Acta Cardiologica Sinica最新文献

{"title":"Clinical Impact of the Early Use of Sacubitril/Valsartan in Newly Diagnosed Heart Failure and Reduced Ejection Fraction.","authors":"Tzyy-Jer Hsu, Fu-Chih Hsiao, Cze-Ci Chan, Chi Chuang, Pao-Hsien Chu, Yu-Shien Ko","doi":"10.6515/ACS.202505_41(3).20250224C","DOIUrl":"10.6515/ACS.202505_41(3).20250224C","url":null,"abstract":"<p><strong>Background: </strong>To investigate the clinical impact of early sacubitril/valsartan initiation on clinical outcomes and left ventricular reverse remodeling in patients with newly diagnosed heart failure with reduced ejection fraction (HFrEF).</p><p><strong>Methods: </strong>Patients with newly diagnosed HFrEF and prescriptions for sacubitril/valsartan were identified from a multi-institutional database in Taiwan from 2016 to 2020. The patients were categorized as early users if they initiated sacubitril/valsartan within 6 months of the initial diagnosis, and late users if they initiated sacubitril/valsartan 6 months or more after the diagnosis. Clinical outcomes and changes in left ventricular ejection fraction (LVEF) assessed by echocardiography were compared between the early and late users after inverse probability of treatment weighting (IPTW) adjustment.</p><p><strong>Results: </strong>Among the 410 enrolled patients, 188 were early users and 222 were late users. The early users were younger and had a lower LVEF, while the late users had higher rates of hypertension, diabetes, dyslipidemia, and chronic kidney disease. After IPTW, the two groups had similar baseline characteristics. There were no significant differences in the incidence rates of all-cause death, cardiovascular death, and heart failure hospitalization before and after IPTW. However, post-IPTW, the early user group had a lower risk of cumulative emergency department visits (hazard ratio: 0.84, 95% confidence interval: 0.71-0.99; p = 0.0353). Both groups demonstrated reverse remodeling, with an increase in LVEF from 28.7% to 45.3% in the early users, and from 28.9% to 40.1% in the late users, which was significantly more prominent in the early users (p < 0.0001).</p><p><strong>Conclusions: </strong>In patients with newly-diagnosed HFrEF, the early initiation of sacubitril/valsartan was associated with a lower risk of the cumulative number of emergency visits and a greater improvement in LVEF.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 3","pages":"372-381"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Taiwan Consensus for the Management of Cardiovascular Risks and Complications in Patients with Prostate Cancer.","authors":"Wei-Ting Chang, Jiang-Huang Hong, Dong-Yi Chen, Chao-Yuan Huang, Yen-Chou Chen, Tai-Lung Cha, Yen-Wen Wu, Tzu-Ping Lin, Kai-Hung Cheng, Pei-Jhang Chiang, Chung-Lieh Hung, Shian-Shiang Wang, Wen-Hwa Wang, I-Hung Shao, Jo-Nan Liao, Sheng-Chun Hung, Hung-Ju Lin, Shu-Pin Huang, Ping-Yen Liu, Kuan-Hua Huang, Tzung-Dau Wang, Jen-Tai Lin, Yi-Heng Li, Hsi-Chin Wu, Jacob See-Tong Pang, Wen-Jone Chen","doi":"10.6515/ACS.202505_41(3).20250224A","DOIUrl":"10.6515/ACS.202505_41(3).20250224A","url":null,"abstract":"<p><p>Prostate cancer (PC) is one of the leading causes of cancer-related deaths among men globally, and it frequently coexists with cardiovascular disease (CVD). With increasing cancer survival rates and an aging population, the incidence of CVD among PC patients is also on the rise. The treatments for PC include androgen deprivation therapy, androgen receptor pathway inhibitors, and docetaxel-based chemotherapy, and the cardiovascular complications include hypertension, metabolic syndrome, heart failure and arrhythmias. As it is important to provide personalized treatment planning and close monitoring, cardio-oncology collaboration plays a crucial role in optimizing treatment outcomes, emphasizing cardiovascular risk assessments and tailored treatment plans that balance cancer control and cardiovascular health. In this consensus statement, we review several important issues including the association between CVD and PC, screening for cardiovascular diseases and risk factors, timing and criteria for cardiology referral, cardiovascular risk assessments and management, and multidisciplinary collaboration and patient education. However, challenges remain in screening and preventive measures, and future research should focus on developing robust cardiovascular risk assessment tools, preventive measures, and interdisciplinary approaches to improve patient outcomes and reduce cardiovascular morbidity in patients being treated for PC.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 3","pages":"288-310"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central Conducting Lymphatic Anomaly in a Child with Chylopericardium.","authors":"Mansi Verma, Niraj Nirmal Pandey, Priyanka Naranje, Sanjeev Kumar, Saurabh Kumar Gupta","doi":"10.6515/ACS.202505_41(3).20250201A","DOIUrl":"10.6515/ACS.202505_41(3).20250201A","url":null,"abstract":"","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 3","pages":"411-413"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Fetuin-A Affected by Nutritional Status as a Novel Biomarker for Coronary Artery Disease.","authors":"Mehmet Arif Icer, Hilal Yıldıran, Asife Sahinarslan, Salih Topal, Yakup Yalcın","doi":"10.6515/ACS.202505_41(3).20241201A","DOIUrl":"10.6515/ACS.202505_41(3).20241201A","url":null,"abstract":"<p><strong>Background: </strong>The mechanisms underlying coronary artery disease (CAD), which is characterized by atherosclerotic plaque accumulation in the arteries, are still not fully understood. The role of serum fetuin-A level in the development of CAD and its effects on other risk factors are important research topics that have attracted increasing attention. The aim of this study was to evaluate serum fetuin-A level and the effects of nutritional status on serum fetuin-A concentration in CAD patients.</p><p><strong>Methods: </strong>The study was carried out on 47 male participants (case group) who were newly diagnosed with CAD by conventional coronary angiography and 40 male participants without CAD (control group) aged between 35-75 years. Biochemical parameters, anthropometric measurements and three-day food records of all participants were recorded. In addition, Gensini and SYNTAX scores were calculated using angiography images to determine the extent and severity of CAD.</p><p><strong>Results: </strong>Serum fetuin-A concentration in the case group was higher than that in the control group (p < 0.001). Waist circumference, hip circumference, waist/height ratio, Gensini and SYNTAX scores and serum fetuin-A levels in the participants in the case group were positively correlated (p < 0.05). In addition, there were negative correlations between serum fetuin-A concentration and dietary polyunsaturated fatty acids, omega-6 fatty acids, vitamin E, vitamin B₁, folate, potassium, and selenium intake in the participants in the case group (p < 0.05).</p><p><strong>Conclusions: </strong>The results of the study indicate that high serum fetuin-A levels may be a risk factor for the development of CAD, and that nutritional status might affect serum fetuin-A level.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 3","pages":"335-345"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inferior Wall STEMI Resulting from Anomalous Origin of Right Coronary Artery from Left Coronary Sinus.","authors":"Chi-Yuan Huang, Ying-Chieh Liao","doi":"10.6515/ACS.202505_41(3).20250106C","DOIUrl":"10.6515/ACS.202505_41(3).20250106C","url":null,"abstract":"","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 3","pages":"423-425"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Challenge in Subtyping Cardiac Amyloidosis with Immunohistochemistry Staining: A Case Report.","authors":"Yi-Hsin Hung, Feng-Ming Tien, Chia-Tung Shun, Mei-Fang Cheng, Cheng-Hsuan Tsai, Yen-Hung Lin","doi":"10.6515/ACS.202505_41(3).20250106D","DOIUrl":"10.6515/ACS.202505_41(3).20250106D","url":null,"abstract":"","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 3","pages":"426-430"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099245/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2025 Expert Consensus Recommendations on Vaccinations in Adults with High Cardiovascular Risk and Cardiovascular Disease: A Report of the Task Force of the Taiwan Society of Cardiology and the Infectious Diseases Society of Taiwan.","authors":"Yen-Wen Wu, Wei-Wen Lin, Hung-Ju Lin, Po-Lin Lin, Li-Min Huang, Yee-Chun Chen, Hsin Chi, Ching-Fen Shen, Tsung-Hsien Lin, Ting-Hsing Chao, Hung-I Yeh, Wen-Jone Chen, I-Chang Hsieh, Jann-Tay Wang, Feng-Yee Chang, Yi-Heng Li","doi":"10.6515/ACS.202505_41(3).20250407A","DOIUrl":"10.6515/ACS.202505_41(3).20250407A","url":null,"abstract":"<p><p>Cardiovascular disease (CVD) is a leading cause of death worldwide, and infections often worsen the clinical condition of these patients. Respiratory infections, either bacterial or viral sources, are important causes of high morbidity and mortality in older adults. Beyond the burden of infection-related complications, they are also associated with non-infection-related complications such as cardiovascular (CV) events. For example, herpes zoster is associated with an increased risk of stroke and myocardial infarction. Vaccination is an effective preventive strategy for patients with CVD by reducing viral and bacterial infections, and minimizing systemic inflammatory responses to support plaque stability and reduce the likelihood of CV events in high-risk patients, thereby reducing the risks of CV and non-CV hospitalizations and mortality. Despite evidence on the effectiveness, safety, and benefits of vaccines and recommendations to vaccinate older patients and those with risk factors, vaccination rates remain sub-optimal in this population. The Taiwan Society of Cardiology and the Infectious Diseases Society of Taiwan recently appointed a task force to formulate a consensus on vaccinations for adults with high CV risk or CVD. Based on the most up-to-date information, the consensus provides current evidence-based important recommendations.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 3","pages":"271-287"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To See is to Act - Improving Cardiovascular Health in Patients with Prostate Cancer.","authors":"Ya-Wen Lu, Kang-Ling Wang, David E Newby","doi":"10.6515/ACS.202505_41(3).20250414A","DOIUrl":"10.6515/ACS.202505_41(3).20250414A","url":null,"abstract":"","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 3","pages":"311-313"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter Aortic Valve Replacement for a Severe Aortic Valve Stenosis Coexisting with Hypertrophic Obstructive Cardiomyopathy - A Tale of Two Obstructions.","authors":"Yu-Sheng Lin, Chu-Leng Yu, Wen-Lieng Lee, Wei-Wen Lin, Kae-Woei Liang","doi":"10.6515/ACS.202505_41(3).20250331A","DOIUrl":"10.6515/ACS.202505_41(3).20250331A","url":null,"abstract":"","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 3","pages":"435-438"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prognostic Value of the Visually Assessed Time Difference between Mitral Valve and Tricuspid Valve Opening Score for Patients with Acute Heart Failure.","authors":"Yin Yue, Xiaopeng Wu, Dan Qi, Wenting Liu, Jianjun Zhang","doi":"10.6515/ACS.202505_41(3).20250106E","DOIUrl":"10.6515/ACS.202505_41(3).20250106E","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to investigate the prognostic value of visually assessed time difference between mitral valve and tricuspid valve opening (VMT) score in patients with acute heart failure (AHF).</p><p><strong>Methods: </strong>Potential confounding factors associated with all-cause and cardiovascular disease (CVD)-cause mortality in AHF patients were explored using a univariate Cox regression model, and the relationship between the VMT score and all-cause/CVD-cause mortality was analyzed using a multivariable Cox regression model. Hazard ratios (HRs) and 95% confidence intervals (CIs) were used as the effect size. The prognostic value of the VMT score was evaluated using the C-index.</p><p><strong>Results: </strong>The all-cause mortality rate and CVD-cause mortality rate in the VMT score < 2 group were lower than in the VMT score ≥ 2 group. VMT score > 2 was correlated with an elevated risk of all-cause mortality in the AHF patients (HR = 1.97, 95% CI: 1.20-3.25). An increased risk of CVD-cause mortality was observed in the VMT score > 2 group. The C-index of the VMT score for all-cause mortality in the AHF patients was 0.621 (95% CI: 0.570-0.672), while for CVD-cause mortality it was 0.644 (95% CI: 0.573-0.715). Combining the VMT score with variables associated with all-cause mortality and CVD-cause mortality, the C-index of the VMT score-based model for all-cause mortality in the AHF patients was 0.859 (95% CI: 0.820-0.898), while for CVD-cause mortality it was 0.872 (95% CI: 0.825-0.919).</p><p><strong>Conclusions: </strong>The VMT score showed moderate prognostic value for all-cause and CVD-cause mortality in patients with AHF. Combining the VMT score with other related variables resulted in good prognostic value for all-cause and CVD-cause mortality in patients with AHF.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 3","pages":"382-406"},"PeriodicalIF":1.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12099241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}