Allergy最新文献

{"title":"Flash talks (FT)","authors":"","doi":"10.1111/all.16299","DOIUrl":"10.1111/all.16299","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"79 S113","pages":"165-357"},"PeriodicalIF":12.6,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.16299","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142490296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"JM case report session","authors":"","doi":"10.1111/all.16301","DOIUrl":"10.1111/all.16301","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"79 S113","pages":"905-909"},"PeriodicalIF":12.6,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.16301","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142490302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preclinical development of virus‐like particle (VLP)‐based immunotherapy against HDM allergy","authors":"Piyachat Patniboon, Chanatip Thanasarnthungcharoen, Supapich Chanasit, Laurence Fievez, Theerayuth Kaewamatawong, Fabrice Bureau, Alain Jacquet","doi":"10.1111/all.16375","DOIUrl":"https://doi.org/10.1111/all.16375","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"98 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142489591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity, reliability and responsiveness of digital visual analogue scales for chronic spontaneous urticaria monitoring: A CRUSE® mobile health study.","authors":"Bernardo Sousa-Pinto,Aiste Ramanauskaite,Sophia Neisinger,Ellen Witte-Händel,Ana M Gimenez-Arnau,Carole Guillet,Claudio Alberto S Parisi,Constance H Katelaris,Daria Fomina,Désirée Larenas-Linnemann,Elizabeth García,Emek Kocatürk,Frank Siebenhaar,Hermenio Lima,Igor Kaidashev,Iman Nasr,Isabel Ogueta Canales,Ivan Cherrez Ojeda,Jacques Hébert,Jean Bousquet,Jonathan A Bernstein,Jonny Peter,Jorge Sanchez,Jose Ignacio Larco Sousa,Kanokvalai Kulthanan,Karsten Weller,Kiran Godse,Krzysztof Rutkowski,Lasma Lapina,Laurence Bouillet,Leo Lianyi Han,Luis Felipe Ensina,Margarida Gonçalo,Markus Magerl,Martijn van Doorn,Martin Metz,Maryam Khoshkhui,Michihiro Hide,Murat Türk,Nataļja Kurjāne,Niall Conlon,Pascale Salameh,Pavel Kolkhir,Riccardo Asero,Roman Stepanenko,Sabine Altrichter,Sara Gil-Mata,Simon Francis Thomsen,Torsten Zuberbier,Vladyslav Tsaryk,Young-Min Ye,Zenon Brzoza,Zuotao Zhao,Marcus Maurer","doi":"10.1111/all.16371","DOIUrl":"https://doi.org/10.1111/all.16371","url":null,"abstract":"BACKGROUNDCRUSE® is an app that allows patients with chronic spontaneous urticaria (CSU) to monitor their daily disease activity through the use of visual analogue scales (VASs). We aimed to determine the concurrent validity, reliability, responsiveness and minimal important difference (MID) of CRUSE® VASs.METHODSWe evaluated the properties of three daily VASs: VAS for how much patients were affected by their CSU ('VAS urticaria'), VAS for the impact of urticaria on work/school productivity ('VAS productivity') and the VAS of EQ-5D. Concurrent validity was assessed by measuring the association between each VAS and the Urticaria Activity Score (UAS). Intra-rater reliability was determined based on the data of users providing multiple daily questionnaires within the same day. Test-retest reliability and responsiveness (ability to change), respectively, were tested in clinically stable and clinically unstable users. MIDs were determined using distribution-based methods.RESULTSWe included 5938 patients (67,380 days). Concurrent validity was high, with VAS urticaria being more strongly associated with the UAS score than the remaining VASs. Intra-rater reliability was also high, with intraclass correlation coefficients (ICC) being above 0.950 for all VASs. Moderate-high test-retest reliability and responsiveness were observed, with reliability ICC being highest for VAS EQ-5D and responsiveness being highest for VAS urticaria. The MID for VAS urticaria was 17 (out of 100) units, compared to 15 units for VAS productivity and 11 units for VAS EQ-5D.CONCLUSIONDaily VASs for CSU available in the CRUSE® app display high concurrent validity and intra-rater reliability and moderate-high test-retest reliability and responsiveness.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"14 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142489797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved quality control of allergen products: Assessing the molecular allergen composition by mass spectrometry.","authors":"Steffen Augustin,Thomas Eichhorn,Martin Wald,Frank Fischer,Marek Jutel,Oliver Pfaar,Christoph Willers","doi":"10.1111/all.16339","DOIUrl":"https://doi.org/10.1111/all.16339","url":null,"abstract":"BACKGROUNDNatural allergen sources contain a variety of allergens, against which allergic subjects have developed individual sensitization profiles. Ideal allergen products for skin prick testing (SPT) and allergen immunotherapy (AIT) should contain the complete set of allergens of the respective allergen sources to cover all sensitization profiles. However, commercially available allergen products were shown to vary regarding their allergen composition.METHODSThe qualitative allergen composition of different SPT and AIT products produced from pollen of grasses, birch, mugwort and from house dust mites was assessed by a consistent high-resolution liquid chromatography-coupled tandem mass spectrometry method (LC-MS/MS).RESULTSAll major, mid-tier and most minor allergens were detected in each of the investigated three batches of SPT and AIT products, demonstrating the completeness of the allergen composition and a high degree of batch-to-batch consistency.CONCLUSIONThis is the first study using a single consistent high-resolution LC-MS/MS method to provide solid data on the qualitative allergen composition of SPT and AIT products manufactured from various common allergen sources. The applied method showed high reliability in qualitative batch-to-batch consistency testing and can be performed fast and with high throughput. High-resolution LC-MS/MS is applicable for process development and quality control to ensure market availability of allergen products corresponding to the composition of the respective natural allergen sources.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"211 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142489670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing prevalence of galactose-α-1,3-galactose sensitization in the Danish general adult population.","authors":"Katja Biering Leth-Møller,Marianne van Hage,Danijela Apostolovic,Jennifer Astrup Sørensen,Christian Vestergaard,Flemming Madsen,Lene Jung Kjær,Torben Hansen,Anna Jonsson,Simon Francis Thomsen,Allan Linneberg","doi":"10.1111/all.16360","DOIUrl":"https://doi.org/10.1111/all.16360","url":null,"abstract":"BACKGROUNDAlpha-gal syndrome is a novel food allergy to the oligosaccharide galactose-α-1,3-galactose (alpha-gal) present in mammalian meat. Tick bites are considered an important route of sensitization to alpha-gal. Data on alpha-gal sensitization in the general population is scant. We utilized a unique data source of repeated population-based health examination studies to assess prevalence, time trends, risk factors, and characteristics of alpha-gal sensitization.METHODSAlpha-gal sensitization was assessed in >11.000 adults from four health examination studies of randomly invited residents in the Copenhagen region conducted in 1990-1991, 2011-2012, 2012-2015, and 2016-2017. Alpha-gal sensitization was defined as serum specific IgE (sIgE) to alpha-gal ≥0.1 kUA/L; ≥0.35 kUA/L; ≥0.7 kUA/L; ≥3.5 kUA/L. The population was characterized according to genetically determined ABO blood group, aeroallergen sensitization, and pets at home.RESULTSThe prevalence of sIgE to alpha-gal ≥0.1 kUA/L was 1.3% in 1990-1991, 3.7% in 2012-2015 and 3.2% in 2016-2017. Of those sensitized to alpha-gal >97% reported to consume red meat at least once a week, even for sIgE to alpha-gal ≥3.5 kUA/L. Male sex, older age, aeroallergen sensitization, cat at home, and blood group A were associated with increased odds of alpha-gal sensitization. The known protective effect of blood group B was confirmed.CONCLUSIONIn this general adult population, the prevalence of alpha-gal sensitization had doubled from 1990-1991 to 2016-2017. This could potentially be due to increased tick exposure and an increased atopic predisposition.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"194 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142488282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of CoronaVac versus BNT162b2 based on neutralizing antibody response: A systematic review.","authors":"Zeynep Ece Kuloğlu, Şiran Keske, Mert Ahmet Kuşkucu, Füsun Can, Önder Ergönül","doi":"10.1111/all.16364","DOIUrl":"https://doi.org/10.1111/all.16364","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early-life exposure to residential greenness and risk of asthma in a U.S. bronchiolitis cohort","authors":"Wojciech Feleszko,&nbsp;Heidi Makrinioti,&nbsp;Marta Nalej,&nbsp;Tadao Ooka,&nbsp;Zhaozhong Zhu,&nbsp;Ashley F. Sullivan,&nbsp;Tuomas Jartti,&nbsp;Kohei Hasegawa,&nbsp;Carlos A. Camargo Jr","doi":"10.1111/all.16359","DOIUrl":"10.1111/all.16359","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Severe bronchiolitis (i.e., bronchiolitis requiring hospitalization) is linked to childhood asthma development. Despite a growing understanding of risk factors for developing post-bronchiolitis asthma, protective factors remain unclear. In this study, we aimed to investigate whether exposure to residential greenness between birth and bronchiolitis hospitalization is associated with asthma and atopic asthma development by age 6 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed a US severe bronchiolitis cohort from hospitalization to age 6 years, investigating how the normalized difference vegetation index (NDVI) and chlorophyll index green (CI green), measured in small (100 m) and large (500 m) radiuses around homes, relate to asthma and atopic asthma by age 6 years. We also explored whether maternal antibiotic use, daycare attendance, and respiratory virus type during hospitalization act as effect modifiers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study cohort included 861 infants, with 239 (28%) developing asthma by age 6 years—152 atopic, 17 nonatopic, and 70 unclassified. Early life residential exposure to high NDVI and CI green levels was associated with lower odds of asthma (OR_Adj for NDVI within a 100 m radius, 0.18; 95% CI, 0.05–0.78; and OR_Adj for CI green levels within a 100 m radius, 0.53; 95% CI, 0.31–0.90). Associations also were significant for the development of atopic asthma (OR_Adj 0.16; 95% CI, 0.03–0.96; and OR_Adj 0.46; 95% CI, 0.25–0.92; respectively). Results were similar for the 500 m radius exposures. No effect modification was noted.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In a U.S. bronchiolitis cohort, exposure to residential greenness between birth and bronchiolitis hospitalization is linked to lower asthma and atopic asthma risk by age 6 years.</p>\u0000 </section>\u0000 </div>","PeriodicalId":122,"journal":{"name":"Allergy","volume":"79 11","pages":"3036-3046"},"PeriodicalIF":12.6,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early-life exposure to residential greenness and risk of asthma in a U.S. bronchiolitis cohort.","authors":"Wojciech Feleszko,Heidi Makrinioti,Marta Nalej,Tadao Ooka,Zhaozhong Zhu,Ashley F Sullivan,Tuomas Jartti,Kohei Hasegawa,Carlos A Camargo","doi":"10.1111/all.16359","DOIUrl":"https://doi.org/10.1111/all.16359","url":null,"abstract":"INTRODUCTIONSevere bronchiolitis (i.e., bronchiolitis requiring hospitalization) is linked to childhood asthma development. Despite a growing understanding of risk factors for developing post-bronchiolitis asthma, protective factors remain unclear. In this study, we aimed to investigate whether exposure to residential greenness between birth and bronchiolitis hospitalization is associated with asthma and atopic asthma development by age 6 years.METHODSWe analyzed a US severe bronchiolitis cohort from hospitalization to age 6 years, investigating how the normalized difference vegetation index (NDVI) and chlorophyll index green (CI green), measured in small (100 m) and large (500 m) radiuses around homes, relate to asthma and atopic asthma by age 6 years. We also explored whether maternal antibiotic use, daycare attendance, and respiratory virus type during hospitalization act as effect modifiers.RESULTSThe study cohort included 861 infants, with 239 (28%) developing asthma by age 6 years-152 atopic, 17 nonatopic, and 70 unclassified. Early life residential exposure to high NDVI and CI green levels was associated with lower odds of asthma (ORAdj for NDVI within a 100 m radius, 0.18; 95% CI, 0.05-0.78; and ORAdj for CI green levels within a 100 m radius, 0.53; 95% CI, 0.31-0.90). Associations also were significant for the development of atopic asthma (ORAdj 0.16; 95% CI, 0.03-0.96; and ORAdj 0.46; 95% CI, 0.25-0.92; respectively). Results were similar for the 500 m radius exposures. No effect modification was noted.CONCLUSIONIn a U.S. bronchiolitis cohort, exposure to residential greenness between birth and bronchiolitis hospitalization is linked to lower asthma and atopic asthma risk by age 6 years.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"8 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142486344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining tryptase norms in the pediatric population reveals sex-based differences: Clinical implications.","authors":"Mathilde Puel,Julien Rossignol,Clotilde Devin,Marine Madrange,Antoine Diep,Pascale Nicaise Roland,Sylvie Chollet-Martin,Julien Husson,Olivier Hermine,Christine Bodemer,Chantal Brouzes,Luc De Chaisemartin,Laura Polivka,","doi":"10.1111/all.16365","DOIUrl":"https://doi.org/10.1111/all.16365","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"31 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142451863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}