Predictive Value of Atherogenic Index of Plasma for 1-Year and 5-Year Outcomes after Transcatheter Aortic Valve Implantation.

Abstract

Background: Transcatheter aortic valve implantation (TAVI) is a treatment option for severe aortic stenosis; various factors have been associated with mortality after TAVI. The Atherogenic Index of Plasma (AIP) is calculated as the logarithmic ratio of triglycerides to high-density lipoprotein cholesterol (log [TG/HDL-C]), and it has been associated with multiple clinical conditions and might be a predictor of mortality in some populations. This study aimed to investigate the relationship between AIP and mortality at 1 and 5 years following TAVI.

Methods: This study included 448 consecutive patients who underwent TAVI. Based on their AIP values, they were divided into three groups. One- and 5-year mortality rates were analyzed using the Kaplan-Meier method, and factors influencing mortality were identified through Cox regression analysis.

Results: The overall 1-year cardiac mortality rate was 21%, and the 5-year mortality rate was 42%. For the high AIP group, both 1-year (29%; p = 0.02) and 5-year (57%; p = 0.05) mortality rates were significantly higher compared to the other groups. Kaplan-Meier analysis with the log-rank test demonstrated significantly lower event- free survival rates in the high AIP group at 1 year (p = 0.001) and 5 years (p = 0.005). Multivariable Cox regression revealed a 4.447-fold increased risk of mortality in the high AIP group (hazard ratio: 4.447, p = 0.01).

Conclusions: This study found a significant association between AIP and cardiac mortality in patients undergoing TAVI. Higher AIP levels were correlated with increased 1-year and 5-year mortality risks.