Impact of Residential Greeness Exposure on the Development of Allergic Diseases and Asthma and on Asthma Control—A Systematic Review for the EAACI Guidelines of Environmental Science for Allergic Diseases and Asthma

IF 12.6 1区医学 Q1 ALLERGY

Allergy Pub Date : 2025-07-09 DOI:10.1111/all.16653

Ioana Agache, Graciela J. Balbin‐Ramon, Fiorella Karina Fernandez Saenz, Ivan Sola‐Arnau, Pablo Alonso‐Coello, Tari Haahtela, Claudia Traidl‐Hoffmann, Liam O'Mahony, Athanasios Damialis, Antti Lauerma, Kari C. Nadeau, Isabella Pali‐Schöll, Oscar Palomares, Harald Renz, Jurgen Schwarze, Donata Vercelli, Carlos Canelo‐Aybar, Marek Jutel, Cezmi A. Akdis

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引用次数: 0

Abstract

The role of residential greenness exposure (RGE) in prevention and control of allergic diseases remains controversial. This systematic review evaluated the association between RGE and the risk of developing asthma, allergic rhinitis (AR), food allergy, atopic dermatitis (AD), and asthma control. MEDLINE and EMBASE searches retrieved 17 cohort and case–control longitudinal studies (12 for asthma, 6 AR, 1 food allergy, 1 ad). Risk of bias was assessed with ROBINS‐E, and certainty of evidence with GRADE. Data were meta‐analyzed using adjusted odds ratios (aORs) with random‐effects models. For “ever asthma” and “ever AR” a non‐significant protective trend of RGE was observed (aOR 0.92, 95% CI 0.72–1.18; aOR 0.61; 95% CI 0.24–1.55). For “current asthma” RGE was associated with increased risk (aOR 1.17, 95% CI 1.04–1.33), with no clear association for “current AR” (aOR 1.03; 95% CI 0.80–1.32). Prenatal RGE reduced the risk of “ever asthma” (aOR 0.94, 95% CI 0.93–0.950) and AD (aOR 0.996, 95% CI 0.993–0.999). RGE increased the risk for peanut (aOR 1.78, 95% CI 1.13–2.82) and egg allergy (aOR 1.38, 95% CI [1.05–1.82]). Reduced RGE decreased asthma control (OR: 2.662, 95% CI [1.043–6.799]). Potential benefits or potential harms of RGE should be judged in a context‐specific manner.

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住宅绿化暴露对变态反应性疾病和哮喘发展及哮喘控制的影响——EAACI变态反应性疾病和哮喘环境科学指南系统综述

住宅绿化暴露（RGE）在预防和控制过敏性疾病中的作用仍然存在争议。本系统综述评估了RGE与哮喘、变应性鼻炎（AR）、食物过敏、特应性皮炎（AD）和哮喘控制风险之间的关系。MEDLINE和EMBASE检索检索了17项队列和病例对照纵向研究（12项哮喘，6项AR， 1项食物过敏，1项ad）。用ROBINS‐E评估偏倚风险，用GRADE评估证据的确定性。使用随机效应模型调整优势比（aORs）对数据进行meta分析。对于“曾经哮喘”和“曾经AR”，观察到RGE的非显著保护趋势(aOR 0.92, 95% CI 0.72-1.18；优势比0.61;95% ci 0.24-1.55)。对于“当前哮喘”，RGE与风险增加相关（aOR 1.17, 95% CI 1.04-1.33），与“当前AR”无明显关联(aOR 1.03；95% ci 0.80-1.32)。产前RGE降低了“永远哮喘”（aOR 0.94, 95% CI 0.93-0.950）和AD （aOR 0.996, 95% CI 0.993-0.999）的风险。RGE增加了花生过敏（aOR 1.78, 95% CI 1.13-2.82）和鸡蛋过敏（aOR 1.38, 95% CI[1.05-1.82]）的风险。RGE降低可降低哮喘控制（OR: 2.662, 95% CI[1.043-6.799]）。RGE的潜在益处或潜在危害应根据具体情况进行判断。

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来源期刊

Allergy 医学-过敏

CiteScore

26.10

自引率

9.70%

发文量

393

审稿时长

2 months

期刊介绍： Allergy is an international and multidisciplinary journal that aims to advance, impact, and communicate all aspects of the discipline of Allergy/Immunology. It publishes original articles, reviews, position papers, guidelines, editorials, news and commentaries, letters to the editors, and correspondences. The journal accepts articles based on their scientific merit and quality. Allergy seeks to maintain contact between basic and clinical Allergy/Immunology and encourages contributions from contributors and readers from all countries. In addition to its publication, Allergy also provides abstracting and indexing information. Some of the databases that include Allergy abstracts are Abstracts on Hygiene & Communicable Disease, Academic Search Alumni Edition, AgBiotech News & Information, AGRICOLA Database, Biological Abstracts, PubMed Dietary Supplement Subset, and Global Health, among others.