从出生到青春期晚期脂联素浓度与胰岛素抵抗的关系。

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity Pub Date : 2025-04-23 DOI:10.1111/ijpo.70015

Yeran Lee, Soren Harnois-Leblanc, Sheryl L. Rifas-Shiman, Emily Oken, Marie-France Hivert

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引用次数: 0

摘要

前言：我们研究了从出生到青春期脂联素浓度与青春期后期胰岛素抵抗的关系，使用的数据来自Viva项目前瞻性出生队列（马萨诸塞州东部，1999-2002）。方法：采用胰岛素抵抗稳态模型（HOMA-IR）对出生时、幼儿期、幼儿期中期、青春期早期和晚期的脂联素（内部z分数）与青春期晚期的胰岛素抵抗进行多变量线性回归模型。结果：在468名儿童（52%为女性，59%为非西班牙裔白人）中，我们观察到青春期中期（-0.16,95% CI: -0.33, 0.01）、青春期早期（-0.19,95% CI: -0.37, -0.01）和青春期晚期（-0.40,95% CI: -0.57, -0.23）的脂联素z-评分与青春期晚期HOMA-IR呈负相关；在计入BMI z-score后，这些关联减弱。当按性别分层时，我们在男性中观察到这些关联，而在女性中估计更为温和。结论：总的来说，从童年中期开始，较低的脂联素浓度与青春期后期较高的胰岛素抵抗有关，这种联系在男性中最为明显。

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Associations of adiponectin concentrations from birth until late adolescence with insulin resistance

Introduction

We investigated associations of adiponectin concentrations from birth to adolescence with insulin resistance in late adolescence using data from Project Viva prospective birth cohort (Eastern Massachusetts, 1999-2002).

Methods

We conducted multivariable linear regression models between adiponectin (internal z-scores) at birth, early childhood, mid-childhood, early and late adolescence and insulin resistance in late adolescence with the homeostasis model for insulin resistance (HOMA-IR).

Results

In 468 children (52% female, 59% Non–Hispanic White), we observed inverse associations of adiponectin z-scores in mid–childhood (–0.16, 95% CI: –0.33, 0.01), early adolescence (–0.19, 95% CI: –0.37, –0.01) and late adolescence (–0.40, 95% CI: –0.57, –0.23) with HOMA-IR in late adolescence; these associations were attenuated after accounting for BMI z-score. When stratified by sex, we observed these associations in males, while estimates were more modest in females.

Conclusion

Overall, starting in mid-childhood, lower adiponectin concentrations were linked with higher insulin resistance in late adolescence, with associations apparent mostly in males.

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.