Acta Cardiologica Sinica最新文献

{"title":"Nirmatrelvir/Ritonavir-Induced Calcium Channel Blocker Intoxication Successfully Treated by High Dose Insulin Therapy.","authors":"Chun-Yuan Chen, Cong-Tat Cia","doi":"10.6515/ACS.202603_42(2).20251213B","DOIUrl":"10.6515/ACS.202603_42(2).20251213B","url":null,"abstract":"","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"42 2","pages":"282-284"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidisciplinary Approaches for Diagnosing Underrecognized Transthyretin Amyloidosis in Real-World Practice.","authors":"Hao-Chih Chang, Ling Kuo, Tsyr-Yan Yu, Yo-Tsen Liu, Kon-Ping Lin, Wen-Chung Yu","doi":"10.6515/ACS.202603_42(2).20250821A","DOIUrl":"10.6515/ACS.202603_42(2).20250821A","url":null,"abstract":"<p><strong>Background: </strong>Transthyretin amyloidosis (ATTR) is a rare but progressive disease. Its heterogeneous clinical presentation often leads to a delayed diagnosis. This study aimed to review the clinical manifestations of ATTR at diagnosis across cardiology and neurology subspecialties and to identify common red-flag symptoms in real-world practice.</p><p><strong>Methods: </strong>We analyzed consecutive patients diagnosed with ATTR between March 2018 and December 2024. Variant ATTR (ATTR-v) was confirmed by genetic testing, while wild-type ATTR (ATTR-wt) was diagnosed based on the absence of monoclonal protein, a positive ^99mtechnetium-pyrophosphate scan, and no transthyretin gene mutations. All patients underwent clinical assessments, electrocardiography (ECG), and comprehensive echocardiography at diagnosis.</p><p><strong>Results: </strong>Among the 63 enrolled ATTR patients (median age 64 years, 66.7% men), 27% were diagnosed in cardiology clinics and 73% in neurology clinics. Six had ATTR-wt (all diagnosed by cardiologists), while 57 had ATTR-v (94.7% with the Ala97Ser mutation), predominantly diagnosed by neurologists. Some patients presenting to cardiology clinics had considerable neurological symptoms or a history of bilateral carpal tunnel syndrome in addition to prominent cardiac involvement. Conversely, patients presenting to neurology clinics had significant cardiac involvement comparable to those diagnosed in cardiology clinics. Peripheral neuropathy was the most prevalent red flag, followed by autonomic dysfunction, discordant QRS voltages on ECG, and a history of bilateral carpal tunnel syndrome. Notably, the absence of low-voltage QRS or the presence of left ventricular hypertrophy on ECG did not necessarily exclude ATTR.</p><p><strong>Conclusions: </strong>Recognizing red-flag symptoms remains the key to identifying ATTR. Early detection of ATTR requires clinical vigilance and multidisciplinary collaboration across subspecialties.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"42 2","pages":"216-227"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between VO₂ Max and Heart Rate Variability Parameters in Individuals with High Risk for Cardiovascular Disease.","authors":"Selin Cilli Hayıroğlu, Mehmet Uzun","doi":"10.6515/ACS.202603_42(2).20250725A","DOIUrl":"10.6515/ACS.202603_42(2).20250725A","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to evaluate the relationship between heart rate variability (HRV) parameters, classified into frequency and time domains, and maximal oxygen uptake (VO₂ max) in individuals at high risk of cardiovascular disease but without a clinical diagnosis.</p><p><strong>Methods: </strong>Based on a 10-year atherosclerotic cardiovascular disease risk score, 311 patients at high cardiovascular risk were included in this retrospective analysis. The study population was divided into tertiles according to VO₂ max values. Demographic, clinical, echocardiographic, laboratory and HRV data were compared across tertiles. The associations between VO₂ max and HRV parameters including standard deviation of normal-to-normal (NN) intervals over 24 hours, standard deviation of the averages of NN intervals in all 5-minute segments, standard deviation of NN intervals in 5-minute segments (SDNN index), root mean square of successive differences (rMSSD), percentage of successive NN intervals that differ by more than 50 ms, total power (TP), low frequency (LF), and high frequency (HF) were analyzed using Spearman correlation analysis.</p><p><strong>Results: </strong>VO₂ max showed a moderate correlation with TP, LF and HF (rho = 0.211, p < 0.001; rho = 0.181, p = 0.001; and rho = 0.361, p < 0.001, respectively). In addition, significant correlations were found between VO₂ max and rMSSD (rho = 0.122, p = 0.032) and SDNN index (rho = 0.184, p = 0.001). These associations remained statistically significant after adjusting for age using partial Spearman correlation analysis.</p><p><strong>Conclusions: </strong>This study demonstrated significant correlations between HRV frequency and time domains with VO₂ max in asymptomatic individuals with high cardiovascular risk.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"42 2","pages":"269-277"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Goal Attainment Rate in Secondary Prevention in Taiwan - A Chang Gung Research Database Study.","authors":"Tien-Yu Chen, Chia-Chen Wu, Yi-Ting Chen, Bang-Yan Hou, Cheng-I Cheng","doi":"10.6515/ACS.202603_42(2).20251012A","DOIUrl":"10.6515/ACS.202603_42(2).20251012A","url":null,"abstract":"<p><strong>Background: </strong>Effective lipid control is essential in the secondary prevention of cardiovascular disease to reduce recurrent events. However, the low-density lipoprotein cholesterol (LDL-C) goal attainment rates among high-risk patients in Taiwan remain unclear.</p><p><strong>Objective: </strong>This study aimed to evaluate LDL-C goal attainment and adherence to lipid-lowering therapy (LLT) in Taiwanese patients with atherosclerotic cardiovascular disease (ASCVD) using data from the Chang Gung Research Database.</p><p><strong>Methods: </strong>We conducted a retrospective observational study of 116,228 ASCVD patients treated between 2017 and 2021. LDL-C levels, LLT intensity, and goal attainment (< 70 mg/dL) were analyzed. Multivariate logistic regression was used to identify factors associated with LDL-C goal attainment.</p><p><strong>Results: </strong>The mean age of the patients was 67.4 years, and 63.8% were male. Coronary artery disease (CAD) comprised 57.3% of the diagnoses. At baseline, 12.2% of the patients achieved LDL-C < 70 mg/dL, improving to 25.1% at 12 months. High-intensity LLT was associated with a significantly higher likelihood of goal attainment (relative risk 1.54, p < 0.001). Male sex, diabetes mellitus, and prior percutaneous coronary intervention were positively correlated with LDL-C goal attainment. Despite treatment, LDL-C control remained suboptimal, particularly in cerebrovascular disease and peripheral artery disease subgroups.</p><p><strong>Conclusions: </strong>Real-world LDL-C goal attainment among Taiwanese ASCVD patients is low, underscoring the need for intensified lipid management and improved adherence to guideline-based therapy. Tailored interventions are especially warranted for non-CAD ASCVD patients to reduce cardiovascular risk.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"42 2","pages":"258-268"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atrial Septal Aneurysms: The Heart's Hidden Bulge.","authors":"Murat Özmen, Ramazan Aslan, Onur Akgün, İsa Ardahanlı","doi":"10.6515/ACS.202603_42(2).20251008B","DOIUrl":"10.6515/ACS.202603_42(2).20251008B","url":null,"abstract":"<p><p>Atrial septal aneurysms (ASAs) are usually asymptomatic and discovered incidentally during routine cardiac imaging. While their exact prevalence is unclear, ASAs can be associated with structural heart defects (such as patent foramen ovale or atrial septal defect) and carry risks of systemic embolization, arrhythmias, and potentially migraine headaches. The diversity of current diagnostic criteria highlights the need for a standardized approach in research and clinical practice. Imaging modalities such as echocardiography, cardiac magnetic resonance imaging, and computed tomography are used for diagnosis. Isolated ASAs may only require follow-up, while those with complications or associated defects may require invasive interventions. This review aims to provide a detailed overview of ASAs, emphasizing the need for standardized diagnostic criteria and a multidisciplinary approach to patient management.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"42 2","pages":"153-159"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Mechanism of KLF4-Mediated NF-κB/NLRP3 Pathway Regulating Arteriovenous Fistula Dysfunction.","authors":"Yuanyuan Wang, Jihong Deng, Jinping Tan, Yu Meng","doi":"10.6515/ACS.202603_42(2).20250727B","DOIUrl":"10.6515/ACS.202603_42(2).20250727B","url":null,"abstract":"<p><strong>Objective: </strong>Arteriovenous fistula (AVF) is the lifeline of maintenance hemodialysis (MHD), and AVF dysfunction is a major burden for MHD patients. It is important to modulate the vascular inflammatory response in pathological settings to protect endothelial proliferation and reduce AVF dysfunction. Krüppel-like factor 4 (KLF4) plays a key role in regulating the vascular endothelium in vascular homeostasis. In this study, we investigated the role of KLF4 in regulating the inflammatory pathway in vascular endothelial cells and its effect on biological behavior.</p><p><strong>Methods: </strong>An lipopolysaccharide (LPS)-induced inflammatory injury human umbilical vein endothelial cell (HUVEC) model was established, and cell morphology changes were observed microscopically. The overexpression or knockdown efficiency of KLF4 was verified by reverse transcription quantitative polymerase chain reaction (RT-qPCR), and the migration, proliferation, interleukin-6 and high sensitivity C-reactive protein expression levels of HUVECs were detected by Transwell assay, Cell Counting Kit-8 assay, and enzyme-linked immunosorbent assay, respectively. The expression levels of nuclear factor kappa-B (NF-κB) and nod-like receptor family pyrin domain containing 3 (NLRP3) were detected by RT-qPCR and Western blot. In addition, rescue experiments were performed by interfering with the NF-κB pathway to observe changes in experimental phenomena.</p><p><strong>Results: </strong>Compared with conventional culture, morphological changes, proliferation and mobility of continuous LPS-induced HUVECs significantly increased, along with significantly increased levels of NF-κB, NLRP3 and inflammatory factors. The overexpression of KLF4 resulted in the inhibition of NF-κB, NLRP3 and inflammatory factors, while cell proliferation and migration were significantly reduced. In comparison, knockdown of KLF4 produced opposite effects. When combined with NF-κB inhibitors, the effect of knockdown KLF4 was reversed.</p><p><strong>Conclusions: </strong>KLF4 protects endothelial cell proliferation by modulating the vascular inflammatory response, and is a potential target for reducing AVF dysfunction.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"42 2","pages":"186-197"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The First JenaValve Trilogy System Transcatheter Aortic Valve Replacement for Pure Severe Native Aortic Valve Regurgitation in Taiwan: A Case Report.","authors":"Kuo-Hsuan Hung, Mao-Shin Lin, Tsung-Yu Ko, Chih-Yang Chan, Hien-Li Kao, Ying-Hsien Chen","doi":"10.6515/ACS.202603_42(2).20251213A","DOIUrl":"10.6515/ACS.202603_42(2).20251213A","url":null,"abstract":"","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"42 2","pages":"278-281"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network Pharmacology & Validation of Dihydrotanshinone I's Regulation of HIF-1α via STAT3 in Cardiomyocytes.","authors":"Jianxun Zhao, Xiaoling Zhang, Yefu Liu, Can Jiang, Lin Wang","doi":"10.6515/ACS.202603_42(2).20250818G","DOIUrl":"10.6515/ACS.202603_42(2).20250818G","url":null,"abstract":"<p><p>This study investigates the molecular mechanisms underlying the cardioprotective effects of dihydrotanshinone I (DT). Bioinformatics analysis of proteomic data was applied to explore the broad regulatory effects of DT on cellular processes in cardiomyocytes. Molecular docking and surface plasmon resonance (SPR) analysis were performed to identify potential targets of DT. Bioinformatics analysis identified key pathways influenced by DT, suggesting its potential for modulating cellular processes involved in stress responses. Molecular docking analysis predicted signal transducer and activator of transcription 3 (STAT3) as a high-affinity target of DT, which was confirmed by SPR and thermal stability assays. DT treatment enhanced STAT3 phosphorylation and promoted both transcriptional upregulation and nuclear accumulation of hypoxia-inducible factor-1α (HIF-1α) in cardiomyocytes. These effects were abolished by STAT3 inhibition. Single-cell ribonucleic acid sequencing of human heart tissues demonstrated similar expression patterns of STAT3 and hypoxia inducible factor 1 subunit alpha across cardiac cell types, particularly in cardiomyocytes. Analysis of ischemic cardiomyopathy patients revealed significantly downregulated expressions of both genes compared to normal hearts, supporting their relevance in cardiac pathology. These findings suggest that DT confers cardioprotection through modulation of the STAT3/HIF-1α axis, potentially mimicking or enhancing ischemic preconditioning effects. In summary, this study provides new insights into the cardioprotective mechanisms of DT and highlights the STAT3/HIF-1α pathway as a promising target for ischemia/reperfusion injury.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"42 2","pages":"160-170"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Significance of Estimated Plasma Volume Status in Patients with Heart Failure: A Systematic Review and Meta-Analysis.","authors":"Jing Wang, Xu Liu, Yikang Xu, Lihui Ge","doi":"10.6515/ACS.202603_42(2).20250820B","DOIUrl":"10.6515/ACS.202603_42(2).20250820B","url":null,"abstract":"<p><strong>Background: </strong>Heart failure (HF) remains a leading cause of global mortality; however, despite treatment advances, improvements in prognosis are limited. Non-invasive estimation of plasma volume status (ePVS) from hemoglobin and hematocrit may enhance prognostic accuracy and management. This meta-analysis investigates the association of ePVS with adverse outcomes in HF patients.</p><p><strong>Methods: </strong>We searched PubMed, Embase, Cochrane, and Web of Science up to June 8, 2024, using specific keywords. Two independent researchers performed the literature search and data extraction, resolving discrepancies through discussion or a third researcher if necessary. Hazard ratios (HRs) and 95% confidence intervals (CIs) were extracted and synthesized using a random-effects model. Sensitivity and subgroup analyses were conducted to explore heterogeneity.</p><p><strong>Results: </strong>We included 12 articles with 23,282 patients. The highest ePVS group had increased all-cause mortality (HR: 1.66; 95% CI: 1.14-2.40; I² = 73%) and a higher composite endpoint of mortality or HF re-hospitalization (HR: 1.53; 95% CI: 1.26-1.87; I² = 0%) compared to the lowest group. Per unit increase in ePVS corresponded to HRs of 1.18 for mortality (95% CI: 1.07-1.31; I² = 88%) and 1.21 for mortality or re-hospitalization (95% CI: 1.14-1.29; I² = 43%). Sensitivity analysis confirmed result stability, and subgroup analysis showed persistent heterogeneity.</p><p><strong>Conclusions: </strong>Elevated ePVS predicts HF mortality and rehospitalization. Prospective validation of ePVS is warranted to assess its potential utility for improving risk stratification in clinical practice.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"42 2","pages":"198-215"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Resuscitation Performance: The Impact of Team Resource Management and In-Situ Simulation on Teamwork and Procedure Adherence.","authors":"Ming-Yuan Hsieh, An-Kuo Chou, Cheng-Heng Liu, Mu-Yang Hsieh, Chien-Feng Lee, Chih-Wei Yang, Chih-Cheng Wu","doi":"10.6515/ACS.202603_42(2).20250916A","DOIUrl":"10.6515/ACS.202603_42(2).20250916A","url":null,"abstract":"<p><strong>Background: </strong>Ward resuscitation requires both technical and teamwork skills, however conventional drills rarely address teamwork. We evaluated whether a brief Team Resource Management (TRM) curriculum combined with in-situ simulations could improve the quality of resuscitation and safety culture.</p><p><strong>Methods: </strong>This retrospective study analyzed data from a hospital-wide quality-improvement project at a 250-bed regional hospital. Ward teams (physicians, nursing specialists, and nurses) completed three training cycles at baseline, 6 months, and 12 months. Each cycle included 30-min online modules plus two in-situ simulations with TRM-focused debriefs. The primary outcome was resuscitation protocol adherence (RPA) using a 28-item checklist based on the 2020 ILCOR recommendations. The secondary outcomes were Safety Attitudes Questionnaire (SAQ) and Teamwork Perception Questionnaire (TPQ) scores.</p><p><strong>Results: </strong>Fifty-three of 94 eligible staff (56%) provided complete responses. The mean RPA rate increased from 76.5 ± 16.5% at baseline to 92.6 ± 9.7% after cycle three (p = 0.030), primarily driven by improvements in the \"Transmission of Rescue Information\" domain (62.5% vs. 90.6%, p = 0.028). No significant changes occurred in composite SAQ/TPQ scores.</p><p><strong>Conclusions: </strong>Three low-fidelity TRM <i>in-situ</i> simulations significantly increased the rate of RPA, particularly team communication, without immediate changes in the overall safety culture. Short, recurring TRM drills rapidly enhanced process reliability; sustained coaching may be needed for broader cultural transformation.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"42 2","pages":"246-257"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13017508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}