Acta Ophthalmologica最新文献

{"title":"Exploring fundus-controlled mesopic and scotopic perimetry in inherited retinal disease.","authors":"Laura J Taylor, Amandeep S Josan, Daniel A O Adeyoju, Isabella Farrance, Robert E MacLaren","doi":"10.1111/aos.70142","DOIUrl":"https://doi.org/10.1111/aos.70142","url":null,"abstract":"<p><strong>Purpose: </strong>Microperimetry is increasingly used as an outcome measure in clinical trials for retinal disease. This study compares mesopic and scotopic microperimetry in a heterogeneous cohort of patients with inherited retinal disease to assess their suitability as clinical trial outcome measures and to determine the most appropriate testing modality.</p><p><strong>Methods: </strong>Participants completed mesopic and scotopic microperimetry (S-MAIA) after 20 min of dark adaptation, as part of the Visual Function in Retinal Degeneration study (ISRCTN24016133). Testing was performed on both eyes (right first) without formal pupil dilation. Reliability and sensitivity performance were explored. A subset of participants (n = 23 patients and n = 16 controls) underwent repeat scotopic testing for repeatability analyses.</p><p><strong>Results: </strong>Twenty-nine participants with inherited retinal disease and 40 healthy control participants completed microperimetry testing. Mesopic microperimetry in patients and in healthy controls showed good reliability and sensitivity performance. Scotopic microperimetry in patient participants was limited by poor test reliability, reflected by a high number of test exclusions from reliability screening, and significant floor effects in measured sensitivity. In addition, scotopic microperimetry showed no greater improvement in sensitivity or specificity than mesopic microperimetry. Repeatability analyses were limited by the small sample size following elimination of unreliable tests.</p><p><strong>Conclusion: </strong>Mesopic microperimetry is recommended as a stable and reliable outcome measure. Scotopic microperimetry appears to be limited by poor reliability and floor effects in patients with inherited retinal disease. The utility of scotopic microperimetry in patients with very early disease presentation, who present with highly preserved central vision (i.e. highly preserved mesopic microperimetry), remains unexplored.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraocular lens power calculation in highly myopic eyes with axial length ≥ 28 mm: Impact of two corneal keratometries and anterior segment parameters.","authors":"Yiwei Wu, Lingyun Chi, Bijun Zhu, Baojiang Li, Ying Zheng, Yuyu Miao, Qian Sun, Mingxing Wu, Haidong Zou, Huiyi Jin","doi":"10.1111/aos.70153","DOIUrl":"https://doi.org/10.1111/aos.70153","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the accuracy of 12 intraocular lens (IOL) formulas in eyes with axial length (AL) ≥ 28 mm and to identify the anterior segment parameters independently affecting prediction error (PE).</p><p><strong>Methods: </strong>A total of 415 eyes undergoing phacoemulsification with IOL implantation at Shanghai General Hospital were included in this retrospective observational study. Refractive PEs were calculated for 5 conventional formulas (Haigis, Hoffer Q, Holladay 1, Holladay 2 and SRK/T) with optimization and 7 new-generation formulas (Barrett Universal II [BUII], Cooke K6, EVO 2.0, Hoffer QST, Kane, Ladas Super Formula [LSF] and Pearl-DGS). Predicted postoperative spherical equivalent (SE) was calculated using keratometry (K) and total keratometry (TK) measured by IOLMaster 700. Q values, posterior mean keratometry, corneal volume, anterior chamber volume and angle and back-to-front corneal radius ratio were measured by Pentacam. Stepwise linear regression identified parameters associated with PE.</p><p><strong>Results: </strong>Using the K method, BUII, EVO 2.0, Hoffer QST, Holladay 2, Kane and Pearl-DGS showed the lowest median absolute PE (MedAE = 0.32, 0.31, 0.32, 0.30, 0.30 and 0.32 D) and highest formula performance index (FPI = 0.74, 0.80, 0.69, 0.68, 0.60 and 0.69). BUII, Cooke K6, EVO 2.0, Holladay 2 and Pearl-DGS performed stably across axial groups (p > 0.05). K achieved lower AE than TK for all formulas (p < 0.05), except Hoffer QST (p = 0.497), Holladay 2 (p = 0.140) and Pearl-DGS (p = 0.912), with Kane performing better using TK (p = 0.024). Lens thickness (LT) independently affected PE for Holladay 2 and all new-generation formulas, with greater LT associated with myopic shifts (p < 0.05).</p><p><strong>Conclusions: </strong>EVO 2.0 formula provided the most accurate predictions with K method. Except for Kane, K outperformed TK. LT independently influences PE and should be considered in future IOL calculations.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of a modified full-thickness graft flap following Boston type I keratoprosthesis implantation in patients with advanced corneal melting.","authors":"Ewa Wróblewska-Czajka, Edward Wylęgała","doi":"10.1111/aos.70003","DOIUrl":"10.1111/aos.70003","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate a modified full-thickness corneal graft technique as a remedial strategy for advanced corneal melting following Boston type I keratoprosthesis (KPro) implantation.</p><p><strong>Methods: </strong>Eleven patients with significant corneal melting and >180° KPro exposure underwent corrective surgery. A donor graft, matching the primary transplant diameter and with a 3-mm central aperture, was thinned circumferentially and positioned beneath the KPro optical cylinder after debridement of necrotic tissue.</p><p><strong>Results: </strong>Over 6-12 months of follow-up, globe integrity was preserved in all cases. Two patients required repeat procedures for recurrence. Visual acuity improved in five patients; in others, it remained stable or declined due to comorbidities.</p><p><strong>Conclusion: </strong>The modified full-thickness graft technique is a promising alternative for managing advanced corneal melting after Boston type I KPro. Further studies with larger cohorts and longer follow-up are warranted.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":"e312-e316"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The longitudinal associations of reading, writing and screen time with myopia at age 9 years among children from the GUSTO birth cohort.","authors":"Fan Wu, Chen-Hsin Sun, Hla Myint Htoon, Jonathan Y Bernard, Fabian Yap, Yih-Chung Tham, Charumathi Sabanayagam, Seang-Mei Saw","doi":"10.1111/aos.70009","DOIUrl":"10.1111/aos.70009","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the associations between paper-based reading and writing time, screen-based time at ages 2, 3, 6 and 9 years and myopia at age 9 in the GUSTO birth cohort.</p><p><strong>Methods: </strong>The GUSTO study recruited pregnant women from two Singapore public maternity hospitals between 2009 and 2010. Parent-reported reading and writing time, screen time and outdoor time were collected at ages 2, 3, 6 and 9 years. Cycloplegic autorefraction and axial length were measured at age 9. Myopia was defined as a spherical equivalent ≤-0.5 D. Associations between near work exposures and myopia were examined using multivariable regression with generalised estimating equations.</p><p><strong>Results: </strong>Among 471 children (942 eyes), 37.3% were myopic at age 9 years. Greater reading and writing time at ages 6 and 9 were associated with higher odds of myopia at age 9 (OR [95% CI] = 1.20 [1.02-1.42] and 1.11 [1.02-1.22] per h/day, respectively). Children spending >3 h/day reading and writing at age 9 had 76% higher odds of myopia than those spending ≤3 h/day (OR = 1.76, 95% CI: 1.08-2.85). Reading and writing time at ages 2 and 3 years, and screen time at all age groups showed no significant association with myopia at age 9.</p><p><strong>Conclusions: </strong>Traditional paper-based reading and writing, but not screen time, were associated with myopia in Singaporean children. Future studies with larger samples and objective screen time measures are needed to evaluate the distinct role of screen time in myopia.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":"e337-e345"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13058689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterising PRPF31-associated retinal dystrophy: Clinical insights from baseline data in a natural history study.","authors":"Kathrine Olaussen Eriksen, Jon Roger Eidet, Ulrika Kjellström, Jacopo Baldesi, Ragnheidur Bragadóttir, Leonardo Colombo, Josephine Prener Holtan","doi":"10.1111/aos.70005","DOIUrl":"10.1111/aos.70005","url":null,"abstract":"<p><strong>Purpose: </strong>To characterise the baseline clinical features and genotypes of adults with pre-mRNA processing factor 31 (PRPF31)-associated retinal dystrophy (RD) enrolled in a prospective, multicentre 4-year natural history study, and to explore correlations between selected baseline parameters.</p><p><strong>Methods: </strong>Thirty-one patients with PRPF31-RD underwent comprehensive multimodal assessment, including slit-lamp ophthalmoscopy, best-corrected visual acuity (BCVA), low-luminance visual acuity (LLVA), mesopic and scotopic microperimetry (MP), full-field stimulus threshold (FST) testing, spectral-domain optical coherence tomography (SD-OCT) to assess retinal structure and measure ellipsoid zone (EZ) width, and ultra-widefield fundus autofluorescence (UWF-FAF) to define hyperautofluorescent ring (HAR) area. Correlations between structural and functional measures were analysed using Spearman's rank correlation.</p><p><strong>Results: </strong>Patients from 21 families carrying 17 distinct disease-causing variants in the PRPF31 gene were identified. The median age was 38 years (range 19-84). Thirty patients exhibited a classic retinitis pigmentosa (RP) phenotype, and one had a pericentral pattern of dystrophy. Frequent findings included cystoid macular oedema (52%), epiretinal membrane (55%) and current or prior cataract (71%). Most patients could complete FST (84%-90%) and mesopic MP testing (77%), while measures of scotopic MP (57%), HAR area (52%) and EZ (68%) excluded the more advanced-staged patients. The HAR area correlated strongly with the functional measures mesopic MP and FST white. The HAR area, EZ width and scotopic MP were also strongly correlated.</p><p><strong>Conclusion: </strong>This study confirms phenotypic variability in PRPF31-RD and expands the spectrum with pericentral RD. The feasibility of structural and functional assessments depended on disease stage, with scotopic cyan MP limited to eyes with preserved HAR and EZ.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":"e317-e328"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13058679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neovascular age-related macular degeneration without drusen.","authors":"Marc J Sirks, Elon H C van Dijk, Husein Ghalayini, Somayeh Bazdar, WeiFeng Yu, Suzanne Yzer, José P Martinez Ciriano, Reinier O Schlingemann, Roselie M H Diederen, Camiel J F Boon","doi":"10.1111/aos.70010","DOIUrl":"10.1111/aos.70010","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the clinical characteristics and 1-year follow-up of patients with neovascular AMD (nAMD) without drusen in either eye.</p><p><strong>Methods: </strong>This is a multicentre retrospective cohort study in three tertiary referral centres in The Netherlands. We included patients of 55 years or older with nAMD in one or both eyes, without the presence of drusen or signs of another underlying disease in either eye. The medical charts and multimodal imaging (MMI) were evaluated by two independent graders. Eyes were divided into two groups: polypoidal choroidal vasculopathy (PCV)-associated macular neovascularization (MNV) and non-PCV MNV. We evaluated the visual acuity (VA) at baseline and 1 year after baseline; complete resolution of macular fluid on optical coherence tomography (OCT) during 1 year of follow-up; required treatments to achieve a complete resolution of macular fluid on OCT; complication rate.</p><p><strong>Results: </strong>We included 106 eyes of 99 patients, with a median age of 73 years. Seventy-one eyes had PCV-associated MNV, and 35 eyes had non-PCV MNV. The overall median baseline VA was 0.22 logMAR (Snellen 20/30), and 0.15 logMAR (Snellen 20/28) at 1 year follow-up. Subretinal haemorrhage was more common in PCV-associated MNV compared to non-PCV MNV, both at initial presentation (21% vs. 17%) and during the 1 year follow-up period (23% vs. 11%). In total, 31 out of 48 eyes (65%) achieved complete resolution of macular fluid on OCT during follow-up, most commonly achieved with combined photodynamic therapy (PDT) + intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections.</p><p><strong>Conclusion: </strong>nAMD can occur without the presence of drusen in either eye. Treatment with anti-VEGF injections, PDT or a combination thereof appears to be effective, but more research is warranted.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":"e300-e311"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13058669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topiramate-induced acute angle closure with suprachoroidal effusion: Insights from a novel ultra-wide-field OCT device.","authors":"Michael Hafner, Nicolas Pensel, Nicolas C D Scherer, Marc J Mackert, Siegfried G Priglinger, Leonie F Keidel, Maximilian J Gerhardt","doi":"10.1111/aos.70012","DOIUrl":"10.1111/aos.70012","url":null,"abstract":"","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":"e356-e359"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13058677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145204963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized clinical trial on the effectiveness of plano spectacle lenses with lenslets on myopia prevention in pre-myopic children: Study protocol of a randomized controlled trial.","authors":"Jingjing Wang, Linlin Du, Jun Chen, Bo Zhang, Jinliuxing Yang, Yuchen Du, Wei Gao, Haidong Zou, Xun Xu, Xiangui He","doi":"10.1111/aos.70007","DOIUrl":"10.1111/aos.70007","url":null,"abstract":"<p><strong>Purpose: </strong>Myopia is a growing concern in children worldwide, leading to significant visual impairments. This study investigates the efficacy of plano spectacle lenses with lenslets in preventing the onset of myopia in pre-myopic children. This study aims to contribute to the development of evidence-based strategies for myopia prevention by assessing compliance, efficacy and safety of plano spectacle lenses with lenslets.</p><p><strong>Methods: </strong>This randomized controlled trial involves 388 pre-myopic children aged 6-9 years. Participants are randomly assigned to either the intervention group, using plano spectacle lenses with lenslets for at least 8 h daily with smart frames recording wearing time, or the control group, which receives no intervention. The primary outcome is the 1-year cumulative incidence of myopia. Secondary outcomes include changes in spherical equivalent under cycloplegia, axial length, choroidal thickness, visual acuity and accommodation function over the study period. Statistical analyses, including chi-squared tests and t-tests, will evaluate these outcomes.</p><p><strong>Discussion: </strong>This study will offer valuable insights into the use of plano spectacle lenses with lenslets in slowing down the progression to myopia in children at risk. Findings are expected to inform clinical practices and shape guidelines for myopia prevention strategies among the paediatric population.</p><p><strong>Trial registration: </strong>NCT06860737.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":"e329-e336"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring ocular fundus morphology in relation to growth in adolescents born moderate-to-late preterm.","authors":"Alexandra Lind, Sara Ali, Titus Ovik, Zoran Popovic, Eva Aring, Jovanna Dahlgren, Marita Andersson Grönlund","doi":"10.1111/aos.70011","DOIUrl":"10.1111/aos.70011","url":null,"abstract":"<p><strong>Purpose: </strong>To study ocular fundus morphology and its relation to growth in adolescents born moderate-to-late preterm (MLP) and full term.</p><p><strong>Methods: </strong>This prospective and population-based cohort study included 50 MLP adolescents (26 girls, mean age 16.5 years) and 50 full-term controls (30 girls, mean age 16.7 years). Optical coherence tomography measurements were studied in relation to gestational age, auxological data, insulin-like growth factor-I (IGF-I) and IGF-binding protein 3 (IGFBP-3).</p><p><strong>Results: </strong>The MLP group showed an increased central macular retinal thickness (MRT) compared with controls in right eye (RE) (249.7 ± 21.0 vs. 239.9 ± 16.4 μm, p = 0.019). Moreover, the MLP group showed a thinner total peripapillary retinal nerve fibre layer (ppRNFL) thickness in RE (104.3 ± 8.5 vs. 109.1 ± 8.3, p = 0.0011). Nasal ppRNFL thickness was thinner in both RE (79.4 ± 13.2 vs. 85.0 ± 10.8, p = 0.0012) and left eye (LE) (77.0 ± 13.8 vs. 81.7 ± 13.4, p = 0.025) compared with controls. A weak association between total ppRNFL thickness and IGF-I levels was found (RE, r = 0.28, p = 0.032; LE, r = 0.27, p = 0.048), as well as between central MRT and a ratio between IGF-I and IGFBP-3 levels (RE, r = 0.30, p = 0.022). Additionally, there was a correlation between optic cup/disc area ratio and birth weight (RE: r = -0.44, p = 0.0006; LE: r = -0.30, p = 0.026).</p><p><strong>Conclusion: </strong>The present study suggests that growth and MLP birth may impact ocular fundus morphology. The MLP adolescents were shown to have thinner ppRNFL thickness and greater MRT, compared with full-term controls. Furthermore, a weak association between these structures and growth factors was found. In addition, the current study proposes that birth weight may impact optic disc parameters.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":"e346-e355"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13058674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145211336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A modified protocol for fluid collection during diagnostic vitrectomy improves the quality of specimens in vitreoretinal lymphoma patients.","authors":"Ling Qin, Xinyi Zhou, Xiejiu Chen, Junxiang Gu, Jieru Chen, Qing Chang","doi":"10.1111/aos.17565","DOIUrl":"10.1111/aos.17565","url":null,"abstract":"","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":"e360-e362"},"PeriodicalIF":2.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}