Acta Cardiologica Sinica最新文献

{"title":"Efficacy, Safety, Cost, and Clinical Outcomes after the Switch to Generic Rosuvastatin Compared with Consistent Brand-Name Atorvastatin Treatment.","authors":"Mu-Shiang Huang, Chun-I Wu, Ping-Yen Liu","doi":"10.6515/ACS.202511_41(6).20250616B","DOIUrl":"https://doi.org/10.6515/ACS.202511_41(6).20250616B","url":null,"abstract":"<p><strong>Background: </strong>The efficacy, safety, and clinical outcomes in patients switching to generic rosuvastatin compared to those taking other brand-name atorvastatin are unclear.</p><p><strong>Methods: </strong>Electronic medical records were retrospectively collected from January 1, 2013 to December 31, 2020 of patients who switched medication because of hospital policy from brand-name to generic rosuvastatin after March 14, 2018. Only patients who had taken the medication for at least 1 year prior to and 1 year after that date were enrolled. The records of patients who consistently used brand-name atorvastatin during the same period were also collected. The efficacy of lipid control, potential adverse effects, clinical outcomes of major cardiovascular events (MACE), and medical expenses were compared between the 2 groups. Propensity score matching (PSM) was conducted to balance potential cofounders.</p><p><strong>Results: </strong>After 1:1 PSM, 592 patients were enrolled in the rosuvastatin and atorvastatin groups, respectively. No significant differences were observed in total cholesterol level (-4.38 ± 23.0 vs. -3.72 ± 26.95 mg/dL, p = 0.702), low-density lipoprotein (-2.38 ± 19.89 vs. -2.42 ± 23.63 mg/dL, p = 0.976), or glycated hemoglobin (-0.05% ± 0.7% vs. -0.08% ± 0.76%, p = 0.543). No significant difference was noted in cumulative MACE rate (2.70% vs. 3.89%, log-rank p = 0.265) after the switch date, and each person in the generic group had a 16% average reduction in medical expenses.</p><p><strong>Conclusions: </strong>Switching to generic rosuvastatin led to comparable lipid-lowering efficacy, safety, and clinical outcomes and lower medical expenses compared with consistently using brand-name atorvastatin.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 6","pages":"761-771"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12648264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145627641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epicardial Mapping and Ablation of Ventricular Tachycardia in a Patient with Non-Ischemic Cardiomyopathy Post-Thoracotomy Cardiovascular Surgery and Epicardial Pacemaker Implantation: A Case Report of Challenges.","authors":"Lo-Chieh Ling, Chin-Yu Lin, Yenn-Jiang Lin","doi":"10.6515/ACS.202511_41(6).20250818B","DOIUrl":"https://doi.org/10.6515/ACS.202511_41(6).20250818B","url":null,"abstract":"","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 6","pages":"800-804"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12648257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145627599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer Treatment-Induced Arrhythmia with Recurrent Ventricular Tachycardia in a Patient with Lung Cancer.","authors":"Ren-Wei Tsai, Chin-Yu Lin","doi":"10.6515/ACS.202511_41(6).20250818A","DOIUrl":"https://doi.org/10.6515/ACS.202511_41(6).20250818A","url":null,"abstract":"","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 6","pages":"796-799"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12648252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145627629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Impact of Lesion-Specific Hemodynamic Index and Disease Characteristics in Patients with Coronary Artery Disease Assessed by Diastolic Hyperemia-Free Ratio and Instantaneous Wave-Free Ratio (PRIME-DFRiFR).","authors":"Hsiao-Yang Cheng, Men-Ying Lu, Kuang-Te Wang","doi":"10.6515/ACS.202511_41(6).20250624A","DOIUrl":"10.6515/ACS.202511_41(6).20250624A","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to investigate the consistency of diastolic hyperemia-free ratio (DFR) and instantaneous wave-free ratio (iFR) before and after lesions in the distal coronary artery.</p><p><strong>Methods: </strong>The PRIME-DFRiFR Study was a single-center, prospective, observational study that evaluated DFR and iFR at points distal and proximal to lesions in distal coronary vessels after angiography and successful percutaneous coronary intervention (PCI). Target lesions with diameter stenosis of 50% to 70% were selected, and DFR and iFR were evaluated from the vessel distal point, the lesion distal point, the lesion proximal point, and the vessel proximal point, respectively.</p><p><strong>Results: </strong>Thirty patients (23 males [76.7%]; age 70.6 ± 10.2 years) were enrolled between August 2022 and December 2023, with a total of 37 single intermediate coronary lesions, clinical manifestations of unstable angina, acute coronary syndrome, dilated cardiomyopathy, or syncope. The DFR and iFR values at the vessel distal point, lesion distal point, lesion proximal point, and vessel proximal point were 0.95 ± 0.06 and 0.94 ± 0.05, 0.96 ± 0.05 and 0.95 ± 0.05, 0.99 ± 0.03 and 0.99 ± 0.03, and 1.00 ± 0.01 and 1.00 ± 0.02, respectively. The Pearson correlation coefficients of the four point values were 0.894, 0.834, 0.667 and 0.632, respectively (p < 0.001).</p><p><strong>Conclusions: </strong>The significant positive correlations indicate that DFR can show relevant pressure changes before and after lesions in a comparable manner to iFR. In this study, the biggest influencing factor for discordance between DFR and iFR was old myocardial infarction. Post-PCI results indicated that DFR wires appeared to maintain relatively good maneuverability with comparable accuracy to iFR wires.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 6","pages":"744-750"},"PeriodicalIF":1.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12648251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145627753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Cardiac Stress to Organ Distress: Acute Hepatorenal Dysfunction after Dipyridamole Myocardial Perfusion Imaging.","authors":"Yu-Tung Kao, Yu-Cheng Shih, Shan-Ying Wang, Yen-Wen Wu","doi":"10.6515/ACS.202511_41(6).20250818D","DOIUrl":"https://doi.org/10.6515/ACS.202511_41(6).20250818D","url":null,"abstract":"","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 6","pages":"815-821"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12648258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145627689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Obesity Phenotypes on Efficacy and Safety of Catheter Ablation for Patients with Paroxysmal Atrial Fibrillation.","authors":"Lo-Chieh Ling, Ting-Yung Chang, Chin-Yun Lin, Yenn-Jiang Lin, Yu-Feng Hu, Fa-Po Chung, Li-Wei Lo, Ta-Chuan Tuan, Tze-Fan Chao, Jo-Nan Liao, Ling Kuo, Chih-Min Liu, Shin-Huei Liu, Cheng-I Wu, Cheng-Han Chan, Chen Shih-Ann","doi":"10.6515/ACS.202511_41(6).20250616E","DOIUrl":"https://doi.org/10.6515/ACS.202511_41(6).20250616E","url":null,"abstract":"<p><strong>Background: </strong>Obesity is a major risk factor for atrial fibrillation (AF). Individuals with obesity can be further classified into metabolically unhealthy obesity (MUO) or healthy obesity (MHO) groups based on the metabolic health subtype. The influence of these phenotypes and overweight status on AF ablation outcomes remains unclear.</p><p><strong>Objective: </strong>This study aimed to examine the recurrence of paroxysmal AF (PAF) after ablation in patients across distinct obesity phenotypes.</p><p><strong>Methods: </strong>From January 2019 to November 2023, 599 patients with drug-refractory PAF undergoing a first ablation were retrospectively analyzed. Based on the World Health Organization-defined body mass index thresholds for Asians regarding overweight (23-25 kg/m²) and obesity (> 25 kg/m²), the participants were categorized into normal-weight, metabolically healthy overweight (MHOW), metabolically unhealthy overweight (MUOW), MHO, or MUO groups. Metabolic health required the absence of hypertension, diabetes, and dyslipidemia. Pulmonary vein isolation was achieved using either a force-sensing catheter or cryoablation.</p><p><strong>Results: </strong>The mean age of the patients was 60.7 ± 11.7 years, and 64.1% were men. Compared with the normal-weight patients, AF recurrence was higher in the MUOW (19.8%), MHO (18.0%), and MUO (14.9%) groups after an average follow-up of 534 days, with respective hazard ratios (HRs) of 3.240 (p = 0.003), 2.973 (p = 0.013), and 2.182 (p = 0.033) after adjusting for chronic kidney disease. MHOW (14.9%; HR 2.593, p = 0.053) showed a non-significant trend toward a higher risk. Complete pulmonary vein isolation was achieved in all patients.</p><p><strong>Conclusions: </strong>Overweight and obesity, regardless of metabolic status, were associated with a significantly higher risk of AF recurrence after ablation compared to normal-weight, underscoring the importance of weight management in PAF.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 6","pages":"691-702"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12648262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145627763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Erratum.","authors":"Wei-Ting Chang","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.6515/ACS.202505_41(3).20250224A.].</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 6","pages":"828"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12648247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145627621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative Adenosine Deaminase Activity Predicts Complications After On-Pump Cardiac Surgery.","authors":"Inayet Gunturk, Rifat Ozmen, Cevat Yazici, Ertugrul Emre Gunturk","doi":"10.6515/ACS.202511_41(6).20250710A","DOIUrl":"https://doi.org/10.6515/ACS.202511_41(6).20250710A","url":null,"abstract":"<p><strong>Background: </strong>Various factors associated with cardiopulmonary bypass (CPB) can produce an inflammatory response, resulting in morbidity and mortality. The aim of this study was to investigate how adenosine deaminase (ADA) activity changes after surgery in relation to the emergence of CPB-related complications.</p><p><strong>Methods: </strong>The study included 78 patients, of whom 30 had complications. Blood samples were collected three times: on admission to the ward (preoperative), on the first postoperative day, and on the fifth postoperative day. The blood samples were analyzed for routine hematological and biochemical variables. In addition, serum ADA activity was evaluated, and normalized ADA [ADA_(Nor)] levels were calculated.</p><p><strong>Results: </strong>On postoperative day 1, ADA and ADA_(Nor) levels differed between the groups. In multivariate analysis, left atrium diameter (p = 0.015), and ADA_(Nor) (p = 0.001) on postoperative day 1 were significant predictors of CPB-related complications. Receiver operating characteristic curve analysis showed that the area under curve for postoperative first day ADA_(Nor) was 0.767 (95% confidence interval 0.664-0.871). Using a cut-off value of 11.87, postoperative first day ADA_(Nor) predicted postoperative complication emergencies with 63.3% sensitivity and 77.1% specificity.</p><p><strong>Conclusions: </strong>This study is the first to identify blood ADA_(Nor) activity as an independent risk factor for the development of postoperative CPB-related complications.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 6","pages":"720-730"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12648254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145627782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"2024 Guidelines of the Taiwan Society of Cardiology on the Primary Prevention of Atherosclerotic Cardiovascular Disease\".","authors":"Wei-Ting Chiang, Bor-Jen Lee","doi":"10.6515/ACS.202511_41(6).20241211A","DOIUrl":"https://doi.org/10.6515/ACS.202511_41(6).20241211A","url":null,"abstract":"","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 6","pages":"825-826"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12648266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145627666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Blood Pressure Variability with Contrast Nephropathy in STEMI Patients Undergoing Primary PCI.","authors":"Cahit Coskun, Semih Eren, Feyza Mollaalioglu, Alihan Ayata, Mehmet Baran Karatas","doi":"10.6515/ACS.202511_41(6).20250428E","DOIUrl":"https://doi.org/10.6515/ACS.202511_41(6).20250428E","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular disease, particularly ST-segment elevation myocardial infarction (STEMI), continues to be a leading cause of death worldwide despite advances in treatment options. Contrast-induced nephropathy (CIN) increases the risk of morbidity and mortality after percutaneous coronary intervention (PCI) in STEMI patients. Blood pressure variability (BPV), defined as fluctuations in blood pressure (BP) over time, has been associated with cardiovascular events, stroke, target organ damage and renal dysfunction independently of BP levels. The relationship between BPV and CIN is unknown.</p><p><strong>Methods: </strong>This prospective study investigated the relationship between invasively measured short-term BPV and CIN in haemodynamically stable STEMI patients undergoing PCI. In 220 patients, BP was monitored through the femoral sheath for six hours after PCI, and systolic and diastolic standard deviation (SD), average real variability (ARV) and delta parameters were calculated using universal formulae.</p><p><strong>Results: </strong>The results indicated a significant association between short-term BPV, especially systolic BPV, and the development of CIN (p < 0.01). In particular, systolic SD [odds ratio (OR): 1.055, 95% confidence interval (CI) 1.003-1.110, p = 0.04] and systolic ARV (OR: 1.084, 95% CI 1.011-1.162, p = 0,02) emerged as independent predictors of CIN.</p><p><strong>Conclusions: </strong>Our study demonstrated that intra-arterially measured short-term BPV was associated with the development of CIN in STEMI patients. Notably, systolic SD and systolic ARV were independent predictors of CIN, which may be of clinical importance for early diagnosis and prevention. These results suggest that BPV may be an indicator of CIN risk, and further large-scale randomised trials are warranted to clarify this relationship.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"41 6","pages":"703-711"},"PeriodicalIF":1.8,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12648249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145627519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}