Pediatric Obesity最新文献

{"title":"Factors that shape dietary intake in children in the context of increasing risk for obesity development","authors":"Michael I. Goran,&nbsp;Alexandra Descarpentrie,&nbsp;Shana Adise","doi":"10.1111/ijpo.70004","DOIUrl":"10.1111/ijpo.70004","url":null,"abstract":"<div>\u0000 \u0000 <p>The development of obesity in childhood is the result of interplay between a complex array of multi-level factors, one of which is dietary intake. However, dietary intake in childhood itself is impacted by many factors operating at different levels. This special issue brings together a collection of papers that examine various factors influencing children's dietary intake. Rather than issuing a call for papers, this collection came together organically based on regular submissions, highlighting the growing body of research dedicated to understanding how children's dietary habits can contribute to obesity risk. These papers represent studies that have focused on the external (e.g., fast-food environment, ongoing rapid proliferation of ultra-processed foods) and social (e.g., the role of parents and schools, stress and adversity) environment, behavioural factors (e.g., reward and gratification, sleeping behaviour) and genetic factors, as well as maternal factors that promote intra-generational transmission. This is summarized in Figure 1. In a time when obesity development continues to rise globally, these studies may shed light on the complexity of one of the main drivers, namely dietary intake. Below we summarize the latest research in these areas resulting from the papers in this Special Issue.</p>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"20 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrition transition's latest stage: Are ultra-processed food increases in low- and middle-income countries dooming our preschoolers' diets and future health?","authors":"Barry M. Popkin,&nbsp;Amos Laar","doi":"10.1111/ijpo.70002","DOIUrl":"10.1111/ijpo.70002","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Rapid shifts in dietary patterns, marked by increased consumption of ultra-processed foods (UPFs), are increasingly impacting the health and wellbeing of infants and toddlers in low- and middle-income countries.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Utilizing data from the Demographic and Health Surveys, other national surveys, NCD-RisC data and Euromonitor sales data, we examine changes in stunting and overweight/obesity prevalence alongside the latest data on UPF consumption trends.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The prevalence of overweight/obesity among children and mothers is increasing rapidly while stunting rates decline slowly. Simultaneously, there is a significant increase in consumption of UPFs, especially among preschool-aged children. Increasingly, poorer households are experiencing faster rates of increase in overweight and obesity prevalence compared to wealthier households. Results highlight the early socialization of infants and toddlers to unhealthy discretionary foods including UPFs, potentially setting the stage for long-term dietary preferences that favour food with high sugar or excess sodium.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>There is an urgent need to address the rapid increases in UPF consumption among infants and toddlers. Options include expanding the WHO Code on marketing to protect 0–3-year-olds; creating front-of-package warning labels focusing on products for children ages 0–3 years to remove all added sugar and limit sodium in foods and beverages they consume.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"20 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijpo.70002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of 24-h movement behaviour with overweight and obesity among school-aged children and adolescents in Pakistan: An empirical cross-sectional study","authors":"Moazzam Tanveer,&nbsp;Yujun Cai,&nbsp;Georgian Badicu,&nbsp;Ejaz Asghar,&nbsp;Alexios Batrakoulis,&nbsp;Luca Paolo Ardigò,&nbsp;Serge Brand","doi":"10.1111/ijpo.13208","DOIUrl":"10.1111/ijpo.13208","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Overweight and obesity among children and adolescents poses a significant public health challenge. In Pakistan, the prevalence of childhood overweight and obesity continues to rise, leading to long-term adverse effects on health. Various external influences shape children's health behaviours and outcomes, with parents, peers, schools, and communities playing crucial roles, particularly during formative years.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objectives&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This cross-sectional study aimed to investigate the associations between 24-h movement behaviour and overweight/obesity among school-aged children and adolescents, focusing on the intrapersonal, interpersonal, community, and school levels from a Social-Ecological Perspective.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A population-based cross-sectional study was conducted from 15 January to 15 March 2023, using a representative multistage random cluster sampling method. The study enrolled 4200 participants aged 9–17 years and 3371 parents from 62 schools in central Punjab, Pakistan. Participants' body mass index (BMI) was classified based on CDC US 2000 BMI percentiles. Socio-ecological factors were analyzed using chi-square tests, binary logistic regression, and stepwise logistic regression to examine their associations with overweight and obesity.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The results of this study revealed that boys had 18.7% overweight and 9% obesity, while girls had 20.5% overweight and 13.2% obesity. Gender exhibited a significant association with weight status. A considerable proportion of participants did not meet recommended guidelines for junk food consumption (31.5% boys, 33.3% girls), physical activity (70% boys, 83.8% girls), screen time (37.7% boys, 41.1% girls), and sleep (55.7% boys, 54% girls). Individuals engaging in certain 24-h movement behaviours exhibited higher odds of obesity. Specifically, consuming fast food three or more days per week was associated with higher odds of obesity (odds ratio: 9.95, &lt;i&gt;p&lt;/i&gt; &lt; 0.01). Engaging in physical activity for less than 60 min per day, twice a week or less, was associated with higher odds of obesity (odds ratio: 3.47, &lt;i&gt;p&lt;/i&gt; &lt; 0.01). Spending three or more hours per day on screen time was linked to higher odds of obesity (odds ratio: 2.50, &lt;i&gt;p&lt;/i&gt; &lt; 0.01). Furthermore, being a short sleeper was associated with higher odds of overweight (odds ratio: 3.54, &lt;i&gt;p&lt;/i&gt; &lt; 0.01).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Children failing to meet none or only ","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"20 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent prevalence and trends of obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) among US adolescents: 1999 to 2020","authors":"Michael Sun,&nbsp;Hongbing Sun","doi":"10.1111/ijpo.70003","DOIUrl":"10.1111/ijpo.70003","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease (NAFLD), is understudied among US adolescents despite rising obesity rates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study analysed the prevalence and trends of obesity and MASLD among US adolescents aged 12–17 using data from the National Health and Nutrition Examination Survey (NHANES). We developed a new screening model utilizing FibroScan-measured controlled attenuation parameter (CAP) scores, body measurements and blood chemistry data from 2017 to 2020 to assist in analysing MASLD trends from 1999 to 2020.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Between 2017 and 2020, the prevalence of obesity and MASLD was approximately 20%, with about 70% of obese adolescents affected by MASLD. The condition was more common in boys, particularly among Mexican American adolescents. Additionally, 97.2% of those with NAFLD also had MASLD. Adolescents with MASLD had significantly higher body weight, waist circumference, triglyceride levels and alanine transaminase (ALT) levels, along with lower high-density lipoprotein (HDL) cholesterol and an increased risk of liver fibrosis. Insufficient physical activity and poor diet quality were key risk factors for developing MASLD. From 1999 to 2020, the prevalence of MASLD rose significantly, paralleling the increasing rates of obesity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The study underscores the pressing need to screen at-risk adolescents for metabolic issues associated with steatotic liver diseases, given the rising obesity rates among adolescents. The high overlap between MASLD and NAFLD diagnoses indicates that the transition from NAFLD to MASLD can be effectively integrated into paediatric practice.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"20 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight development in children with obesity without treatment: A Danish cohort study with long-term follow-up","authors":"Rasmus Møller Jørgensen,&nbsp;Jens Meldgaard Bruun,&nbsp;Mette Fogh,&nbsp;Iris Iglesia Altaba,&nbsp;Luis A. Moreno,&nbsp;Henrik Støvring,&nbsp;Jane Nautrup Østergaard","doi":"10.1111/ijpo.70001","DOIUrl":"10.1111/ijpo.70001","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Limited insight exists into the weight development in children with obesity not receiving obesity treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cohort study included 467 Danish children aged 5–10 years with obesity (iso-BMI &gt;30 kg/m²) not receiving treatment. Data from mandatory health check-ups on school-children's height and weight (converted to BMI <i>z</i>-scores) were merged with the Danish National Registries. A multivariable logistic regression weighted for the duration of follow-up was used to estimate odds ratios (OR) for normalization of BMI (iso-BMI 18.5–25 kg/m²) and obesity remission (iso-BMI 18.5–30 kg/m²).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>During a median follow-up of more than 6 years, 7.9% of the children normalized their BMI, while 45.4% obtained obesity remission. BMI <i>z</i>-score at inclusion acted as a strong inverse predictor for normalizing BMI (OR 0.14 per one-unit SD, CI: 0.03–0.53) and for obesity remission (OR 0.17 per one-unit SD, CI: 0.08–0.37). No other significant predictors were observed in the weighted multivariable models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Higher BMI <i>z</i>-scores inversely predict normalizing BMI and achieving obesity remission in untreated children. Given that many children naturally achieve obesity remission or weight normalization, resources should focus on understanding barriers of obesity maintenance and to develop effective strategies for those who do not experience improvement.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"20 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijpo.70001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood obesity trajectories and adolescent mental health: A UK cohort study","authors":"I Gusti Ngurah Edi Putra,&nbsp;Michael Daly,&nbsp;Eric Robinson","doi":"10.1111/ijpo.13206","DOIUrl":"10.1111/ijpo.13206","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>There is limited evidence on how changes in obesity from childhood to adolescence are associated with adolescent mental health. We examined the associations between childhood obesity trajectories, obesity episodes, and mental health at age 17.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data were from the UK Millennium Cohort Study. Obesity trajectory groups at ages 7 and 17 (<i>n</i> = 8306) and previous obesity episodes (number of sweeps with obesity) at ages 7, 11 and 14 (<i>n</i> = 7246) were examined. Caregiver and self-reported internalising and externalising symptoms at age 17 were used to measure mental health. Linear regression models were used.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Relative to never developing obesity, obesity development (<i>β</i> = 1.01; 95% CI = 0.71, 1.32) and persistence (<i>β</i> = 1.18; 95% CI = 0.74, 1.61) were associated with higher internalising symptoms at age 17 and worsening (increase in scores) of these symptoms between ages 7 and 17 (<i>β</i> = 0.87; 95% CI = 0.57, 1.17 and <i>β</i> = 0.86; 95% CI = 0.56, 1.26 for development and persistence, respectively). Obesity development was associated with higher externalising symptoms at age 17 (<i>β</i> = 0.52; 95% CI = 0.25, 0.80) and worsening of these symptoms over time (<i>β</i> = 0.30; 95% CI = 0.07, 0.53). Having multiple past obesity episodes was not associated with worsening mental health independent of follow-up weight status. There were no differences in mental health outcomes between children who reversed versus never developed obesity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Obesity development or persistence from ages 7 to 17 are associated with worsening mental health. If childhood obesity is reversed, there appears to be no evidence of a negative association between previous obesity and mental health at age 17.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"20 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijpo.13206","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep-disordered breathing and cardiometabolic and inflammatory markers in children with overweight/obesity: The role of cardiorespiratory fitness","authors":"Lucia V. Torres-Lopez,&nbsp;Abel Plaza-Florido,&nbsp;Jose J. Gil-Cosano,&nbsp;Jairo H. Migueles,&nbsp;Francisco B. Ortega,&nbsp;Cristina Cadenas-Sanchez","doi":"10.1111/ijpo.13207","DOIUrl":"10.1111/ijpo.13207","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To investigate the association of sleep-disordered breathing (SDB) severity with cardiometabolic and inflammatory markers independently of the adiposity levels; and to explore the role of cardiorespiratory fitness in these associations in children with overweight/obesity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 109 children aged 8–11 years with overweight/obesity were included in this cross-sectional study. SDB was assessed using a scale of the reduce version of the Paediatric Sleep Questionnaire. Cardiometabolic markers included fasting blood lipids biomarkers (i.e., low- and high-density lipoprotein cholesterol, and triglycerides), blood pressure, insulin, glucose, and the homeostatic model assessment index. Inflammatory markers (i.e., interleukin-6, interleukin-1β, C-reactive protein [CRP], and tumour necrosis factor alpha) were analysed. Cardiorespiratory fitness was assessed by the 20 m shuttle-run test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>No significant associations were found between SDB severity and most of the cardiometabolic markers after correcting for adiposity and multiple comparisons (all <i>p</i>'s &gt;0.05). SDB severity was positively related to CRP (<i>β</i> = 0.352, <i>p</i> = 0.002), yet not with the remaining inflammatory markers analysed. The interaction effect of cardiorespiratory fitness presented a positive trend in the association of SDB with CRP (<i>p</i> = 0.1). When stratified analyses by cardiorespiratory fitness levels were conducted, a positive relation was found between SDB and CRP in the low cardiorespiratory fitness group (<i>β</i> = 0.465, <i>p</i> = 0.014), but not in the high cardiorespiratory fitness group (<i>β</i> = 0.236, <i>p</i> = 0.108).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>SDB severity was positively associated with CRP independently of the adiposity levels, but not with other inflammatory or cardiometabolic risk factors in children with overweight/obesity. Moreover, our results suggest that higher levels of cardiorespiratory fitness may attenuate the adverse effect of SDB severity on systematic inflammation in children with overweight/obesity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"20 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction between breastfeeding duration and an obesity genetic risk score to predict body fat composition in European adolescents: The HELENA study","authors":"Georgios K. Baxevanis,&nbsp;Iris Iglesia,&nbsp;Miguel Seral-Cortes,&nbsp;Sergio Sabroso-Lasa,&nbsp;Paloma Flores-Barrantes,&nbsp;Frédéric Gottrand,&nbsp;Aline Meirhaeghe,&nbsp;Anthony Kafatos,&nbsp;Kurt Widhalm,&nbsp;Nele Hockamp,&nbsp;Dénes Molnár,&nbsp;Ascensión Marcos,&nbsp;Esther Nova,&nbsp;Marcela González-Gross,&nbsp;Eva Gesteiro,&nbsp;Ángel Gutiérrez,&nbsp;Yannis Manios,&nbsp;Costas A. Anastasiou,&nbsp;Gerardo Rodríguez,&nbsp;Luis A. Moreno,&nbsp;the HELENA Study Group","doi":"10.1111/ijpo.13205","DOIUrl":"10.1111/ijpo.13205","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Although the genetic interplay with the environment has a major impact on obesity development, little is known on whether breastfeeding could modulate the genetic predisposition to obesity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To investigate whether breastfeeding attenuates the effect of an obesity genetic risk score (GRS) on adiposity in European adolescents.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Totally 751 adolescents from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study were included, divided according to breastfeeding status into never breastfed, 1–3 months and ≥4 months. Adjusting by socioeconomic status and lifestyle factors multiple linear regression models were used to assess (1) the main effect of breastfeeding duration and (2) its interaction effect with an obesity GRS, to predict different adiposity measures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A significant negative association between ≥4 months of breastfeeding and waist circumference (WC) z-score was observed [β (95% confidence interval), <i>p</i>-value] = [β = −0.189 (−0.37, −0.00), <i>p</i> = 0.044]. Also, significant interaction effects were observed for 1–3 and ≥4 months of breastfeeding and obesity GRS regarding body mass index (BMI) z-score [β = 0.155 (0.06, 0.24), <i>p</i> = 0.001] and [β = 0.108 (0.01, 0.18), <i>p</i> = 0.020, respectively] and fat mass index (FMI) z-score [β = 0.134 (0.04, 0.22), <i>p</i> = 0.003] and [β = 0.100 (0.01, 0.18), <i>p</i> = 0.026, respectively].</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Breastfeeding modulates the association between the obesity GRS and body composition in adolescents.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"20 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijpo.13205","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a physical activity and healthy eating lifestyle intervention in pregnancy on fetal growth trajectories: The DALI randomised controlled trial","authors":"Anna M. Dieberger,&nbsp;Mireille N. M. van Poppel,&nbsp;Gernot Desoye,&nbsp;David Simmons,&nbsp;Jürgen Harreiter,&nbsp;Roland Devlieger,&nbsp;Carmen Medina,&nbsp;Deborah A. Lawlor,&nbsp;Ahmed Elhakeem,&nbsp;the DALI core investigator group","doi":"10.1111/ijpo.13199","DOIUrl":"10.1111/ijpo.13199","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Obesity during pregnancy is related to fetal overgrowth. Effective interventions that can mitigate this risk are needed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to investigate the effect of a lifestyle intervention for pregnant women with obesity on fetal growth trajectories.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In the DALI trial, pregnant women with a body mass index ≥29.0 kg/m² and without gestational diabetes at baseline were randomized to counselling on physical activity (PA), healthy eating (HE) or a combination (PA + HE), or to usual care (UC). Fetal growth trajectories were modelled based on a combination of estimated fetal weight (EFW) from repeated ultrasound scans and weight measured at birth. Differences in fetal growth trajectories between groups were assessed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Three hundred eighty-four women were included. Those in the PA + HE intervention had slower EFW gain from 32 weeks onwards, with differences (PA + HE vs. UC) at 32, 36 and 40 weeks of −54.1 g (−146.7 to 38.9 g), −84.9 g (−194.0 to 24.7 g), and −99.8 g (−227.1 to 28.1 g), respectively. Effects appeared stronger in males, with a difference at 40 weeks of −185.8 g (−362.5 g to −9.2 g) versus −23.4 g (−190.4 g to 143.5 g) in females.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>A lifestyle intervention for pregnant women with obesity resulted in attenuated fetal growth, which only reached significance in male offspring. Future larger trials are needed to confirm these findings and elucidate underlying pathways.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"20 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijpo.13199","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term follow-up of the impact of brief sleep and lifestyle interventions in infancy on BMI z-score at 11 years of age: The POI randomized controlled trial","authors":"Rachael W. Taylor,&nbsp;Barbara C. Galland,&nbsp;Anne-Louise M. Heath,&nbsp;Andrew R. Gray,&nbsp;Kim A. Meredith-Jones,&nbsp;Sarah A. Fortune,&nbsp;Trudy A. Sullivan,&nbsp;Taiwo Adebowale,&nbsp;Deborah McIntosh,&nbsp;Rosie F. Jackson,&nbsp;Barry J. Taylor","doi":"10.1111/ijpo.13204","DOIUrl":"10.1111/ijpo.13204","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To determine whether BMI differences observed at 5 years of age, from early intervention in infancy, remained apparent at 11 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Participants (<i>n</i> = 734) from the original randomized controlled trial (<i>n</i> = 802) underwent measures of body mass index (BMI), body composition (DXA), sleep and physical activity (24-h accelerometry, questionnaire), diet (repeated 24-h recalls), screen time (daily diaries), wellbeing (CHU-9D, WHO-5), and family functioning (McMaster FAD) around their 11th birthday. Following multiple imputation, regression models explored the effects of two interventions (‘Sleep’ vs. ‘Food, Activity and Breastfeeding’ [FAB]) using a 2 × 2 factorial design.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Five hundred twelve children (48% female, mean [SD] age 11.1 [0.1] years) returned for the 11-year assessment (63% of original sample). Significant differences in BMI <i>z</i>-score (mean difference; 95% CI: −0.16; −0.41, 0.08) or the risk of overweight (including obesity) (odds ratio; 95% CI: 0.85; 0.56, 1.29) were no longer observed between children who had received the sleep intervention compared with those who had not. By contrast, children who had received the FAB intervention had greater BMI <i>z</i>-scores (0.24; 0.01, 0.47) and a higher risk of obesity (1.56; 1.03, 2.36) than children not enrolled in FAB. No significant differences were observed in any lifestyle variables nor wellbeing measures across all groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Sustained reductions in BMI and obesity risk from an early sleep intervention were not apparent 9 years later, whereas a more traditional lifestyle intervention resulted in increased rates of obesity, not explained by any differences in lifestyle behaviours measured.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical Trial Registry</h3>\u0000 \u0000 <p>ClinicalTrials.gov number NCT00892983, https://clinicaltrials.gov/study/NCT00892983.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"20 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}