Allergy最新文献

{"title":"Transcriptomic evidence for T cell‐fibroblast‐keratinocyte axis via IL‐13‐periostin‐integrin in atopic dermatitis","authors":"Nguyen Quoc Vuong Tran, Yoshiaki Kobayashi, Yuki Nakamura, Kayoko Ishimaru, Kenji Izuhara, Atsuhito Nakao","doi":"10.1111/all.16352","DOIUrl":"https://doi.org/10.1111/all.16352","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"78 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142448248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epithelial barrier dysfunction and associated diseases in companion animals: Differences and similarities between humans and animals and research needs.","authors":"Sena Ardicli,Ozge Ardicli,Duygu Yazici,Yagiz Pat,Huseyn Babayev,Peng Xiong,Can Zeyneloglu,Asuncion Garcia-Sanchez,Li-Li Shi,Oliva Giannelli Viscardi,Stephen Skolnick,Ismail Ogulur,Raja Dhir,Marek Jutel,Ioana Agache,Jozef Janda,Isabella Pali-Schöll,Kari C Nadeau,Mubeccel Akdis,Cezmi A Akdis","doi":"10.1111/all.16343","DOIUrl":"https://doi.org/10.1111/all.16343","url":null,"abstract":"Since the 1960s, more than 350,000 new chemicals have been introduced into the lives of humans and domestic animals. Many of them have become part of modern life and some are affecting nature as pollutants. Yet, our comprehension of their potential health risks for both humans and animals remains partial. The \"epithelial barrier theory\" suggests that genetic predisposition and exposure to diverse factors damaging the epithelial barriers contribute to the emergence of allergic and autoimmune conditions. Impaired epithelial barriers, microbial dysbiosis, and tissue inflammation have been observed in a high number of mucosal inflammatory, autoimmune and neuropsychiatric diseases, many of which showed increased prevalence in the last decades. Pets, especially cats and dogs, share living spaces with humans and are exposed to household cleaners, personal care products, air pollutants, and microplastics. The utilisation of cosmetic products and food additives for pets is on the rise, unfortunately, accompanied by less rigorous safety regulations than those governing human products. In this review, we explore the implications of disruptions in epithelial barriers on the well-being of companion animals, drawing comparisons with humans, and endeavour to elucidate the spectrum of diseases that afflict them. In addition, future research areas with the interconnectedness of human, animal, and environmental well-being are highlighted in line with the \"One Health\" concept.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"11 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142447996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The IL‐4–IL‐4Rα axis modulates olfactory neuroimmune signaling to induce loss of smell","authors":"Yannis Hara, Mithilesh Kumar Jha, Jeremy Y. Huang, Yingnan Han, Ingeborg M. Langohr, Giorgio Gaglia, Cheng Zhu, Peter Piepenhagen, Kaitlyn Gayvert, Wei Keat Lim, Seblewongel Asrat, Scott Nash, Juby A. Jacob‐Nara, Jamie M. Orengo, Dinesh S. Bangari, Emanuele de Rinaldis, Hamid Mattoo, Alexandra Hicks","doi":"10.1111/all.16338","DOIUrl":"https://doi.org/10.1111/all.16338","url":null,"abstract":"BackgroundLoss of smell is a part of the diagnostic criteria for CRSwNP. Although the mechanistic understanding is poor, inhibition of IL‐4Rα and IL‐4/IL‐13 signaling improves loss of smell in CRSwNP patients. In the present study, we compare the effects of IL‐4, IL‐13, and IL‐4Rα blockade on murine olfaction and identify the underlying pathophysiological mechanisms of loss of smell.MethodsTo evaluate the effects of IL‐4 and IL‐13 on olfactory function, we administered these cytokines intranasally to BALB/c mice for 5 consecutive days and assessed their latency to find hidden food. Calcium uptake assays were conducted to measure olfactory neuronal activity in vitro and ex vivo. We also performed histological analyses, proteomics, bulk RNA sequencing, and single‐cell RNA sequencing to assess the impact of IL‐4, IL‐13, and IL‐4Rα blockade on the olfactory epithelium and to identify potential molecular or cellular correlations with smell loss in human CRSwNP patients.ResultsHere, we provide evidence for non‐redundant effects of IL‐4 and IL‐13 in olfaction, with loss of smell in mice evoked by intranasal administration of IL‐4, not IL‐13. We demonstrate that an IL‐4–IL‐4Rα axis has a direct functional impact on murine olfactory sensory neurons and evokes inflammatory cell infiltration and pathophysiologic modulation of unique molecular signatures in olfactory epithelium without compromising structural integrity. Furthermore, single‐cell analysis of olfactory epithelium reveals that IL‐4–IL‐4Rα signaling modulates neuronal crosstalk with mast cells, macrophages, and NK cells, suggesting a functional link between olfactory impairment and neuroinflammation.ConclusionCollectively, this study suggests that an IL‐4–IL‐4Rα signaling axis plays a unique pathophysiological role in olfactory dysfunction via direct effect on neurons and modulation of neuroimmune interactions.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"1 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142448211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D in early life and risk of daily registered childhood infection episodes.","authors":"Nicklas Brustad,Julie Nyholm Kyvsgaard,Casper-Emil Tingskov Pedersen,Laura Marie Hesselberg,Anders U Eliasen,Signe Kjeldgaard Jensen,Luo Yang,Nilofar Vahman,Jakob Stokholm,Klaus Bønnelykke,Bo L Chawes","doi":"10.1111/all.16354","DOIUrl":"https://doi.org/10.1111/all.16354","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"74 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142443724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of patient satisfaction with dupilumab for chronic rhinosinusitis with nasal polyps.","authors":"Aiko Oka,Kengo Kanai,Shoji Matsune,Kei Hosoya,Taro Komachi,Ryosuke Murakami,Kimihiro Okubo,Kojiro Hirano,Isao Suzaki,Tomotaka Shimura,Takatoshi Tokudome,Sho Kanzaki,Ken-Ichiro Wakabayashi,Hiroyuki Ozawa,Yasuhide Okamoto,Kenji Kondo,Hironobu Nishijima,Ami Nishijima,Mitsuhiro Okano","doi":"10.1111/all.16355","DOIUrl":"https://doi.org/10.1111/all.16355","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"124 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142443753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A fungal spore calendar for England: Analysis of 13 years of daily concentrations.","authors":"Fiona A Symon,Samuel Anees-Hill,Jack Satchwell,Abbie Fairs,Richard Edwards,Andrew J Wardlaw,Leah Cuthbertson,Anna L Hansell,Catherine H Pashley","doi":"10.1111/all.16356","DOIUrl":"https://doi.org/10.1111/all.16356","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"11 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142443723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical algorithm: Diagnosis and treatment of drug hypersensitivity reactions to biologicals, 2024 update.","authors":"Barbara Carolyn Yang,Mariana Castells","doi":"10.1111/all.16353","DOIUrl":"https://doi.org/10.1111/all.16353","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"56 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142435979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Farm-dust mediated protection of childhood asthma: Mass cytometry reveals novel cellular regulation","authors":"Claudia Carina Beerweiler,&nbsp;Michael Salvermoser,&nbsp;Johanna Theodorou,&nbsp;Andreas Böck,&nbsp;Franziska Sattler,&nbsp;Paulina Kulig,&nbsp;Vinko Tosevski,&nbsp;Bianca Schaub","doi":"10.1111/all.16347","DOIUrl":"10.1111/all.16347","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Farm-dust mediated asthma protection in childhood was replicated in numerous epidemiological studies. Central immune mechanisms are not fully understood. This exploratory study aimed to disentangle underlying immunological regulation of farm-dust mediated protection in peripheral blood on a single-cell level.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Single-cell protein expression of in vitro farm-dust stimulated and unstimulated cells from allergic asthmatics and healthy controls were measured using mass cytometry. Analysis of innate and adaptive cellular proportions (linear regression) and T-cell proliferation was performed. Functional marker intensity was investigated using Earth Mover's Distance and the Monte Carlo permutation test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Farm-dust stimulation induced cell type-specific regulation: Key-features of farm-dust stimulation comprised opposing regulation of immune-cell frequencies (downregulated innate cell populations (monocytes/DCs (<i>p</i> &lt; .001), NK-cells (<i>p</i> &lt; .05)) and upregulated adaptive populations (B-cells, CD4⁺ T-cells (both <i>p</i> &lt; .05)), reduced CD4⁺ CD25⁻ T-cell proliferation, and differential cell type-specific functional marker expression. Following stimulation, functional marker analysis revealed induced activation (CD25) in T-cells and NK-T-cells in both phenotypes even after correction for multiple testing. Cytotoxicity (GZMB) and inflammation (pERK1/2, pp38) related markers were reduced in T-cells exclusively in asthmatic children. Asthma-associated markers (Gata3, RORγ, and HLA-DR) were reduced in T- and innate- cell populations of asthmatics following stimulation. B-cells displayed a phenotypically independent increase of diverse functional markers upon farm-dust stimulation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study mimicking in vivo environmental exposure identified a novel profile of immune-regulatory markers using mass cytometry demonstrating decreased asthma-associated markers following farm-dust stimulation. These findings may be key for further studies on asthma prevention in childhood.</p>\u0000 </section>\u0000 </div>","PeriodicalId":122,"journal":{"name":"Allergy","volume":"79 11","pages":"3022-3035"},"PeriodicalIF":12.6,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.16347","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142436127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting the IL-5 pathway in eosinophilic asthma: A comparison of anti-IL-5 versus anti-IL-5 receptor agents","authors":"David J. Jackson,&nbsp;Michael E. Wechsler,&nbsp;Guy Brusselle,&nbsp;Roland Buhl","doi":"10.1111/all.16346","DOIUrl":"10.1111/all.16346","url":null,"abstract":"<p>Eosinophilic asthma is characterized by frequent exacerbations, poor symptom control and accelerated lung function decline. It is now recognized that the immune response underlying eosinophilic asthma involves a complex network of interconnected pathways from both the adaptive and innate immune systems. Within this response, interleukin-5 (IL-5) plays a central role in eosinophil differentiation, activation and survival and has emerged as a key target for therapies treating severe asthma. The monoclonal antibodies mepolizumab and reslizumab target the ligand IL-5, preventing its interaction with eosinophils; in contrast, benralizumab binds to the IL-5 receptor (IL-5R), preventing IL-5 from binding and leading to substantially greater eosinophil reduction by enhanced antibody-dependent cell-mediated cytotoxicity. Although no direct head-to-head clinical trials of asthma have been published to formally evaluate the clinical significance of these different therapeutic approaches, the potential benefits of partial versus complete eosinophil depletion continue to remain an important area of study and debate. Here, we review the existing real-world and clinical study data of anti-IL-5/anti-IL-5R therapies in severe eosinophilic asthma.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":"79 11","pages":"2943-2952"},"PeriodicalIF":12.6,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.16346","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142431116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The developing immune system in preterm born infants: From contributor to potential solution for respiratory tract infections and wheezing","authors":"Inger C. van Duuren,&nbsp;Oscar R. J. van Hengel,&nbsp;John Penders,&nbsp;Liesbeth Duijts,&nbsp;Hermelijn H. Smits,&nbsp;Gerdien A. Tramper-Stranders","doi":"10.1111/all.16342","DOIUrl":"10.1111/all.16342","url":null,"abstract":"<p>Moderate-late preterm-born infants experience more frequent and severe respiratory tract infections and wheezing compared to term-born infants. Decreasing the risk on respiratory tract infections and wheezing in this group is vital to improve quality of life and reduce medical consumption during infancy, but also to reduce the risk on asthma and COPD later in life. Until now, moderate-late preterm infants are underrepresented in research and mechanisms underlying their morbidity are largely unknown, although they represent 80% of all preterm-born infants. In order to protect these infants effectively, it is essential to understand the role of the immune system in early life respiratory health and to identify strategies to optimize immune development and respiratory health. This review elaborates on risk factors and preventative measures concerning respiratory tract infections and wheezing in preterm-born infants, exploring their impact on the immune system and microbiome. Factors discussed are early life antibiotic use, birth mode, feeding type and living environment. Further, differences in adaptive and innate immune maturation between term and preterm infants are discussed, as well as differences in local immune reactions in the lungs. Finally, preventative strategies are being explored, including microbiota transplantation, immune modulation (through pre-, pro-, syn- and postbiotics, bacterial lysates, vaccinations, and monoclonal antibodies) and antibiotic prophylaxis.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":"79 11","pages":"2924-2942"},"PeriodicalIF":12.6,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.16342","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142386567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}