Pediatric Obesity最新文献

{"title":"Effectiveness of behavioural and psychological interventions for managing obesity in children and adolescents: A systematic review and meta-analysis framed using minimal important difference estimates based on GRADE guidance to inform a clinical practice guideline","authors":"M. Henderson,&nbsp;S. A. Moore,&nbsp;S. Harnois-Leblanc,&nbsp;B. C. Johnston,&nbsp;D. Fitzpatrick-Lewis,&nbsp;A. M. Usman,&nbsp;D. Sherifali,&nbsp;R. Merdad,&nbsp;A. M. Rigsby,&nbsp;Z. Esmaeilinezhad,&nbsp;K. M. Morrison,&nbsp;J. Hamilton,&nbsp;G. D. C. Ball,&nbsp;C. S. Birken,&nbsp;the Steering Committee for Updating Canada's Clinical Practice Guideline for Managing Pediatric Obesity","doi":"10.1111/ijpo.13193","DOIUrl":"10.1111/ijpo.13193","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) of behavioural and psychological interventions for managing paediatric obesity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Eligible studies, published between 1985 and 2022, included 0 to 18 year olds with outcomes reported ≥3 months post-baseline, including patient-reported outcome measures (PROMs), cardiometabolic and anthropometric outcomes, and adverse events (AEs). We pooled data using a random effects model and assessed certainty of evidence (CoE) related to minimally important difference estimates for outcomes using GRADE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We included 73 unique RCTs (<i>n</i> = 6305 participants, 53% female). Intervention types included physical activity (<i>n</i> = 1437), nutrition (<i>n</i> = 447), psychological (<i>n</i> = 1336), technology-based (<i>n</i> = 901) or multicomponent (≥2 intervention types, <i>n</i> = 2184). Physical activity had a small effect on health-related quality of life (HRQoL), varying effects ranging from moderate to very large on blood pressure, lipids and insulin resistance, and a small effect on BMIz. Nutrition had a small effect on lipids, insulin resistance and BMIz. Psychological interventions showed a small effect on HRQoL and triglycerides and moderate benefits on depressive symptoms, while technology interventions showed small benefits on blood pressure and BMIz. Multicomponent interventions had a large benefit on anxiety, small benefit on depressive symptoms, with large to very large benefits on lipids, and small benefits for diastolic blood pressure, insulin resistance and BMIz. AEs were reported infrequently, and when reported, were described as mild.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Physical activity and multicomponent interventions showed improvements in PROMs, cardiometabolic and anthropometric outcomes. Future trials should consistently measure PROMs, evaluate outcomes beyond the intervention period, and study children &lt;6 years of age.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"20 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijpo.13193","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142997126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between body mass index at birth and neonatal health outcomes in preterm infants: A retrospective analysis","authors":"Chuntian Liu,&nbsp;Yijia Chen,&nbsp;Mengqing Pan,&nbsp;Xiaoyu Lu,&nbsp;Jianhong Xu,&nbsp;Xiaochun Chen","doi":"10.1111/ijpo.13203","DOIUrl":"10.1111/ijpo.13203","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Studies on how birth body mass index (BMI) affects health outcomes in preterm infants are relatively limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To analyze the association between BMI at birth and neonatal health outcomes in extremely low and very low birth weight preterm infants in China.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Used data from the Chinese Premature Infant Informatization Platform (2022–2023). Preterm infants were categorized based on their birth BMI z-scores into three groups: low BMI group (&lt; −2), normal BMI group (−2 to 2) and high BMI group (&gt;2). The relationship between BMI and neonatal health outcomes was then analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The final analysis included 1662 extremely low and very low birth weight preterm infants. The results indicated that low BMI was significantly associated with an increased risk of respiratory distress syndrome (RDS) (AOR 1.61, 95% CI 1.31–2.30), bronchopulmonary dysplasia (BPD) (AOR 1.34, 95% CI 1.00–1.80) and necrotizing enterocolitis (NEC) (AOR 1.57, 95% CI 1.01–2.42). High BMI was significantly associated with an increased risk of RDS (AOR 1.60, 95% CI 1.05–2.45).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>BMI at birth is significantly associated with the risks of RDS, BPD and NEC in ELBW and VLBW, highlighting the importance of monitoring BMI as an additional risk predictor in a population of neonates already at high risk for adverse outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"20 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal exposure to particulates and anthropometry through 9 years of age in a birth cohort","authors":"Ian R. Trees,&nbsp;Abhisek Saha,&nbsp;Diane L. Putnick,&nbsp;Priscilla K. Clayton,&nbsp;Pauline Mendola,&nbsp;Rajeshwari Sundaram,&nbsp;Edwina H. Yeung","doi":"10.1111/ijpo.13202","DOIUrl":"10.1111/ijpo.13202","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Previous research observed links between prenatal air pollution and risk of childhood obesity but the timing of the exposure is understudied. Aim: We examined prenatal particulate matter (PM₁₀, PM_2.5) exposure and child anthropometry.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials &amp; Methods</h3>\u0000 \u0000 <p>Children's body mass index <i>z</i>-scores (zBMI) at 0–3 (<i>N</i> = 4370) and 7–9 (<i>n</i> = 1191) years were derived from reported anthropometry at paediatric visits. We ran linear mixed models for six windows, adjusting for maternal, child, and neighbourhood factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>PM₁₀ exposure across pregnancy and at multiple windows was associated with higher zBMI in both early and middle childhood. For instance, one interquartile range increase in PM₁₀ exposure during the first 2 weeks of pregnancy was associated with higher zBMI at 0–3 (0.05, 95% CI: 0.01, 0.10) and 7–9 (0.14, 95% CI: 0.02, 0.23). PM_2.5 exposure during the final 2 weeks of gestation was associated with higher zBMI at 7–9 years (B: 0.12, 95% CI: 0.04, 0.22).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Even at low levels of air pollution, prenatal PM₁₀ exposure was associated with higher zBMI in childhood.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"20 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijpo.13202","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142941922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between parent and adolescent weight outcomes within two parent approaches to family-based adolescent obesity treatment: Secondary analyses from the TEENS+ pilot trial","authors":"Kristina L. Tatum,&nbsp;Katlyn Garr,&nbsp;Elizabeth L. Adams,&nbsp;Laura J. Caccavale,&nbsp;Edmond P. Wickham III,&nbsp;Jessica Gokee LaRose,&nbsp;Suzanne E. Mazzeo,&nbsp;Hollie A. Raynor,&nbsp;Melanie K. Bean","doi":"10.1111/ijpo.13198","DOIUrl":"10.1111/ijpo.13198","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To examine associations between parent and adolescent weight change within two parent approaches to adolescent obesity treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Adolescent (<i>M</i>_age = 13.7 ± 1.2 years; <i>M</i>_BMI = 34.9 ± 7.0 kg/m²) and parent (<i>M</i>_BMI = 36.4 ± 7.3 kg/m²) dyads (<i>N</i> = 82) were randomized to TEENS+Parents as Coaches (PAC) or TEENS+parent weight loss (PWL). Anthropometrics were assessed at baseline (0-month), 4 months (post) and 7 months (after 3-month maintenance period). Regression analyses examined associations between parent and adolescent ΔBMI_0-4m and ΔBMI_4-7m, with parent group as a moderator.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Post-treatment, parent and adolescent ∆BMI_0-4m were positively related (<i>β</i> = 0.68, <i>p</i> &lt; 0.001), with no group interaction. Parent and adolescent ΔBMI_4-7m were related (<i>β</i> = 0.48, <i>p</i> = 0.012) during maintenance, moderated by parent group (<i>β</i> = −0.49, <i>p</i> = 0.010): positive relationships persisted in PAC (<i>β</i> = 0.39, <i>p</i> = 0.011), but not PWL (<i>β</i> = −0.19, <i>p</i> = 0.211).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>Parent and adolescent weight changes were positively related during treatment in both parent groups. During maintenance, weight change associations persisted only in PAC. These patterns prompt further exploration of parent factors driving weight change relationships.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"20 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijpo.13198","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142941918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The long-term effects of a school-based intervention on preventing childhood overweight: Propensity score matching analysis within the Generation R Study cohort","authors":"Famke J. M. Mölenberg,&nbsp;Michel S. Smit,&nbsp;Daan Nieboer,&nbsp;Trudy Voortman,&nbsp;Wilma Jansen","doi":"10.1111/ijpo.13200","DOIUrl":"https://doi.org/10.1111/ijpo.13200","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This study investigated the long-term impact of the primary school-based multicomponent lifestyle intervention “Lekker Fit!” (LF) on obesity-related outcomes, and studied whether the impact differed between population subgroups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Children from the Generation R Study (Rotterdam, the Netherlands) were categorized into the LF group (6 years exposure, between the ages 6/7 to 12/13 years) or regular school group (no exposure). BMI and DXA-derived fat mass were assessed after 4 years of intervention (age 10 years), and 1.5 years post-intervention (age 14 years). A propensity score matching model was fitted to examine the intervention effect on BMI-z-score and percent fat mass, and we tested for differences by sex, pre-intervention weight status, ethnic background, and income.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We found no effect on BMI-z-score [0.06 (95% confidence interval [CI]: −0.04 to 0.17)] and percent fat mass (0.4%-point [95% CI: −0.2 to 1.1]) after 4 years of intervention. 1.5 years post-intervention and after 6 years of exposure, BMI-z-score (0.11 [95% CI: 0.00–0.22]) and percent fat mass (1.1%-point [95% CI: 0.2–1.9]) were significantly higher for children in the LF group. No subgroup differences were found.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Findings suggest the need for obesity prevention programs that extend beyond primary education.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"20 3","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ijpo.13200","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute simulated weight gain might not increase the energy cost of walking in adolescents with obesity.","authors":"D Thivel, G Ennequin, J Siroux, A Couret, D Beraud, B Pereira, M Duclos, S Lazzer, Y Boirie, L Isacco","doi":"10.1111/ijpo.13197","DOIUrl":"https://doi.org/10.1111/ijpo.13197","url":null,"abstract":"<p><strong>Introduction: </strong>This work aims at evaluating the adaptations of the energy cost of walking (Cw) to simulated weight gain at different walking speeds in adolescents with obesity.</p><p><strong>Methods: </strong>Substrate use and Cw were evaluated during a graded walking exercise (4 × 5min at 0.75, 1, 1.25, 1.5 m.s^-1) performed under three randomized body weight conditions (BW-conditions): (i) at the adolescents' body weight (BW + 0%) or with a simulated weight gain of (ii) 5%(BW + 5%) and (iii) 10%(BW + 10%), in 18 adolescents with obesity (14.2 ± 1.4 years, BMI:33.86 ± 2.55 kg.m-²). Body composition was assessed by absorptiometry and perceived exertion rated after every walking speed stage.</p><p><strong>Results: </strong>EE in absolute or relative to BW and FFM was different between BW-conditions (p = 0.017, 0.006 and 0.007, respectively) being lower on BW + 5% than BW + 10%. Gross Cw (absolute, relative to BW and fat-free mass) showed overall speed (p < 0.001) and BW-conditions effects, being lower on BW + 5% compared with BW + 10% (p < 0.001). Net Cw (absolute, relative to BW and fat-free mass) showed a significant speed effect (<0.001) but no BW-conditions nor interaction effect.</p><p><strong>Conclusion: </strong>While EE and Cw have been shown to decrease in response to weight loss, potentially as a way to save stored energy and limit further weight loss, inverse adaptations do not seem to occur with increased acute simulated weight gain in weight stable adolescents with obesity.</p>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":" ","pages":"e13197"},"PeriodicalIF":2.7,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolescent experiences of weight-related communication: Sociodemographic differences and the role of parents","authors":"Leah M. Lessard,&nbsp;Rui Wu,&nbsp;Rebecca M. Puhl,&nbsp;Gary D. Foster,&nbsp;Michelle I. Cardel","doi":"10.1111/ijpo.13196","DOIUrl":"10.1111/ijpo.13196","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Weight-related conversations are common between adolescents and parents. However, there is limited understanding of how these conversations vary across sociodemographic groups, such as sex, sexual orientation, race/ethnicity, or parents' level of education. This study assessed the prevalence of weight-related communication among adolescents and parents across sociodemographic characteristics, and identified adolescents' preferred sources for these discussions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Quantitative data were collected through online surveys from two independent U.S. samples: adolescents aged 10–17 years of age (<i>N</i> = 2032), and parents of children aged 10–17 years of age (<i>N</i> = 1936). Frequency and sources of weight-related communication were assessed. Sociodemographic factors were analysed for their associations with these communication patterns.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>While few differences emerged based on race/ethnicity or grade level, significant variation was observed for sex, sexual orientation, and parental education. Girls, sexual minority youth, high school students, and those with college-educated parents were more likely to communicate about their own weight, whereas boys were more likely to comment on others' weight. Most adolescents preferred healthcare professionals (71%) and parents (69%) for these conversations, although sexual minority youth preferred mental health professionals considerably more than parents. Among parents, 77% discussed their child's weight, with fathers and Latinx parents engaging more frequently in these conversations, and Black parents engaging least frequently.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Weight-related communication is prevalent among adolescents and parents, with variation across sociodemographic characteristics. As healthcare professionals and parents were identified as the preferred sources for weight-related communication by adolescents across sociodemographic groups, it is important that paediatricians and parents are equipped to engage in these conversations without imparting stigma.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"20 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19-related lockdowns and changes in overweight and obesity, movement behaviours, diet quality, and health-related quality of life among regional Australian primary school children: A repeat cross-sectional study","authors":"Claudia Strugnell,&nbsp;Cadeyrn J. Gaskin,&nbsp;Denise Becker,&nbsp;Liliana Orellana,&nbsp;Michelle Jackson,&nbsp;Monique Hillenaar,&nbsp;Jillian Whelan,&nbsp;Andrew D. Brown,&nbsp;Vicki Brown,&nbsp;Colin Bell,&nbsp;Josh Hayward,&nbsp;Lena D. Stephens,&nbsp;Hayley Jensen,&nbsp;Izzy Gribben,&nbsp;Lee Coller,&nbsp;Diana Tatlock,&nbsp;Elizabeth Lehman,&nbsp;Steven Allender","doi":"10.1111/ijpo.13195","DOIUrl":"10.1111/ijpo.13195","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>During the coronavirus disease 2019 (COVID-19) pandemic, the Australian state of Victoria (in particular, its capital, Melbourne) experienced some of the longest lockdowns in the world.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This repeated cross-sectional study examined changes between March to June 2019 (pre-pandemic) and April to August 2022 (6 to 11 months following pandemic-related lockdowns) in overweight and obesity prevalence, physical activity, sedentary behaviour, sleep, diet quality, and health-related quality of life (HRQoL) among primary school children in north-east Victoria, Australia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Height and weight were measured for Grade 2, 4, and 6 students in 2019 (3889 children) and 2022 (1816 children). Grade 4 and 6 students self-reported on their movement behaviours, diet quality, and HRQoL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Participation declined among schools (2019:56%, 2022:34%) and students (2019:87%, 2022:75%). Compared to children in 2019, children in 2022 had a higher prevalence of overweight and obesity; were less likely to have met guidelines for moderate-to-vigorous physical activity, recreational screen time, and vegetable consumption; had higher intakes of takeaway food, energy-dense nutrient-poor snacks, and sugar-sweetened beverages; and had lower HRQoL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Children's health-related behaviours and outcomes seemed not to have returned to pre-pandemic levels 6 to 11 months after the final lockdowns lifted for their communities. Continued monitoring and interventions targeting the drivers of childhood obesity are urgently needed.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"20 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11710946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of prenatal exposure to delta 9-tetrahydrocannabinol and cannabidiol on birth size and postnatal growth trajectories","authors":"Brianna F. Moore,&nbsp;Noel T. Mueller,&nbsp;Wei Perng,&nbsp;Katherine A. Sauder,&nbsp;Emily T. Hébert,&nbsp;Adrienne T. Hoyt,&nbsp;Erica M. Wymore,&nbsp;Kristen E. Boyle,&nbsp;Emily J Su,&nbsp;Allison L. B. Shapiro,&nbsp;Gregory Kinney,&nbsp;Cristina Sempio,&nbsp;Jost Klawitter,&nbsp;Uwe Christians,&nbsp;Dana Dabelea","doi":"10.1111/ijpo.13187","DOIUrl":"10.1111/ijpo.13187","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Prenatal exposure to cannabis (or more specifically, delta 9-tetrahydrocannabinol [Δ9-THC]) has been consistently linked to low birthweight. Animal models further show that Δ9-THC is associated with rapid postnatal growth. Whether this association is modified by breastfeeding is unknown.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this exploratory study, we followed 128 mother–child pairs through 3 years. Urinary Δ9-THC and cannabidiol (CBD) were measured mid-gestation. Generalized linear models estimated the associations between Δ9-THC and neonatal body composition. A mixed-effects model estimated the association between Δ9-THC and body mass index (BMI) <i>z</i>-score trajectories. Interaction was assessed by a three-way product term (Δ9-THC × breastmilk months × age).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fifteen children (12%) had Δ9-THC exposure; three had concomitant CBD exposure. Prenatal exposure to Δ9-THC alone was associated with lower fat mass (−95 g, 95% confidence interval [CI]: −174, −14) and neonatal adiposity (−2.1%; 95% CI: −4.2, −0.4) followed by rapid postnatal growth (0.42 increase in BMI <i>z</i>-score per square root year; 95% CI: 0.12, 0.72). Breastfeeding modified this association (<i>p</i> = 0.04), such that growth was similar for those breastfed for 5 months whereas a shorter duration of breastfeeding was associated with 1.1 higher BMI <i>z</i>-score at 3 years (95% CI: 0.21, 2.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our study suggests that prenatal exposure to Δ9-THC may alter early-life growth. Breastfeeding may stabilize rapid postnatal growth, but the impact of lactational exposure requires further investigation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"20 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidized high-density lipoprotein and low-density lipoprotein in adolescents with obesity and metabolic dysfunction-associated steatotic liver disease","authors":"Alyssa M. Bartlett,&nbsp;Ali M. Boone,&nbsp;Jordan A. Bays,&nbsp;Youngsil Kim,&nbsp;Sirish K. Palle,&nbsp;Kevin R. Short","doi":"10.1111/ijpo.13194","DOIUrl":"10.1111/ijpo.13194","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly common in the pediatric population and may increase risk for developing cardiovascular disease (CVD) in people with MASLD. Oxidized high-density lipoprotein (oxHDL) and oxidized low-density lipoprotein (oxLDL) are modified, pro-atherosclerotic lipoproteins that are increased in adults with MASLD and CVD but have not been reported in adolescents with MASLD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To determine if oxLDL and oxHDL are increased in adolescents with MASLD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Fasting oxHDL and oxLDL were measured in adolescents (11–20 years) with obesity and biopsy-confirmed MASLD (<i>n</i> = 47), and peers without MASLD but with obesity (Ob; <i>n</i> = 28), or normal weight (NW; <i>n</i> = 29).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>oxHDL was 27% higher (<i>p</i> &lt; 0.05) in the MASLD group (mean ± SD: 11.9 ± 4.7 ng/mL) compared to the Ob group (9.3 ± 3.7 ng/mL, <i>p</i> &lt; 0.05) but only 7% higher than the NW group (11.1 ± 3.8 ng/mL, <i>p</i> &gt; 0.05). However, HDL-C was 19% and 32% lower in the MASLD group than in the Ob and NW groups, respectively. Thus, oxHDL/HDL-C ratio was 55% and 66% higher in MASLD compared to the Ob group (<i>p</i> &lt; 0.004) and the NW group (<i>p</i> &lt; 0.001), respectively. oxLDL (52.4 ± 16.0, 46.7 ± 10.1 and 47.1 ± 15.2 U/L for MASLD, Ob and NW, respectively), LDL-C and the oxLDL/LDL-C ratio did not differ among groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The elevated oxHDL and oxHDL/HDL-C in adolescents with MASLD compared to peers with Ob or NW suggests that there is some oxidative stress in MASLD independent of obesity and potential for increased CVD risk in the future.</p>\u0000 </section>\u0000 </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"20 2","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}