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Annals of Neurology最新文献

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AI in Neurology: Everything, Everywhere, all at Once PART 2: Speech, Sentience, Scruples, and Service. 神经学中的人工智能：一切，无处不在，同时发生。第二部分：语言，感知，顾忌和服务。
IF 8.1 1区 医学
Annals of Neurology Pub Date : 2025-05-27 DOI: 10.1002/ana.27229
Matthew Rizzo
{"title":"AI in Neurology: Everything, Everywhere, all at Once PART 2: Speech, Sentience, Scruples, and Service.","authors":"Matthew Rizzo","doi":"10.1002/ana.27229","DOIUrl":"https://doi.org/10.1002/ana.27229","url":null,"abstract":"<p><p>Artificial intelligence (AI) applications are finding use in real-world neurological settings. Whereas part 1 of this 3-part review series focused on the birth of AI and its foundational principles, this part 2 review shifts gears to explore more practical aspects of neurological care. The review details how large language models, generative AI, and robotics are supporting diagnostic accuracy, patient interaction, and treatment personalization. Special attention is given to ethical and philosophical facets of AI that nonetheless impact practical aspects of care and patient safety, such as accountability for AI-driven decisions and the \"black box\" nature of many algorithms. We will discuss whether AI systems can develop sentience, and the implications for human-AI collaboration. By examining human-robot interactions in neurology, this part 2 review highlights the profound impact AI could have on patient care and, as covered in the ensuing part 3, on global health care delivery and data analytics, while maintaining ethical oversight and human control. ANN NEUROL 2025.</p>","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Crossed Facial Muscle Atrophy in Facioscapulohumeral Muscular Dystrophy. 面肩肱肌营养不良患者交叉面肌萎缩。
IF 8.1 1区 医学
Annals of Neurology Pub Date : 2025-05-27 DOI: 10.1002/ana.27264
Masayuki Ohira, Masaki Takao, Ichizo Nishino
{"title":"Crossed Facial Muscle Atrophy in Facioscapulohumeral Muscular Dystrophy.","authors":"Masayuki Ohira, Masaki Takao, Ichizo Nishino","doi":"10.1002/ana.27264","DOIUrl":"https://doi.org/10.1002/ana.27264","url":null,"abstract":"","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cognitive Outcome in Young Adults after Resolution of Epilepsy in Childhood. 儿童期癫痫消退后年轻人的认知结局。
IF 8.1 1区 医学
Annals of Neurology Pub Date : 2025-05-22 DOI: 10.1002/ana.27258
Jacob Megreli, Leo Arkush, Estela Derazne, Arnon Afek, Gilad Twig, Bruria Ben-Zeev, Jaana Ahonniska Assa, Gali Heimer
{"title":"Cognitive Outcome in Young Adults after Resolution of Epilepsy in Childhood.","authors":"Jacob Megreli, Leo Arkush, Estela Derazne, Arnon Afek, Gilad Twig, Bruria Ben-Zeev, Jaana Ahonniska Assa, Gali Heimer","doi":"10.1002/ana.27258","DOIUrl":"https://doi.org/10.1002/ana.27258","url":null,"abstract":"<p><p>Self-limited epilepsies of childhood are common and were considered benign. We aim to determine whether cognitive function in young adults who experienced epilepsy as children and are subsequently seizure-free and unmedicated differ from the general population. We report on a cross-sectional population-based study including 2,124,871 men and women aged 16-19 years. Participants > 5 years following the last seizure and > 2 years without anti-seizure medication (n = 3,452) had an odds ratio (OR) of having low cognitive function of 1.44 (95% confidence interval [CI] = 1.24-1.68, p < 0.001) using a multinominal regression model. Our results underscore the need to avoid the term \"benign\" in the classification of childhood epilepsies. ANN NEUROL 2025.</p>","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Annals of Neurology: Volume 97, Number 6, June 2025 神经病学年鉴：第97卷，第6号，2025年6月
IF 8.1 1区 医学
Annals of Neurology Pub Date : 2025-05-15 DOI: 10.1002/ana.26983
{"title":"Annals of Neurology: Volume 97, Number 6, June 2025","authors":"","doi":"10.1002/ana.26983","DOIUrl":"https://doi.org/10.1002/ana.26983","url":null,"abstract":"","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":"97 6","pages":"C1"},"PeriodicalIF":8.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ana.26983","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"Intravenous Thrombolysis in Patients Taking Direct Oral Anticoagulation Treatment before Stroke Onset: Results from the Safe Implementations of Treatments in Stroke International Stroke Registry" Recently Published by Matusevicius and Colleagues. Matusevicius和他的同事最近发表了一篇题为“在中风发作前接受直接口服抗凝治疗的患者的静脉溶栓：来自中风国际卒中登记中治疗安全实施的结果”的文章。
IF 8.1 1区 医学
Annals of Neurology Pub Date : 2025-05-14 DOI: 10.1002/ana.27254
Senta Frol, Peter Alan Barber
{"title":"\"Intravenous Thrombolysis in Patients Taking Direct Oral Anticoagulation Treatment before Stroke Onset: Results from the Safe Implementations of Treatments in Stroke International Stroke Registry\" Recently Published by Matusevicius and Colleagues.","authors":"Senta Frol, Peter Alan Barber","doi":"10.1002/ana.27254","DOIUrl":"https://doi.org/10.1002/ana.27254","url":null,"abstract":"","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to "Letter to the Editor, Regarding 'Intravenous Thrombolysis in Patients Taking Direct Oral Anticoagulation Treatment Before Stroke Onset: Results from the Safe Implementations of Treatments in Stroke International Stroke Registry'" recently Published by Matusevicius et al. 回复Matusevicius等人最近发表的“致编辑的信，关于‘卒中发病前直接口服抗凝治疗的患者静脉溶栓：卒中国际卒中登记中安全实施治疗的结果’”。
IF 8.1 1区 医学
Annals of Neurology Pub Date : 2025-05-14 DOI: 10.1002/ana.27256
Marius Matusevicius, Malin Säflund, Niaz Ahmed
{"title":"Reply to \"Letter to the Editor, Regarding 'Intravenous Thrombolysis in Patients Taking Direct Oral Anticoagulation Treatment Before Stroke Onset: Results from the Safe Implementations of Treatments in Stroke International Stroke Registry'\" recently Published by Matusevicius et al.","authors":"Marius Matusevicius, Malin Säflund, Niaz Ahmed","doi":"10.1002/ana.27256","DOIUrl":"https://doi.org/10.1002/ana.27256","url":null,"abstract":"","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to "Revolutionizing Neuroprognostication: The Enduring Value of Pupillary Reflexes Enhanced by Quantitative Pupillometry". 回复“革命性的神经预测：定量瞳孔测量法增强瞳孔反射的持久价值”。
IF 8.1 1区 医学
Annals of Neurology Pub Date : 2025-05-07 DOI: 10.1002/ana.27257
Yili Du, Charlene J Ong
{"title":"Reply to \"Revolutionizing Neuroprognostication: The Enduring Value of Pupillary Reflexes Enhanced by Quantitative Pupillometry\".","authors":"Yili Du, Charlene J Ong","doi":"10.1002/ana.27257","DOIUrl":"https://doi.org/10.1002/ana.27257","url":null,"abstract":"","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revolutionizing Neuroprognostication: The Enduring Value of Pupillary Reflexes Enhanced by Quantitative Pupillometry. 革命性的神经预测：定量瞳孔测量增强瞳孔反射的持久价值。
IF 8.1 1区 医学
Annals of Neurology Pub Date : 2025-05-07 DOI: 10.1002/ana.27255
Calixto Machado, Jose Jesus Sanchez
{"title":"Revolutionizing Neuroprognostication: The Enduring Value of Pupillary Reflexes Enhanced by Quantitative Pupillometry.","authors":"Calixto Machado, Jose Jesus Sanchez","doi":"10.1002/ana.27255","DOIUrl":"https://doi.org/10.1002/ana.27255","url":null,"abstract":"","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of Cerebral Amyloid Angiopathy and Associated Risk of Subsequent Ischemic and Hemorrhagic Stroke and Mortality in a Nationwide Cohort. 脑淀粉样血管病的患病率和随后缺血性和出血性卒中的相关风险以及全国队列的死亡率
IF 8.1 1区 医学
Annals of Neurology Pub Date : 2025-05-01 DOI: 10.1002/ana.27253
Samuel S Bruce, Cenai Zhang, Ava L Liberman, Alexander E Merkler, Babak B Navi, Gloria C Chiang, Costantino Iadecola, Hooman Kamel, Santosh B Murthy
{"title":"Prevalence of Cerebral Amyloid Angiopathy and Associated Risk of Subsequent Ischemic and Hemorrhagic Stroke and Mortality in a Nationwide Cohort.","authors":"Samuel S Bruce, Cenai Zhang, Ava L Liberman, Alexander E Merkler, Babak B Navi, Gloria C Chiang, Costantino Iadecola, Hooman Kamel, Santosh B Murthy","doi":"10.1002/ana.27253","DOIUrl":"https://doi.org/10.1002/ana.27253","url":null,"abstract":"<p><strong>Objective: </strong>There are limited population-based data regarding the prevalence of cerebral amyloid angiopathy (CAA) and associated risks of mortality and incident cerebrovascular events.</p><p><strong>Methods: </strong>We performed a retrospective cohort study using inpatient and outpatient claims from 2008 to 2022 from a 5% national sample of Medicare beneficiaries. CAA and ischemic and hemorrhagic stroke were identified using validated International Classification of Diseases 10th Revision (ICD-10) codes. We ascertained CAA from October 1, 2015 through 2022, and used data from 2008 through September 30, 2015 to ascertain comorbidities including prevalent stroke. We used Cox regression to examine the association of CAA with subsequent death and incident stroke subtypes after adjustment for demographics, vascular risk factors, and Charlson comorbidities.</p><p><strong>Results: </strong>Among 1,920,312 Medicare beneficiaries in our sample, 2,161 (11.3 per 10,000) had a diagnosis of CAA. In adjusted Cox regression analysis, there was an association between CAA and subsequent mortality (HR 4.9; 95% CI 4.6-5.2). Among 1,872,474 patients without prevalent stroke, including 900 of the CAA patients, there was a significant association between CAA and an increased risk of any stroke (HR 8.0; 95% CI 6.7-9.6), ischemic stroke (HR 4.6; 95% CI 3.6-6.0), intracerebral hemorrhage (HR 26.9; 95% CI 20.3-35.6), and subarachnoid hemorrhage (HR 21.6; 95% CI 12.2-38.1). After a diagnosis of CAA, absolute risks of ischemic stroke and intracerebral hemorrhage were broadly similar.</p><p><strong>Interpretation: </strong>In a large, nationwide cohort of Medicare beneficiaries, the prevalence of clinically diagnosed CAA was approximately 11 per 10,000. CAA was associated with an increased risk of mortality and incident stroke, both hemorrhagic and ischemic. ANN NEUROL 2025.</p>","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elevated α-Synuclein Aggregate Levels in the Urine of Patients with Isolated REM Sleep Behavior Disorder and Parkinson's Disease. 孤立性快速眼动睡眠行为障碍和帕金森病患者尿液中α-突触核蛋白聚集水平升高
IF 8.1 1区 医学
Annals of Neurology Pub Date : 2025-04-26 DOI: 10.1002/ana.27250
Laura Müller, Pelin Özdüzenciler, Charlotte Schedlich-Teufer, Aline Seger, Hannah Jergas, Gereon R Fink, Dieter Willbold, Michael Sommerauer, Michael T Barbe, Gültekin Tamgüney
{"title":"Elevated α-Synuclein Aggregate Levels in the Urine of Patients with Isolated REM Sleep Behavior Disorder and Parkinson's Disease.","authors":"Laura Müller, Pelin Özdüzenciler, Charlotte Schedlich-Teufer, Aline Seger, Hannah Jergas, Gereon R Fink, Dieter Willbold, Michael Sommerauer, Michael T Barbe, Gültekin Tamgüney","doi":"10.1002/ana.27250","DOIUrl":"https://doi.org/10.1002/ana.27250","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a neurodegenerative disorder characterized by α-synuclein aggregation in neurons. Recent advances suggest α-synuclein aggregates could serve as a biomarker for PD and related synucleinopathies. This study used surface-based fluorescence intensity distribution analysis (sFIDA) to measure α-synuclein aggregates in urine. Patients with PD and isolated rapid eye movement sleep behavior disorder, a precursor to PD, had elevated concentrations compared with healthy controls. Sensitivity and specificity were 83% and 65% for PD versus controls and 89% and 62% for isolated rapid eye movement sleep behavior disorder versus controls. The findings highlight sFIDA's potential for diagnosing synucleinopathies. ANN NEUROL 2025.</p>","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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