Acta Cardiologica Sinica最新文献

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Are There Any Renoprotective Effects of SGLT2 Inhibitors in Heart Transplant Recipients with Diabetes?
IF 1.8 4区 医学
Acta Cardiologica Sinica Pub Date : 2025-03-01 DOI: 10.6515/ACS.202503_41(2).20241111C
You-Min Lu, Chih-Ying Chang, Mei-Fei Chen, Kai-Hsi Lu, Chung-Yi Chang, Jeng Wei, Hou-Sheng Yang
{"title":"Are There Any Renoprotective Effects of SGLT2 Inhibitors in Heart Transplant Recipients with Diabetes?","authors":"You-Min Lu, Chih-Ying Chang, Mei-Fei Chen, Kai-Hsi Lu, Chung-Yi Chang, Jeng Wei, Hou-Sheng Yang","doi":"10.6515/ACS.202503_41(2).20241111C","DOIUrl":"10.6515/ACS.202503_41(2).20241111C","url":null,"abstract":"<p><strong>Background: </strong>Sodium-glucose cotransporter-2 (SGLT2) inhibitors have shown renoprotective effects in diabetic patients, however their impact on heart transplant recipients remains controversial due to limited data.</p><p><strong>Methods: </strong>This retrospective cohort study included heart transplant recipients with diabetes from January 2016 to December 2023. The patients were divided into a treatment group who used SGLT2 inhibitors for at least 1 year, and a control group who had never used SGLT2 inhibitors. We used propensity score matching to balance baseline characteristics between the two groups. The primary outcome was a renal-specific composite, including a sustained decline of ≥ 50% in estimated glomerular filtration rate (eGFR), end-stage kidney disease, or death from renal causes.</p><p><strong>Results: </strong>After 15-18 months, the SGLT2 inhibitor group showed significant improvements in eGFR compared to the control group. The renal-specific composite outcome occurred less frequently in the SGLT2 inhibitor group compared with the control group (log-rank test, p = 0.0064). The SGLT2 inhibitor group had a lower risk of the renal-specific composite outcome compared to the control group, and this finding was consistent across the study cohort [adjusted hazard ratio (aHR): 0.30; p = 0.0270] and propensity-matched cohort (aHR: 0.26; p = 0.0341).</p><p><strong>Conclusions: </strong>The long-term use of SGLT2 inhibitors in heart transplant recipients with diabetes mellitus was associated with significant renal function preservation and reduced risk of adverse renal outcomes. These findings support the renoprotective potential of SGLT2 inhibitors in this population, warranting further prospective studies.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 2","pages":"242-250"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum: Erratum.
IF 1.8 4区 医学
Acta Cardiologica Sinica Pub Date : 2025-03-01
{"title":"Erratum: Erratum.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.6515/ACS.202501_41(1).20240722C.].</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 2","pages":"265"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Prognostic Role of Residual SYNTAX Score in Older Patients with Acute Coronary Syndrome.
IF 1.8 4区 医学
Acta Cardiologica Sinica Pub Date : 2025-03-01 DOI: 10.6515/ACS.202503_41(2).20241024B
Kudret Keskin, Mert Sarılar, Ahmet Gürdal, Mutlu Çağan Sümerkan, Zeynep Pelin Orhan, Sinan Şahin, Ömer Alyan
{"title":"The Prognostic Role of Residual SYNTAX Score in Older Patients with Acute Coronary Syndrome.","authors":"Kudret Keskin, Mert Sarılar, Ahmet Gürdal, Mutlu Çağan Sümerkan, Zeynep Pelin Orhan, Sinan Şahin, Ömer Alyan","doi":"10.6515/ACS.202503_41(2).20241024B","DOIUrl":"10.6515/ACS.202503_41(2).20241024B","url":null,"abstract":"<p><strong>Background: </strong>Approximately half of the patients presenting with acute coronary syndrome have multivessel disease. There has been conflicting data regarding the residual coronary artery disease (CAD) burden and its impact on mortality, especially in older people. Therefore, we aimed to assess all-cause mortality and residual CAD burden in older patients with acute coronary syndrome.</p><p><strong>Methods: </strong>Patients over 75 years of age who presented with acute coronary syndrome and underwent percutaneous coronary intervention were retrospectively included in the study. After the index procedure, residual The Synergy Between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) scores were calculated and the patients were divided into two groups as residual SYNTAX > 8 and < 8. In-hospital and long-term all-cause mortality were defined as the endpoints of the study.</p><p><strong>Results: </strong>Overall, 352 patients were included in the study. The mean age was 82.0 ± 4.8 years and 188 (53.4%) patients were female. The median follow-up was 35 (3-57) months. Both in-hospital and long-term mortality were significantly higher in the patients with residual SYNTAX sore > 8 (33.9% vs. 12.0% and 70.1% vs. 48.4% both p < 0.01, respectively). Kaplan-Meier analysis survival curves continued to separate showing increased mortality in the patients with residual SYNTAX score > 8 (p < 0.01). In multivariate Cox regression analysis, high residual CAD burden [residual Syntax score > 8, hazard ratio: 1.83 (1.30-2.56 95% confidence interval), p < 0.01], age, diabetes mellitus, left ventricular ejection fraction and renal insufficiency were associated with long-term all-cause mortality.</p><p><strong>Conclusions: </strong>Elderly patients with residual SYNTAX score > 8 had higher in-hospital and long-term all-cause mortality rates. Strategies aiming to reduce residual CAD burden by revascularization seem reasonable.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 2","pages":"192-199"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Frailty Associated with Cardiovascular Mortality in Hemodialysis Patients.
IF 1.8 4区 医学
Acta Cardiologica Sinica Pub Date : 2025-03-01 DOI: 10.6515/ACS.202503_41(2).20241111B
Chiu-Hui Chen, Tzu-Shan Yeh, Li-Pei Dai, Chien-Ming Luo, Chung-Wei Yang, Chih-Cheng Wu
{"title":"Frailty Associated with Cardiovascular Mortality in Hemodialysis Patients.","authors":"Chiu-Hui Chen, Tzu-Shan Yeh, Li-Pei Dai, Chien-Ming Luo, Chung-Wei Yang, Chih-Cheng Wu","doi":"10.6515/ACS.202503_41(2).20241111B","DOIUrl":"10.6515/ACS.202503_41(2).20241111B","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease is the leading cause of mortality among hemodialysis patients. Frailty, characterized by diminished physiological reserve, is increasingly recognized as an important risk factor for adverse outcomes in this population.</p><p><strong>Objectives: </strong>This study aimed to investigate the role of frailty in cardiovascular mortality among patients undergoing maintenance hemodialysis.</p><p><strong>Methods: </strong>This prospective cohort study enrolled 1,136 hemodialysis patients from 12 centers in Hsinchu, Taiwan. Baseline data on demographics, comorbidities, dialysis-related factors, and laboratory results were collected. Frailty was assessed using modified Fried frailty criteria, and the patients were followed for a median of 1,187 days. Cardiovascular death was the primary outcome, with a particular emphasis on sudden cardiac death. Cox proportional hazards models were used to analyze the data.</p><p><strong>Results: </strong>Of the 1,136 participants, 34.3% were classified as frail. The frail patients had significantly higher rates of cardiovascular death [25% vs. 12%, hazard ratio (HR) = 2.34, p < 0.001] and sudden cardiac death (16% vs. 6%, HR = 3.12, p < 0.001) compared to the non-frail patients. Multivariate analysis confirmed frailty as an independent predictor of cardiovascular death (HR = 1.62, 95% confidence interval 1.20, 2.19, p = 0.002). The association between frailty and sudden cardiac death was more pronounced than that between frailty and non-sudden cardiac death.</p><p><strong>Conclusions: </strong>Frailty was a strong predictor of cardiovascular mortality, and particularly sudden cardiac death, in the enrolled hemodialysis patients. These findings underscore the importance of frailty assessments and targeted interventions to reduce cardiovascular risk in this vulnerable group. Further research is needed to elucidate the mechanisms linking frailty with cardiovascular outcomes and to develop effective management strategies.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 2","pages":"219-229"},"PeriodicalIF":1.8,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Body Mass Index and Clinical Outcomes in Patients with Coronary Artery Disease Undergoing Percutaneous Coronary Intervention. 经皮冠状动脉介入治疗的冠心病患者体重指数与临床结果的关系
IF 1.8 4区 医学
Acta Cardiologica Sinica Pub Date : 2025-01-01 DOI: 10.6515/ACS.202501_41(1).20241021B
Ting-Yu Lin, Hsin-Bang Leu
{"title":"Association of Body Mass Index and Clinical Outcomes in Patients with Coronary Artery Disease Undergoing Percutaneous Coronary Intervention.","authors":"Ting-Yu Lin, Hsin-Bang Leu","doi":"10.6515/ACS.202501_41(1).20241021B","DOIUrl":"https://doi.org/10.6515/ACS.202501_41(1).20241021B","url":null,"abstract":"<p><strong>Background: </strong>The obesity paradox refers to lower mortality rates among overweight or obese individuals within certain populations. However, whether this paradox is applicable to patients undergoing percutaneous coronary intervention (PCI) remains unclear.</p><p><strong>Methods: </strong>A total of 5,427 patients with coronary artery disease (CAD) who underwent successful PCI between 2005 and 2015 were enrolled. The association between body mass index (BMI) and future adverse cardiovascular events post PCI was analyzed. The study endpoints encompassed total cardiovascular (CV) events, including cardiac death, nonfatal myocardial infarction (MI), ischemic stroke, and hospitalization for congestive heart failure (CHF).</p><p><strong>Results: </strong>Over an average follow-up period of 65.1 ± 32.1 months, 942 patients (17.4%) had CV events, including 200 CV deaths (3.7%), 294 acute MIs (5.4%), 111 ischemic strokes (2.0%), 469 CHF hospitalizations (8.6%), and 1,098 revascularizations (20.2%). A J-shaped relationship between BMI and future adverse events was observed, in which individuals with a BMI of 25.0-29.9 kg/m<sup>2</sup> had significantly lower risks of total CV events [hazard ratio (HR) = 0.84, 95% confidence interval (CI) = 0.72-0.98], major adverse cardiovascular events (HR = 0.76, 95% CI = 0.63-0.93), acute MI (HR = 0.76, 95% CI = 0.58-1.00), and ischemic stroke (HR = 0.61, 95% CI = 0.39-0.95), compared to those with a BMI of 22.0-24.9 kg/m<sup>2</sup>.</p><p><strong>Conclusions: </strong>We found a J-shaped relationship between baseline BMI and future adverse events in CAD patients undergoing PCI. Overweight individuals (BMI 25.0-29.9 kg/m<sup>2</sup>) had the lowest future risk of total CV events compared to those with a normal BMI (22.0-24.9 kg/m<sup>2</sup>).</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 1","pages":"82-93"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11701491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Feasibility and Safety of Distal Radial Artery Access with Recanalization of a Chronic Radial Artery Occlusion for Subsequent Coronary Angiography and Intervention. 桡动脉远端再通对慢性桡动脉闭塞患者冠脉造影和介入治疗的可行性和安全性。
IF 1.8 4区 医学
Acta Cardiologica Sinica Pub Date : 2025-01-01 DOI: 10.6515/ACS.202501_41(1).20241024A
Min-Ping Huang, Shu-Kai Hsueh, Wen-Jung Chung, Chiung-Jen Wu
{"title":"Feasibility and Safety of Distal Radial Artery Access with Recanalization of a Chronic Radial Artery Occlusion for Subsequent Coronary Angiography and Intervention.","authors":"Min-Ping Huang, Shu-Kai Hsueh, Wen-Jung Chung, Chiung-Jen Wu","doi":"10.6515/ACS.202501_41(1).20241024A","DOIUrl":"https://doi.org/10.6515/ACS.202501_41(1).20241024A","url":null,"abstract":"<p><strong>Aims: </strong>This study aims to verify the feasibility and safety of percutaneous coronary intervention (PCI) after a distal transradial approach (dTRA) with radial artery occlusion (RAO) recanalization.</p><p><strong>Methods: </strong>Between July 2018 and January 2022, 30 patients underwent PCI following attempted RAO recanalization via dTRA. Among these cases, the target radial arteries could not be recanalized in five patients, necessitating alternative vascular access. The remaining 25 patients with successful RAO recanalization were divided into a standard group (n = 19) and tough group (n = 6), the latter requiring more than 10 minutes and complex techniques and devices for recanalization.</p><p><strong>Results: </strong>The procedural success rate was 96.7%, with vascular access-site complications occurring in 20% of the cases, including five perforations easily managed with prolonged balloon inflation and one pseudoaneurysm without flow limitation. In the tough group, no significant increase in procedural complications, access-site vascular complications, or total major adverse cardiac and cerebrovascular events was observed. However, Doppler ultrasound one month later for the recanalized radial artery revealed a significantly higher rate of severe stenosis and re-occlusion at 100% compared to 10% in the standard group, as supported by receiver operating characteristic curve analysis.</p><p><strong>Conclusions: </strong>The feasibility and safety of PCI following RAO recanalization via dTRA were acceptable. We propose a 10-minute threshold to differentiate between standard and tough groups during RAO recanalization. Given the uncertainty of long-term patency in recanalized RAs, the primary goal in tough cases is to ensure the guide catheter reaches the ascending aorta for subsequent PCI.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 1","pages":"94-105"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11701496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rhythm Control Better Prevents Stroke than Rate Control in Patients with Concomitant Hypertrophic Cardiomyopathy and Atrial Fibrillation: A Nationwide Population Based Cohort Study with Long-Term Follow-Up. 心律控制比心率控制更能预防肥厚性心肌病和心房颤动患者的卒中:一项长期随访的全国性人群队列研究。
IF 1.8 4区 医学
Acta Cardiologica Sinica Pub Date : 2025-01-01 DOI: 10.6515/ACS.202501_41(1).20241111A
Shang-Ju Wu, Yun-Yu Chen, Yu-Shan Chien, Ming-Jen Kuo, Cheng-Hung Li, Chi-Jen Weng, Jiunn-Cherng Lin, Yu-Yu Hsiao, Guan-Yi Li, Ching-Heng Lin, Jin-Long Huang, Yenn-Jiang Lin, Yu-Cheng Hsieh, Shih-Ann Chen
{"title":"Rhythm Control Better Prevents Stroke than Rate Control in Patients with Concomitant Hypertrophic Cardiomyopathy and Atrial Fibrillation: A Nationwide Population Based Cohort Study with Long-Term Follow-Up.","authors":"Shang-Ju Wu, Yun-Yu Chen, Yu-Shan Chien, Ming-Jen Kuo, Cheng-Hung Li, Chi-Jen Weng, Jiunn-Cherng Lin, Yu-Yu Hsiao, Guan-Yi Li, Ching-Heng Lin, Jin-Long Huang, Yenn-Jiang Lin, Yu-Cheng Hsieh, Shih-Ann Chen","doi":"10.6515/ACS.202501_41(1).20241111A","DOIUrl":"https://doi.org/10.6515/ACS.202501_41(1).20241111A","url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation (AF) increases the risks of stroke and mortality. It remains unclear whether rhythm control reduces the risk of stroke in patients with AF concomitant with hypertrophic cardiomyopathy (HCM).</p><p><strong>Methods: </strong>We identified AF patients with HCM who were ≥ 18 years old in the Taiwan National Health Insurance Database. Patients using antiarrhythmic medications for ≥ 30 defined daily doses (DDDs) or receiving catheter ablation for AF constituted the rhythm control group. Patients using rate control medications for ≥ 30 DDDs constituted the rate control group. A multivariable Cox regression model was used to evaluate the hazard ratio (HR) for adverse cardiovascular events.</p><p><strong>Results: </strong>We enrolled a total of 178 patients with both AF and HCM without pre-existing cardiovascular diseases. Among them, 99 were in the rhythm control group and 79 were in the rate control group. After a follow-up period of 6.47 ± 0.98 years, the rhythm control group had a lower risk of stroke than the rate control group (adjusted HR: 0.380, p = 0.031) after adjusting for covariates including use of antithrombotic agents. After excluding patients receiving catheter ablation, the rhythm control group still had a lower risk of stroke than the rate control group (adjusted HR: 0.380, p = 0.037).</p><p><strong>Conclusions: </strong>In patients with AF and HCM, rhythm control with mainly pharmacological treatment better prevented stroke than rate control in long-term follow-up. The beneficial effect of lowering stroke risk through rhythm control was independent of oral anticoagulant use.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 1","pages":"72-81"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11701490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammatory-Related Biomarkers in Patients Undergoing Percutaneous Transluminal Angioplasty for Femoropopliteal Artery Lesions. 经皮腔内血管成形术治疗股腘动脉病变患者的炎症相关生物标志物。
IF 1.8 4区 医学
Acta Cardiologica Sinica Pub Date : 2025-01-01 DOI: 10.6515/ACS.202501_41(1).20241024A
Nart Zafer Baytugan, Hasan Caglayan Kandemir, Muharrem Dağlı, Tahir Bezgin, Aziz İnan Çelik, Ahmet Zengin, Metin Çağdaş
{"title":"Inflammatory-Related Biomarkers in Patients Undergoing Percutaneous Transluminal Angioplasty for Femoropopliteal Artery Lesions.","authors":"Nart Zafer Baytugan, Hasan Caglayan Kandemir, Muharrem Dağlı, Tahir Bezgin, Aziz İnan Çelik, Ahmet Zengin, Metin Çağdaş","doi":"10.6515/ACS.202501_41(1).20241024A","DOIUrl":"https://doi.org/10.6515/ACS.202501_41(1).20241024A","url":null,"abstract":"<p><strong>Background: </strong>The systemic immune-inflammation index (SII), systemic inflammatory response index (SIRI), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) are novel inflammation-related markers calculated based on peripheral blood count. Data on biomarkers for the prognosis of peripheral artery disease (PAD) are limited. We aimed to evaluate the impact of these four inflammation-related biomarkers on mid-term restenosis and mortality rates in PAD patients.</p><p><strong>Methods: </strong>This retrospective single-center study was conducted at a tertiary hospital between March 2020 and May 2023. Patients admitted to our catheterization laboratory for percutaneous coronary intervention for PAD were enrolled. The primary endpoint was all-cause mortality, and the secondary endpoint was restenosis.</p><p><strong>Results: </strong>A total of 418 participants were enrolled, including 211 in the study group and 207 in the control group. The average follow-up period was 20.80 ± 10.11 months. During the follow-up period, 39 patients (18.5%) died and restenosis occurred in 37 patients (17.5%). The mortality rate was significantly higher in the patients with high SII, SIRI, NLR, and PLR (p = 0.001, p = 0.001, p = 0.001, and p = 0.001, respectively). No significant correlations were found between SII, SIRI, NLR, PLR, and restenosis (all p > 0.05). In multivariate logistic regression analysis, only NLR was found to be an independent risk factor for mortality [(odds ratio) 6.91, 95% confidence interval: 3.18-14.99, p = 0.001].</p><p><strong>Conclusions: </strong>The SII, SIRI, NLR, and PLR were higher in non-survivors, and NLR was independently associated with mortality in patients with PAD.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 1","pages":"138-147"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11701489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real-World Analyses of the De-Escalation of Dual Antiplatelet Therapy in Treatment of Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention in Taiwan. 台湾经皮冠状动脉介入治疗急性心肌梗死患者双重抗血小板治疗降压的现实世界分析。
IF 1.8 4区 医学
Acta Cardiologica Sinica Pub Date : 2025-01-01 DOI: 10.6515/ACS.202501_41(1).20240916B
Yi-Heng Li, I-Chang Hsieh, Hui-Wen Lin, Sheng-Hsiang Lin
{"title":"Real-World Analyses of the De-Escalation of Dual Antiplatelet Therapy in Treatment of Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention in Taiwan.","authors":"Yi-Heng Li, I-Chang Hsieh, Hui-Wen Lin, Sheng-Hsiang Lin","doi":"10.6515/ACS.202501_41(1).20240916B","DOIUrl":"https://doi.org/10.6515/ACS.202501_41(1).20240916B","url":null,"abstract":"<p><strong>Background: </strong>Dual antiplatelet therapy (DAPT) is the standard treatment for acute myocardial infarction (MI). This study aimed to investigate the use of DAPT and de-escalation after discharge in real-world practice among patients with acute MI undergoing percutaneous coronary intervention (PCI) in Taiwan.</p><p><strong>Methods: </strong>Using the Taiwan National Health Insurance Research Database, we included patients who received PCI for acute MI and survived to discharge with DAPT from 2011 to 2021. The choice of different P2Y12 inhibitors at discharge and de-escalation therapy after discharge were analyzed.</p><p><strong>Results: </strong>Overall, 58989 patients (mean age 61.9 ± 13.2 years, male 81.4%) were included. The initial use of aspirin plus ticagrelor (A + T) increased from 4.8% in 2013 to 73.2% in 2021 (p < 0.01). Switch to de-escalation therapy occurred in 52.7% of the A + T users at 9 months follow-up. Aspirin plus clopidogrel (A + C) and ticagrelor monotherapy were the most commonly used de-escalation therapies in the first 6 months. Multivariable logistic regression analysis demonstrated that older patients and those with non-ST-segment elevation MI, multi-vessel PCI, baseline bleeding risk and bleeding events during follow-up were more likely to receive ticagrelor monotherapy than A + C.</p><p><strong>Conclusions: </strong>A + T has become the major initial DAPT for patients with acute MI undergoing PCI in Taiwan, but de-escalation is not uncommon after discharge. Ticagrelor monotherapy was more likely to be prescribed than A + C in those with multi-vessel PCI or bleeding concern.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 1","pages":"106-120"},"PeriodicalIF":1.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11701495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lenalidomide-Induced Myocarditis in a Young Male Patient with Multiple Myeloma: A Rare and Life-Threatening Complication of Immunotherapy. 来那度胺诱导的年轻男性多发性骨髓瘤患者心肌炎:免疫治疗中一种罕见且危及生命的并发症。
IF 1.8 4区 医学
Acta Cardiologica Sinica Pub Date : 2025-01-01 DOI: 10.6515/ACS.202501_41(1).20241018A
Furkan Karahan, Çağlar Kaya, Nilay Solak, Muhammet Gürdoğan, Fethi Emre Ustabaşıoğlu
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