Medicinal Research Reviews最新文献

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Arginine Competition in Tumor Microenvironment: A Potential Target for Cancer Therapy. 肿瘤微环境中的精氨酸竞争:癌症治疗的潜在靶点。
IF 11.6 1区 医学
Medicinal Research Reviews Pub Date : 2025-10-07 DOI: 10.1002/med.70015
Junlei Zhang, Sijie Wang, Huihui Liu, Lihua Luo, Jian You
{"title":"Arginine Competition in Tumor Microenvironment: A Potential Target for Cancer Therapy.","authors":"Junlei Zhang, Sijie Wang, Huihui Liu, Lihua Luo, Jian You","doi":"10.1002/med.70015","DOIUrl":"https://doi.org/10.1002/med.70015","url":null,"abstract":"<p><p>Arginine is critical in biosynthesis, energy generation, cell proliferation, and immune regulation. In the tumor microenvironment (TME), due to limited supply and high consumption, the competition for arginine is extremely fierce. It always ends up with the victory of tumor cells and immunosuppressive cells, which leads to the arginine deficiency for anti-tumor immune cells, resulting in immune tolerance of tumors. Therapies based on arginine metabolism have been extensively studied. An arginine deprivation therapy has been developed as the tumor progression relies on arginine support. To reverse the arginine shortage of anti-tumor immune cells in TME, supplying arginine to enhance immune therapy has been proposed. Achieving the optimal antitumor effects of these two opposed therapies requires a better understanding of arginine metabolism in TME. In this review, we compared the transport, synthesis, and metabolism of arginine in tumor cells and various immune cells, and proposed key processes that may serve as potential therapeutic targets. In addition, for the two therapies for arginine, deprivation and supplementation, the recent research of them was discussed, and the relevant clinical trials were collected and summarized, which might provide reliable references for the further study and application of arginine-based therapies.</p>","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145237452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HMGB1: From Molecular Functions to Clinical Applications in Cancer and Inflammatory Diseases. HMGB1:从分子功能到肿瘤和炎症疾病的临床应用。
IF 11.6 1区 医学
Medicinal Research Reviews Pub Date : 2025-10-07 DOI: 10.1002/med.70017
Linghong Guo, Daihan Wang, Xian Jiang, Gu He
{"title":"HMGB1: From Molecular Functions to Clinical Applications in Cancer and Inflammatory Diseases.","authors":"Linghong Guo, Daihan Wang, Xian Jiang, Gu He","doi":"10.1002/med.70017","DOIUrl":"https://doi.org/10.1002/med.70017","url":null,"abstract":"<p><p>High Mobility Group Box 1 (HMGB1) is a nuclear protein crucial for nucleosome stability, gene regulation, DNA repair, cell differentiation, and development. Extracellularly, HMGB1 functions as a cytokine, significantly impacting inflammation, immune response, and the pathogenesis of various diseases, including cancer and inflammatory disorders. Research highlights HMGB1's complex role in cancer, where it promotes tumorigenesis through chronic inflammation and immune suppression while enhancing chemotherapy and genome stability. It also influences cell proliferation, angiogenesis, metastasis, and chemotherapy resistance. In inflammatory diseases, HMGB1 has a dual role: it can promote inflammation in conditions like ischemia-reperfusion injury and sepsis but also induces immune tolerance and suppression. This review provides a comprehensive overview of HMGB1's structure, functions, and regulatory mechanisms, discussing recent advances in understanding its roles in cancer and inflammatory diseases. We emphasize the evolving therapeutic strategies targeting HMGB1, underscoring its potential as a promising target for treating both cancer and inflammatory disorders.</p>","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145237493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches. 胆固醇和角鲨烯合成酶在癌症中的作用:分子机制、脂筏和治疗方法。
IF 11.6 1区 医学
Medicinal Research Reviews Pub Date : 2025-10-07 DOI: 10.1002/med.70012
Danai Mavridi, Theodora Katavati, Angeliki P Kourounakis
{"title":"The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches.","authors":"Danai Mavridi, Theodora Katavati, Angeliki P Kourounakis","doi":"10.1002/med.70012","DOIUrl":"https://doi.org/10.1002/med.70012","url":null,"abstract":"<p><p>A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS), a pivotal enzyme in the cholesterol biosynthetic pathway downstream of the molecular target of statins, has drawn attention as a potential therapeutic target in cancer. Being the first enzyme in the pathway solely responsible for sterol formation, SQS presents an appealing approach for studying the explicit role of cholesterol in cancer. In recent years, research has re-focused on SQS inhibitors, which modulate cellular cholesterol levels, ultimately regulating crucial processes for cancer progression. However, the mechanisms through which they exert anticancer activity have not been fully elucidated to date. In this review, we examine the roles of cholesterol, lipid rafts, and SQS in cancer and metastasis, and the potential therapeutic implications of SQS inhibitors.</p>","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145237474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling the Function of Antimicrobial Peptides in Relation to Source and Structure. 揭示抗菌肽的来源和结构功能。
IF 11.6 1区 医学
Medicinal Research Reviews Pub Date : 2025-10-04 DOI: 10.1002/med.70016
Kun Zhang, Da Teng, Ruoyu Mao, Na Yang, Ya Hao, Jianhua Wang
{"title":"Unveiling the Function of Antimicrobial Peptides in Relation to Source and Structure.","authors":"Kun Zhang, Da Teng, Ruoyu Mao, Na Yang, Ya Hao, Jianhua Wang","doi":"10.1002/med.70016","DOIUrl":"https://doi.org/10.1002/med.70016","url":null,"abstract":"<p><p>Antimicrobial peptides (AMPs), essential components of the body's innate defense system, are expected to exert and enhance their potential antimicrobials, immunomodation and other bio-activities that combine with traditional antimicrobial agents and vaccines efficiently against multi-drug-resistant (MDR) bacteria. They are multi-source (animal, plant, microbial, etc.) and multi-functional (antimicrobial, immunomodulatory, anticancer, antiviral, antioxidant, etc.), and have been clearly categorized according to source, function, and structure in several AMP databases. However, there is insufficient evidence to support recognizing, developing, and utilizing the source-function relationship of AMPs, as their first function is usually unknown or unclear; in addition, they are usually accompanied by some shortcomings such as weak stability, high toxicity, and production cost. These have seriously hindered their development for clinical application. Therefore, it is necessary to clarify the relationship between the AMP source and function, and establish a complete system to distinguish the first function, so that more AMP candidates can enter the pipeline of new drugs as early as possible. At the same time, the key fundamental elements, scaffold and bottom logistics were proposed for the R & D pipeline of AMPs as new antimicrobial agents, including the following key points: high yielding, stability, and safety of AMPs using heterologous expression, modification, encapsulation, and coadministration toward their final successful application.</p>","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145224781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting PDGFR, EGFR, FGFR, and VEGFR: Key Receptor Tyrosine Kinases-Driven Metabolic Reprogramming in Pulmonary Arterial Hypertension. 靶向PDGFR、EGFR、FGFR和VEGFR:关键受体酪氨酸激酶驱动的肺动脉高压代谢重编程
IF 11.6 1区 医学
Medicinal Research Reviews Pub Date : 2025-09-29 DOI: 10.1002/med.70014
Yanfei Mo, Desheng Wang, Yang Bai
{"title":"Targeting PDGFR, EGFR, FGFR, and VEGFR: Key Receptor Tyrosine Kinases-Driven Metabolic Reprogramming in Pulmonary Arterial Hypertension.","authors":"Yanfei Mo, Desheng Wang, Yang Bai","doi":"10.1002/med.70014","DOIUrl":"https://doi.org/10.1002/med.70014","url":null,"abstract":"<p><p>Pulmonary arterial hypertension (PAH) is a rare and life-threatening pulmonary vascular disease distinguished by vasoconstriction and remodeling of the pulmonary artery, leading to sustained elevated pulmonary artery pressure, right ventricular failure, and even death. Receptor tyrosine kinases (RTKs) are critical in PAH pathogenesis, and targeted therapies against RTKs are becoming a research hotspot due to their potential to inhibit cell proliferation and right ventricular hypertrophy. Abnormal activation of RTKs induces downstream signaling cascades, including metabolic reprogramming through multiple regulatory crosstalk, to meet high energy requirements during cell proliferation. However, the crucial connection between metabolic reprogramming and RTKs in PAH remains largely unexplored. In this review, we focus on four key RTKs: Platelet-Derived Growth Factor Receptor (PDGFR), Epidermal Growth Factor Receptor (EGFR), Fibroblast Growth Factor Receptor (FGFR), and Vascular Endothelial Growth Factor Receptor (VEGFR) in the metabolic reprogramming of PAH and explore hypotheses that require further validation. The aim is to highlight how these mechanisms can be applied to develop better therapeutic strategies.</p>","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management. 探索自噬诱导分子:在阿尔茨海默病管理中的多种途径。
IF 11.6 1区 医学
Medicinal Research Reviews Pub Date : 2025-09-29 DOI: 10.1002/med.70013
Baljinder Singh, Shubham Mahajan, Sadikalmahdi Abdella, Rehan Khan, Sanjay Garg
{"title":"Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management.","authors":"Baljinder Singh, Shubham Mahajan, Sadikalmahdi Abdella, Rehan Khan, Sanjay Garg","doi":"10.1002/med.70013","DOIUrl":"https://doi.org/10.1002/med.70013","url":null,"abstract":"<p><p>Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders. This review aims to provide a comprehensive overview of autophagy's role in neurodegenerative diseases, focusing on AD. The pathogenesis of AD involves the accumulation of misfolded proteins, such as beta-amyloid (Aβ) and tau, leading to neuronal dysfunction and cognitive impairment. Autophagy can be crucial in clearing these protein aggregates and maintaining cellular homeostasis. Nevertheless, autophagic dysregulation and mitochondrial dysfunction contribute to further progression of neurodegeneration. Furthermore, recent studies have demonstrated the therapeutic potential of several plant-based phytoconstituents and repurposed molecules that modulate autophagy. These compounds target both mTOR-dependent and independent pathways, highlighting their potential to alleviate disease pathology. This review aims to pave the way for future research and development in this field.</p>","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145184414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Navigating Solute Carrier Transporters-A Comprehensive Review of Functionalized Small Molecule Probes for Target Identification and Characterization. 导航溶质载流子-功能化小分子探针的目标识别和表征的综合综述。
IF 11.6 1区 医学
Medicinal Research Reviews Pub Date : 2025-09-02 DOI: 10.1002/med.70009
Majlen A Dilweg, Tracie Widjaja, Adriaan P IJzerman, Daan van der Es
{"title":"Navigating Solute Carrier Transporters-A Comprehensive Review of Functionalized Small Molecule Probes for Target Identification and Characterization.","authors":"Majlen A Dilweg, Tracie Widjaja, Adriaan P IJzerman, Daan van der Es","doi":"10.1002/med.70009","DOIUrl":"10.1002/med.70009","url":null,"abstract":"<p><p>Solute carrier transporters (SLCs) are integral membrane proteins that play pivotal roles in maintaining cellular homeostasis by mediating the transport of a diverse range of substrates across cell membranes. With their involvement in fundamental physiological processes such as nutrient uptake, neurotransmitter signaling, and drug transport, SLCs have emerged as crucial players in health and disease. Dysregulation of SLC function has been implicated in a spectrum of disorders, including metabolic diseases, cancer, and neurological afflictions. Despite their significance, SLCs remain relatively understudied compared to other protein classes, resulting in a gap in understanding their molecular mechanisms of action and potential as therapeutic targets. This review aims to address this gap by providing a comprehensive overview of the diverse array of small-molecule probes utilized in the study of SLCs. Various types of functionalized probes, amongst which fluorescent probes, bivalent probes, covalent inhibitors, affinity-based probes, photoswitchable inhibitors and proteolysis targeting chimeras (PROTACs), have been designed to investigate transporter function, substrate specificity, and regulatory mechanisms. In this review, we describe the principles underlying the design and synthesis of these probes, highlights key examples of their application in elucidating transporter function and regulation, and discuss insights gained from such studies. Furthermore, we examine current challenges and future directions in the development and utilization of small-molecule probes for SLC transporter research. By shedding light on the intricate mechanisms involved in transporter function and regulation, this review not only enhances the understanding of SLCs but also highlights their potential as therapeutic targets in drug discovery and thereby may facilitate systematic implementation of these innovative research approaches and the refinement of existing methodologies.</p>","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Astatine-211-Towards In Vivo Stable Astatine-211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications. Astatine-211-迈向体内稳定的Astatine-211标记放射性药物及其(预)临床应用。
IF 11.6 1区 医学
Medicinal Research Reviews Pub Date : 2025-09-01 DOI: 10.1002/med.70008
Marius Müller, Nadia Bom Pedersen, Vladimir Shalgunov, Andreas Ingemann Jensen, Umberto Maria Battisti, Matthias Manfred Herth
{"title":"Astatine-211-Towards In Vivo Stable Astatine-211 Labeled Radiopharmaceuticals and Their (Pre)Clinical Applications.","authors":"Marius Müller, Nadia Bom Pedersen, Vladimir Shalgunov, Andreas Ingemann Jensen, Umberto Maria Battisti, Matthias Manfred Herth","doi":"10.1002/med.70008","DOIUrl":"https://doi.org/10.1002/med.70008","url":null,"abstract":"<p><p>Targeted radioligand therapy has emerged as a promising treatment option for eradicating advanced cancer forms. α-Emitters are considered particularly promising as they can obliterate (micro)-metastases. The α-emitter astatine-211 (<sup>211</sup>At) has experienced increased interest due to its favorable decay properties. As a result, various <sup>211</sup>At-astatination strategies have been developed to address challenges associated with working with this \"halogenic metalloid.\" This review summarizes efforts to produce and scale <sup>211</sup>At, describes its physicochemical properties, discusses the advantages and disadvantages of using a radionuclide with a half-life of 7.2 h and outlines procedures for astatinating radiopharmaceuticals. Moreover, a key focus of this review is to rationalize strategies aimed at minimizing in vivo deastatination. A brief overview of on-going (pre)clinical development with <sup>211</sup>At-labeled radiopharmaceuticals is provided. Astatinated radiopharmaceuticals will play a pivotal role in cancer management in the near future when challenges related to scalability and in vivo stability have been addressed and clinical studies have shown the benefit of <sup>211</sup>At compared to longer-lived therapeutic radionuclides.</p>","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Covalent Bifunctional Molecules (CBMs): Achievements and Challenges. 共价双功能分子:成就与挑战。
IF 11.6 1区 医学
Medicinal Research Reviews Pub Date : 2025-08-30 DOI: 10.1002/med.70011
Yuting Xin, Fangsu Chen, Qidong You, Lei Wang, Qiuyue Zhang
{"title":"Covalent Bifunctional Molecules (CBMs): Achievements and Challenges.","authors":"Yuting Xin, Fangsu Chen, Qidong You, Lei Wang, Qiuyue Zhang","doi":"10.1002/med.70011","DOIUrl":"https://doi.org/10.1002/med.70011","url":null,"abstract":"<p><p>The burgeoning field of CBMs represents a significant stride in the evolution of targeted therapeutics. This class of compounds, characterized by their ability to form stable covalent bonds with specific proteins of interest (POIs) or biological effectors, has emerged as a promising avenue for addressing complex pathological conditions such as drug-resistant diseases, undruggable targets, and chronic disorders requiring sustained target modulation. The integration of covalent chemistry in molecular design allows for the creation of highly specific and potent agents capable of modulating protein function with unprecedented precision. Herein, we meticulously classify CBMs according to the object of covalent bond formation and provide a discussion of the progress of CBMs since 2001, covering the design principles, molecular composition, covalent properties, and their reaction efficiencies, which not only reveals the potential of CBMs in drug discovery, but also emphasizes the importance of achieving innovations and breakthroughs in this field.</p>","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modulators of Diacylglycerol Kinase Activity: A Review of Advances and Challenges. 二酰基甘油激酶活性调节剂:进展与挑战的综述。
IF 11.6 1区 医学
Medicinal Research Reviews Pub Date : 2025-08-26 DOI: 10.1002/med.70010
Luisa Racca, Gianluca Baldanzi, Alberto Massarotti
{"title":"Modulators of Diacylglycerol Kinase Activity: A Review of Advances and Challenges.","authors":"Luisa Racca, Gianluca Baldanzi, Alberto Massarotti","doi":"10.1002/med.70010","DOIUrl":"https://doi.org/10.1002/med.70010","url":null,"abstract":"<p><p>Catalyzing the conversion of diacylglycerol (DAG) in phosphatidic acid (PA), diacylglycerol kinases (DGKs) play a pivotal role in all the physiological processes modulated by these two bioactive lipids, such as lipid metabolism and immune regulation. Consequently, abnormalities due to a dysregulation of DGK's activity are involved in several pathological contexts, from cancer to autoimmune diseases. Interestingly, ten DGK isoforms with specific structure and expression pattern are present in humans, suggesting nonredundant roles. Despite their potential as therapeutic targets, the possibility of selective DGK pharmacological modulation remains limited to two isoforms. However, the research for DGK isoform-specific modulators is growing, as well as the interest in the structure and functioning of all DGK family members. This review aims to present all the information on DGK modulators, from the literature to patents' databases, starting from what we know about DGK's structure, the key physiological and pathological processes where they are involved and, above all, to understand which are nowadays the possibilities for DGK activation/inhibition. Our aim is to inspire future investigations which could accelerate the discovery of new DGK-targeting compounds.</p>","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":" ","pages":""},"PeriodicalIF":11.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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