International Journal of Cancer最新文献_第3页

Inhibition of autotaxin activity with IOA-289 decreases fibrosis in mouse E0771 breast tumors. IOA-289抑制自身taxin活性可减少小鼠E0771乳腺肿瘤的纤维化。

IF 5.7 2区医学

International Journal of Cancer Pub Date : 2025-05-09 DOI: 10.1002/ijc.35471

Xiaoyun Tang, Humayara Khan, Karolina Niewola-Staszkowska, Frank Wuest, David N Brindley

{"title":"Inhibition of autotaxin activity with IOA-289 decreases fibrosis in mouse E0771 breast tumors.","authors":"Xiaoyun Tang, Humayara Khan, Karolina Niewola-Staszkowska, Frank Wuest, David N Brindley","doi":"10.1002/ijc.35471","DOIUrl":"https://doi.org/10.1002/ijc.35471","url":null,"abstract":"Tumor-associated fibrosis contributes to an immunosuppressive microenvironment that hinders effective anti-tumor immune responses. This study investigates the potential of IOA-289, a novel autotaxin (ATX) inhibitor, which blocks lysophosphatidate (LPA) production and signaling, in modulating fibrosis in breast tumors. Bioinformatic analysis of human breast tumors revealed a strong correlation between levels of LPA1,-4 receptors and extracellular matrix (ECM) genes. Interaction of ECM molecules and integrin β1/CD44 between myofibroblasts and other cell types had the highest contribution to cell-cell communication. We showed that LPA induced α-smooth muscle actin mRNA in mouse mammary fibroblasts and increased expressions of collagen type-I α1 chain (COL1A1) and lamininγ1. IOA-289 decreased the expressions of COL1A1, fibronectin-1, and transforming growth factor β1 (TGFβ1) in E0771 breast tumors in mice. Masson's trichrome staining revealed a marked decrease in collagen deposition within breast tumors of IOA-289-treated mice. Decreased tumor fibrosis aligns with previous findings that IOA-289 enhanced the infiltration of CD8+ cytotoxic T cells and decreased fibrotic factors including leukemia inhibitory factor and transforming growth factor-beta1 in tumors. We also demonstrated that E0771 cells express negligible ATX and LPA receptors. Therefore, ATX inhibition did not affect cancer cells directly in our model. These results underscore the potential of ATX inhibitors in reprogramming the tumor microenvironment to favor anti-tumor immunity and attenuate fibrosis. ATX inhibitors are in clinical trials for treating idiopathic pulmonary fibrosis and pancreatic cancer. Our results support the development of ATX inhibitors as a strategy for improving the treatment of breast cancer and other diseases involving fibrosis.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term risk of major cardiac events in breast cancer patients treated with intensity-modulated and 3-dimensional conformal radiotherapy: Secondary analysis of a randomized clinical trial. 接受调强和三维适形放疗的乳腺癌患者发生主要心脏事件的长期风险：一项随机临床试验的二次分析

IF 5.7 2区医学

International Journal of Cancer Pub Date : 2025-05-09 DOI: 10.1002/ijc.35476

Nam Kyu Kang, Kyu Hye Choi, Jae Uk Jeong, Sung Ja Ahn, Mina Yu, Jin Hee Kim, Bae Kwon Jeong, Han Byul Kang, Hyo Chun Lee, Jong Hoon Lee

{"title":"Long-term risk of major cardiac events in breast cancer patients treated with intensity-modulated and 3-dimensional conformal radiotherapy: Secondary analysis of a randomized clinical trial.","authors":"Nam Kyu Kang, Kyu Hye Choi, Jae Uk Jeong, Sung Ja Ahn, Mina Yu, Jin Hee Kim, Bae Kwon Jeong, Han Byul Kang, Hyo Chun Lee, Jong Hoon Lee","doi":"10.1002/ijc.35476","DOIUrl":"https://doi.org/10.1002/ijc.35476","url":null,"abstract":"We assess the relationship between radiation dose to the heart and cardiac disease within the context of modern radiotherapy techniques of 3-dimensional and intensity-modulated radiotherapy (IMRT). The KROG 15-03 study was a multicenter phase III trial involving 693 breast cancer patients who underwent breast-conserving surgery (BCS). Patients were randomly assigned to receive either IMRT or 3D-CRT following BCS. Major cardiac event (MCE), defined as the occurrence of angina pectoris or myocardial infarction requiring coronary angiography, and admission for cardiac arrhythmia related to the irradiation of the heart. The primary outcome of the study was to investigate the incidence of MCE and factors associated with MCEs. At a median follow-up of 6.5 years, the incidence of MCEs at 6.5 years was 1.8%. The mean heart dose (MHD) for the entire cohort of 647 patients was 2.1 (±2.3) Gy. The cumulative incidence of MCEs at 6.5 years was 1.1% for the subgroup of MHD <2.9 Gy and 3.3% for the subgroup of MHD >2.9 Gy (p = 0.010), and 0.9% for the subgroup of age ≤55 years and 3.3% for the subgroup of age >55 years (p = 0.006), respectively. Multivariate analyses confirmed that MHD (p = 0.044; hazard ratio [HR], 1.21 per 1 Gy; 95% confidence interval [CI], 1.09-1.46) and age (p = 0.034; HR, 1.07 per 1 year; 95% CI, 1.03-1.14) were significant factors of MCEs. The incidence of MCE increased by 21% per 1-Gy increase in MHD within 6.5 years after radiotherapy.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differences in cancer mortality among solid organ transplant recipients. 实体器官移植受者癌症死亡率的性别差异。

IF 5.7 2区医学

International Journal of Cancer Pub Date : 2025-05-09 DOI: 10.1002/ijc.35415

Sarah S Jackson, Ruth M Pfeiffer, Erin Gardner, Mei-Chin Hsieh, Tabassum Insaf, Charles F Lynch, Bozena Morawski, Shuhui Wang, Kelly J Yu, Eric A Engels

{"title":"Sex differences in cancer mortality among solid organ transplant recipients.","authors":"Sarah S Jackson, Ruth M Pfeiffer, Erin Gardner, Mei-Chin Hsieh, Tabassum Insaf, Charles F Lynch, Bozena Morawski, Shuhui Wang, Kelly J Yu, Eric A Engels","doi":"10.1002/ijc.35415","DOIUrl":"https://doi.org/10.1002/ijc.35415","url":null,"abstract":"Males have increased mortality after a cancer diagnosis than females, possibly due to poorer immunosurveillance. We tested whether the female survival advantage is lost with immunosuppression by evaluating 17,048 cancer patients (68% male) with a prior solid organ transplant using data from the US Transplant Cancer Match Study and 1,221,914 cancer patients (58% male) from the general population using data from the Surveillance, Epidemiology, and End Results Program. We evaluated 13 solid cancers that occur in both sexes. We compared mortality due to cancer in males and females using a male:female hazard ratio (M:F HR) derived from Cox proportional hazards models adjusted for age, race/ethnicity, diagnosis year, stage, and cancer treatment. Among cancer patients in the general population, males had higher cancer-specific mortality than females for cancers of the lip, stomach, colorectum, anus, liver, lung, skin, brain, and thyroid, with M:F HRs ranging from 1.06 to 1.59. Only colorectal cancer showed an attenuation in the female mortality advantage in transplant recipients (M:F HRTransplant: 0.89; 95% CI: 0.77, 1.03; vs. M:F HRGenPop: 1.07; 95% CI: 1.06, 1.08; P-interaction = 0.007). Among kidney cancer patients, the female mortality advantage was stronger in the transplant population (M:F HRTransplant: 1.33; 95% CI: 1.11, 1.60; M:F HRGenPop: 1.02; 95% CI: 0.99, 1.04; P-interaction = 0.003). Overall, we did not find consistent evidence that the female advantage in cancer mortality is weakened among immunosuppressed transplant recipients, suggesting that non-immune factors contribute to the female advantage among cancer patients in the general population.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment outcomes in nasopharyngeal carcinoma patients with parotid lymph node metastasis: An 11-year experience at a tertiary cancer center. 鼻咽癌伴腮腺淋巴结转移的治疗结果：在三级癌症中心11年的经验。

IF 5.7 2区医学

International Journal of Cancer Pub Date : 2025-05-07 DOI: 10.1002/ijc.35470

Linghui Yan, Yuhao Lin, Wenrong Lin, Jiabiao Hong, Muling Deng, Chuanben Chen, Zhaodong Fei, Jianming Ding

{"title":"Treatment outcomes in nasopharyngeal carcinoma patients with parotid lymph node metastasis: An 11-year experience at a tertiary cancer center.","authors":"Linghui Yan, Yuhao Lin, Wenrong Lin, Jiabiao Hong, Muling Deng, Chuanben Chen, Zhaodong Fei, Jianming Ding","doi":"10.1002/ijc.35470","DOIUrl":"https://doi.org/10.1002/ijc.35470","url":null,"abstract":"Parotid lymph node (PLN) metastasis in nasopharyngeal carcinoma (NPC) is rare, with limited data guiding its management and prognosis. We retrospectively analyzed 6924 non-metastatic NPC patients at our tertiary cancer center, identifying 126 patients with PLN metastasis confirmed by fine-needle aspiration cytology (FNAC) and magnetic resonance imaging (MRI). Survival outcomes and prognostic factors were assessed using Kaplan-Meier estimates, log-rank tests, propensity score matching (PSM), and Cox regression. Compared to patients with N3 disease, those with PLN metastasis had worse regional relapse-free survival, distant metastasis-free survival, and progression-free survival. However, overall survival was not significantly affected. When PLN received radical-intensity radiation doses, outcomes were comparable to patients without PLN metastasis. Treatment failures with PLN involvement frequently co-occurred with regional relapse and distant metastasis. Among patients who were treated with PLN-sparing intensity-modulated radiotherapy (IMRT), compared to non-parotid relapse patients, parotid relapse patients were older, had more advanced N classification, lower baseline Epstein-barr virus DNA (EBV-DNA) level, and received fewer cycles of chemotherapy. Additionally, these recurrent PLNs were characterized by smaller size, being typically unilateral and isolated, exhibiting poor sensitivity to chemotherapy, and receiving lower doses of radiotherapy. In our study, PLN metastasis does not upstage the patient's N classification if comprehensive radiotherapy is administered at radical doses. We advise prudence when implementing parotid-sparing IMRT and strongly recommend FNAC for clinically suspicious lesions.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

p16^INK4a and HPV E4 immunohistochemistry for the prediction of regression of cervical intraepithelial neoplasia grade 2-A historical cohort study. p16INK4a和HPV E4免疫组化预测宫颈上皮内瘤变2-A级历史队列研究

IF 5.7 2区医学

International Journal of Cancer Pub Date : 2025-05-05 DOI: 10.1002/ijc.35469

Rikke Damgaard, David Jenkins, Mark H Stoler, Miekel van de Sandt, Maurits N C de Koning, Wim G V Quint, Johnny Kahlert, Patti E Gravitt, Torben Steiniche, Lone K Petersen, Anne Hammer

{"title":"p16INK4a and HPV E4 immunohistochemistry for the prediction of regression of cervical intraepithelial neoplasia grade 2-A historical cohort study.","authors":"Rikke Damgaard, David Jenkins, Mark H Stoler, Miekel van de Sandt, Maurits N C de Koning, Wim G V Quint, Johnny Kahlert, Patti E Gravitt, Torben Steiniche, Lone K Petersen, Anne Hammer","doi":"10.1002/ijc.35469","DOIUrl":"https://doi.org/10.1002/ijc.35469","url":null,"abstract":"Cervical intraepithelial neoplasia grade 2 (CIN2) is a heterogeneous diagnosis with a high likelihood of spontaneous regression. Therefore, active surveillance for CIN2 has been implemented as an option in younger women in many countries. Yet, little is known about markers that may accurately predict the likelihood of regression to support active surveillance. Here, we aimed to assess whether p16INK4a and HPV E4 status are associated with the likelihood of CIN2 regression. We conducted a historical cohort study on women aged 23-40 diagnosed with untreated CIN2 following cytology-based screening. Women were diagnosed at Aarhus University Hospital, Denmark from January 2000 to December 2010. Archived tissue samples were sectioned for p16INK4a and HPV E4 immunohistochemistry and HPV genotyping. We used a modified Poisson model to estimate the relative risk of regression, adjusting for age and cytology (aRR). A total of 443 women with CIN2 were included. Most women (73.8%) were aged ≤30, and half had a high-grade cytology (48.8%). Overall, 47.6% regressed, and regression was less likely in p16INK4a-positive compared to p16INK4a-negative women (aRR 0.77; 95% CI 0.64-0.94). Among p16INK4a-positive women, the risk of regression varied by HPV type and HPVE4 status, with lower risk in HPV16-positive women compared to those without (aRR 0.54; 95% CI 0.40-0.75) and in HPVE4-negative compared to HPVE4 positive women (aRR 0.73; 95% CI 0.54-0.98). When we restricted to expert-confirmed CIN2, the risk of regression did not vary by p16INK4a or HPVE4 status, while HPV16 positive remained at a lower risk of regression compared to women without HPV16.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Whole-genome sequencing of 1,083 HPV45 cases and controls identifies genetic variants associated with glandular cervical lesions. 1083例HPV45病例和对照组的全基因组测序确定了与腺性宫颈病变相关的遗传变异。

IF 5.7 2区医学

International Journal of Cancer Pub Date : 2025-05-05 DOI: 10.1002/ijc.35464

Aimee J Koestler, Chase W Nelson, Meredith Yeager, Zigui Chen, Sambit K Mishra, Laurie Burdett, Michael Dean, Elizabeth Suh-Burgmann, Thomas Lorey, Gary M Clifford, Nicolas Wentzensen, Philip E Castle, Mark Schiffman, Robert D Burk, Lisa Mirabello

{"title":"Whole-genome sequencing of 1,083 HPV45 cases and controls identifies genetic variants associated with glandular cervical lesions.","authors":"Aimee J Koestler, Chase W Nelson, Meredith Yeager, Zigui Chen, Sambit K Mishra, Laurie Burdett, Michael Dean, Elizabeth Suh-Burgmann, Thomas Lorey, Gary M Clifford, Nicolas Wentzensen, Philip E Castle, Mark Schiffman, Robert D Burk, Lisa Mirabello","doi":"10.1002/ijc.35464","DOIUrl":"https://doi.org/10.1002/ijc.35464","url":null,"abstract":"Human papillomavirus type 45 (HPV45) causes ~6% of all cervical cancers and an even greater proportion of adenocarcinomas, the latter of which are challenging to detect using current cervical cancer screening. Little is known about how HPV45 genetic variation is related to the risk of cervical precancer/cancer. To investigate this, we whole-genome sequenced a total of 1,083 HPV45-positive samples from two large studies. We evaluated associations of HPV45 genetic variation (sublineages, subclades, and SNPs) with histology-specific precancer/cancer risk using logistic regression and evaluated risk modification by self-reported race/ethnicity. Compared to the common A1 sublineage, A2 and B1 were associated with increased precancer/cancer (A2, OR = 3.9, 95% CI = 1.9-8.5; B1, OR = 2.7, 95% CI = 1.3-5.8; B2, OR = 3.3, 95% CI = 1.6-7.3), and most strongly with the glandular precancers/cancers (AIS/ADC; A2, OR = 6.9, 95% CI = 1.0-184; B1, OR = 6.2, 95% CI = 1.1-159). The A2 sublineage was most prevalent in women in East Asia and women who self-reported as Asian/Pacific Islander (PI) in the U.S.; East Asian and Asian/PI women had the greatest precancer/cancer risk associated with A2 infections (OR = 5.8, 95% CI = 1.3-37.4) compared to all other sublineages among these women. We further evaluated precancer/cancer risk associations for 262 individual HPV45 SNPs and identified four SNPs significantly associated with only glandular precancers/cancers after correction for multiple tests (ORs ranged 7.8-20.7). One of these SNPs was a nonsynonymous variant in both overlapping viral E2/E4 ORFs. In summary, we show that HPV45 genetic variation influences the risk of precancer/cancer, specifically glandular precancer/cancer. Further studies of these genetic variants may improve our understanding of glandular lesions.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Timing of surgery and 1-year postoperative outcomes in patients with breast cancer and preoperative COVID-19 history: A matched, longitudinal, ambidirectional cohort study. 乳腺癌患者手术时间和术后1年预后与术前COVID-19病史：一项匹配、纵向、双向队列研究

IF 5.7 2区医学

International Journal of Cancer Pub Date : 2025-05-05 DOI: 10.1002/ijc.35466

Yali Wang, Lijuan He, Minyan Chen, Lili Chen, Yuxiang Lin, Jialin Hou, Jing Li, Liuwen Yu, Xiaobin Chen, Weifeng Cai, Yibin Qiu, Qindong Cai, Peng He, Wenhui Guo, Hui Han, Chunsen Xu, Shunguo Lin, Fangmeng Fu, Chuan Wang

{"title":"Timing of surgery and 1-year postoperative outcomes in patients with breast cancer and preoperative COVID-19 history: A matched, longitudinal, ambidirectional cohort study.","authors":"Yali Wang, Lijuan He, Minyan Chen, Lili Chen, Yuxiang Lin, Jialin Hou, Jing Li, Liuwen Yu, Xiaobin Chen, Weifeng Cai, Yibin Qiu, Qindong Cai, Peng He, Wenhui Guo, Hui Han, Chunsen Xu, Shunguo Lin, Fangmeng Fu, Chuan Wang","doi":"10.1002/ijc.35466","DOIUrl":"https://doi.org/10.1002/ijc.35466","url":null,"abstract":"Preoperative severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection increases the risk of postoperative complications and mortality and has long-lasting effects on multiple organ systems. The scheduling of elective surgery after SARS-CoV-2 infection depends on infection severity, vaccination status, patient factors, and surgical urgency. In the post-vaccination Omicron era of the coronavirus disease 2019 (COVID-19) pandemic, there is limited evidence regarding the medium- and long-term postoperative outcomes and optimal surgical timing for patients with breast cancer recovering from COVID-19. This ambidirectional cohort study included 392 patients who underwent breast cancer surgery either more than 2 weeks after or 12 weeks before a COVID-19 diagnosis. Patients were stratified according to the time from COVID-19 diagnosis to surgery and were followed longitudinally for 1 year to evaluate the evolution of postoperative outcomes. Propensity score matching and stabilized inverse probability of treatment weighting methods were used to mitigate confounding factors, determine the optimal timing of surgery, and assess risk factors. No deaths or severe postoperative complications occurred within 1 year of surgery. Patients with preoperative COVID-19 history had a higher risk of medium-term adverse postoperative outcomes than those without (26.2% vs. 10.2%). Multiple analyses revealed that for patients with breast cancer and preoperative COVID-19 history, delaying surgery beyond 4 or even 8 weeks after COVID-19 diagnosis did not significantly reduce the risk of medium- or long-term adverse postoperative outcomes (p > .05). In the post-vaccination Omicron era, our evidence supports timely performing surgery 2 weeks after COVID-19 diagnosis in fully vaccinated patients with breast cancer.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nationwide trends and the impact of an oncology hospital network on reducing the burden of thyroid cytology procedures. 全国趋势和肿瘤医院网络对减轻甲状腺细胞学检查负担的影响。

IF 5.7 2区医学

International Journal of Cancer Pub Date : 2025-05-02 DOI: 10.1002/ijc.35462

Roos G F M van der Ven, Felice N van Erning, Daan D Westra, Ignace H J T de Hingh, Aggie T G Paulus, Sanne M E Engelen, Bart de Vries, Grard A P Nieuwenhuijzen

{"title":"Nationwide trends and the impact of an oncology hospital network on reducing the burden of thyroid cytology procedures.","authors":"Roos G F M van der Ven, Felice N van Erning, Daan D Westra, Ignace H J T de Hingh, Aggie T G Paulus, Sanne M E Engelen, Bart de Vries, Grard A P Nieuwenhuijzen","doi":"10.1002/ijc.35462","DOIUrl":"https://doi.org/10.1002/ijc.35462","url":null,"abstract":"The diagnostic care pathway of thyroid nodules spans multiple institutions. Collaborative networks are important to deal with such pathways that result from centralization and differentiation of care. Despite the high prevalence of thyroid nodules and the increase in cancer diagnoses, most nodules are benign and attributable to overdiagnosis, leading to an increase in fine-needle aspirations (FNAs). This study assessed the effectiveness of a multi-hospital network that implemented a unified thyroid care pathway in reducing the number of FNAs without compromising malignancy detection. In this nationwide population-based cohort study, Bethesda scores were extracted from all thyroid FNA reports from 2010 to 2021 in the Netherlands using text mining. Trends in the number of FNAs and Bethesda scores were visualized for the network and the rest of the country. Joinpoint analyses with the Davies test determined the statistical significance of observed trend changes. Nationwide, FNAs increased by an average of 5.7% annually from 2010 to 2018. In the network, FNAs started to decrease in 2016-2017, coinciding with the care pathway implementation (p < 0.001). In contrast, in the rest of the Netherlands, a decline was observed in 2020, potentially attributable to the COVID-19 pandemic. In both cases, the reduction mainly involved Bethesda categories 1 and 2, without compromising malignancy detection. High-volume surgical centers seemed to initiate a decline more rapidly compared to non-high-volume surgical centers. This study indicates that a unified care pathway within a multi-hospital network can reduce the number of FNAs without compromising malignancy detection, which could alleviate the burden on both patients and the healthcare system.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosomes, autophagy, and cancer: A complex triad. 外泌体、自噬和癌症：一个复杂的三位一体。

IF 5.7 2区医学

International Journal of Cancer Pub Date : 2025-05-02 DOI: 10.1002/ijc.35388

María Guerra-Andrés, Álvaro F Fernández, Tania Fontanil

{"title":"Exosomes, autophagy, and cancer: A complex triad.","authors":"María Guerra-Andrés, Álvaro F Fernández, Tania Fontanil","doi":"10.1002/ijc.35388","DOIUrl":"https://doi.org/10.1002/ijc.35388","url":null,"abstract":"Cancer remains one of the leading causes of death worldwide. Despite remarkable progress in prevention, diagnosis, and therapy, the incidence of certain types of cancer persists, urging the identification of clinically relevant biomarkers and the development of novel therapeutic strategies to improve clinical outcomes and overcome treatment resistance. Exosomes, small extracellular vesicles released by diverse types of cells, have attracted interest in biomedical research due to their potential as carriers for different treatments. Moreover, exosomes play a pivotal role in intercellular communication, modulating various cellular processes. One of those is autophagy, a pro-survival pathway that is essential for human cells. Even though autophagy is traditionally described as a catabolic route, its machinery is intricately involved in various cellular responses, including vesicle formation and secretion. In this regard, the link between autophagy and exosomes is complex, bidirectional, and highly dependent on the cellular context. Interestingly, both processes have been extensively implicated in cancer pathogenesis, highlighting their potential as therapeutic targets. This review updates our understanding of how exosomes can participate in cancer development and progression, with a specific focus on their influence on tumor growth, angiogenesis, and metastasis. Additionally, the interplay between these extracellular vesicles and autophagy is minutely reviewed and discussed, as we hypothesize that this crosstalk may hold valuable clues for biomarker discovery and the development of novel therapeutic strategies.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-cancer early detection via a DNA methylation multiplex ddPCR-based blood test. 通过基于DNA甲基化多重ddpcr的血液检测来早期检测多种癌症。

IF 5.7 2区医学

International Journal of Cancer Pub Date : 2025-05-02 DOI: 10.1002/ijc.35467

Tiago Brito-Rocha, Vera Constâncio, Pedro Leite-Silva, Carina Carvalho-Maia, José Pedro Sequeira, Sofia Salta, João Lobo, Diana Inês Machado, Sandra P Nunes, Rui Silva-Santos, Rui Freitas, Carlos Gonçalves Dias, Cláudia Vieira, Marta Soares, Rui Henrique, Carmen Jerónimo

{"title":"Multi-cancer early detection via a DNA methylation multiplex ddPCR-based blood test.","authors":"Tiago Brito-Rocha, Vera Constâncio, Pedro Leite-Silva, Carina Carvalho-Maia, José Pedro Sequeira, Sofia Salta, João Lobo, Diana Inês Machado, Sandra P Nunes, Rui Silva-Santos, Rui Freitas, Carlos Gonçalves Dias, Cláudia Vieira, Marta Soares, Rui Henrique, Carmen Jerónimo","doi":"10.1002/ijc.35467","DOIUrl":"https://doi.org/10.1002/ijc.35467","url":null,"abstract":"Early cancer detection through minimally invasive methods is key for improving patient outcomes. We aimed to assess the performance of a novel blood-based test leveraging DNA methylation patterns for simultaneous detection of lung (LC), breast (BrC), colorectal (CRC), and prostate (PCa) cancer. Using The Cancer Genome Atlas (TCGA) methylation data, we identified shared hypermethylated gene promoters (ADCY4, MIR129-2, NID2, and MAGI2) among those four cancers. Validation was performed using online datasets, an in-house tissue set (N = 179), and plasma samples (N = 485) using droplet digital PCR (ddPCR). The test showed sensitivities of 81.82% (lung), 45% (breast), 69.23% (colorectal), and 44.14% (prostate), with 91.04% specificity. Overall, the PanCancer panel achieved 60.1% sensitivity and 87.4% specificity in detecting these four cancers. In early-stage cancers, sensitivities were slightly lower but followed a similar trend. Additionally, the test detected nine other cancer types in plasma. This proof-of-concept study demonstrates the feasibility of a single methylation-targeted blood test for multi-cancer detection, offering potential as an affordable and scalable screening tool for early cancer detection.","PeriodicalId":180,"journal":{"name":"International Journal of Cancer","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0