Allergy最新文献

{"title":"Why Anti–IL‐17 Therapy Fails: The Role of Autonomous IL‐17R Signaling in Autoimmune Inflammation","authors":"Fabio S. Ryser, Joseena Iype, Lisa Christ","doi":"10.1111/all.16487","DOIUrl":"https://doi.org/10.1111/all.16487","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"53 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143056774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Mental Health Symptoms in Chronic Urticaria: A Systematic Review and Meta-Analysis.","authors":"Daniel G Rayner, David Gou, Laura Weiler, Lola Irelewuyi, Grace Xiong, Elaine Wang, Tresha Sivanesanathan","doi":"10.1111/all.16482","DOIUrl":"https://doi.org/10.1111/all.16482","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143050944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Complex Nomenclature of Allergic Diseases and Hypersensitivity Reactions: An Addendum to the EAACI Position Paper.","authors":"Andrea Szegedi, Zsolt I Komlósi, Anikó Kapitány, Zsuzsanna Bata-Csörgő, Gábor Koncz, Attila Bácsi","doi":"10.1111/all.16486","DOIUrl":"https://doi.org/10.1111/all.16486","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143050950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EAACI Clinical and Research Fellowship Program: Shaping the Future of Allergy and Clinical Immunology.","authors":"Ruben Fernandez Santamaria, Aspasia Karavelia, Mattia Giovannini, Leticia De Las Vecillas, Patrizia Bonadonna, Stefano Del Giacco, Oliver Pfaar, Jolanta Walusiak Skorupa, Andre Moreira, Maria Jose Torres, Mohamed Shamji, Oscar Palomares","doi":"10.1111/all.16484","DOIUrl":"https://doi.org/10.1111/all.16484","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MHC Class II-Expressing Mucosal Mast Cells Promote Intestinal Mast Cell Hyperplasia in a Mouse Model of Food Allergy.","authors":"Kenji Oishi, Nobuhiro Nakano, Masamu Ota, Eisuke Inage, Kumi Izawa, Ayako Kaitani, Tomoaki Ando, Mutsuko Hara, Yoshikazu Ohtsuka, Chiharu Nishiyama, Hideoki Ogawa, Jiro Kitaura, Ko Okumura, Toshiaki Shimizu","doi":"10.1111/all.16477","DOIUrl":"https://doi.org/10.1111/all.16477","url":null,"abstract":"<p><strong>Background: </strong>IgE-mediated food allergy is accompanied by mucosal mast cell (MMC) hyperplasia in the intestinal mucosa. Intestinal MMC numbers correlate with the severity of food allergy symptoms. However, the mechanisms by which MMCs proliferate excessively are poorly understood. Here, we clarify the role of newly identified MHC class II (MHCII)-expressing MMCs in the effector phase of IgE-mediated food allergy.</p><p><strong>Methods: </strong>Mice reconstituted with MHCII-deficient or wild-type MMCs were used to generate a mouse mode of IgE-mediated food allergy. We assessed the extent of intestinal MMC hyperplasia and the severity of hypothermia in these mice. In addition, we performed in vitro antigen presentation assay using induced MHCII-expressing MMCs generated from bone marrow cells to evaluate the effect of CD4⁺ T cell activation on MMC proliferation.</p><p><strong>Results: </strong>In food-allergic mice, we identified the appearance of MHCII-expressing MMCs in the intestinal mucosa and showed that MMC hyperplasia was suppressed in mice with MHCII-deficient MMCs compared to mice with wild-type MMCs. In vitro assays demonstrated that MHCII-expressing MMCs incorporate food antigens directly and through the high-affinity IgE receptor FcεRI-mediated endocytosis and activate antigen-specific CD4⁺ T cells from food-allergic mice by antigen presentation. Activated CD4⁺ T cells secrete IL-4 and large amounts of IL-5, which enhance production of the mast cell growth factor IL-9 by IL-33-activated MMCs. Excess IL-9 causes excessive MMC proliferation, leading to the development of MMC hyperplasia.</p><p><strong>Conclusion: </strong>Antigen presentation to CD4⁺ T cells by MHCII-expressing MMCs triggers intestinal MMC hyperplasia and exacerbates IgE-mediated food allergy.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GWAS Identifies CACNA2D3 Associated With Asthma and Atopic Dermatitis Multimorbidity in Children.","authors":"Dong Yun Kim, Soyeon Lee, Jae Hwa Jung, Yujin Sub, Sumin Lee, Eun Gyul Kim, Mi Na Kim, Soo Yeon Kim, Yoon Hee Kim, Myung Hyun Sohn, Heon Yung Gee, Kyung Won Kim","doi":"10.1111/all.16483","DOIUrl":"https://doi.org/10.1111/all.16483","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Long‐Term Exposure to Ambient Air Pollution and the Risk of Recurrent Asthma Hospitalizations","authors":"Jin‐Lun Zhang, Chong‐Ye Zhao, Xiao‐Han Xu, Chen Shi, Hao‐Neng Huang, Yi‐Ming Tao, Li Li, Chun‐Quan Ou","doi":"10.1111/all.16476","DOIUrl":"https://doi.org/10.1111/all.16476","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"22 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Silver (Birch) Bullet for Children With Tree Pollen Allergy: Single Allergen Immunotherapy With Birch Extract Protects Across the Birch Homologous Group Pollen Season","authors":"Eve Denton,&nbsp;Mark Hew,&nbsp;Robyn E. O'Hehir","doi":"10.1111/all.16480","DOIUrl":"10.1111/all.16480","url":null,"abstract":"&lt;p&gt;Allergic rhino-conjunctivitis (ARC) is common in children and markedly impairs quality of life. Children with ARC not only suffer significant morbidity but also face a threefold higher risk of developing asthma [&lt;span&gt;1&lt;/span&gt;]. Tree pollens are a major cause of seasonal ARC in Europe and parts of North America. Significant among these is birch pollen, with sensitisation rates in 14 European countries estimated generally at 24%, but as high as 54% in selected parts of Northern Europe [&lt;span&gt;2, 3&lt;/span&gt;]. In these regions, the birch homologous group (incorporating birch, hazel, alder, hornbeam, and oak) is characterised by Bet v 1-homologous allergens that lead to a high degree of IgE cross-reactivity of the immune response to other tree pollens within the group. This cross-reactivity confers a longer overall pollen season and extends the geographical region triggering symptoms [&lt;span&gt;4&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Due to treatment burden, cost, and potential systemic reactions, allergen immunotherapy (AIT) is generally reserved for non-response to allergen avoidance combined with medical therapy. While symptoms of ARC can be ameliorated with medical therapies, only AIT can modify its natural history. There is also evidence to suggest AIT for ARC can prevent the ‘atopic march’ toward the development of new allergic sensitisations and incident asthma [&lt;span&gt;5&lt;/span&gt;]. Given these considerations, it could be argued that greater consideration should be given to the use of AIT in ARC, particularly in children. However, regarding tree pollen immunotherapy, there is currently a lack of consensus regarding monotherapy with birch pollen extract versus multiple pollen extracts, and consequent regional variation in practice [&lt;span&gt;6&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Investigations of sublingual immunotherapy (SLIT) birch pollen tablet (SQ-tree SLIT tablet) have previously culminated in a Phase III Randomised Controlled Trial RCT in 634 allergic individuals, aged 12 and above, which demonstrated efficacy over placebo with the use of 6–9 months of pre- and co-seasonal treatment [&lt;span&gt;7&lt;/span&gt;]. In that study, both adolescents (12–17 years) and adults experienced substantial reductions in symptoms and medication use during birch and tree pollen seasons.&lt;/p&gt;&lt;p&gt;In this issue of Allergy, Gappa et al. [&lt;span&gt;8&lt;/span&gt;] report their results from a paediatric Phase III RCT of pre- and co-seasonal birch pollen SLIT versus placebo in 952 children and adolescents (5–17 years) in Europe and North America with moderate to severe seasonal AR due to birch pollen allergy. This is the first large, double-blind Phase III RCT in a paediatric population with tree pollen SLIT (Table 1 provides a comparison of this trial to previous randomised studies). The primary outcome was positive, with the trial finding a significantly greater improvement in combined symptom and medication-use scores with AIT compared to placebo during the birch pollen season. Although primarily focused on clinical outcomes, there were ","PeriodicalId":122,"journal":{"name":"Allergy","volume":"80 3","pages":"647-650"},"PeriodicalIF":12.6,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.16480","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and Safety of Dupilumab for Prurigo Nodularis in China: A Multicentric and Observational Study.","authors":"Zuotao Zhao,Xiaoting Song,Yuanyuan Shang,Lijuan Liu,Rui Zheng,Jianxin Xia,Qiang Liu,Guodong Hao,Jie Li,Songmei Geng,Jingang An,Qiang Wang,Xiaoyan Liu,Jianping Tang,Yizhu Xiao,Litao Zhang","doi":"10.1111/all.16478","DOIUrl":"https://doi.org/10.1111/all.16478","url":null,"abstract":"BACKGROUNDThe efficacy and safety of dupilumab in patients with refractory prurigo nodularis (PN) is well established in clinical trials, but there is a lack of multicenter data regarding its effectiveness and safety in real-world settings.METHODSPatients with moderate-to-severe PN who initiated dupilumab treatment between July 2023 and January 2024, with a follow-up period of at least 16 weeks at 10 hospitals in China were included. We used peak pruritus numeric rating scale (PP-NRS), investigator global assessment (IGA) for PN, and dermatology life quality index for adults or children (DLQI/CDLQI) to assess disease control status and quality of life impairment, and monitored adverse events to assess the safety.RESULTSA total of 73 PN patients (33 female, 40 male; mean age 45.9 ± 21.5 years) were included. A clinically meaningful improvement of ≥ 4 points in PP-NRS (PP-NRS4) was achieved in 84.9% of patients at Week 12. The percentage of patients achieving IGA 0/1 significantly increasing from 0% to 37.0% and 46.6% at Week 12 and 16, respectively. Patient-reported quality of life outcomes showed substantial improvement, with decreasing from 16.6 ± 6.8 at baseline to 7.2 ± 4.9 at Week 12, 6.4 ± 4.5 at Week 16. The safety profile of dupilumab was favorable, with one patient reporting dry eyes.CONCLUSIONDupilumab can effectively improve the pruritus, nodular lesions and quality of life for PN in real-world settings.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"74 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recombinant IgE-Reactive Functional Can f 5 Devoid of Cross-Reactive Carbohydrate Determinants.","authors":"Evgenii Kozlov,Daria Trifonova,Alexandra Dubovets,Anastasia Usanova,Inna Tulaeva,Pia Gattinger,Daria Fomina,Wolfgang Hemmer,Neonila Gorokhovets,Rudolf Valenta,Alexander Karaulov","doi":"10.1111/all.16465","DOIUrl":"https://doi.org/10.1111/all.16465","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"46 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}