International Journal of Cancer最新文献

Associations of plasma omega-6 and omega-3 fatty acids with overall and 19 site-specific cancers: A population-based cohort study in UK Biobank. 血浆中欧米茄-6 和欧米茄-3 脂肪酸与总体癌症和 19 种特定部位癌症的关系：英国生物库的一项人群队列研究。

IF 5.7 2区医学

International Journal of Cancer Pub Date : 2025-03-15 Epub Date: 2024-10-17 DOI: 10.1002/ijc.35226

Yuchen Zhang, Yitang Sun, Suhang Song, Nikhil K Khankari, J Thomas Brenna, Ye Shen, Kaixiong Ye

{"title":"Associations of plasma omega-6 and omega-3 fatty acids with overall and 19 site-specific cancers: A population-based cohort study in UK Biobank.","authors":"Yuchen Zhang, Yitang Sun, Suhang Song, Nikhil K Khankari, J Thomas Brenna, Ye Shen, Kaixiong Ye","doi":"10.1002/ijc.35226","DOIUrl":"10.1002/ijc.35226","url":null,"abstract":"Previous epidemiological studies on the associations between polyunsaturated fatty acids (PUFAs) and cancer incidence have been inconsistent. We investigated the associations of plasma omega-3 and omega-6 PUFAs with the incidence of overall and 19 site-specific cancers in a large prospective cohort. 253,138 eligible UK Biobank participants were included in our study. With a mean follow-up of 12.9 years, 29,838 participants were diagnosed with cancer. The plasma levels of omega-3 and omega-6 PUFAs were expressed as percentages of total fatty acids (omega-3% and omega-6%). In our main models, both omega-6% and omega-3% were inversely associated with overall cancer incidence (HR per SD = 0.98, 95% CI = 0.96-0.99; HR per SD = 0.99, 95% CI = 0.97-1.00; respectively). Of the 19 site-specific cancers available, 14 were associated with omega-6% and five with omega-3%, all indicating inverse associations, with the exception that prostate cancer was positively associated with omega-3% (HR per SD = 1.03, 95% CI = 1.01-1.05). Our population-based cohort study in UK Biobank indicates small inverse associations of plasma omega-6 and omega-3 PUFAs with the incidence of overall and most site-specific cancers, although there are notable exceptions, such as prostate cancer.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":"1154-1172"},"PeriodicalIF":5.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142454138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Residential exposure to solar ultraviolet radiation and risk of childhood hematological malignancies in Switzerland: A census-based cohort study. 瑞士居民暴露于太阳紫外线辐射与罹患儿童血液恶性肿瘤的风险：基于人口普查的队列研究。

IF 5.7 2区医学

International Journal of Cancer Pub Date : 2025-03-15 Epub Date: 2024-10-12 DOI: 10.1002/ijc.35214

Astrid Coste, Christian Kreis, Claudine Backes, Jean-Luc Bulliard, Christophe Folly, Eva Brack, Raffaele Renella, David Vernez, Ben D Spycher

{"title":"Residential exposure to solar ultraviolet radiation and risk of childhood hematological malignancies in Switzerland: A census-based cohort study.","authors":"Astrid Coste, Christian Kreis, Claudine Backes, Jean-Luc Bulliard, Christophe Folly, Eva Brack, Raffaele Renella, David Vernez, Ben D Spycher","doi":"10.1002/ijc.35214","DOIUrl":"10.1002/ijc.35214","url":null,"abstract":"Still little is known about possible environmental risk factors of childhood hematological malignancies (CHM). Previous studies suggest that ultraviolet radiation (UVR) exposure is associated with a lower risk of acute lymphoblastic leukemia (ALL) in children. We investigated the association between solar UVR exposure and risk of CHM in Switzerland, a country with greatly varying topography and weather conditions. We included all resident children aged 0-15 years from the Swiss National Cohort during 1990-2016 and identified incident cancer cases through probabilistic record linkage with the Swiss Childhood Cancer Registry. We estimated the overall annual mean UV level and the mean level for the month of July during 2004-2018 at children's homes using a climatological model of the midday (11 am-3 pm) UV-index (UVI) with a spatial resolution of 1.5-2 km. Using risk-set sampling, we obtained a nested case-control data set matched by birth year and fitted conditional logistic regression models (virtually equivalent to analyzing full cohort data using proportional hazards models) adjusting for sex, neighborhood socio-economic position, urbanization, air pollution, and background ionizing radiation. Our analyses included 1446 cases of CHM. Estimated adjusted hazard ratios (HR) per unit increase in UVI in July were 0.76 (95% CI 0.59-0.98) for leukemia and 0.74 (0.55-0.98) for ALL. Results for annual exposure were similar but confidence intervals were wider and included one. We found no evidence for an association for lymphoma overall (HR 1.14, 95% CI 0.59-2.19 for annual exposure) or diagnostic subgroups. Our study provides further support for an inverse association between exposure to ambient solar UVR and childhood ALL.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":"1121-1130"},"PeriodicalIF":5.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142454247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Latent class analysis-derived classification improves the cancer-specific death stratification of lymphomas: A large retrospective cohort study. 潜类分析衍生分类改善了淋巴瘤的癌症特异性死亡分层：一项大型回顾性队列研究。

IF 5.7 2区医学

International Journal of Cancer Pub Date : 2025-03-15 Epub Date: 2024-10-12 DOI: 10.1002/ijc.35219

Xiaojie Liang, Yuzhe Wu, Weixiang Lu, Tong Li, Dan Liu, Bingyu Lin, Xinyu Zhou, Zhihao Jin, Baiwei Luo, Yang Liu, Shengyu Tian, Liang Wang

{"title":"Latent class analysis-derived classification improves the cancer-specific death stratification of lymphomas: A large retrospective cohort study.","authors":"Xiaojie Liang, Yuzhe Wu, Weixiang Lu, Tong Li, Dan Liu, Bingyu Lin, Xinyu Zhou, Zhihao Jin, Baiwei Luo, Yang Liu, Shengyu Tian, Liang Wang","doi":"10.1002/ijc.35219","DOIUrl":"10.1002/ijc.35219","url":null,"abstract":"Lymphomas have diverse etiologies, treatment approaches, and prognoses. Accurate survival estimation is challenging for lymphoma patients due to their heightened susceptibility to non-lymphoma-related mortality. To overcome this challenge, we propose a novel lymphoma classification system that utilizes latent class analysis (LCA) and incorporates demographic and clinicopathological factors as indicators. We conducted LCA using data from 221,812 primary lymphoma patients in the Surveillance, Epidemiology, and End Results (SEER) database and identified four distinct LCA-derived classes. The LCA-derived classification efficiently stratified patients, thereby adjusting the bias induced by competing risk events such as non-lymphoma-related death. This remains effective even in cases of limited availability of cause-of-death information, leading to an enhancement in the accuracy of lymphoma prognosis assessment. Additionally, we validated the LCA-derived classification model in an external cohort and observed its improved prognostic stratification of molecular subtypes. We further explored the molecular characteristics of the LCA subgroups and identified potential driver genes specific to each subgroup. In conclusion, our study introduces a novel LCA-based lymphoma classification system that provides improved prognostic prediction by accounting for competing risk events. The proposed classification system enhances the clinical relevance of molecular subtypes and offers insights into potential therapeutic targets.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":"1131-1141"},"PeriodicalIF":5.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142454243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic potential of targeting the FLNA-regulated Wee1 kinase in adrenocortical carcinomas. 肾上腺皮质癌中以 FLNA 调节的 Wee1 激酶为靶点的治疗潜力。

IF 5.7 2区医学

International Journal of Cancer Pub Date : 2025-03-15 Epub Date: 2024-11-11 DOI: 10.1002/ijc.35239

Emanuela Esposito, Giusy Marra, Rosa Catalano, Sara Maioli, Emma Nozza, Anna Maria Barbieri, Constanze Hantel, Guido Di Dalmazi, Sandra Sigala, Jens Geginat, Elisa Cassinotti, Ludovica Baldari, Serena Palmieri, Alessandra Mangone, Alfredo Berruti, Emanuele Ferrante, Giovanna Mantovani, Erika Peverelli

{"title":"Therapeutic potential of targeting the FLNA-regulated Wee1 kinase in adrenocortical carcinomas.","authors":"Emanuela Esposito, Giusy Marra, Rosa Catalano, Sara Maioli, Emma Nozza, Anna Maria Barbieri, Constanze Hantel, Guido Di Dalmazi, Sandra Sigala, Jens Geginat, Elisa Cassinotti, Ludovica Baldari, Serena Palmieri, Alessandra Mangone, Alfredo Berruti, Emanuele Ferrante, Giovanna Mantovani, Erika Peverelli","doi":"10.1002/ijc.35239","DOIUrl":"10.1002/ijc.35239","url":null,"abstract":"Filamin A (FLNA) is poorly expressed in adrenocortical carcinomas (ACC) compared to adenomas (ACA). Its presence is associated to a less aggressive tumour behaviour, potentially due to its role in negatively regulating IGF1R signalling. Upregulation of G2/M Wee1 kinase was shown in FLNA-deficient mouse neural progenitor cells, and it has been reported in several tumours. This study explored Wee1 expression in ACC and its regulation by FLNA, the effects of Wee1 inhibitor AZD1775, and the impact of FLNA on its efficacy in ACC cell lines and primary cells. Analysis of FLNA and Wee1 proteins revealed elevated Wee1 and reduced FLNA in ACC compared to normal adrenal gland. FLNA knockdown increased Wee1 protein in NCI-H295R, MUC-1, and in primary ACC cells. Higher p-CDK1 and cyclin B1 were shown in FLNA-silenced MUC-1, while decreased Wee1, p-CDK1 and cyclin B1 resulted after FLNA overexpression. Wee1 reduction was reverted by lactacystin treatment and FLNA transfection increased p-Wee1 (Ser123), suggesting FLNA's role in targeting Wee1 for degradation. AZD1775 dose-dependently reduced proliferation and viability in ACC cell lines and primary cultures, and it triggered MUC-1 cell death. Similar effects were induced by Wee1 silencing. FLNA depletion augmented AZD1775's efficacy in reducing proliferation and potentiating apoptosis in MUC-1 and primary cells. In conclusion, we demonstrated that FLNA regulates Wee1 expression by promoting its degradation, suggesting that low FLNA typical of ACC leads to increased Wee1 with consequent cancer cells growth. It proposes Wee1 inhibition as a new potential therapeutic approach for ACC, particularly for those lacking FLNA.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":"1256-1271"},"PeriodicalIF":5.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mammographic density and breast cancer risk among Black American women. 美国黑人妇女的乳腺密度与乳腺癌风险。

IF 5.7 2区医学

International Journal of Cancer Pub Date : 2025-03-15 Epub Date: 2024-10-19 DOI: 10.1002/ijc.35223

Etienne X Holder, Zahna Bigham, Kerrie P Nelson, Mollie E Barnard, Julie R Palmer, Kimberly A Bertrand

{"title":"Mammographic density and breast cancer risk among Black American women.","authors":"Etienne X Holder, Zahna Bigham, Kerrie P Nelson, Mollie E Barnard, Julie R Palmer, Kimberly A Bertrand","doi":"10.1002/ijc.35223","DOIUrl":"10.1002/ijc.35223","url":null,"abstract":"High mammographic density is a well-established risk factor for breast cancer; however, data from Black women are limited. It is largely unknown how mammographic density is associated with breast cancer subtypes among Black women. We examined the association between percent mammographic density (PMD) and breast cancer risk among participants in the Black Women's Health Study. Digital screening mammograms were available for 363 cases and 5541 non-cases. Cumulus software was used to assess PMD. We used inverse probability of sampling weights and Cox proportional hazards models, adjusted for age and body mass index, to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) overall and by age at mammography and estrogen receptor (ER) status of the breast tumors. Multivariable models included additional breast cancer risk factors. Tests of statistical significance were 2-sided. In simple models, women in the highest quartile of PMD had 53% increased odds of breast cancer compared to those in the lowest quartile (HR 1.53; 95% CI: 1.11, 2.11). HRs were 1.37 (95% CI: 0.83, 2.24) among women <55 years of age and 1.68 (95% CI: 1.10, 2.56) among women aged ≥55 years. HRs were 1.49 (95% CI: 1.02, 2.16) for ER+ cancer and 1.45 (95% CI: 0.73, 2.87) for ER- cancer. Associations were largely unchanged in multivariable models. In this study of U.S. Black women, higher PMD was associated with ER+ and ER- breast cancer risk. Findings from this study reinforce the importance of breast density as a risk factor for breast cancer in Black women.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":"1173-1180"},"PeriodicalIF":5.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11738672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142454245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of radiotherapy receipt with lung cancer risk by histological subtype among breast cancer survivors in the United States. 按组织学亚型划分的美国乳腺癌幸存者接受放射治疗与肺癌风险的关系。

IF 5.7 2区医学

International Journal of Cancer Pub Date : 2025-03-15 Epub Date: 2024-11-13 DOI: 10.1002/ijc.35257

Chenxi Jiang, Rachel A Freedman, Rinaa S Punglia, Ahmedin Jemal, Hyuna Sung

{"title":"Associations of radiotherapy receipt with lung cancer risk by histological subtype among breast cancer survivors in the United States.","authors":"Chenxi Jiang, Rachel A Freedman, Rinaa S Punglia, Ahmedin Jemal, Hyuna Sung","doi":"10.1002/ijc.35257","DOIUrl":"10.1002/ijc.35257","url":null,"abstract":"Radiotherapy for breast cancer has been associated with an increased risk of secondary malignancies, including primary lung cancer. Whether this association varies by histological subtype of lung cancer remains unknown. Based on the data from 12 Surveillance, Epidemiology, and End Results registries, we examined the association between radiotherapy receipt and the risk of subtype-specific subsequent primary lung cancer (SPLC) among female first primary breast cancer cases diagnosed between ages 20 and 84 from 1992 to 2020. More than half (53%) of the 550,007 breast cancer survivors identified had undergone radiotherapy as part of their initial breast cancer treatment. Over an average follow-up of 9.7 years, 8014 survivors developed SPLCs. For small-cell carcinoma, the standardized incidence ratio (SIR) compared with the general population was higher for survivors who received radiotherapy (SIR = 1.15, 95% confidence interval [CI] = 1.06-1.25) but similar for those who did not receive radiotherapy (SIR = 1.00, 95% CI = 0.91-1.09), with the difference in SIRs being statistically significant (p = .003). Similar associations were found for squamous cell carcinoma (SIRyes = 1.16, 95% CI = 1.08-1.24 vs. SIRno/unknown = 1.06, 95% CI = 0.98-1.15; p = .07). The increased risks were confined to ipsilateral SPLC, with the greatest SIRs for small-cell carcinoma occurring 5-10 years since breast cancer diagnosis (SIR = 1.83, 95% CI = 1.53-2.19) and for squamous cell carcinoma with a latency of 10 years or more (SIR = 1.64, 95% CI = 1.42-1.88). In contrast, the risk of developing adenocarcinoma did not vary by radiotherapy receipt (SIRyes = 1.23, 95% CI = 1.18-1.28 vs. SIRno/unknown = 1.17, 95% CI = 1.12-1.22; p = .18), indicating additional risk factors in play. The findings suggest a distinct carcinogenic pathway of radiation-induced lung cancer across histological subtypes and may inform risk-stratified surveillance guidelines for SPLC.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":"1114-1120"},"PeriodicalIF":5.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Tumor deposits should not be placed in the M category of TNM: A comparative survival analysis using SEER data". 就 "肿瘤沉积不应归入 TNM 的 M 类：利用 SEER 数据进行的生存比较分析 "发表评论。

IF 5.7 2区医学

International Journal of Cancer Pub Date : 2025-03-15 Epub Date: 2024-11-11 DOI: 10.1002/ijc.35256

Chong-Jie Zhang

引用次数: 0

Cancers attributable to diet in Italy. 意大利可归因于饮食的癌症。

IF 5.7 2区医学

International Journal of Cancer Pub Date : 2025-03-15 Epub Date: 2024-10-24 DOI: 10.1002/ijc.35227

Federica Turati, Gianfranco Alicandro, Giulia Collatuzzo, Claudio Pelucchi, Matteo Malvezzi, Fabio Parazzini, Eva Negri, Paolo Boffetta, Carlo La Vecchia, Matteo Di Maso

{"title":"Cancers attributable to diet in Italy.","authors":"Federica Turati, Gianfranco Alicandro, Giulia Collatuzzo, Claudio Pelucchi, Matteo Malvezzi, Fabio Parazzini, Eva Negri, Paolo Boffetta, Carlo La Vecchia, Matteo Di Maso","doi":"10.1002/ijc.35227","DOIUrl":"10.1002/ijc.35227","url":null,"abstract":"Cancer burden can be reduced by controlling modifiable risk factors, including diet. We provided an evidence-based assessment of cancer cases and deaths attributable to diet in Italy in 2020. We considered dietary factor-cancer type pairs for which the World Cancer Research Fund/American Institute for Cancer Research - Continuous Update Project reported either 'convincing' or 'probable' evidence of causal association. Relative risks were retrieved from recent meta-analyses and dietary intakes (around 2005) from a national food consumption survey. Sex-specific population attributable fractions (PAFs) were computed by comparing the distribution of dietary intakes in the Italian population against counterfactual scenarios based on dietary recommendations. Using data from national cancer and mortality registries in 2020, we estimated the number of attributable cancer cases and deaths, assuming ~15-year lag period. Unhealthy diet accounted for 6.3% (95% CI: 2.5%-9.9%) of all cancer cases in men and 4.5% (95% CI: 1.7%-7.4%) in women. PAFs of colorectal cancer were 10.5% and 7.0% for any intake of processed meat, 3.3% and 2.0% for high red meat, 4.8% and 4.3% for low dairy products, and 7.9% and 9.0% for low fiber intakes in men and women, respectively. PAFs for low intake of non-starchy vegetables and fruit ranged from 0.8% to 16.5% in men and 0.6%-17.8% in women for cancers of the aerodigestive tract. The estimated cancer burden associated with unfavorable dietary habits in Italy is considerable, but appears lower than for other high-income countries, reflecting the typically Mediterranean diet.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":"1181-1190"},"PeriodicalIF":5.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142491658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HBcrAg is associated with prognosis of hepatitis B virus-related hepatocellular carcinoma in patients after hepatectomy undergoing antiviral therapy. 肝切除术后接受抗病毒治疗的患者中，HBcrAg 与乙肝病毒相关肝细胞癌的预后有关。

IF 5.7 2区医学

International Journal of Cancer Pub Date : 2025-03-15 Epub Date: 2024-10-25 DOI: 10.1002/ijc.35224

Jian Liu, Xiaofeng Zhang, Jianbo Lin, Chun Dai, Zhihao Xie, Xintong Shi, Bin Zhu, Longjiu Cui, Yeye Wu, Yuanming Jing, Xiaohui Fu, Wenlong Yu, Kui Wang, Jun Li

{"title":"HBcrAg is associated with prognosis of hepatitis B virus-related hepatocellular carcinoma in patients after hepatectomy undergoing antiviral therapy.","authors":"Jian Liu, Xiaofeng Zhang, Jianbo Lin, Chun Dai, Zhihao Xie, Xintong Shi, Bin Zhu, Longjiu Cui, Yeye Wu, Yuanming Jing, Xiaohui Fu, Wenlong Yu, Kui Wang, Jun Li","doi":"10.1002/ijc.35224","DOIUrl":"10.1002/ijc.35224","url":null,"abstract":"Serum hepatitis B core-related antigen (HBcrAg) is considered a surrogate marker of the amount and activity of intrahepatic covalently closed circular DNA. This study aimed to explore the prognostic value of HBcrAg on patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after curative hepatectomy undergoing antiviral therapy (AVT). Data of 949 consecutive patients with HBV-related HCC undergoing curative resection between 2010 and 2013 were reviewed. Serum HBcrAg levels were measured at surgery (baseline) for all patients and at the time of 2 years postoperatively (on-treatment) for those without recurrence. Primary endpoint was tumor recurrence. High HBcrAg levels are associated with malignant phenotypes. HBcrAg independently affected both recurrence and overall survival (OS) in patients with negative hepatitis B e antigen (HBeAg-, p = .007 and p = .042, respectively) but not in their positive HBeAg (HBeAg+) counterparts (p = .100 and p = .075, respectively). Patients with high baseline HBcrAg had higher late, but not early recurrence rates than those with low baseline HBcrAg levels, regardless of HBeAg status (HBeAg+: p = .307 for early, p = .001 for late; HBeAg-: p = .937 for early, p < .001 for late). On-treatment HBcrAg independently affected late recurrence in patients stratified by both cirrhosis and HBeAg (p < .001 for all). The predictive power of HBcrAg kinetics for late recurrence was better than that of the baseline and on-treatment HBcrAg. High HBcrAg levels during long-term AVT are associated with late recurrence of HCC after hepatectomy. Combining baseline and on-treatment HBcrAg might be valuable in identifying patients at a high risk of relapse and stratifying surveillance strategies postoperatively.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":"1293-1303"},"PeriodicalIF":5.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142491663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A randomized trial of early cardiotoxicity in breast cancer patients receiving postoperative IMRT with or without serial cardiac dose constraints. 一项关于乳腺癌患者术后接受 IMRT（有或无系列心脏剂量限制）时早期心脏毒性的随机试验。

IF 5.7 2区医学

International Journal of Cancer Pub Date : 2025-03-15 Epub Date: 2024-11-05 DOI: 10.1002/ijc.35245

Lu Cao, Dan Ou, Wei-Xiang Qi, Cheng Xu, Ming Ye, Yue-Hua Fang, Mei Shi, Xiao-Bo Huang, Qing Lin, Tong Liu, Gang Cai, Rong Cai, Mei Chen, Yi-Bin Zhang, Xiu-Xiu Su, Xiao-Fang Qian, Kun-Wei Shen, Jia-Yi Chen

{"title":"A randomized trial of early cardiotoxicity in breast cancer patients receiving postoperative IMRT with or without serial cardiac dose constraints.","authors":"Lu Cao, Dan Ou, Wei-Xiang Qi, Cheng Xu, Ming Ye, Yue-Hua Fang, Mei Shi, Xiao-Bo Huang, Qing Lin, Tong Liu, Gang Cai, Rong Cai, Mei Chen, Yi-Bin Zhang, Xiu-Xiu Su, Xiao-Fang Qian, Kun-Wei Shen, Jia-Yi Chen","doi":"10.1002/ijc.35245","DOIUrl":"10.1002/ijc.35245","url":null,"abstract":"Optimal cardiac dose constraints in breast cancer (BC) patients undergoing postoperative intensity-modulated radiation therapy (IMRT) are unclear, although as low as possible is recommended. This trial proposes serial cardiac dose constraint to optimize cardiac safety. Postoperative BC patients eligible for anthracycline/taxanes-based chemotherapy or HER2-targeted therapy were randomized to cardiac safety arm with prespecified mean heart dose (MHD) (≤6 Gy), V30 (≤20%), and V10 (≤50%) constraints, or to a control arm with in-house protocol (mainly MHD ≤8 Gy). The primary endpoint was cumulative incidence of newly onset cardiac events within 1-year post-RT. An exploratory analysis examined the relationship between whole heart dose metrics and those of substructures. Of 199 participants, 93 were in the cardiac safety and 106 in the control arm. The cardiac safety group showed lower MHD, V10, and V30. The 1-year cardiac event incidence was slightly lower in the cardiac safety group (19.4%) compared to controls (24.9%). The LVEF and diastolic dysfunction rates were 0% and 5.4% in the study arm, and 1.9% and 8.8% in the control arm, respectively. The LAD, LV, and RV received the highest doses for left-sided patients. For right-sided patients, RA, RCA, and RV were most irradiated. The MHD, V10, and Dmax of heart significantly correlated with all substructure doses in either laterality. Our study supports the early cardiac safety profile using IMRT in BC patients receiving cardiac-toxic systemic therapy, with serial cardiac dose constraints. Combined constraints on MHD and dose-volume parameters are representative of the cardiac substructure dose.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":"1213-1224"},"PeriodicalIF":5.7,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0