HMGB1: From Molecular Functions to Clinical Applications in Cancer and Inflammatory Diseases.

IF 11.6 1区医学 Q1 CHEMISTRY, MEDICINAL

Medicinal Research Reviews Pub Date : 2025-10-07 DOI:10.1002/med.70017

Linghong Guo, Daihan Wang, Xian Jiang, Gu He

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引用次数: 0

Abstract

High Mobility Group Box 1 (HMGB1) is a nuclear protein crucial for nucleosome stability, gene regulation, DNA repair, cell differentiation, and development. Extracellularly, HMGB1 functions as a cytokine, significantly impacting inflammation, immune response, and the pathogenesis of various diseases, including cancer and inflammatory disorders. Research highlights HMGB1's complex role in cancer, where it promotes tumorigenesis through chronic inflammation and immune suppression while enhancing chemotherapy and genome stability. It also influences cell proliferation, angiogenesis, metastasis, and chemotherapy resistance. In inflammatory diseases, HMGB1 has a dual role: it can promote inflammation in conditions like ischemia-reperfusion injury and sepsis but also induces immune tolerance and suppression. This review provides a comprehensive overview of HMGB1's structure, functions, and regulatory mechanisms, discussing recent advances in understanding its roles in cancer and inflammatory diseases. We emphasize the evolving therapeutic strategies targeting HMGB1, underscoring its potential as a promising target for treating both cancer and inflammatory disorders.

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HMGB1：从分子功能到肿瘤和炎症疾病的临床应用。

HMGB1是一种对核小体稳定性、基因调控、DNA修复、细胞分化和发育至关重要的核蛋白。在细胞外，HMGB1作为一种细胞因子，显著影响炎症、免疫反应和各种疾病的发病机制，包括癌症和炎症性疾病。研究强调HMGB1在癌症中的复杂作用，它通过慢性炎症和免疫抑制促进肿瘤发生，同时增强化疗和基因组稳定性。它还影响细胞增殖、血管生成、转移和化疗耐药性。在炎症性疾病中，HMGB1具有双重作用：在缺血-再灌注损伤、败血症等情况下，它可以促进炎症，但也可以诱导免疫耐受和抑制。本文综述了HMGB1的结构、功能和调控机制，讨论了其在癌症和炎症性疾病中的作用的最新进展。我们强调了针对HMGB1的不断发展的治疗策略，强调了它作为治疗癌症和炎症性疾病的有希望的靶点的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicinal Research Reviews 医学-药学

CiteScore

29.30

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： Medicinal Research Reviews is dedicated to publishing timely and critical reviews, as well as opinion-based articles, covering a broad spectrum of topics related to medicinal research. These contributions are authored by individuals who have made significant advancements in the field. Encompassing a wide range of subjects, suitable topics include, but are not limited to, the underlying pathophysiology of crucial diseases and disease vectors, therapeutic approaches for diverse medical conditions, properties of molecular targets for therapeutic agents, innovative methodologies facilitating therapy discovery, genomics and proteomics, structure-activity correlations of drug series, development of new imaging and diagnostic tools, drug metabolism, drug delivery, and comprehensive examinations of the chemical, pharmacological, pharmacokinetic, pharmacodynamic, and clinical characteristics of significant drugs.