Relative Fat Mass as an Estimator of Abdominal Adiposity in Youth Across the BMI Spectrum from Normal Weight to Obesity.

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity Pub Date : 2025-10-15 DOI:10.1111/ijpo.70059

Wonhee Cho, Joon Young Kim, Silva Arslanian

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引用次数: 0

Abstract

Background: Relative fat mass (RFM) has been used to estimate whole-body fat percentage (%BF). However, whether RFM can mirror abdominal adiposity is unknown.

Objective: In youth, we examined if RFM reflects abdominal adiposity, if there are age/race/sex differences in the relationships between RFM and abdominal adiposity, and if our present-youth-cohort-derived RFM (RFM-Y) improves the prediction of %BF and abdominal adiposity.

Methods: In 358 youth (aged 10-19 years; 168 black/198 white) with normal weight and overweight/obesity (without secondary or syndromic obesity), visceral (VAT), subcutaneous (SAT) and total abdominal adipose tissue (TAT) were assessed by MRI/CT and %BF with DXA. RFM was calculated for ages 10-14 years as [74 - (22 × height/waist circumference [WC]) + (5 × sex)] and 15-19 years as [64 - (20 × height/WC) + (12 × sex)]; sex = 0 for boys, 1 for girls. To develop and validate RFM-Y, linear regression, concordance correlation coefficient, Bland-Altman plots and intraclass correlation coefficient were conducted.

Results: RFM associated with VAT, SAT and TAT (r = 0.66, 0.79, 0.79, respectively; all p < 0.001). The slope was significantly greater in (a) younger versus older youth for VAT, SAT and TAT; (b) whites versus blacks for VAT; and (c) girls versus boys for SAT and TAT. RFM-Y versus traditional RFM showed improved predictive ability for %BF (R² = 0.83 vs. 0.77) and abdominal adiposity (R² ranging from 0.51 to 0.80 vs. 0.37 to 0.63).

Conclusions: RFM reflects abdominal adiposity besides %BF and could be used in longitudinal/interventional youth trials, obviating the need for expensive imaging to assess changes in total and abdominal adiposity.

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相对脂肪量作为从正常体重到肥胖的BMI谱中青少年腹部肥胖的估计。

背景：相对脂肪量（RFM）已被用来估计全身脂肪百分比（%BF）。然而，RFM是否能反映腹部肥胖尚不清楚。目的：在年轻人中，我们研究了RFM是否反映了腹部肥胖，RFM和腹部肥胖之间的关系是否存在年龄/种族/性别差异，以及我们现在的青年队列衍生的RFM （RFM- y）是否改善了BF %和腹部肥胖的预测。方法：对358例体重正常、超重/肥胖（无继发性或综合征性肥胖）的青年（10-19岁；黑人168例/白人198例），采用MRI/CT和%BF结合DXA对内脏（VAT）、皮下（SAT）和腹部总脂肪组织（TAT）进行评估。10-14岁的RFM为[74 - (22 ×身高/腰围[WC]) + （5 ×性别）]，15-19岁的RFM为[64 - （20 ×身高/腰围）+ （12 ×性别）]；性别=男孩0，女孩1。采用线性回归、一致性相关系数、Bland-Altman图和类内相关系数等方法对RFM-Y进行开发和验证。结果：RFM与VAT、SAT和TAT （r分别为0.66、0.79、0.79；p均为0.83 vs. 0.77）和腹部肥胖相关（R2为0.51 ~ 0.80 vs. 0.37 ~ 0.63）。结论：RFM除反映BF %外还反映腹部脂肪，可用于纵向/介入性青年试验，无需昂贵的成像来评估总脂肪和腹部脂肪的变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.