Medicinal Research Reviews最新文献_第10页

Diverse biological functions of the renin-angiotensin system 肾素-血管紧张素系统的多种生物学功能。

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2023-11-10 DOI: 10.1002/med.21996

Adithi Rao, Shabir A. Bhat, Tomohiro Shibata, Jorge F. Giani, Florian Rader, Kenneth E. Bernstein, Zakir Khan

引用次数: 0

FXR agonists for MASH therapy: Lessons and perspectives from obeticholic acid 用于MASH治疗的FXR激动剂：奥贝胆酸的经验教训和展望。

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2023-10-30 DOI: 10.1002/med.21991

Kang Wang, Yuecan Zhang, Guangji Wang, Haiping Hao, Hong Wang

{"title":"FXR agonists for MASH therapy: Lessons and perspectives from obeticholic acid","authors":"Kang Wang, Yuecan Zhang, Guangji Wang, Haiping Hao, Hong Wang","doi":"10.1002/med.21991","DOIUrl":"10.1002/med.21991","url":null,"abstract":"Nonalcoholic fatty liver disease, also called metabolic dysfunction-associated steatotic liver disease, is the most common liver disease worldwide and has no approved pharmacotherapy. Due to its beneficial effects on metabolic regulation, inflammation suppression, cell death prevention, and fibrogenesis inhibition, farnesoid X receptor (FXR) is widely accepted as a promising therapeutic target for nonalcoholic steatosis (NASH) or called metabolic dysfunction-associated steatohepatitis (MASH). Many FXR agonists have been developed for NASH/MASH therapy. Obeticholic acid (OCA) is the pioneering frontrunner FXR agonist and the first demonstrating success in clinical trials. Unfortunately, OCA did not receive regulatory approval as a NASH pharmacotherapy because its moderate benefits did not outweigh its safety risks, which may cast a shadow over FXR-based drug development for NASH/MASH. This review summarizes the milestones in the development of OCA for NASH/MASH and discuss its limitations, including moderate hepatoprotection and the undesirable side effects of dyslipidemia, pruritus, cholelithiasis, and liver toxicity risk, in depth. More importantly, we provide perspectives on FXR-based therapy for NASH/MASH, hoping to support a successful bench-to-clinic transition.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"44 2","pages":"568-586"},"PeriodicalIF":13.3,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71410055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Front Cover Image, Volume 43, Issue 6 封面图片，第43卷第6期

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2023-10-03 DOI: 10.1002/med.21911

Lijuan Xu, Chunlin Zhuang

引用次数: 0

The triangular relationship between traditional Chinese medicines, intestinal flora, and colorectal cancer 中药、肠道菌群与大肠癌之间的三角关系。

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2023-09-03 DOI: 10.1002/med.21989

Yuqing Zou, Shuling Wang, Honghua Zhang, Yuxin Gu, Huijuan Chen, Zhihua Huang, Feifei Yang, Wenqi Li, Cheng Chen, Lianhui Men, Qingchang Tian, Tian Xie

{"title":"The triangular relationship between traditional Chinese medicines, intestinal flora, and colorectal cancer","authors":"Yuqing Zou, Shuling Wang, Honghua Zhang, Yuxin Gu, Huijuan Chen, Zhihua Huang, Feifei Yang, Wenqi Li, Cheng Chen, Lianhui Men, Qingchang Tian, Tian Xie","doi":"10.1002/med.21989","DOIUrl":"10.1002/med.21989","url":null,"abstract":"Over the past decade, colorectal cancer has reported a higher incidence in younger adults and a lower mortality rate. Recently, the influence of the intestinal flora in the initiation, progression, and treatment of colorectal cancer has been extensively studied, as well as their positive therapeutic impact on inflammation and the cancer microenvironment. Historically, traditional Chinese medicine (TCM) has been widely used in the treatment of colorectal cancer via promoted cancer cell apoptosis, inhibited cancer metastasis, and reduced drug resistance and side effects. The present research is more on the effect of either herbal medicine or intestinal flora on colorectal cancer. The interactions between TCM and intestinal flora are bidirectional and the combined impacts of TCM and gut microbiota in the treatment of colon cancer should not be neglected. Therefore, this review discusses the role of intestinal bacteria in the progression and treatment of colorectal cancer by inhibiting carcinogenesis, participating in therapy, and assisting in healing. Then the complex anticolon cancer effects of different kinds of TCM monomers, TCM drug pairs, and traditional Chinese prescriptions embodied in apoptosis, metastasis, immune suppression, and drug resistance are summarized separately. In addition, the interaction between TCM and intestinal flora and the combined effect on cancer treatment were analyzed. This review provides a mechanistic reference for the application of TCM and intestinal flora in the clinical treatment of colorectal cancer and paves the way for the combined development and application of microbiome and TCM.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"44 2","pages":"539-567"},"PeriodicalIF":13.3,"publicationDate":"2023-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10500245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant peptides, the guardian of life from oxidative stress 抗氧化肽--抵御氧化压力的生命卫士

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2023-08-25 DOI: 10.1002/med.21986

Yiyun Zhu, Kang Wang, Xinyi Jia, Caili Fu, Haining Yu, Yipeng Wang

引用次数: 1

Rheumatoid arthritis molecular targets and their importance to flavonoid-based therapy 类风湿性关节炎分子靶点及其对黄酮类疗法的重要性。

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2023-08-21 DOI: 10.1002/med.21990

Ana T. Rufino, Marisa Freitas, Carina Proença, José M. P. Ferreira de Oliveira, Eduarda Fernandes, Daniela Ribeiro

{"title":"Rheumatoid arthritis molecular targets and their importance to flavonoid-based therapy","authors":"Ana T. Rufino, Marisa Freitas, Carina Proença, José M. P. Ferreira de Oliveira, Eduarda Fernandes, Daniela Ribeiro","doi":"10.1002/med.21990","DOIUrl":"10.1002/med.21990","url":null,"abstract":"Rheumatoid arthritis (RA) is a progressive, chronic, autoimmune, inflammatory, and systemic condition that primarily affects the synovial joints and adjacent tissues, including bone, muscle, and tendons. The World Health Organization recognizes RA as one of the most prevalent chronic inflammatory diseases. In the last decade, there was an expansion on the available RA therapeutic options which aimed to improve patient's quality of life. Despite the extensive research and the emergence of new therapeutic approaches and drugs, there are still significant unwanted side effects associated to these drugs and still a vast number of patients that do not respond positively to the existing therapeutic strategies. Over the years, several references to the use of flavonoids in the quest for new treatments for RA have emerged. This review aimed to summarize the existing literature about the flavonoids' effects on the major pathogenic/molecular targets of RA and their potential use as lead compounds for the development of new effective molecules for RA treatment. It is demonstrated that flavonoids can modulate various players in synovial inflammation, regulate immune cell function, decrease synoviocytes proliferation and balance the apoptotic process, decrease angiogenesis, and stop/prevent bone and cartilage degradation, which are all dominant features of RA. Although further investigation is necessary to determine the effectiveness of flavonoids in humans, the available data from in vitro and in vivo models suggest their potential as new disease-modifying anti-rheumatic drugs. This review highlights the use of flavonoids as a promising avenue for future research in the treatment of RA.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"44 2","pages":"497-538"},"PeriodicalIF":13.3,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10031645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Limonoids from neem (Azadirachta indica A. Juss.) are potential anticancer drug candidates 印楝（Azadirachta indica A.Juss.）中的柠檬酸是潜在的抗癌药物候选。

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2023-08-17 DOI: 10.1002/med.21988

Siddavaram Nagini, Manikandan Palrasu, Anupam Bishayee

{"title":"Limonoids from neem (Azadirachta indica A. Juss.) are potential anticancer drug candidates","authors":"Siddavaram Nagini, Manikandan Palrasu, Anupam Bishayee","doi":"10.1002/med.21988","DOIUrl":"10.1002/med.21988","url":null,"abstract":"Neem (Azadirachta indica A. Juss.), a versatile evergreen tree recognized for its ethnopharmacological value, is a rich source of limonoids of the triterpenoid class, endowed with potent medicinal properties. Extracts of neem have been documented to display anticancer effects in diverse malignant cell lines as well as in preclinical animal models that has largely been attributed to the constituent limonoids. Of late, neem limonoids have become the cynosure of research attention as potential candidate agents for cancer prevention and therapy. Among the various limonoids found in neem, azadirachtin, epoxyazadiradione, gedunin, and nimbolide, have been extensively investigated for anticancer activity. Azadirachtin, a potent biodegradable pesticide, exhibits profound antiproliferative effects by preventing mitotic spindle formation and cell division. The antiproliferative activity of gedunin has been demonstrated to be mediated primarily via inhibition of heat shock protein90 and its client proteins. Epoxyazadiradione inhibits pro-inflammatory and kinase-driven signaling pathways to block tumorigenesis. Nimbolide, the most potent cytotoxic neem limonoid, inhibits the growth of cancer cells by regulating the phosphorylation of keystone kinases that drive oncogenic signaling besides modulating the epigenome. There is overwhelming evidence to indicate that neem limonoids exert anticancer effects by preventing the acquisition of hallmark traits of cancer, such as cell proliferation, apoptosis evasion, inflammation, invasion, angiogenesis, and drug resistance. Neem limonoids are value additions to the armamentarium of natural compounds that target aberrant oncogenic signaling to inhibit cancer development and progression.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"44 2","pages":"457-496"},"PeriodicalIF":13.3,"publicationDate":"2023-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10368315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Communal interaction of glycation and gut microbes in diabetes mellitus, Alzheimer's disease, and Parkinson's disease pathogenesis 糖化与肠道微生物在糖尿病、阿尔茨海默病和帕金森病发病机制中的共同作用

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2023-08-17 DOI: 10.1002/med.21987

Rahul Shivaji Patil, Rashmi Santosh Tupe

{"title":"Communal interaction of glycation and gut microbes in diabetes mellitus, Alzheimer's disease, and Parkinson's disease pathogenesis","authors":"Rahul Shivaji Patil, Rashmi Santosh Tupe","doi":"10.1002/med.21987","DOIUrl":"10.1002/med.21987","url":null,"abstract":"Diabetes and its complications, Alzheimer's disease (AD), and Parkinson's disease (PD) are increasing gradually, reflecting a global threat vis-à-vis expressing the essentiality of a substantial paradigm shift in research and remedial actions. Protein glycation is influenced by several factors, like time, temperature, pH, metal ions, and the half-life of the protein. Surprisingly, most proteins associated with metabolic and neurodegenerative disorders are generally long-lived and hence susceptible to glycation. Remarkably, proteins linked with diabetes, AD, and PD share this characteristic. This modulates protein's structure, aggregation tendency, and toxicity, highlighting renovated attention. Gut microbes and microbial metabolites marked their importance in human health and diseases. Though many scientific shreds of evidence are proposed for possible change and dysbiosis in gut flora in these diseases, very little is known about the mechanisms. Screening and unfolding their functionality in metabolic and neurodegenerative disorders is essential in hunting the gut treasure. Therefore, it is imperative to evaluate the role of glycation as a common link in diabetes and neurodegenerative diseases, which helps to clarify if modulation of nonenzymatic glycation may act as a beneficial therapeutic strategy and gut microbes/metabolites may answer some of the crucial questions. This review briefly emphasizes the common functional attributes of glycation and gut microbes, the possible linkages, and discusses current treatment options and therapeutic challenges.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"44 1","pages":"365-405"},"PeriodicalIF":13.3,"publicationDate":"2023-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10368313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Front Cover Image, Volume 43, Issue 5 封面图像，第43卷，第5期

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2023-08-07 DOI: 10.1002/med.21908

Jesus Shrestha, Keshav Raj Paudel, Hojjatollah Nazari, Vivek Dharwal, Sajad Razavi Bazaz, Matt D. Johansen, Kamal Dua, Philip M. Hansbro, Majid Ebrahimi Warkiani

引用次数: 0

The entrancing role of dietary polyphenols against the most frequent aging-associated diseases 膳食多酚在预防最常见的衰老相关疾病方面的神奇作用

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2023-07-24 DOI: 10.1002/med.21985

Muhammad Ajmal Shah, Hafiza Ishmal Faheem, Ayesha Hamid, Rimsha Yousaf, Muhammad Haris, Uzma Saleem, Ghulam Mujtaba Shah, Reem H. Alhasani, Norah A. Althobaiti, Ifat Alsharif, Ana Sanches Silva

{"title":"The entrancing role of dietary polyphenols against the most frequent aging-associated diseases","authors":"Muhammad Ajmal Shah, Hafiza Ishmal Faheem, Ayesha Hamid, Rimsha Yousaf, Muhammad Haris, Uzma Saleem, Ghulam Mujtaba Shah, Reem H. Alhasani, Norah A. Althobaiti, Ifat Alsharif, Ana Sanches Silva","doi":"10.1002/med.21985","DOIUrl":"10.1002/med.21985","url":null,"abstract":"Aging, a fundamental physiological process influenced by innumerable biological and genetic pathways, is an important driving factor for several aging‐associated disorders like diabetes mellitus, osteoporosis, cancer, and neurodegenerative diseases including Alzheimer's and Parkinson's diseases. In the modern era, the several mechanisms associated with aging have been deeply studied. Treatment and therapeutics for age‐related diseases have also made considerable advances; however, for the effective and long‐lasting treatment, nutritional therapy particularly including dietary polyphenols from the natural origin are endorsed. These dietary polyphenols (e.g., apigenin, baicalin, curcumin, epigallocatechin gallate, kaempferol, quercetin, resveratrol, and theaflavin), and many other phytochemicals target certain molecular, genetic mechanisms. The most common pathways of age‐associated diseases are mitogen‐activated protein kinase, reactive oxygen species production, nuclear factor kappa light chain enhancer of activated B cells signaling pathways, metal chelation, c‐Jun N‐terminal kinase, and inflammation. Polyphenols slow down the course of aging and help in combatting age‐linked disorders. This exemplified in the form of clinical trials on specific dietary polyphenols in various aging‐associated diseases. With this context in mind, this review reveals the new insights to slow down the aging process, and consequently reduce some classic diseases associated with age such as aforementioned, and targeting age‐associated diseases by the activities of dietary polyphenols of natural origin.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"44 1","pages":"235-274"},"PeriodicalIF":13.3,"publicationDate":"2023-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9912716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2