Medicinal Research Reviews最新文献_第9页

Front Cover Image, Volume 42, Issue 4 封面图像，第42卷，第4期

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2022-06-10 DOI: 10.1002/med.21829

Giuseppe Floresta, Vincenzo Abbate

引用次数: 0

The ethnomedicinal and functional uses, phytochemical and pharmacology of compounds from Ardisia species: An updated review 紫荆属植物化合物的民族医药和功能用途、植物化学和药理研究进展

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2022-06-06 DOI: 10.1002/med.21894

Bingrui Liu, Rongyu Liu, Qifeng Liu, Charles R. Ashby Jr., Hang Zhang, Zhe-Sheng Chen

{"title":"The ethnomedicinal and functional uses, phytochemical and pharmacology of compounds from Ardisia species: An updated review","authors":"Bingrui Liu, Rongyu Liu, Qifeng Liu, Charles R. Ashby Jr., Hang Zhang, Zhe-Sheng Chen","doi":"10.1002/med.21894","DOIUrl":"https://doi.org/10.1002/med.21894","url":null,"abstract":"Medicinal plants are considered to be a critical source of novel compounds and pharmacophores. The genus Ardisia, consisting of approximately 500 species, is the largest genus in the Myrsinaceae family. Ardisia species are widely distributed throughout tropical and subtropical regions of the world and have been used for the treatment of cancer, hypertension, irregular menstruation, gonorrhea, diarrhea and postnatal syndromes, among others. Phytochemical studies of Ardisia species have resulted in the isolation and identification of 111 compounds, including triterpenoid saponins, quinones, phenols, coumarins, cyclic depsipepetide and flavonoids. Crude extracts and isolates from Ardisia have been reported to have in vitro and in vivo efficacies, including but not limited to anticancer, antiinflammatory, antimicrobial, antioxidant, antithrombotic and antidiabetic, antitubercular compounds. This review focuses on the medical and functional uses, phytochemical profile and pharmacological efficacies of Ardisia species over the past 15 years. This review will provide information indicating that Ardisia species represent an invaluable source of potential therapeutic compounds.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"42 5","pages":"1888-1929"},"PeriodicalIF":13.3,"publicationDate":"2022-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5727053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progress and perspective on hydrogen sulfide donors and their biomedical applications 硫化氢供体及其生物医学应用的进展与展望

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2022-06-03 DOI: 10.1002/med.21913

Zi-Long Song, Lanning Zhao, Tao Ma, Alsiddig Osama, Tong Shen, Yilin He, Jianguo Fang

{"title":"Progress and perspective on hydrogen sulfide donors and their biomedical applications","authors":"Zi-Long Song, Lanning Zhao, Tao Ma, Alsiddig Osama, Tong Shen, Yilin He, Jianguo Fang","doi":"10.1002/med.21913","DOIUrl":"https://doi.org/10.1002/med.21913","url":null,"abstract":"Following the discovery of nitric oxide (NO) and carbon monoxide (CO), hydrogen sulfide (H2S) has been identified as the third gasotransmitter in humans. Increasing evidence have shown that H2S is of preventive or therapeutic effects on diverse pathological complications. As a consequence, it is of great significance to develop suitable approaches of H2S-based therapeutics for biomedical applications. H2S-releasing agents (H2S donors) play important roles in exploring and understanding the physiological functions of H2S. More importantly, accumulating studies have validated the theranostic potential of H2S donors in extensive repertoires of in vitro and in vivo disease models. Thus, it is imperative to summarize and update the literatures in this field. In this review, first, the background of H2S on its chemical and biological aspects is concisely introduced. Second, the studies regarding the H2S-releasing compounds are categorized and described, and accordingly, their H2S-donating mechanisms, biological applications, and therapeutic values are also comprehensively delineated and discussed. Necessary comparisons between related H2S donors are presented, and the drawbacks of many typical H2S donors are analyzed and revealed. Finally, several critical challenges encountered in the development of multifunctional H2S donors are discussed, and the direction of their future development as well as their biomedical applications is proposed. We expect that this review will reach extensive audiences across multiple disciplines and promote the innovation of H2S biomedicine.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"42 5","pages":"1930-1977"},"PeriodicalIF":13.3,"publicationDate":"2022-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5685531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Dual roles of drug or its metabolite−protein conjugate: Cutting-edge strategy of drug discovery using shotgun proteomics 药物或其代谢物-蛋白质偶联物的双重作用:利用鸟枪蛋白质组学发现药物的前沿策略

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2022-05-31 DOI: 10.1002/med.21889

Shilin Gong, Xiaolan Hu, Shengshuang Chen, Baoqing Sun, Jian-Lin Wu, Na Li

{"title":"Dual roles of drug or its metabolite−protein conjugate: Cutting-edge strategy of drug discovery using shotgun proteomics","authors":"Shilin Gong, Xiaolan Hu, Shengshuang Chen, Baoqing Sun, Jian-Lin Wu, Na Li","doi":"10.1002/med.21889","DOIUrl":"https://doi.org/10.1002/med.21889","url":null,"abstract":"Many drugs can bind directly to proteins or be bioactivated by metabolizing enzymes to form reactive metabolites (RMs) that rapidly bind to proteins to form drug−protein conjugates or metabolite−protein conjugates (DMPCs). The close relationship between DMPCs and idiosyncratic adverse drug reactions (IADRs) has been recognized; drug discovery teams tend to avoid covalent interactions in drug discovery projects. Covalent interactions in DMPCs can provide high potency and long action duration and conquer the intractable targets, inspiring drug design, and development. This forms the dual role feature of DMPCs. Understanding the functional implications of DMPCs in IADR control and therapeutic applications requires precise identification of these conjugates from complex biological samples. While classical biochemical methods have contributed significantly to DMPC detection in the past decades, the low abundance and low coverage of DMPCs have become a bottleneck in this field. An emerging transformation toward shotgun proteomics is on the rise. The evolving shotgun proteomics techniques offer improved reproducibility, throughput, specificity, operability, and standardization. Here, we review recent progress in the systematic discovery of DMPCs using shotgun proteomics. Furthermore, the applications of shotgun proteomics supporting drug development, toxicity mechanism investigation, and drug repurposing processes are also reviewed and prospected.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"42 4","pages":"1704-1734"},"PeriodicalIF":13.3,"publicationDate":"2022-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5942923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Inflammatory bowel disease biomarkers 炎症性肠病生物标志物

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2022-05-23 DOI: 10.1002/med.21893

Dandan Liu, Varma Saikam, Katie A. Skrada, Didier Merlin, Suri S. Iyer

引用次数: 19

Natural products as Zika antivirals 作为寨卡病毒抗病毒药物的天然产物

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2022-05-20 DOI: 10.1002/med.21891

Yuhui Deborah Fong, Justin Jang Hann Chu

{"title":"Natural products as Zika antivirals","authors":"Yuhui Deborah Fong, Justin Jang Hann Chu","doi":"10.1002/med.21891","DOIUrl":"https://doi.org/10.1002/med.21891","url":null,"abstract":"Zika virus (ZIKV) is an arbovirus belonging to the flavivirus genus and is transmitted in Aedes mosquito vectors. Since its discovery in humans in 1952 in Uganda, ZIKV has been responsible for many outbreaks in South America, Africa, and Asia. Patients infected with ZIKV are usually asymptomatic; mild symptoms include fever, joint and muscle pain, and fatigue. However, severe infections may have neurological implications, such as Guillain-Barré syndrome and fetal microcephaly. To date, there are no existing approved therapeutic drugs or vaccines against ZIKV infections; treatments mainly target the symptoms of infection. Preventive measures against mosquito breeding are the main strategy for limiting the spread of the virus. Antiviral drug research for the treatment of ZIKV infection has been rapidly developing, with many drug candidates emerging from drug repurposing studies, and compound screening. In particular, several studies have demonstrated the potential of natural products as antivirals for ZIKV infection. Hence, this paper will review recent advances in natural products in ZIKV antiviral drug discovery.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"42 5","pages":"1739-1780"},"PeriodicalIF":13.3,"publicationDate":"2022-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/med.21891","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5749009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Crystallographic landscape of SHP2 provides molecular insights for SHP2 targeted drug discovery SHP2的晶体景观为SHP2靶向药物的发现提供了分子视角

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2022-05-16 DOI: 10.1002/med.21890

Yihui Song, Xinyu Yang, Shu Wang, Min Zhao, Bin Yu

引用次数: 11

Small-molecule inhibitors of cyclophilin D as potential therapeutics in mitochondria-related diseases 小分子亲环蛋白D抑制剂作为线粒体相关疾病的潜在治疗药物

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2022-05-16 DOI: 10.1002/med.21892

Annamaria Haleckova, Ondrej Benek, Lucie Zemanová, Rafael Dolezal, Kamil Musilek

引用次数: 9

Purinergic receptors modulators: An emerging pharmacological tool for disease management 嘌呤能受体调节剂:一种新兴的疾病管理药理工具

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2022-05-13 DOI: 10.1002/med.21888

Abid Mahmood, Jamshed Iqbal

{"title":"Purinergic receptors modulators: An emerging pharmacological tool for disease management","authors":"Abid Mahmood, Jamshed Iqbal","doi":"10.1002/med.21888","DOIUrl":"https://doi.org/10.1002/med.21888","url":null,"abstract":"Purinergic signaling is mediated through extracellular nucleotides (adenosine 5′-triphosphate, uridine-5'-triphosphate, adenosine diphosphate, uridine-5'-diphosphate, and adenosine) that serve as signaling molecules. In the early 1990s, purines and pyrimidine receptors were cloned and characterized drawing the attention of scientists toward this aspect of cellular signaling. This signaling pathway is comprised of four subtypes of adenosine receptors (P1), eight subtypes of G-coupled protein receptors (P2YRs), and seven subtypes of ligand-gated ionotropic receptors (P2XRs). In current studies, the pathophysiology and therapeutic potentials of these receptors have been focused on. Various ligands, modulating the functions of purinergic receptors, are in current clinical practices for the treatment of various neurodegenerative disorders and cardiovascular diseases. Moreover, several purinergic receptors ligands are in advanced phases of clinical trials as a remedy for depression, epilepsy, autism, osteoporosis, atherosclerosis, myocardial infarction, diabetes, irritable bowel syndrome, and cancers. In the present study, agonists and antagonists of purinergic receptors have been summarized that may serve as pharmacological tools for drug design and development.","PeriodicalId":207,"journal":{"name":"Medicinal Research Reviews","volume":"42 4","pages":"1661-1703"},"PeriodicalIF":13.3,"publicationDate":"2022-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6245138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Front Cover Image, Volume 42, Issue 3 封面图像，第42卷，第3期

IF 13.3 1区医学

Medicinal Research Reviews Pub Date : 2022-04-05 DOI: 10.1002/med.21827

Shipeng He, Guoqiang Dong, Junfei Cheng, Ying Wu, Chunquan Sheng

引用次数: 0