Yeran Lee, Soren Harnois-Leblanc, Sheryl L Rifas-Shiman, Emily Oken, Marie-France Hivert
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Associations of adiponectin concentrations from birth until late adolescence with insulin resistance.
Introduction: We investigated associations of adiponectin concentrations from birth to adolescence with insulin resistance in late adolescence using data from Project Viva prospective birth cohort (Eastern Massachusetts, 1999-2002).
Methods: We conducted multivariable linear regression models between adiponectin (internal z-scores) at birth, early childhood, mid-childhood, early and late adolescence and insulin resistance in late adolescence with the homeostasis model for insulin resistance (HOMA-IR).
Results: In 468 children (52% female, 59% Non-Hispanic White), we observed inverse associations of adiponectin z-scores in mid-childhood (-0.16, 95% CI: -0.33, 0.01), early adolescence (-0.19, 95% CI: -0.37, -0.01) and late adolescence (-0.40, 95% CI: -0.57, -0.23) with HOMA-IR in late adolescence; these associations were attenuated after accounting for BMI z-score. When stratified by sex, we observed these associations in males, while estimates were more modest in females.
Conclusion: Overall, starting in mid-childhood, lower adiponectin concentrations were linked with higher insulin resistance in late adolescence, with associations apparent mostly in males.
期刊介绍:
Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large.
Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following:
Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes
Metabolic consequences of child and adolescent obesity
Epidemiological and population-based studies of child and adolescent overweight and obesity
Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition
Clinical management of children and adolescents with obesity including studies of treatment and prevention
Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment
Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity
Nutrition security and the "double burden" of obesity and malnutrition
Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents
Community and public health measures to prevent overweight and obesity in children and adolescents.