Pediatric Obesity最新文献

Community and School Programs, Policies and Environments Related to Child Dietary Intake:The Healthy Communities Study. 与儿童饮食摄入相关的社区和学校项目、政策和环境：健康社区研究。

IF 2.7 3区医学

Pediatric Obesity Pub Date : 2025-07-22 DOI: 10.1111/ijpo.70043

Gail Woodward-Lopez, Alexander C McLain, Edward A Frongillo, Natalie Colabianchi, Vicki Collie-Akers, Lorrene D Ritchie

{"title":"Community and School Programs, Policies and Environments Related to Child Dietary Intake:The Healthy Communities Study.","authors":"Gail Woodward-Lopez, Alexander C McLain, Edward A Frongillo, Natalie Colabianchi, Vicki Collie-Akers, Lorrene D Ritchie","doi":"10.1111/ijpo.70043","DOIUrl":"https://doi.org/10.1111/ijpo.70043","url":null,"abstract":"Background: To reverse the epidemic of unhealthy eating and related chronic disease in the United States, intervening early in life is essential.Objective: Identify features of community- and school-based programmes, policies and environments related to child intake of fruits and vegetables (FV) and sugar-sweetened beverages (SSB).Methods: Dietary intake of children 4-15 years old (n = 5138) from elementary and middle schools in 130 US communities was collected by survey (of parent and/or child) in 2013-2015. Features of community programs and policies (CPPs) and school environments were collected by staff surveys, direct observation, key informant interviews, and/or document review. Community characteristics included socioeconomic status and predominant race/ethnicity. Classification and regression trees identified CPP and school environment features related to child dietary intake.Results: Community sociodemographic characteristics were the first-selected variables related to child intakes. Children in communities with lower socioeconomic status and larger proportions of African Americans tended to have lower FV and higher SSB intakes. Associations of dietary intake with race/ethnicity varied with SES. CPPs that addressed certain social determinants of health were related to higher FV intake among community race/ethnicity-SES sub-groups. Few other CPPs and no school environment characteristics were related to child FV or SSB intake.Conclusion: Findings suggest the importance of addressing social determinants of health such as education, poverty and transportation to reduce disparities in dietary intake, and the need to tailor interventions to community characteristics. More research is needed to explore the interaction of race/ethnicity and SES on dietary intake and intervention effectiveness.","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":" ","pages":"e70043"},"PeriodicalIF":2.7,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Racial Disparities in Paediatric Metabolic and Bariatric Surgery: An MBSAQIP Analysis. 儿科代谢和减肥手术的种族差异：MBSAQIP分析。

IF 2.7 3区医学

Pediatric Obesity Pub Date : 2025-07-21 DOI: 10.1111/ijpo.70045

Zachary Ballinger, Jonathan Green, Muriel Cleary, Kaitlyn Wong, Nicole Cherng, Jeremy Aidlen

{"title":"Racial Disparities in Paediatric Metabolic and Bariatric Surgery: An MBSAQIP Analysis.","authors":"Zachary Ballinger, Jonathan Green, Muriel Cleary, Kaitlyn Wong, Nicole Cherng, Jeremy Aidlen","doi":"10.1111/ijpo.70045","DOIUrl":"https://doi.org/10.1111/ijpo.70045","url":null,"abstract":"Objective: To evaluate disparities in paediatric metabolic and bariatric surgery (MBS) and examine the effects of recent policy changes on access and outcomes.Study design: Adolescents aged 10-18 who underwent MBS between 2017 and 2023 were identified using the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) Participant Use Files. Trends by race and ethnicity and clinical outcomes were assessed using univariate comparisons and multivariable logistic regression.Results: A total of 4940 paediatric patients underwent MBS from 2017 to 2023. The cohort was 71% female, 60% white, and had a mean age of 17.1 years. Female representation declined by approximately 1.1% annually. Hispanic patients comprised 32% of cases, with an average yearly increase of 1.1%. Black patient representation increased from 14% in 2017 to 24% in 2023. Asian, American Indian, and Pacific Islander patients accounted for only 1.5% of cases. Black patients were younger, had higher preoperative BMIs, and more frequently presented with comorbidities including diabetes and sleep apnoea. Hispanic patients had higher rates of hypertension, hyperlipidemia, and sleep apnoea than non-Hispanics. Robotic procedures were more common among Black patients, while Roux-en-Y gastric bypass was more frequent among white patients. Surgical outcomes were similar across racial groups. However, multivariable analysis showed that female patients had increased odds of postoperative complications and emergency department (ED) visits (aOR 1.54 and 2.74, respectively), and Hispanic patients had higher odds of ED visits (aOR 1.32).Conclusions: While MBS use is diversifying, disparities persist. Black and Hispanic youth face higher comorbidity burdens, indicating possible delayed access to surgery.","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":" ","pages":"e70045"},"PeriodicalIF":2.7,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Caffeine and Nicotine Use and Optimal Obesity Measures for Adolescents: A Refugee Adolescent Study. 青少年使用咖啡因和尼古丁与最佳肥胖措施之间的关系：一项难民青少年研究。

IF 2.7 3区医学

Pediatric Obesity Pub Date : 2025-07-17 DOI: 10.1111/ijpo.70042

Basma Damiri, Hamza Abdul-Hafez, Motaz Saifi

{"title":"Association Between Caffeine and Nicotine Use and Optimal Obesity Measures for Adolescents: A Refugee Adolescent Study.","authors":"Basma Damiri, Hamza Abdul-Hafez, Motaz Saifi","doi":"10.1111/ijpo.70042","DOIUrl":"https://doi.org/10.1111/ijpo.70042","url":null,"abstract":"Background: The weight impact of caffeine and nicotine use by adolescents, unlike adults, has not been conclusively determined. The prevalence of obesity among adolescents, especially in vulnerable populations such as refugee adolescents, is a crucial public health concern. The study aimed to investigate the prevalence of central obesity and its associated risk factors among refugee adolescents.Methods: This cross-sectional study was conducted in 2022 on refugee teenagers aged 11-15 in four refugee camps in West Bank. Data was collected through surveys and anthropometric measurements to assess waist circumference, waist-to-hip ratio and body mass index. Statistical analyses evaluated the relationship between caffeine and nicotine use and central obesity measures while accounting for potential confounders.Results: A total of 454 participants (51.3% boys, 48.7% girls) were included in the study. The median age was 14.49 years, with a median BMI of 21.7. The prevalence of overweight and obesity was 24% and 21.1%, respectively. 14.1% had high waist circumferences. The study found significant associations between central obesity and cigarette smoking (p = 0.03), waterpipe smoking (p = 0.008) and energy drink (p = 0.016) and coffee (p = 0.027) consumption. Adjusted multiple logistic regression revealed an association between overweight status and energy drink consumption (AOR = 3.035, p = 0.009) and the interaction between energy drink and coffee consumption (AOR = 3.924, p = 0.010). Obese status showed a significant association with waterpipe smoking (AOR = 2.975, p = 0.021).Conclusion: Obesity is a significant health concern among Palestinian refugee adolescents, with various factors contributing to its prevalence. Central obesity, in particular, is associated with increased health risks, emphasising the importance of identifying its determinants, including caffeine and nicotine use among adolescents.","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":" ","pages":"e70042"},"PeriodicalIF":2.7,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Association of Eating Behaviours, and Self-Concept, With Weight Status of Indian Adolescents. 印度青少年饮食行为和自我概念与体重状况的关系。

IF 2.7 3区医学

Pediatric Obesity Pub Date : 2025-07-17 DOI: 10.1111/ijpo.70044

Shivangi Choudhary, Anmol Bhandari, Suninder Tung, Gurcharan Kaur

{"title":"The Association of Eating Behaviours, and Self-Concept, With Weight Status of Indian Adolescents.","authors":"Shivangi Choudhary, Anmol Bhandari, Suninder Tung, Gurcharan Kaur","doi":"10.1111/ijpo.70044","DOIUrl":"https://doi.org/10.1111/ijpo.70044","url":null,"abstract":"Background: The epidemiological and sociocultural context of Indian adolescents is rapidly changing, thus affecting their eating behaviours and increasing overweight and obesity prevalence.Objectives: The current study was aimed at exploring associations of problematic eating behaviours and self-concept with overweight/obesity in adolescents.Methods: This cross-sectional study was conducted in six schools in Punjab, India, and enrolled 538 randomly selected adolescents aged 10-16 years. The cut-off of > 23rd adult equivalent BMI for overweight/obesity and < 23rd adult equivalent for healthy weight (IAP, 2015) was used. The Three-Factor Eating Questionnaire Revised 18-item version and Piers-Harris Self-Concept Scale were used. Pearson's correlation coefficient was used to quantify linear relationships among eating behaviours, self-concept and BMI-based weight status. An independent t-test was applied to determine eating behaviour and self-concept variations.Results: Eating behaviour such as cognitive restraint showed a statistically significant positive correlation with BMI in adolescents (p ≤ 0.001). Higher cognitive restraint significantly increased the probability of being overweight/obese (odds ratio [OR] = 1.153; 95% confidence interval [CI] 1.097-1.211). Physical appearance (PHY) and happiness and satisfaction (HAP) domains of adolescents' self-concept showed a significant negative correlation with BMI. In girls, the domain of social acceptance (SOC) showed a significant negative correlation with BMI.Conclusion: The study highlights the relationship of overweight/obesity with certain aspects of problematic eating behaviours as well as self-concept in adolescents. These findings warrant further longitudinal studies to establish causality, which may provide a comprehensive understanding of the epidemic of adolescent overweight/obesity in India.","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":" ","pages":"e70044"},"PeriodicalIF":2.7,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mediating Effect of Infant Rapid Weight Gain on the Association Between Exclusive Breastfeeding and the Risk of Obesity Later in Life. 婴儿体重快速增加在纯母乳喂养与后期肥胖风险之间的中介作用。

IF 2.7 3区医学

Pediatric Obesity Pub Date : 2025-07-14 DOI: 10.1111/ijpo.70039

Carlos Nagore González, Iris Iglesia Altaba, Cristina Guillén Sebastián, Maria Luisa Alvarez Sauras, Sheila García Enguita, Luis A Moreno, Gerardo Rodríguez

{"title":"Mediating Effect of Infant Rapid Weight Gain on the Association Between Exclusive Breastfeeding and the Risk of Obesity Later in Life.","authors":"Carlos Nagore González, Iris Iglesia Altaba, Cristina Guillén Sebastián, Maria Luisa Alvarez Sauras, Sheila García Enguita, Luis A Moreno, Gerardo Rodríguez","doi":"10.1111/ijpo.70039","DOIUrl":"https://doi.org/10.1111/ijpo.70039","url":null,"abstract":"Introduction: Obesity is a global health problem, with an impact on future health. Early factors such as infant feeding and rapid weight gain (RWG) may play a role in its development. However, their contribution is not fully understood.Objective: To analyse associations and potential interactions between the type of infant feeding during the first 4 months of age, RWG and later development of obesity in children at 6 years of age.Materials and methods: This observational longitudinal study examines growth in 834 children born at term with adequate weight for their gestational age. Data were collected from birth to 6 years, focusing on weight, height and body mass index (BMI) z-scores. The relationships between infant feeding, RWG, and BMI at 6 years were explored using mediation models.Results: Formula-fed infants showed higher BMI z-scores and obesity prevalence at 6 years compared to exclusively breastfed infants (p = 0.012 and p = 0.003 respectively). RWG also was associated with higher BMI z-scores and obesity (p < 0.001 in both cases), with formula-fed infants more likely to experience RWG (39.7% vs. 32.2%; p = 0.036). Mediation analysis revealed that the association between feeding type and BMI at 6 years is partly positively mediated by infant RWG up to 6 months.Conclusions: Infant feeding practices, particularly exclusive breastfeeding in the first 4 months, are associated with weight and BMI trajectories up to 6 years. Rapid weight gain mediates this relationship in the first 6 months, but from 6 to 12 months.","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":" ","pages":"e70039"},"PeriodicalIF":2.7,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144635817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-Nutritive Sweeteners Intake and Its Association With Sugars Intake Among Chilean Toddlers. 非营养性甜味剂的摄入量及其与智利幼儿糖摄入量的关系。

IF 2.7 3区医学

Pediatric Obesity Pub Date : 2025-07-13 DOI: 10.1111/ijpo.70036

Paola Arévalo, Natalia Rebolledo, Marcela Reyes

{"title":"Non-Nutritive Sweeteners Intake and Its Association With Sugars Intake Among Chilean Toddlers.","authors":"Paola Arévalo, Natalia Rebolledo, Marcela Reyes","doi":"10.1111/ijpo.70036","DOIUrl":"https://doi.org/10.1111/ijpo.70036","url":null,"abstract":"Non-nutritive sweeteners (NNS) are used as sugar alternatives in foods and beverages. However, their intake and dietary sources in toddlers and their association with total sugars intake have been scarcely explored. We aimed to characterise NNS intake (sucralose, acesulfame-K, aspartame, steviol glycosides, saccharin and cyclamate) and their individual association with dietary total sugars in a sample of Chilean toddlers. Participants of the Chilean Infant Nutrition Randomised Controlled Trial (N = 450, 50% girls) were assessed at 3 years of age with sociodemographic information from their families, anthropometry of the participants and their mothers and dietary intake (via a single 24-h recall). For reported packaged foods, we obtained the energy, nutrients and NNS information from nutrition facts panels (NFP). We estimated the dietary intake (total energy, macronutrients, total sugars and NNS intake) and NNS dietary sources for each participant. We used linear regression models to study crude and adjusted associations. Mean total energy intake was 1006 ± 351 kcal/day, with 27% of those calories coming from total sugars. Seventy-six percent of the toddlers consumed at least one NNS: 63% sucralose, 35% acesulfame-K, 32% aspartame, 27% steviol, < 1% saccharin and < 1% cyclamate. Beverages were the top contributors to NNS intake. NNS intake was not significantly associated with total sugars intake. In conclusion, we found a high prevalence of NNS intake among 3-year-old children, with sucralose being the most frequently consumed. NNS intake was not associated with lower sugars consumption. These results support new recommendations discouraging NNS intake among healthy populations, which can be even more relevant in young children.","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":" ","pages":"e70036"},"PeriodicalIF":2.7,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying Children With Obesity at High Risk for Metabolic Syndrome: Sensitivity and Specificity of the Monocyte/HDL Index. 识别代谢综合征高危肥胖儿童：单核细胞/高密度脂蛋白指数的敏感性和特异性

IF 2.7 3区医学

Pediatric Obesity Pub Date : 2025-07-08 DOI: 10.1111/ijpo.70040

Juan Pablo Rojas, Tamara Robles, Delma Salinas, Francisco Moraga, Verónica Mericq

{"title":"Identifying Children With Obesity at High Risk for Metabolic Syndrome: Sensitivity and Specificity of the Monocyte/HDL Index.","authors":"Juan Pablo Rojas, Tamara Robles, Delma Salinas, Francisco Moraga, Verónica Mericq","doi":"10.1111/ijpo.70040","DOIUrl":"https://doi.org/10.1111/ijpo.70040","url":null,"abstract":"Background: Visceral fat accumulation causes a low-grade chronic inflammatory state in individuals with Metabolic Syndrome (MetS). MetS detection, with simple and non-invasive tests, is crucial.Objective: To establish the sensitivity and specificity of the monocyte/HDL (MHR), neutrophils/lymphocytes (NLR), platelets/lymphocytes (PLR) and lymphocytes/monocytes (LMR) ratios to identify clinical characteristics of MetS in prepubertal children.Methods: Prospective cross-sectional study comparing 79 children fulfilling MetS IDF criteria and 75 control children. A clinical history and physical examination were performed. Blood glucose levels, lipid profile, ESR, usCRP, and complete blood count were determined, and the different ratios were calculated manually. The sensitivity and specificity of each ratio were determined using ROC curves.Results: MHR was the most sensitive and specific haematological index to determine clinical characteristics of MetS with a cut-off point of 8.62, allowing for the identification of low HDL, hypertriglyceridemia, large waist circumference, high blood pressure, sedentary lifestyle, and a family history of obesity as the main factors related to MetS in childhood.Conclusion: MHR is the best proxy of MetS and reveals the early elevation of proinflammatory factors in childhood, suggesting that it serves as a diagnostic tool in patients under 10 years of age, where the identification of MetS is controversial.","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":" ","pages":"e70040"},"PeriodicalIF":2.7,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic Dysfunction-Associated Steatotic Liver Disease in an Urban Paediatric Cohort With High Socioeconomic Deprivation. 高社会经济剥夺的城市儿童队列中代谢功能障碍相关的脂肪变性肝病

IF 2.7 3区医学

Pediatric Obesity Pub Date : 2025-07-05 DOI: 10.1111/ijpo.70037

Christine Brichta, Ariel Porto, Mark Fishbein, Saeed Mohammad, Catherine A Chapin

{"title":"Metabolic Dysfunction-Associated Steatotic Liver Disease in an Urban Paediatric Cohort With High Socioeconomic Deprivation.","authors":"Christine Brichta, Ariel Porto, Mark Fishbein, Saeed Mohammad, Catherine A Chapin","doi":"10.1111/ijpo.70037","DOIUrl":"https://doi.org/10.1111/ijpo.70037","url":null,"abstract":"Background: Whether higher socioeconomic deprivation indices are associated with more severe paediatric metabolic dysfunction-associated steatotic liver disease (MASLD), formerly non-alcoholic fatty liver disease (NAFLD), remains unknown.Objective: We aimed to evaluate differences in MASLD characteristics and social deprivation in a cohort of urban children.Methods: Retrospective study of 277 paediatric patients ≤ 18 years old evaluated between January 2009 and December 2019 with a suspected diagnosis of MASLD who underwent liver biopsy. Patients were classified as having metabolic dysfunction-associated steatohepatitis (MASH) based on their NAFLD Activity Score (NAS). Fibrosis was determined based on biopsy presence. Social deprivation index (SDI) scores were calculated using patient address.Results: Patients were predominantly Hispanic males with obesity and a median age of 12 years. Median SDI score was 85 (65-93). Median ALT was significantly higher in patients with MASH compared with MASLD (136 vs. 92 IU/L, p < 0.001) or with fibrosis compared with no fibrosis (120 vs. 68 IU/L, p < 0.001). High SDI group patients had a significantly higher median AST (60 vs. 47 IU/L, p = 0.022), NAS score (4 vs. 3, p = 0.026) and rates of bridging fibrosis (24% vs. 10%, p = 0.023) compared with the lower SDI group.Conclusion: Within a cohort of predominantly Hispanic children with MASLD and high socioeconomic disadvantage, there are significant laboratory and histologic differences in patients with higher SDI scores, suggesting increased MASLD severity.","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":" ","pages":"e70037"},"PeriodicalIF":2.7,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144566865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anthropometry and Body Composition in Childhood: Follow-Up of a Randomised, Double-Blinded Controlled Trial With a Modified, Low-Protein Infant Formula During Infancy. 儿童时期的人体测量和身体组成：一项随机、双盲对照试验的随访，在婴儿期使用改良的低蛋白婴儿配方奶粉。

IF 2.7 3区医学

Pediatric Obesity Pub Date : 2025-07-04 DOI: 10.1111/ijpo.70038

Jacqueline Muts, Stefanie M P Kouwenhoven, Nadja Antl, Marieke Abrahamse-Berkeveld, Britt J van Keulen, Jos W R Twisk, Dewi van Harskamp, Chris H P van den Akker, Berthold Koletzko, Johannes B van Goudoever

{"title":"Anthropometry and Body Composition in Childhood: Follow-Up of a Randomised, Double-Blinded Controlled Trial With a Modified, Low-Protein Infant Formula During Infancy.","authors":"Jacqueline Muts, Stefanie M P Kouwenhoven, Nadja Antl, Marieke Abrahamse-Berkeveld, Britt J van Keulen, Jos W R Twisk, Dewi van Harskamp, Chris H P van den Akker, Berthold Koletzko, Johannes B van Goudoever","doi":"10.1111/ijpo.70038","DOIUrl":"https://doi.org/10.1111/ijpo.70038","url":null,"abstract":"Introduction: Formula feeding is associated with an increased obesity risk compared to breastfeeding, possibly due to its higher protein content. We aimed to investigate the influence of feeding a modified, low-protein infant formula during the first 6 months of life on growth and body composition at 6 years.Methods: Healthy term-born infants were randomised to receive a low-protein (mLP) infant formula with modified amino acid composition (n = 90; 1.7 g protein/100 kcal) or a control infant formula (CTRL) (n = 88; 2.1 g protein/100 kcal) up to 6 months. A breastfed (BF, n = 67) group served as a reference. At 6 years, anthropometry and body composition (air-displacement plethysmography) were measured.Results: A total of 106 infants were measured at 6y follow-up, (n = 39 mLP; n = 33 CTRL; n = 34 BF). No significant differences were observed in mean weight, length, BMI, or fat mass percentage. However, the mean fat-free mass was lower in the mLP compared to the CTRL group (-1240 g; 95% CI: -1889 to -591, p < 0.001). Moreover, both formula groups had a higher absolute fat mass when compared to the breastfed group (p = 0.01).Conclusions: Feeding a mLP formula during early life did not have beneficial effects on body composition in a subset of infants studied at age 6 year.","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":" ","pages":"e70038"},"PeriodicalIF":2.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144566864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of continuous glucose monitoring feedback on glycaemic variability in youth with obesity: A within-participant feasibility study. 连续血糖监测反馈对青少年肥胖患者血糖变异性的影响：一项参与者内可行性研究。

IF 2.7 3区医学

Pediatric Obesity Pub Date : 2025-07-01 DOI: 10.1111/ijpo.70035

Sri Nikhita Chimatapu, Steven D Mittelman, Alexandra Klomhaus, My H Vu, Manal Habib, Lauren E Wisk, David S Black, Alaina P Vidmar

{"title":"The effect of continuous glucose monitoring feedback on glycaemic variability in youth with obesity: A within-participant feasibility study.","authors":"Sri Nikhita Chimatapu, Steven D Mittelman, Alexandra Klomhaus, My H Vu, Manal Habib, Lauren E Wisk, David S Black, Alaina P Vidmar","doi":"10.1111/ijpo.70035","DOIUrl":"10.1111/ijpo.70035","url":null,"abstract":"Background: Continuous glucose monitors (CGM) offer real-time biofeedback that might support behavioural changes to reduce obesity in youth. However, the feasibility and acceptability of CGM in this population remain underexplored.Methods: A 6-week crossover trial was conducted with youth aged 10-18 years with a body mass index above the 95th percentile. Participants experienced two phases in random order: (1) masked CGM (without data access) and (2) unmasked CGM (with real-time data access). The primary objective was to assess feasibility through recruitment, retention and adherence rates. Secondary measures included CGM-derived glucose metrics, sleep patterns, dietary intake, physical activity, eating behaviours and weight change. Descriptive analyses and mixed-effects regression models were used to examine between-condition differences on an intention-to-treat basis.Results: Of 30 eligible participants, 27 were enrolled (90% recruitment rate; age: 14.5 ± 2.2 years, HbA1c: 5.5 ± 0.24%, 15/27 [55%] Hispanic, 16/27 [59%] female). Of the enrolled participants, 24 completed the protocol. Adherence averaged 35.1 days over 42 days (87% of days). The CGM was well tolerated, with no adverse effects reported. There was no significant difference in glycaemic variability metrics between masked and unmasked conditions over the 6-week period.Conclusions: This trial supports the feasibility and acceptability of CGM use in youth with obesity. Given the exploratory nature of this study, longer-term research is needed to evaluate its effectiveness in modifying health behaviours and metabolic outcomes in this population.","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":" ","pages":"e70035"},"PeriodicalIF":2.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0