Yucheng Tian, Dylan M Wallace, Paul S Cederna, Cynthia A Chestek, Stephen W P Kemp
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Toward Natural Limb Function: A New Era in Prosthetic Innovation.
The past decade has witnessed groundbreaking clinical implementation of neuroprosthetic limbs driven by signals from peripheral targets (eg, nerves and muscle) and the brain to restore limb function for individuals with limb loss or impairment. In this review, we highlight recent key clinical trials in peripheral neuroprosthetic interfaces directly with nerve, residual muscle, and reinnervated muscle. We then highlight the key advances in brain interfaces, including clinical trials using electroencephalography, electrocorticography, and intracortical electrodes to control neuroprosthetics. Finally, we explore the future of neuroprosthetic control where both peripheral and brain interfaces can be combined to improve neuroprosthetic performance. ANN NEUROL 2025.
期刊介绍:
Annals of Neurology publishes original articles with potential for high impact in understanding the pathogenesis, clinical and laboratory features, diagnosis, treatment, outcomes and science underlying diseases of the human nervous system. Articles should ideally be of broad interest to the academic neurological community rather than solely to subspecialists in a particular field. Studies involving experimental model system, including those in cell and organ cultures and animals, of direct translational relevance to the understanding of neurological disease are also encouraged.