Acta Cardiologica Sinica最新文献

{"title":"2024 Guidelines of the Taiwan Society of Cardiology on the Primary Prevention of Atherosclerotic Cardiovascular Disease --- Part I.","authors":"Ting-Hsing Chao, Tsung-Hsien Lin, Cheng-I Cheng, Yen-Wen Wu, Kwo-Chang Ueng, Yih-Jer Wu, Wei-Wen Lin, Hsing-Ban Leu, Hao-Min Cheng, Chin-Chou Huang, Chih-Cheng Wu, Chao-Feng Lin, Wei-Ting Chang, Wen-Han Pan, Pey-Rong Chen, Ke-Hsin Ting, Chun-Hung Su, Chih-Sheng Chu, Kuo-Liong Chien, Hsueh-Wei Yen, Yu-Chen Wang, Ta-Chen Su, Pang-Yen Liu, Hsien-Yuan Chang, Po-Wei Chen, Jyh-Ming Jimmy Juang, Ya-Wen Lu, Po-Lin Lin, Chao-Ping Wang, Yu-Shien Ko, Chern-En Chiang, Charles Jia-Yin Hou, Tzung-Dau Wang, Yen-Hung Lin, Po-Hsun Huang, Wen-Jone Chen","doi":"10.6515/ACS.202409_40(5).20240724A","DOIUrl":"10.6515/ACS.202409_40(5).20240724A","url":null,"abstract":"<p><p>Atherosclerotic cardiovascular disease (ASCVD) is one of the leading causes of death worldwide and in Taiwan. It is highly prevalent and has a tremendous impact on global health. Therefore, the Taiwan Society of Cardiology developed these best-evidence preventive guidelines for decision-making in clinical practice involving aspects of primordial prevention including national policies, promotion of health education, primary prevention of clinical risk factors, and management and control of clinical risk factors. These guidelines cover the full spectrum of ASCVD, including chronic coronary syndrome, acute coronary syndrome, cerebrovascular disease, peripheral artery disease, and aortic aneurysm. In order to enhance medical education and health promotion not only for physicians but also for the general public, we propose a slogan <b>(2H2L)</b> for the primary prevention of ASCVD on the basis of the essential role of healthy dietary pattern and lifestyles: \"<b>Healthy Diet and Healthy Lifestyles to Help Your Life and Save Your Lives</b>\". We also propose an acronym of the modifiable risk factors/enhancers and relevant strategies to facilitate memory: \" <b>ABC₂D₂EFG-I'M₂ ACE\"</b>: Adiposity, Blood pressure, Cholesterol and Cigarette smoking, Diabetes mellitus and Dietary pattern, Exercise, Frailty, Gout/hyperuricemia, Inflammation/infection, Metabolic syndrome and Metabolic dysfunction-associated fatty liver disease, Atmosphere (environment), Chronic kidney disease, and Easy life (sleep well and no stress). Some imaging studies can be risk enhancers. Some risk factors/clinical conditions are deemed to be preventable, and healthy dietary pattern, physical activity, and body weight control remain the cornerstone of the preventive strategy.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"40 5","pages":"479-543"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11413940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atlas Drug-Eluting Coronary Stents Inhibit Neointimal Hyperplasia in Sheep Modeling.","authors":"Rasit Dinc, Halit Yerebakan","doi":"10.6515/ACS.202409_40(5).20240618A","DOIUrl":"10.6515/ACS.202409_40(5).20240618A","url":null,"abstract":"<p><strong>Background: </strong>Coronary artery disease (CAD) is one of the leading causes of mortality and morbidity worldwide. Many patients with CAD require mechanical revascularization. However, restenosis after minimally invasive interventions is a major problem for these patients. Fortunately, the controlled drug delivery properties of drug-eluting stents seem to be able to overcome this problem. In this study, the pharmacodynamic and pharmacokinetic properties of Atlas Drug-eluting Coronary Stents coated with poly (lactic acid-coglycolic acid) (PLGA) were evaluated.</p><p><strong>Materials and methods: </strong>This study included 20 non-atherosclerotic female sheep divided into 4 groups that included 4 study and 1 control animal randomly assigned to each group. Animals in the study groups were stented with Atlas Drug-eluting Coronary Stents, and the pharmacodynamic and pharmacokinetic properties were evaluated.</p><p><strong>Results: </strong>Sirolimus was shown to have a statistically important effect on the vascular endothelium. With time, the decrease in sirolimus in blood samples was statistically significant. Two animals died after implantation; however no clinically significant side effects were observed in the others.</p><p><strong>Conclusions: </strong>The results in this study showed a significant reduction in neointimal hyperplasia after experimental implantation of Atlas Drug-eluting Coronary Stents coated with PLGA polymer. Pharmacokinetic studies also showed that the stent did not release a significant amount of sirolimus after 28 days.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"40 5","pages":"585-594"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11413949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of Prosthesis-Patient Mismatch after Aortic Valve Replacement-Ten-Year Cohort Data in Single Center of Taiwan.","authors":"Po-Hsueh Su, Ting-Hsing Chao, Mu-Shiang Huang, Wei-Chuan Tsai","doi":"10.6515/ACS.202409_40(5).20240207B","DOIUrl":"10.6515/ACS.202409_40(5).20240207B","url":null,"abstract":"<p><strong>Background: </strong>Patient-prosthesis mismatch (PPM) after surgical aortic valve replacement for severe aortic stenosis has a significant effect on survival. Few studies have identified the risk factors for PPM and related outcomes. This study investigated these risk factors and clarified the outcomes.</p><p><strong>Methods: </strong>This study enrolled consecutive patients who underwent aortic valve replacement surgery between January 2010 and June 2020 in our hospital. Data on clinical profiles, prosthesis types, echocardiographic parameters before and after surgery, and clinical outcomes including the composite of all-cause mortality and redo valve replacement were collected. We defined moderate and severe PPM as an effective orifice area index value of ≤ 0.85 and ≤ 0.65 cm²/m², respectively, measured postoperatively through echocardiography. Potential risk factors for PPM and clinical outcomes were evaluated.</p><p><strong>Results: </strong>A total of 185 patients were enrolled. Body surface area (BSA; 1.68 ± 0.02 vs. 1.62 ± 0.01 m², p = 0.036), renal insufficiency (32.50% vs. 11.70%, p = 0.026), and aortic annulus diameter (1.99 ± 0.05 vs. 2.17 ± 0.03 cm, p = 0.013) were statistically significant risk factors for severe PPM. The primary outcome was observed in 30.00% and 15.86% of the patients with and without severe PPM, respectively (log-rank p = 0.023). Multivariate Cox proportional hazards analysis indicated that severe PPM was a risk factor for the primary outcome (hazard ratio: 2.688, 95% confidence interval: 1.094-6.622, p = 0.031).</p><p><strong>Conclusions: </strong>Our study demonstrated that large BSA, renal insufficiency, and small annulus diameter were risk factors for severe PPM after aortic valve replacement surgery. Severe PPM was associated with worse clinical outcomes.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"40 5","pages":"595-607"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11413942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and Effectiveness of Venoarterial Extracorporeal Membrane Oxygenation Plus Intra-Aortic Balloon Pump Assisted High-Risk Percutaneous Coronary Intervention in Complex Coronary Disease.","authors":"Dong-Tao Li, Yi Cao, Yi-Gang Qiu, Yu Chen, Jian-Yong Zheng","doi":"10.6515/ACS.202409_40(5).20240617F","DOIUrl":"10.6515/ACS.202409_40(5).20240617F","url":null,"abstract":"<p><strong>Background: </strong>Mechanical circulatory support may facilitate high-risk percutaneous coronary intervention (PCI). This study aimed to assess the feasibility, safety and effectiveness of high-risk PCI under the support of venoarterial extracorporeal membrane oxygenation (VA-ECMO) combined with intra-aortic balloon pump (IABP).</p><p><strong>Methods: </strong>We enrolled patients who received VA-ECMO plus IABP-assisted PCI procedures at our center from April 2012 to June 2018. Major adverse cardiac events (MACEs) included all-cause death, myocardial infarction, and target vessel revascularization.</p><p><strong>Results: </strong>A total of 10 patients were included, with a mean age of 71 years, EuroSCORE II of 19.9%, and SYNTAX score of 39.8. Procedural success was achieved in nine (90%) patients. The mean duration of ECMO support was 1.5 hours, and 2.6 stents were implanted per patient. Major complications included contrast-induced nephropathy needing hemodialysis in one (10%) patient, significant hemoglobin drop requiring blood transfusion in two (20%) patients, pulmonary infection in one (10%) patient, and local surgical incision infection in one (10%) patient. The accumulative mortality rates for the nine patients with procedural success were 0, 22.2%, and 44.4% at 1, 3, and 5 years follow-up, respectively. However, cardiac death occurred in only one (11.1%) patient. In addition, two patients received repeat PCI or coronary artery bypass grafting within two years following the index procedure. The overall incidence rates of MACEs were 11.1%, 44.4%, and 66.7% at 1, 3, and 5 years follow-up, respectively.</p><p><strong>Conclusions: </strong>VA-ECMO plus IABP-assisted high-risk PCI was feasible in patients with complex coronary disease, with a high procedural success rate and acceptable mid-term clinical outcomes.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"40 5","pages":"577-584"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11413948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late Cardiac Involvement of the Glycogen Storage Disease Type IIIa with Massive Left Ventricular Hypertrophy and Late Gadolinium Enhancement.","authors":"Bedirhan Bozkurt Çimen, Samet Yilmaz","doi":"10.6515/ACS.202409_40(5).20240528B","DOIUrl":"10.6515/ACS.202409_40(5).20240528B","url":null,"abstract":"","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"40 5","pages":"648-650"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11413943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Significant Role of Post-Acute Care Programs in Individuals with Heart Failure.","authors":"Ercan Akşit, Hakkı Kaya, Emine Gazi","doi":"10.6515/ACS.202409_40(5).20240531A","DOIUrl":"10.6515/ACS.202409_40(5).20240531A","url":null,"abstract":"","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"40 5","pages":"663-664"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11413951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catheter-Directed Thrombolysis for Superficial Femoral Artery Thrombosis via the Ipsilateral Dorsalis Pedis Artery.","authors":"Hsin-Fu Lee, Hung-Chi Su, Chi Chuang","doi":"10.6515/ACS.202409_40(5).20240617B","DOIUrl":"10.6515/ACS.202409_40(5).20240617B","url":null,"abstract":"","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"40 5","pages":"656-658"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11413938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Look is Worth a Thousand Words!! - Case Series of Forearm Compartment Syndrome after Transradial Coronary Intervention.","authors":"Sriram Veeraraghavan, Bharath Raj Kidambi, Prasanna Subbaraju, Vasundhara Ponnaganti, Abhilasha Munisingh","doi":"10.6515/ACS.202409_40(5).20240619A","DOIUrl":"10.6515/ACS.202409_40(5).20240619A","url":null,"abstract":"","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"40 5","pages":"651-655"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11413954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subacute Bioprosthetic Mitral Valve and Inter-Atrial Septum Mural Thrombosis.","authors":"Ping-Ping Wang, Chuan-Chih Hsu, Chih-Wei Chen, Yi-Cheng Lin, Chun-Yao Huang","doi":"10.6515/ACS.202409_40(5).20240617C","DOIUrl":"10.6515/ACS.202409_40(5).20240617C","url":null,"abstract":"","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"40 5","pages":"659-662"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11413946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2024 Update of the TSOC Expert Consensus of Fabry Disease.","authors":"Chung-Lieh Hung, Yen-Wen Wu, Ling Kuo, Kuo-Tzu Sung, Heng-Hsu Lin, Wei-Ting Chang, Chia-Hsiu Chang, Chih-Hung Lai, Chun-Yao Huang, Chun-Li Wang, Chih-Chan Lin, Jyh-Ming Jimmy Juang, Po-Sheng Chen, Chao-Yung Wang, Hao-Chih Chang, Chun-Yuan Chu, Wen-Hwa Wang, Hsinyu Tseng, Yung-Ta Kao, Tzung-Dau Wang, Wen-Chung Yu, Wen-Jone Chen","doi":"10.6515/ACS.202409_40(5).20240731A","DOIUrl":"10.6515/ACS.202409_40(5).20240731A","url":null,"abstract":"<p><p>As an X-linked inherited lysosomal storage disease that is caused by α-galactosidase A gene variants resulting in progressive accumulation of pathogenic glycosphingolipid (Gb3) accumulation in multiple tissues and organs, Fabry disease (FD) can be classified into classic or late-onset phenotypes. In classic phenotype patients, α-galactosidase A activity is absent or severely reduced, resulting in a more progressive disease course with multi-systemic involvement. Conversely, late-onset phenotype, often with missense variants (e.g., IVS4+919G>A) in Taiwan, may present with a more chronic clinical course with predominant cardiac involvement (cardiac subtype), as they tend to have residual enzyme activity, remaining asymptomatic or clinically silent during childhood and adolescence. In either form, cardiac hypertrophy remains the most common feature of cardiac involvement, potentially leading to myocardial fibrosis, arrhythmias, and heart failure. Diagnosis is established through α-galactosidase enzyme activity assessment or biomarker analyisis (globotriaosylsphingosine, Lyso-Gb3), advanced imaging modalities (echocardiography and cardiac magnetic resonance imaging), and genotyping to differentiate FD from other cardiomyopathy. Successful therapeutic response relies on early recognition and by disease awareness from typical features in classic phenotype and cardiac red flags in cardiac variants for timely therapeutic interventions. Recent advances in pharmacological approach including enzyme replacement therapy (agalsidase alfa or beta), oral chaperone therapy (migalastat), and substrate reduction therapy (venglustat) aim to prevent from irreversible organ damage. Genotype- and gender-based monitoring of treatment effects through biomarker (Lyso-Gb3), renal assessment, and cardiac responses using advanced imaging modalities are key steps to optimizing patient care in FD.</p>","PeriodicalId":6957,"journal":{"name":"Acta Cardiologica Sinica","volume":"40 5","pages":"544-568"},"PeriodicalIF":1.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11413953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}