Systematic Review and Meta-Analysis of Oral Immunotherapy Effect on Food Allergy-Related Quality of Life

IF 12 1区医学 Q1 ALLERGY

Allergy Pub Date : 2025-09-08 DOI:10.1111/all.70046

Sophie A. Rosser, Melanie Lloyd, Ping Tang, Audrey M. Walsh, Rachel L. Peters, Rushani Wijesuriya, Catherine J. Hornung, Jennifer J. Koplin, Amalia Karahalios, Mimi L. K. Tang

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引用次数: 0

Abstract

Background

Uncertainty exists regarding the health-related quality of life (HRQL) benefits of food allergen oral immunotherapy (OIT). Up-to-date meta-analyses incorporating HRQL data from recent randomised trials are lacking.

Methods

Systematic searches of MEDLINE, Embase, CENTRAL and Google Scholar were conducted for food OIT randomised trials (versus any comparator) that measured HRQL with a validated instrument (27 July 2023). Hedges' g standardised mean differences in HRQL between OIT and comparator were analysed by allergen, reporting perspective, and treatment/post-treatment periods, and synthesised using random-effects meta-analysis models when results from multiple trials were available.

Results

Ten trials (nine peanut, one baked milk; N = 1330) were included. No between-group differences were observed in parent-reported child HRQL (g = −0.07, 95% CI: −0.19 to 0.04, 9 trials, N = 1259), self-reported child HRQL (g = −0.23, 95% CI: −0.73 to 0.27, 5 trials, N = 435), or self-reported teenager HRQL (g = 0.00, 95% CI: −0.41 to 0.40, 3 trials, N = 209) during peanut OIT treatment. However, 12 months post-treatment, improved parent-reported child HRQL was observed (g = −0.51, 95% CI: −0.84 to −0.19, 3 comparisons from 2 trials, N = 213). No between-group differences were observed in the baked milk OIT trial in children (g = 0.118, 95% CI: −0.63 to 0.87, N = 26).

Conclusion

HRQL benefits were observed after OIT protocol completion, with limited evidence of benefit during active treatment.

Abstract Image

查看原文本刊更多论文

口服免疫治疗对食物过敏相关生活质量影响的系统评价和荟萃分析。

背景：食物过敏原口服免疫疗法（OIT）对健康相关生活质量（HRQL）的益处尚不确定。缺乏纳入近期随机试验HRQL数据的最新荟萃分析。方法系统检索MEDLINE、Embase、CENTRAL和谷歌Scholar中使用验证仪器测量HRQL的食品OIT随机试验（与任何比较物相比）（2023年7月27日）。按过敏原、报告角度和治疗/治疗后时间对OIT和比较组之间的标准化平均HRQL差异进行分析，并在多个试验结果可用时使用随机效应荟萃分析模型进行综合。结果共纳入10个试验（9个花生试验，1个烤牛奶试验，N = 1330）。在花生油浸出治疗期间，父母报告的儿童HRQL （g = -0.07, 95% CI: -0.19至0.04,9项试验，N = 1259）、自我报告的儿童HRQL （g = -0.23, 95% CI: -0.73至0.27,5项试验，N = 435）或自我报告的青少年HRQL （g = 0.00, 95% CI: -0.41至0.40,3项试验，N = 209）均无组间差异。然而，治疗后12个月，观察到父母报告的儿童HRQL改善（g = -0.51, 95% CI: -0.84至-0.19,2项试验的3个比较，N = 213）。在儿童烘焙牛奶OIT试验中没有观察到组间差异（g = 0.118, 95% CI: -0.63 ~ 0.87, N = 26）。结论：在OIT方案完成后观察到hrql获益，在积极治疗期间获益的证据有限。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Allergy 医学-过敏

CiteScore

26.10

自引率

9.70%

发文量

393

审稿时长

2 months

期刊介绍： Allergy is an international and multidisciplinary journal that aims to advance, impact, and communicate all aspects of the discipline of Allergy/Immunology. It publishes original articles, reviews, position papers, guidelines, editorials, news and commentaries, letters to the editors, and correspondences. The journal accepts articles based on their scientific merit and quality. Allergy seeks to maintain contact between basic and clinical Allergy/Immunology and encourages contributions from contributors and readers from all countries. In addition to its publication, Allergy also provides abstracting and indexing information. Some of the databases that include Allergy abstracts are Abstracts on Hygiene & Communicable Disease, Academic Search Alumni Edition, AgBiotech News & Information, AGRICOLA Database, Biological Abstracts, PubMed Dietary Supplement Subset, and Global Health, among others.