath's clocks and associations with allergic diseases were tested applying linear models.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Having any allergy was significantly associated with a mean epigenetic age acceleration of 0.34 years (95% CI = [0.06; 0.63]) using Wu's clock in LISA. Associations with consistent effect directions were found for allergic rhinitis, asthma, and eczema. No associations with aeroallergen sensitization were observed. In BAMSE, an inverse association of epigenetic age acceleration with eczema was found (−0.52 years, 95% CI = [−0.97; −0.07]). In KORA, hay fever was significantly associated with accelerated epigenetic age when using the Horvath pan-tissue clock (1.05 years, 95% CI = [0.21; 1.89]).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>We found an increase in epigenetic age in children with allergic diseases from LISA. 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引用次数: 0
摘要
背景：使用主要针对成人的传统时钟，很少有研究显示儿童过敏性疾病与表观遗传衰老之间的关联。对生命早期DNA甲基化变化的追踪表明，这些时钟在儿童中表现不佳。因此，我们的目的是阐明变应性疾病和表观遗传年龄之间的关系使用儿科时钟。方法我们使用来自德国LISA出生队列研究的6岁（N = 234）和10岁（N = 227）的数据。使用Infinium methylation EPIC头芯片测量血液中的DNA甲基化。我们使用Wu等人开发的儿童时钟（Aging 2019）计算表观遗传年龄（绝对误差中位数= 0.04岁，Spearman与实足年龄相关r = 0.75）。线性混合模型用于检验表观遗传年龄加速与医生诊断的哮喘、鼻炎和湿疹，或其组合（“任何过敏”）以及空气过敏原致敏的纵向关联。采用线性模型对BAMSE进行8年随访（N = 625）的复制。此外，使用Horvath's时钟估计KORA F4成人的表观遗传年龄，并使用线性模型测试与过敏性疾病的关联。结果：任何过敏均与平均表观遗传年龄加速（0.34岁）显著相关(95% CI = [0.06；[0.63])在LISA中使用Wu的时钟。在变应性鼻炎、哮喘和湿疹中发现了一致效果方向的关联。未观察到与空气过敏原致敏的关联。在BAMSE中，发现表观遗传年龄加速与湿疹呈负相关(-0.52年，95% CI = -0.97；-0.07])。在韩国，当使用Horvath泛组织时钟时，花粉热与表观遗传年龄的加速显著相关(1.05年，95% CI = [0.21；1.89])。结论：我们发现过敏性疾病患儿的表观遗传年龄增加。我们的研究结果表明，表观遗传年龄加速似乎与过敏性疾病的持续负担有关，但与无症状的空气过敏原致敏无关。
Childhood Asthma and Allergy Are Related to Accelerated Epigenetic Aging
Background
Few studies showed associations of childhood allergic diseases with epigenetic aging using traditional clocks trained mainly on adults. Tracking DNA methylation variation early in life has suggested poor performance of these clocks in children. Therefore, we aim to elucidate the association between allergic diseases and epigenetic age using a pediatric clock.
Methods
We used data from the German LISA birth cohort study at six (N = 234) and ten (N = 227) years. DNA methylation was measured in blood using the Infinium Methylation EPIC BeadChip. We calculated epigenetic age using the pediatric clock developed by Wu et al. (Aging 2019) (median absolute error = 0.04 years, Spearman correlation with chronological age r = 0.75). Linear mixed models were used to examine longitudinal associations of epigenetic age acceleration with doctor-diagnosed asthma, rhinitis, and eczema, or a combination thereof (“any allergy”) as well as aeroallergen sensitization. Replication was performed in BAMSE at the 8-year follow-up (N = 625) using linear models. Additionally, epigenetic age in adults from KORA F4 was estimated using Horvath's clocks and associations with allergic diseases were tested applying linear models.
Results
Having any allergy was significantly associated with a mean epigenetic age acceleration of 0.34 years (95% CI = [0.06; 0.63]) using Wu's clock in LISA. Associations with consistent effect directions were found for allergic rhinitis, asthma, and eczema. No associations with aeroallergen sensitization were observed. In BAMSE, an inverse association of epigenetic age acceleration with eczema was found (−0.52 years, 95% CI = [−0.97; −0.07]). In KORA, hay fever was significantly associated with accelerated epigenetic age when using the Horvath pan-tissue clock (1.05 years, 95% CI = [0.21; 1.89]).
Conclusions
We found an increase in epigenetic age in children with allergic diseases from LISA. Our results suggest that epigenetic age acceleration seems to be related to the persistent burden of allergic diseases, but not to non-symptomatic aeroallergen sensitization.
期刊介绍：
Allergy is an international and multidisciplinary journal that aims to advance, impact, and communicate all aspects of the discipline of Allergy/Immunology. It publishes original articles, reviews, position papers, guidelines, editorials, news and commentaries, letters to the editors, and correspondences. The journal accepts articles based on their scientific merit and quality.
Allergy seeks to maintain contact between basic and clinical Allergy/Immunology and encourages contributions from contributors and readers from all countries. In addition to its publication, Allergy also provides abstracting and indexing information. Some of the databases that include Allergy abstracts are Abstracts on Hygiene & Communicable Disease, Academic Search Alumni Edition, AgBiotech News & Information, AGRICOLA Database, Biological Abstracts, PubMed Dietary Supplement Subset, and Global Health, among others.
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