Pediatric Obesity最新文献

{"title":"Real-World Use of Subsidised Semaglutide in Icelandic Children With Obesity: A Nationwide Retrospective Cohort Study","authors":"Sigrun Thorsteinsdottir,&nbsp;Berglind Jonsdottir,&nbsp;Anna S. Olafsdottir,&nbsp;Helena B. Arnarsdottir,&nbsp;Sigrun Hallgrimsdottir,&nbsp;Berglind Brynjólfsdóttir,&nbsp;Tryggvi Helgason","doi":"10.1111/ijpo.70139","DOIUrl":"10.1111/ijpo.70139","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Real-world evidence of subsidised semaglutide in children with obesity is scarce.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To describe clinical outcomes (%IOTF30 change) in a nationwide cohort of Icelandic children prescribed subsidised semaglutide, describing outcomes across treatment settings and examining treatment response in children with and without neurodevelopmental disorders (ND).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Retrospective, population-based cohort study using longitudinal anthropometric measurements, March 20, 2021–June 6, 2025. Children aged ≥ 12 with grade 2 obesity were eligible for subsidised semaglutide under a universal reimbursement policy. Main outcomes were changes in %IOTF30 (BMI expressed as a percentage of the age- and sex-specific IOTF obesity threshold), modelled using piecewise linear mixed-effects regression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 113 participants (44% female; mean [SD] age 15.2 [2.0] years), pre-treatment %IOTF30 rose at 0.29 percentage points (pp)/month (95% CI, 0.26, 0.33). Semaglutide was associated with trajectory reversal at −0.86 pp/month (95% CI, −1.06 to −0.66); estimated reductions were 5.17 (95% CI, 3.98, 6.36) and 10.33 (95% CI, 7.96, 12.71) pp at six and 12 months. On-treatment slopes were numerically similar across settings but not interpretable as evidence of equivalent response. ND-status did not significantly modify treatment response among 56 Pediatric Obesity Center participants (interaction <i>p</i> = 0.83; underpowered). Overall, 63% achieved %IOTF30 reductions exceeding 10 pp.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Semaglutide was associated with reversal of a longstanding upward weight trajectory in children with obesity. ND-status did not significantly modify treatment response; analysis was underpowered. Universal subsidisation policy enabled high treatment persistence and may inform reimbursement policy in other countries, though generalisability to settings without universal coverage remains uncertain.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"21 8","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148662971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Liraglutide on Energy Intake in Adolescents With Persistent Obesity After Vertical Sleeve Gastrectomy","authors":"Bao-Vi C. Tran,&nbsp;Anna Zenno,&nbsp;Nazrat M. Mirza,&nbsp;Evan Nadler,&nbsp;Sheila M. Brady,&nbsp;Otiti A. Mayo,&nbsp;Alexa P. Lyman,&nbsp;Stephanie T. Chung,&nbsp;Kong Y. Chen,&nbsp;Peter Walter,&nbsp;Hongyi Cai,&nbsp;Shanna B. Yang,&nbsp;Sara A. Turner,&nbsp;Jack A. Yanovski,&nbsp;Bobby K. Cheon","doi":"10.1111/ijpo.70140","DOIUrl":"https://doi.org/10.1111/ijpo.70140","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>In adolescents with obesity ≥ 1-year post-vertical sleeve gastrectomy (VSG), a pilot trial of liraglutide demonstrated a 4.3% BMI reduction. This secondary analysis evaluated energy intake changes (∆EI) and associations of ∆EI with oral glucose tolerance test (OGTT) outcomes and end-of-trial liraglutide plasma concentrations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>At baseline and after 4 months of liraglutide, participants completed a standardised buffet meal following a 2-h OGTT. Liraglutide plasma area under the curves (AUCs) were quantified using LC–MS/MS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-seven participants (18.1 ± 2.0 years; BMI: 40.4 ± 7.3 kg/m²) completed buffet meals at both visits. Mean energy intake decreased by 161.7 ± 264.3 kcal (<i>p</i> = 0.04) and food mass by 72.5 ± 123.4 g (<i>p</i> = 0.02), with proportional reductions in absolute macronutrient intake but no change in macronutrient distribution. Neither Liraglutide AUC (<i>n</i> = 17) nor OGTT outcomes were significantly associated with ∆EI or changes in body weight.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In adolescents post-VSG treated with liraglutide, overall food intake decreased without significant changes in macronutrient composition.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"21 8","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148647901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent Food Insecurity and Overweight/Obesity Risk in Offspring of Individuals With Gestational Diabetes","authors":"Keally Haushalter,&nbsp;Jaimie N. Davis,&nbsp;Yeyi Zhu,&nbsp;Joan C. Lo,&nbsp;Erin A. Hudson,&nbsp;Alexis King,&nbsp;Louise Greenspan,&nbsp;Jami Josefson,&nbsp;Erica P. Gunderson","doi":"10.1111/ijpo.70138","DOIUrl":"10.1111/ijpo.70138","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Assess how changes in food insecurity in the first 2 years of life are associated with overweight and obesity among children 6–11 years old born to mothers with gestational diabetes mellitus (GDM).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This secondary analysis utilised data from the Study of Women, Infant Feeding and Type 2 Diabetes Mellitus after GDM pregnancy, a prospective cohort of 1033 mother–child dyads. Food insecurity was assessed 6–9 weeks, 1 year and 2 years postpartum. Children were categorized as having persistent food security (food secure all visits), persistent food insecurity (food insecure all visits), or transient food insecurity (experienced both food security and insecurity). Overweight, obesity and severe obesity were classified using height and weight at 6–11 years old. Linear and logistic regressions estimated the relationship between food insecurity groups and BMI percentile, overweight, obesity and severe obesity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 748 youth, 72% had persistent food security, 18% had transient food insecurity and 10% had persistent food insecurity. Compared to those with persistent food security, those with persistent food insecurity had higher odds of overweight (aOR = 2.81, [1.36, 5.80]), obesity (aOR = 2.17, [1.05, 4.47]) and severe obesity (aOR = 2.62, [1.02, 6.74]) (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Screening and addressing food insecurity during early childhood may help identify children at risk for overweight, obesity and severe obesity among children exposed to GDM.</p>\u0000 \u0000 <p><b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT019967030</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"21 7","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13402765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148589853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision Health Approaches in Primary Childhood Obesity Prevention: A Systematic Review of Tailored and Risk-Based Interventions","authors":"Walaa Badawy,&nbsp;Abeer Saleh Alshehri,&nbsp;Mostafa Shaban","doi":"10.1111/ijpo.70137","DOIUrl":"https://doi.org/10.1111/ijpo.70137","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Precision health represents an emerging paradigm in public health that uses individualised risk profiles to guide targeted prevention strategies. In childhood obesity, early-life determinants—such as genetics, growth patterns, family behaviours and environmental exposures—can inform interventions tailored to the specific needs of high-risk populations. Traditional universal approaches have shown limited long-term effectiveness, highlighting the need for more personalised prevention models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This systematic review aimed to (1) evaluate the effectiveness of tailored and risk-based interventions for the primary prevention of childhood obesity in children aged 0–12 years, and (2) examine implementation characteristics and contextual factors influencing intervention outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Following PRISMA 2020 guidelines, we searched six databases (PubMed, Embase, Web of Science, Scopus, PsycINFO and CINAHL). The protocol was registered on PROSPERO (CRD420251103591). Eligible studies included RCTs, quasi-experimental, or pilot studies targeting obesity prevention using tailored or risk-stratified approaches in children aged 0–12, reporting anthropometric or behavioural outcomes. Data extraction and quality appraisal were conducted independently by two reviewers, with synthesis via narrative and thematic methods.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sixteen studies met inclusion criteria. Nine of 16 studies (56.3%) reported statistically significant reductions in BMI z-scores or obesity prevalence, with effect sizes ranging from −0.10 to −0.54 in BMI z-score units. Eleven studies (68.8%) observed significant improvements in dietary intake or physical activity behaviours. Culturally adapted, equity-focused interventions showed higher uptake and effectiveness. Key challenges included limited scalability, short follow-up periods and fidelity variability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Tailored, risk-based interventions hold promise for reducing early obesity risk and improving health behaviours. Precision health strategies, especially those that are family-centred and culturally sensitive, warrant further longitudinal evaluation to enhance equity and impact.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"21 7","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148467430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telehealth Vs. Face-to-Face Treatment for Children and Adolescents With Obesity: A Randomized Controlled Trial","authors":"Lior Friedman,&nbsp;Tzach Itzhak Gil,&nbsp;Amit Yaniv,&nbsp;Eylam Ziv-Av,&nbsp;Alon Manhart,&nbsp;Yftach Gepner,&nbsp;Gal Dubnov-Raz","doi":"10.1111/ijpo.70136","DOIUrl":"10.1111/ijpo.70136","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Telemedicine (TELE) may improve accessibility to paediatric obesity treatment, yet its effectiveness relative to face-to-face (FTF) care remains uncertain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To compare the effects of a high-intensity, multidisciplinary TELE intervention with standard FTF care in children and adolescents with obesity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Participants aged 10–18 years with obesity [body mass index (BMI) ≥ 2 standard deviations] were randomized to a 6-month TELE or FTF program in a tertiary-care centre paediatric obesity clinic. The TELE group received 30 weekly remote multidisciplinary consultations and a gamified step-monitoring application, along with three in-person visits. The FTF group attended six monthly in-clinic visits. The primary outcome was BMI <i>z</i>-score changes. Secondary outcomes included body composition, weight-related-quality-of-life (QOL), adherence, and satisfaction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>One hundred participants were randomized 1:1 to TELE or FTF, of whom 65 completed the intervention (TELE <i>n</i> = 32; FTF <i>n</i> = 33). Baseline BMI <i>z</i>-scores were similar between groups (2.11 ± 0.32 vs. 2.11 ± 0.29). The reduction in BMI <i>z</i>-score was significantly greater in FTF than TELE (−0.16 ± 0.14 vs. −0.05 ± 0.15; <i>p</i> = 0.002), and any reduction was observed among 85% of FTF participants compared with 56% in TELE (<i>p</i> = 0.015). Body composition and QOL improved similarly in both groups, whereas satisfaction was higher in FTF.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>TELE-based care was less effective than FTF in reducing BMI <i>z</i>-score in children with obesity. Hybrid models integrating TELE with FTF visits warrant further investigation.</p>\u0000 \u0000 <p><b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT05700409</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"21 7","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijpo.70136","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148434487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomic Profiles Associated With Sugary Beverage Intakes in Youth","authors":"Catherine C. Cohen,&nbsp;Kyle Salmon,&nbsp;Fatima Pacheco Vasquez,&nbsp;Troy Steckelberg,&nbsp;Oniza Chaman,&nbsp;Dana Dabelea,&nbsp;Wei Perng","doi":"10.1111/ijpo.70135","DOIUrl":"10.1111/ijpo.70135","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Sugar-sweetened beverages (SSBs) have been linked to obesity and metabolic dysfunction in youth; whereas the effects of 100% fruit juice, which is also high in free sugar, remain debated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To compare metabolomic profiles of SSB versus 100% fruit juice intake across childhood and adolescence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data were from 593 youth in the EPOCH cohort collected during childhood (6–14 years) and adolescence (12–19 years). A food frequency questionnaire assessed total-energy-adjusted SSB and fruit juice intakes over the past week and fasting serum samples were assayed by untargeted metabolomics profiling. Least Absolute Shrinkage and Selection Operator (LASSO) regression with bootstrapping identified metabolites associated with each beverage at each visit. Metabolites consistently selected across visits were retained and compared.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Mean (SD) SSB intake was 6.9 (4.9) and 5.2 (3.7) servings/week in childhood and adolescence, respectively, and mean fruit juice intake was 2.4 (2.6) and 1.7 (2.0) servings/week. Of 767 metabolites, 40 were associated with SSB intake and 39 were associated with fruit juice intake at both visits. Only three metabolites were associated with SSB and fruit juice intake (argininate, cortisone, quinate); all others were unique. Both beverages were linked to metabolites of amino acid, xenobiotic, lipid, and carbohydrate metabolism (10, 11, 8 and 1 metabolites, respectively, for SSB; 7, 8, 8 and 3 metabolites, respectively, for juice intake).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>SSB and 100% fruit juice intake are associated with largely distinct metabolomic profiles, suggesting some degree of beverage-specific metabolic effects in youth. Future studies are needed to replicate these findings, explore the role of common endogenous pathways and characterise mechanisms.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"21 7","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148434431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in Fat Depots, Cardiometabolic Risk Factors, and Insulin Resistance Between Active and Passive School Commuters","authors":"David Rodriguez-Sanchez,&nbsp;Francisco Javier Huertas-Delgado,&nbsp;Maria Medrano,&nbsp;Fernando Idoate,&nbsp;Rafael Cabeza,&nbsp;Cristina Cadenas-Sanchez,&nbsp;Idoia Labayen","doi":"10.1111/ijpo.70134","DOIUrl":"10.1111/ijpo.70134","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Active commuting to and from school (ACS) is a feasible strategy to increase daily physical activity in children. Although ACS has been associated with favourable body composition and selected cardiometabolic markers, its association with specific ectopic fat depots remains unclear in paediatric populations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To examine differences in specific fat depots and cardiometabolic risk factors between children who actively and passively commute to school.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Cross-sectional baseline data from 174 children (48.9% girls; mean age 10.8 ± 1.4 years) participating in the EFIGRO and MICROKID projects were analysed. ACS mode was self-reported using a validated questionnaire and classified as active or passive. Visceral adipose tissue, abdominal subcutaneous adipose tissue, intermuscular abdominal adipose tissue, hepatic fat, intrapancreatic fat, and lumbar spine marrow fat were assessed using magnetic resonance imaging. Cardiometabolic risk factors included blood pressure, triglycerides, high-density lipoprotein cholesterol, glucose, insulin, and insulin resistance estimated by the homeostasis model assessment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>No significant differences were observed between active and passive commuters for any fat depot (all <i>p</i> ≥ 0.150) or cardiometabolic risk factors, including insulin resistance and the overall cardiometabolic risk score (all <i>p</i> ≥ 0.220).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Active commuting to/from school was not associated with differences in ectopic fat depots, cardiometabolic risk factors, or insulin resistance in children.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"21 7","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijpo.70134","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148434500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parent–Child Sex Composition Impacts Long-Term Outcomes in Family-Based Behavioural Treatment","authors":"Nicholas V. Neuwald,&nbsp;Jennifer L. Temple,&nbsp;Owen Li,&nbsp;Leonard H. Epstein","doi":"10.1111/ijpo.70130","DOIUrl":"10.1111/ijpo.70130","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Prior research by Temple et al. has shown that opposite-sex parent–child dyads demonstrate superior weight outcomes compared to same-sex dyads, but the analyses for all dyads were underpowered. This study replicates and extends those findings in a larger dataset of families provided with Family-Based Behavioural Treatment (FBT), examining whether dyad sex composition predicts change in zBMI and clinically meaningful weight outcomes at two-year follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Mega-analysis of individual participant data pooled from 9 randomised FBT trials conducted between 1981 and 2013, with weight outcomes assessed at 6, 12 and 24 months. Clinically meaningful change was defined as ≥ 0.25 reduction in child zBMI and ≥ 5% parent weight loss.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Children, but not parents, in opposite-sex dyads showed larger reductions in zBMI and greater odds of achieving clinically meaningful change across 2 years. When examining the four dyad combinations separately, daughters in mother-daughter dyads had the lowest odds of achieving clinically meaningful reductions, whereas daughters in father-daughter dyads had the highest.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Parent–child sex composition meaningfully influences children's long-term response to FBT. Opposite-sex dyads, particularly father-daughter pairs, show more sustained benefits. These findings suggest that dyad composition should be considered when administering FBT and may help inform strategies to enhance treatment effectiveness for families.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"21 7","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148409777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Food Portions During Complementary Feeding and Later Overweight Risk: Analysis From European Childhood Obesity Project","authors":"Irene Hernandez-Perez,&nbsp;Joaquin Escribano,&nbsp;Veit Grote,&nbsp;Berthold Koletzko,&nbsp;Mariona Gispert-Llauradó,&nbsp;Mireia Alcázar,&nbsp;Elvira Verduci,&nbsp;Dariusz Gruszfeld,&nbsp;Annick Xhonneux,&nbsp;Veronica Luque,&nbsp;the CHOP study group.","doi":"10.1111/ijpo.70131","DOIUrl":"10.1111/ijpo.70131","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aim</h3>\u0000 \u0000 <p>Early-life nutrition plays a critical role in long-term health. Although complementary feeding has been widely studied, the influence of portion size during this stage on subsequent overweight risk remains unclear. This study aimed to evaluate whether portion size during complementary feeding is associated with overweight risk in childhood and preadolescence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Secondary analysis of the European Childhood Obesity Project, a randomised clinical trial across five European countries. Dietary data was collected at 6, 12, 18 and 24 months using 3-day food records and food portions standardised as internal <i>z</i>-scores; anthropometry was assessed at 2, 8 and 11 years. Associations between early portion size and later overweight were examined using logistic regression (adjusted for feeding type, country, parental education, birth weight, meal frequency and energy intake) and structural equation modelling.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Larger portion sizes at 6 months were associated with more than a twofold higher risk of overweight at 2 years (OR 2.36, <i>p</i> = 0.031). Portion size at later complementary feeding stages showed positive trends with overweight at 2, 8 and 11 years and indirect associations with overweight at 8 and 11 years mediated by portion size at 8 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Larger portion sizes early in life are associated with increased risk of overweight later in childhood. These findings highlight portion size guidance during complementary feeding as a potential early target for obesity prevention.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"21 7","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijpo.70131","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148395457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlates of Obesity Medication Use in Paediatric Weight Management Programmes: A POWER Consortium Analysis","authors":"Amy L. Christison,&nbsp;Roy Kim,&nbsp;Eileen King,&nbsp;Rashmi Sahay,&nbsp;Roohi Kharofa,&nbsp;Brooke R. Sweeney,&nbsp;Vidhu Thaker,&nbsp;Jared M. Tucker,&nbsp;Alaina P. Vidmar,&nbsp;Jennifer K. Yee,&nbsp;Shelley Kirk","doi":"10.1111/ijpo.70127","DOIUrl":"10.1111/ijpo.70127","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>The national POWER registry of paediatric weight management programmes reported increased obesity medication (ObM) use in recent years. However, factors influencing ObM prescribing are not well understood. This study aimed to compare (1) clinical characteristics between youth prescribed ObMs and those who were not and (2) prescribing patterns among programmes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data from youth aged 6–18 years seen at 12 POWER sites between 2018 and 2024 were analysed. Clinical and demographic variables were compared between ObM and non-ObM groups using Fisher's exact test and logistic regression, adjusting for site. Site-level prescribing patterns were assessed using <i>χ</i>² and Fisher's exact tests.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>ObMs were prescribed to 927 of 4628 (20%) patients. Topiramate (37%) and metformin (43%) were the most prescribed. ObM patients were older [12–15 years aOR (CI) = 1.7 (1.4, 2.0); 16–18 years aOR (CI) = 1.6 (1.3, 2.0) vs. 6–11 years], had more severe obesity [Class 2 aOR (CI) = 1.6 (1.3, 2.2); Class 3 aOR (CI) = 2.9 (2.3, 3.8) vs. Class 1] and had more obesity related co-morbidities, but demographic characteristics were not different. Higher prescribing programmes offered ObMs sooner and multiple ObMs more often.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>ObM prescribing was strongly associated with age, obesity severity and comorbidities, highlighting the need for prospective studies on earlier initiation to prevent disease progression.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"21 7","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148389596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}