International Journal of Cancer最新文献_第2页

Comments on "Meat Intake and Risk of Gastric and Esophageal Adenocarcinoma in the European Prospective Investigation Into Cancer and Nutrition (EPIC) Study". 对“欧洲癌症和营养前瞻性调查（EPIC）研究中肉类摄入量与胃和食管腺癌的风险”的评论。

IF 4.9 2区医学

International Journal of Cancer Pub Date : 2026-11-01 Epub Date: 2026-08-06 DOI: 10.1002/ijc.70621

Man Sun, Dan Zang, Jun Chen

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Reply to: Comments on "Meat Intake and Risk of Gastric and Esophageal Adenocarcinoma in the European Prospective Investigation Into Cancer and Nutrition (EPIC) Study". 回复：关于“欧洲癌症和营养前瞻性调查（EPIC）研究中肉类摄入量与胃和食管腺癌风险的评论”

IF 4.9 2区医学

International Journal of Cancer Pub Date : 2026-11-01 Epub Date: 2026-08-06 DOI: 10.1002/ijc.70622

Catalina Bonet, Antonio Agudo, Paula Jakszyn

引用次数: 0

Sex Hormone Receptors, HBV Integrations and Their Prognostic Predictive Value Among Hepatocellular Carcinoma Patients. 肝细胞癌患者性激素受体、HBV整合及其预后预测价值

IF 4.9 2区医学

International Journal of Cancer Pub Date : 2026-11-01 Epub Date: 2026-07-03 DOI: 10.1002/ijc.70633

Die He, Xi Zeng, Lei Yin, Yang Liu, Weiping Zhou, Xing Liu, Linghao Zhao

{"title":"Sex Hormone Receptors, HBV Integrations and Their Prognostic Predictive Value Among Hepatocellular Carcinoma Patients.","authors":"Die He, Xi Zeng, Lei Yin, Yang Liu, Weiping Zhou, Xing Liu, Linghao Zhao","doi":"10.1002/ijc.70633","DOIUrl":"10.1002/ijc.70633","url":null,"abstract":"Hepatocellular carcinoma (HCC) related to hepatitis B virus (HBV) infection predominantly affects males, yet few studies have investigated the association between sex hormones and HBV integrations, and their involvement in HCC prognosis. We assessed estrogen receptor alpha (ERα) and androgen receptor (AR) expression via immunohistochemistry on tissue microarrays constructed from 426 HBV-related HCC samples. HBV integration features were determined using HBV-captured sequencing data. Logistic regression models were utilized to evaluate the association between sex hormone receptor expression level and HBV integration features. Cox regression models, combined with machine learning (ML) methods, were implemented to investigate the prognostic value of sex hormone receptors and HBV integrations concerning overall survival. We found high AR expression level was significantly associated with higher HBV integration levels (adjusted odds ratio [aOR] = 1.84, 95% confidence interval [CI]: 1.09-3.11, P for trend = 0.012), TERT integration (aOR = 2.34, 95% CI: 1.16-4.74, P for trend = 0.047), intergenic integration (aOR = 2.25, 95% CI: 1.20-4.24, P for trend = 0.021), and promoter integration (aOR = 1.81, 95% CI: 1.00-3.31, P for trend = 0.034). The inclusion of sex hormone receptors and HBV integrations in the predictive models led to improvements across all performance metrics in the Cox regression analyses (AUC improvement: 0.014 [Training], 0.026 [Validation]) and the ML (AUC improvement: 0.022 [Training]), although a slight deterioration in performance was noted in the ML validation set. The results suggested a relationship between AR expression level and HBV integration events, as well as the potential utility of HBV integration biomarkers and sex hormone receptor profiles in assessing post-surgical prognosis among HCC patients.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":"2347-2360"},"PeriodicalIF":4.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148381295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Addition of Concurrent Immune Checkpoint Inhibitors for Chemoradiotherapy With Consolidative Immune Checkpoint Inhibitors in Unresectable Cancers: A Systematic Review and Meta-Analysis. 联合免疫检查点抑制剂对不可切除癌症的放化疗：一项系统综述和荟萃分析

IF 4.9 2区医学

International Journal of Cancer Pub Date : 2026-11-01 Epub Date: 2026-05-14 DOI: 10.1002/ijc.70544

Xu Tong, Zhenting Liu, Xiaoxiang Zhou, Nan Bi, Yibo Gao

{"title":"The Addition of Concurrent Immune Checkpoint Inhibitors for Chemoradiotherapy With Consolidative Immune Checkpoint Inhibitors in Unresectable Cancers: A Systematic Review and Meta-Analysis.","authors":"Xu Tong, Zhenting Liu, Xiaoxiang Zhou, Nan Bi, Yibo Gao","doi":"10.1002/ijc.70544","DOIUrl":"10.1002/ijc.70544","url":null,"abstract":"Following the success of chemoradiotherapy (CRT) combined with consolidative immune checkpoint inhibitors (ICIs) in locally advanced tumors, over 30 ongoing randomized controlled trials (RCTs) are investigating the potential benefits of adding concurrent ICIs. To investigate the differences in efficacy and safety between adding and not adding concurrent ICIs to CRT followed by consolidative ICIs, a literature search was conducted in PubMed, Embase, and the Cochrane Library, incorporating RCTs comparing CRT combined with consolidative ICIs versus CRT alone, or CRT with both concurrent and consolidative ICIs versus CRT alone. The primary outcomes were overall survival (OS) and progression-free survival (PFS). To reduce potential bias, an additional mirror-design analysis was performed through network meta-analysis. A total of 13 RCTs comprising 6868 patients and 14 cohort studies comprising 4724 patients were included. While patients treated with CRT and consolidative ICIs demonstrated significantly superior OS and PFS to patients treated with CRT alone in RCTs (HR of OS, 0.743, 95% CI, 0.654-0.843; HR of PFS, 0.674, 95% CI, 0.577-0.786), CRT and concurrent-plus-consolidative ICIs did not improve OS and PFS compared with CRT alone (HR of OS, 0.942, 95% CI, 0.782-1.134; HR of PFS, 0.880, 95% CI, 0.752-1.030). Significant differences were detected in OS (p = 0.038) and PFS (p = 0.017) between CRT combined with consolidative ICIs treatment versus CRT combined with concurrent and consolidative ICIs treatment from RCTs. In conclusion, adding concurrent ICIs may dampen the survival benefits of CRT combined with consolidative ICIs. This evidence informs future RCT design strategies.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":"2262-2277"},"PeriodicalIF":4.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147939634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Allostatic Load, Genetic Susceptibility, and Liver Cancer Incidence: A Large-Scale Prospective Cohort Study. 适应负荷、遗传易感性和肝癌发病率之间的关系：一项大规模前瞻性队列研究。

IF 4.9 2区医学

International Journal of Cancer Pub Date : 2026-11-01 Epub Date: 2026-07-17 DOI: 10.1002/ijc.70583

Danling Li, Zhongming Zhou, Ganbo Liang, Dongyu Zeng, Zhuoer Zhou, Xinyan Li, Tianchun Qiu, Yanjie Zhang, Jingchao Lin, Yexi Chen, Zhiyang Li

{"title":"Association Between Allostatic Load, Genetic Susceptibility, and Liver Cancer Incidence: A Large-Scale Prospective Cohort Study.","authors":"Danling Li, Zhongming Zhou, Ganbo Liang, Dongyu Zeng, Zhuoer Zhou, Xinyan Li, Tianchun Qiu, Yanjie Zhang, Jingchao Lin, Yexi Chen, Zhiyang Li","doi":"10.1002/ijc.70583","DOIUrl":"10.1002/ijc.70583","url":null,"abstract":"Allostatic load (AL) reflects the cumulative physiological burden of chronic stress throughout life, potentially influencing cancer onset and prognosis. However, its association with primary liver cancer (PLC) risk and potential interaction with genetic susceptibility remains unclear. To investigate this, we analyzed 374,632 UK Biobank participants. AL was evaluated using a composite score of 13 cardiovascular, metabolic, and immune biomarkers, while a weighted polygenic risk score (PRS) categorized genetic susceptibility. Multivariable Cox proportional hazards models and restricted cubic splines were utilized to estimate hazard ratios (HRs) and evaluate dose-response relationships. Over a median 12.4-year follow-up, a significant dose-response correlation between AL and PLC risk was observed. In the fully adjusted model, a 1-unit increase in AL was associated with a 17% increased risk (HR = 1.17, 95% CI: 1.12-1.23), and participants in the highest AL quartile exhibited a 2.60-times higher risk than those in the lowest (HR = 2.60, 95% CI: 1.72-3.95). Despite no multiplicative interaction, stratified analyses revealed AL's impact was most substantial in individuals with intermediate genetic risk (HR = 2.00, 95% CI: 1.38-2.90), who constitute the population majority. Additionally, the risk was heightened in overweight/obese individuals and more pronounced among non-smokers. Ultimately, cumulative physiological stress, indicated by AL, is strongly associated with PLC, supporting the \"wear-and-tear\" theory of its development. This research highlights a \"malleable zone\" in individuals with moderate genetic risk, suggesting that lowering AL may meaningfully aid in preventing PLC.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":"2158-2169"},"PeriodicalIF":4.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148467965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bispecific Antibody-Based Combination Therapies for B-Cell Lymphomas: Current Evidence and Future Perspectives. 基于双特异性抗体的b细胞淋巴瘤联合治疗：目前的证据和未来的展望。

IF 4.9 2区医学

International Journal of Cancer Pub Date : 2026-11-01 Epub Date: 2026-07-01 DOI: 10.1002/ijc.70602

Mo Cheng, Wenke Li, Ming Liu, Liqun Zou

引用次数: 0

Comments on "Artificial Intelligence in Colonoscopy Surveillance for Lynch Syndrome: Emerging Evidence, Lessons Learned From Average-Risk Populations, and Future Directions". 对“Lynch综合征结肠镜监测中的人工智能：新证据、平均风险人群的经验教训和未来方向”的评论。

IF 4.9 2区医学

International Journal of Cancer Pub Date : 2026-11-01 Epub Date: 2026-06-12 DOI: 10.1002/ijc.70603

Zekai Yu, Wei Xiong, Haoyang Hu, Feiwei Qin

引用次数: 0

Systemic Lipid Peroxidation and Colorectal Cancer Risk: A Time-Varying Relationship. 系统性脂质过氧化与结直肠癌风险：一种时变关系。

IF 4.9 2区医学

International Journal of Cancer Pub Date : 2026-11-01 Epub Date: 2026-06-15 DOI: 10.1002/ijc.70585

Gong Yang, Ginger L Milne, Marina S Nogueira, Yu-Tang Gao, Qing Lan, Haoyang Yi, Xiao-Ou Shu, Wei Zheng, Qingxia Chen

{"title":"Systemic Lipid Peroxidation and Colorectal Cancer Risk: A Time-Varying Relationship.","authors":"Gong Yang, Ginger L Milne, Marina S Nogueira, Yu-Tang Gao, Qing Lan, Haoyang Yi, Xiao-Ou Shu, Wei Zheng, Qingxia Chen","doi":"10.1002/ijc.70585","DOIUrl":"10.1002/ijc.70585","url":null,"abstract":"Despite widespread interest, large randomized controlled trials have failed to demonstrate chemopreventive benefits of antioxidant supplementation, raising concerns about its efficacy and safety. Building on our prior observation of a time-dependent inverse association between systemic oxidative stress (OxS), assessed using nucleic acid oxidation biomarkers, and colorectal cancer (CRC) risk, we extended this investigation to systemic lipid peroxidation and evaluated whether a composite OxS index incorporating DNA, RNA, and lipid markers improves risk characterization. We conducted a nested case-control study within two Shanghai cohorts (1938 CRC cases) and replicated findings in a US cohort (285 cases). Systemic lipid peroxidation was assessed using urinary F2-isoprostanes (F2-IsoPs), quantified by UPLC-MS/MS. Conditional logistic regression estimated odds ratios (ORs) for CRC risk. Lower levels of 5-F2t-IsoP, a major F2-IsoP isomer generated exclusively via free radical oxidation, were associated with increased CRC risk in both the primary and replication cohorts. Time-dependent associations were evaluated in the Shanghai cohorts. For CRC diagnosed within 5 years following enrollment, multivariable-adjusted ORs (95% CI) at the 10th and 90th percentiles of 5-F2t-IsoP levels, relative to the median, were 1.57 (1.26-1.96) and 0.61 (0.42-0.89), respectively, indicating a 2.2-fold difference in risk. The composite OxS index showed an even stronger association (3.9-fold difference). No significant associations were observed for diagnoses beyond 5 years. This study provides new evidence that systemic OxS is inversely and time-dependently associated with CRC risk during later stages of disease development, raising concerns that lowering systemic OxS via high-dose antioxidant supplementation potentially carry unintended risks for high-risk individuals.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":"2170-2183"},"PeriodicalIF":4.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148256684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Limb Compression Therapy and Chemotherapy-Induced Peripheral Neuropathy in Women With Gynecologic Cancers: A Prospective Self-Controlled Study(NEURO-GLOVE Trial). 肢体压迫治疗和化疗诱导的女性妇科癌症周围神经病变：一项前瞻性自我对照研究（neuroglove试验）。

IF 4.9 2区医学

International Journal of Cancer Pub Date : 2026-11-01 Epub Date: 2026-06-18 DOI: 10.1002/ijc.70601

Kadriye Başkurt, Galip Can Uyar, Enes Yeşilbaş, Fatma Zehra Altunç, Damla Erimhan Çevik, İsmet Murat Melek, Yasemin Eren, Ömür Berna Çakmak Öksüzoğlu, Kadriye Bir Yücel, Antonio Di Meglio, Isabelle Ray-Coquard, Osman Sütcüoğlu

{"title":"Limb Compression Therapy and Chemotherapy-Induced Peripheral Neuropathy in Women With Gynecologic Cancers: A Prospective Self-Controlled Study(NEURO-GLOVE Trial).","authors":"Kadriye Başkurt, Galip Can Uyar, Enes Yeşilbaş, Fatma Zehra Altunç, Damla Erimhan Çevik, İsmet Murat Melek, Yasemin Eren, Ömür Berna Çakmak Öksüzoğlu, Kadriye Bir Yücel, Antonio Di Meglio, Isabelle Ray-Coquard, Osman Sütcüoğlu","doi":"10.1002/ijc.70601","DOIUrl":"10.1002/ijc.70601","url":null,"abstract":"Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting toxicity of taxane-based chemotherapy with limited preventive options. We evaluated whether dual-site mechanical compression during paclitaxel infusion reduces CIPN in women with gynecologic cancers. In this prospective, intraindividual, self-controlled study, patients receiving carboplatin-paclitaxel underwent compression of the nondominant hand (two surgical gloves) and ipsilateral lower limb (Class II stocking), while contralateral limbs served as controls. CIPN was assessed using CTCAE v5.0 and EORTC QLQ-CIPN20 at baseline, Cycle 3, end of treatment (EOT), and 3- and 6-month follow-up. Among 76 patients (median age, 61 years), moderate-to-severe CIPN was observed less frequently in compression limbs than in control limbs at Cycle 3 (35.5% vs. 53.9%; p = 0.001), EOT (59.2% vs. 69.7%; p = 0.021), 3 months (28.9% vs. 52.6%; p = 0.015), and 6 months (20.3% vs. 33.8%; p = 0.002). Repeated-measures analyzes showed significant time-by-limb interactions for sensory (p = 0.003), lower-extremity sensory (p = 0.018), and motor domains (p = 0.041). Sensory CIPN20 scores were lower in compression limbs in the upper extremities from EOT onward (7.5 vs. 10.2; p < 0.001) and in the lower extremities at 3-month (8.7 vs. 10.7; p < 0.001) and 6-month follow-up (7.0 vs. 10.0; p < 0.001). EORTC QLQ-CIPN20 sensory scores identified grade ≥ 2 neuropathy with AUC values > 0.92 at all time points. Dual-site mechanical compression was associated with reduced incidence and persistence of CIPN. As a low-cost and scalable intervention, this strategy may improve treatment tolerability and survivorship outcomes. Trial Registration: ClinicalTrials.gov identifier: NCT07105553.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":"2300-2313"},"PeriodicalIF":4.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148269479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence Trends of Early-Onset Colorectal Cancer in Germany: A Registry-Based Study From 2003 to 2023. 德国早发性结直肠癌发病率趋势：2003年至2023年的一项基于登记的研究

IF 4.9 2区医学

International Journal of Cancer Pub Date : 2026-11-01 Epub Date: 2026-06-23 DOI: 10.1002/ijc.70600

Sven Voigtländer, Hiltraud Kajüter, Ina Wellmann, Andras Szentkirályi, Bernd Holleczek, Volker Arndt, Jacqueline Müller-Nordhorn

{"title":"Incidence Trends of Early-Onset Colorectal Cancer in Germany: A Registry-Based Study From 2003 to 2023.","authors":"Sven Voigtländer, Hiltraud Kajüter, Ina Wellmann, Andras Szentkirályi, Bernd Holleczek, Volker Arndt, Jacqueline Müller-Nordhorn","doi":"10.1002/ijc.70600","DOIUrl":"10.1002/ijc.70600","url":null,"abstract":"Motivated by studies on early-onset colorectal cancer (EO CRC, below 50 years) from the United States (US) and elsewhere, this study aimed to provide national incidence trends of EO CRC for Germany. We retrieved colorectal cancer cases (ICD-10 codes C18-C20) using pooled data from German cancer registries with high-quality data. Appendix (C18.1) was excluded from the main analyses and investigated separately. We calculated age-standardised incidence rates (ASR) by calendar year, age group, sex, tumour site, histological subtype, tumour size, grading and estimated corresponding average annual percent changes (AAPC). For comparison, US cancer registry data was drawn from the Surveillance, Epidemiology, and End Results programs 21 population-based registries (SEER 21). From 2003 to 2023, ASRs of EO CRC (C18-C20 excluding C18.1) increased for men (AAPC: 0.8%) and women (AAPC: 0.9%) in Germany. By 10-year age groups, the increase was limited to men and women aged 20-29 years (AAPC males: 3.3%; AAPC females: 3.9%) and 30-39 years (AAPC males: 2.2%; AAPC females: 2.0%). For appendix cancer (C18.1), ASRs were rising for all age groups below 50 years of age. Increases for both colorectal cancer (excluding the appendix) and appendix cancer tended to be higher for cancers with good prognosis (neuroendocrine neoplasms, small size, low grading). In contrast to the US, Germany had a substantially lower EO CRC incidence in 2003 that increased at a slower pace. It is important to monitor future EO CRC incidence trends. The causes of the observed trends remain unclear.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":"2207-2218"},"PeriodicalIF":4.9,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148300226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0