Acta Ophthalmologica最新文献

{"title":"Long-term results of conservative and surgical treatment of congenital x-linked retinoschisis: A retrospective multicentre international study.","authors":"Şengül Özdek, Hüseyin Baran Özdemir, Muna Bhende, Pramod Bhende, Parveen Sen, Dhanashree Ratra, Debarati Dasgupta, M Elizabeth Hartnett, Joseph M Simonett, Parag K Shah, Abhishek Das, Shunji Kusaka, Philip J Ferrone, Jessica Lee, Brett Rosenblatt, David Rhee, Eric Shakin, Itsuka Matsushita, Ihab Saad Othman, Anas Ahmed, Mehmet Yasin Teke, Selda Çelik Dülger, Remzi Avcı, Barbara Parolini, Wei Chi Wu, Zofia Anna Nawrocka, Zofia Nawrocka, Jerzy Nawrocki, Ehab El Rayes, Gökhan Gürelik, Nicola Ghazi","doi":"10.1111/aos.70002","DOIUrl":"10.1111/aos.70002","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the demographic and clinical characteristics, treatment indications, long-term outcomes and prognostic factors in patients with congenital x-linked retinoschisis (CXLR) managed conservatively or surgically.</p><p><strong>Methods: </strong>This retrospective, international, multicentre study included data from retina specialists across 14 centres in 9 countries. Demographic information, best corrected visual acuity (BCVA), phenotype, optical coherence tomography (OCT) findings and disease management were analysed. Surgical indications, techniques and anatomical and visual outcomes were evaluated.</p><p><strong>Results: </strong>A total of 635 eyes of 318 patients were included. Median age at presentation was 9 years (range: 0-81). Observation was preferred in 73.5% of eyes, laser photocoagulation (LPC) in 9.3% and vitreoretinal surgery in 18.1%. Surgical patients presented younger (7 vs. 10 years; p = 0.002) and with worse baseline BCVA (1.50 vs. 0.50 LogMAR; p < 0.0001). Disease symmetry was lower in surgical cases (24.4%) than in conservative and LPC groups (p < 0.0001). Vitreous veils, peripheral pigmentary changes and white spiculations were predictive of surgical need, particularly in eyes with rhegmatogenous retinal detachment (RRD) and vitreous haemorrhage (VH). OCT predictors of peripheral progression included absence of ganglion cell layer cysts and presence of outer plexiform layer cysts. Single-surgery anatomical success was 68.7%, increasing to 94.7% with additional procedures. Inner-wall retinectomy significantly improved outcomes in macula-threatening retinoschisis (p = 0.026). Visual acuity improved significantly after surgery in RRD and VH cases (p = 0.003).</p><p><strong>Conclusion: </strong>CXLR shows a broad clinical spectrum requiring individualized care. Fundus and OCT features effectively predicted progression and surgical need. Surgical management achieved high success, with inner-wall retinectomy beneficial in certain cases.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":"e846-e857"},"PeriodicalIF":3.0,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13050312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145224608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid corneal endothelial cell loss following PreserFlo MicroShunt implantation.","authors":"Suzu Deie, Kikuno Hirose, Taro Baba, Naoki Okada, Kana Tokumo, Atsuhiko Fukuto, Tai-Ichiro Chikama, Hirokazu Sakaguchi, Kazuyuki Hirooka","doi":"10.1111/aos.70096","DOIUrl":"10.1111/aos.70096","url":null,"abstract":"","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":"e883-e884"},"PeriodicalIF":3.0,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146148769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outer nuclear layer hyperreflectivity as an optical coherence tomography finding in Danon disease.","authors":"Maria Emfietzoglou, Gustavo Sakuno, Sandra Hoyek, Daniel M Vu, Jason Comander, John B Miller, Srinivas R Sadda, Nimesh A Patel, Demetrios G Vavvas","doi":"10.1111/aos.70098","DOIUrl":"10.1111/aos.70098","url":null,"abstract":"<p><strong>Purpose: </strong>To describe an optical coherence tomography (OCT) finding that is highly prevalent in Danon disease.</p><p><strong>Methods: </strong>Retrospective observational case series at a single centre, combined with a systematic literature review of PubMed and EMBASE for genetically confirmed Danon disease patients with available macular OCT images. Fifty-two macular OCT scans from 29 genetically confirmed Danon disease patients (5 from our institution; 24 from 11 published studies) were included. For each patient, a single foveal-centred macular OCT scan per eye was selected for analysis. Two independent reviewers assessed images for the presence of outer nuclear layer (ONL) hyperreflectivity, with discrepancies resolved by consensus.</p><p><strong>Results: </strong>Evidence of ONL hyperreflectivity appeared in 39 macular scans (75%). Of the 13 scans without this finding (25%), 10 scans (19%) showed macular atrophy (including bull's-eye maculopathy cases) or cystoid macular oedema that obscured evaluation of outer retinal layers at the fovea, and two scans (4%) used colour-encoded OCT that prevented reliable evaluation of the ONL. In only one scan (2%), ONL hyperreflectivity was absent despite preserved foveal architecture and adequate image quality.</p><p><strong>Conclusion: </strong>ONL hyperreflectivity is a highly prevalent OCT finding in Danon disease, most evident in young patients without advanced outer retinal atrophy. This feature may serve as a non-invasive finding of early retinal involvement. Longitudinal studies are warranted to confirm its prognostic value.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":"e810-e822"},"PeriodicalIF":3.0,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146148704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RE: Camp DA, Bakhsh SR, Torkashvand A, et al. Laser prophylaxis for retinal detachment in Stickler syndrome: A systematic review and meta-analysis. Acta Ophthalmologica. 2025. doi: 10.1111/aos.17509. 103 (6): e364- e373. PMID: 40370211.","authors":"Robert E Morris, Ferenc Kuhn, Matthew R West, Matthew H Oltmanns, Cary R Baxter","doi":"10.1111/aos.70079","DOIUrl":"10.1111/aos.70079","url":null,"abstract":"","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":"e878-e879"},"PeriodicalIF":3.0,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146177290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Straatsma syndrome in Legius syndrome.","authors":"Silvia Reichart, Luisa Velez Escola, Yvonne Nowosielski, Roman Lischke, Matus Rehak","doi":"10.1111/aos.70216","DOIUrl":"10.1111/aos.70216","url":null,"abstract":"","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":"e880-e882"},"PeriodicalIF":3.0,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148668055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and burden of mild/moderate versus high myopia in Germany: A claims data analysis.","authors":"Tarcyane Barata Garcia, Nils Kossack, Marc Pignot, Mohammed Dagher, Alexander K Schuster, Kun Shi-van Wielink","doi":"10.1111/aos.17589","DOIUrl":"10.1111/aos.17589","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the prevalence, healthcare resource utilization (HCRU) and associated costs of myopia in Germany, comparing mild/moderate and high myopia across various age groups using real-world data.</p><p><strong>Methods: </strong>A retrospective cross-sectional study was conducted using data from the WIG2 benchmark database. Patients with a diagnosis of myopia (ICD-10-GM H52.1) were categorized into mild/moderate or high myopia. The study population was stratified into preschool (0-5 years), primary school (6-9 years), secondary school (10-17 years), adult (18-59 years), elderly (60-75 years) and very old (>75 years) age groups. Prevalence trends were evaluated across paediatric and adolescent subpopulations. Propensity score matching was applied to balance group differences. HCRU and associated costs were analysed for each cohort.</p><p><strong>Results: </strong>Between 2018 and 2022, mild/moderate myopia consistently exhibited higher prevalence across all age groups compared to high myopia. Prevalence of both myopia types increased significantly with age, particularly in females, with mild/moderate myopia reaching 19.86% (95% CI 19.08-20.66) at age 17, compared to 14.00% (95% CI 13.37-14.67) in males. In 2022, individuals with high myopia had significantly higher ophthalmic HCRU and associated costs compared to those with mild/moderate myopia. The economic burden was notably higher in older age groups, with increased hospitalizations and outpatient visits. High myopia incurred higher costs across all age groups, with the largest difference in the very old cohort (€234.20).</p><p><strong>Conclusion: </strong>This study highlights the significant clinical and economic burden of high myopia in Germany. Targeted interventions are needed to manage myopia progression and reduce healthcare costs, particularly in ageing individuals.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":"e868-e877"},"PeriodicalIF":3.0,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual outcome after vitrectomy for small idiopathic macular hole: Results from the Small idiopathic MAcuLar hoLe (SMALL) study.","authors":"Matteo Fallico, Paolo Caselgrandi, Paola Marolo, Guglielmo Parisi, Enrico Borrelli, Luca Ceroni, Michele Reibaldi","doi":"10.1111/aos.70077","DOIUrl":"10.1111/aos.70077","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate visual outcomes after surgery for small idiopathic full-thickness macular holes (FTMHs) exploring associated clinical variables.</p><p><strong>Methods: </strong>Multicentre, retrospective study including eyes with FTMH ≤250 μm treated with anatomically successful vitrectomy with a 12-month follow-up. The primary outcome was the incidence rate of normal vision outcome, defined as a postoperative best-corrected visual acuity (BCVA) ≤0.1 logMAR and to explore clinical variables associated with it. Rates of suboptimal visual outcome (final BCVA >0.3 logMAR) and intermediate visual outcome (final BCVA >0.1 and ≤0.3 logMAR) were considered as secondary outcomes along with associated clinical variables.</p><p><strong>Results: </strong>Of 539 included eyes, 219 eyes (40.6%) achieved a normal vision outcome. An intermediate visual outcome was shown in 205 eyes (38%) and a suboptimal visual outcome in 115 eyes (21.3%). Vitrectomy with conventional internal limiting membrane (ILM) peeling was performed in 308 eyes (57%), while an inverted flap technique was used in 193 eyes (36%). Thirty-eight eyes (7%) underwent vitrectomy without ILM peeling. Clinical variables associated with normal vision were a better preoperative BCVA and conventional ILM peeling. No ILM peeling vitrectomy proved to be a factor associated with normal vision. Inverted flap technique and a worse preoperative BCVA were associated with suboptimal visual outcome.</p><p><strong>Conclusion: </strong>Surgical treatment of small FTMHs has to be recommended since an excellent final visual outcome has been shown in 40% of cases. Vitrectomy with conventional ILM peeling should be considered the treatment of choice, while the inverted flap technique would not be advisable. Further studies are needed to confirm the role of vitrectomy without ILM peeling.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":"e823-e831"},"PeriodicalIF":3.0,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146148791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The long-term impact of neovascular age-related macular degeneration undergoing routine treatment in first and second eyes on vision-related quality-of-life: FASBAT Report 3.","authors":"Archana Airody, Rachel L W Hanson, Isabel Bunola-Hadfield, Sobha Sivaprasad, Antony B Morland, Usha Chakravarthy, Richard P Gale","doi":"10.1111/aos.70150","DOIUrl":"10.1111/aos.70150","url":null,"abstract":"<p><strong>Purpose: </strong>The study evaluated the long-term effect on vision-related quality-of-life (VRQoL) of routinely treated neovascular age-related macular degeneration (nAMD) in first and second eyes.</p><p><strong>Methods: </strong>The FASBAT (Observing Fibrosis, macular Atrophy and Subretinal highly reflective material Before and After Treatment with anti-VEGF treatment) study followed individuals with new unilateral nAMD (first eye) undergoing routine treatment for up to 4.5 years. Visual acuity (VA) was measured as part of routine care and VRQoL was assessed using the National Eye Institute Visual Functioning Questionnaire (NEI-VFQ-25).</p><p><strong>Results: </strong>Of the 424 participants, 307 had only the first eye affected by nAMD (mean age = 76.5, SD = 8.4 years). The mean VA was 58.1 (SD = 15.5) and 79.4 (SD = 5.6) letters at baseline, and 58.4 (SD = 20.9)/78.5 (SD = 7.8) letters at 36-months in the affected and unaffected eyes, respectively. The mean composite NEI-VFQ-25 score was 87.1 (SD = 11.9) at baseline and 85.2 (SD = 13.5) at 36-months. One hundred and seventeen participants (mean age = 77.6, SD = 7.3 years) developed second eye nAMD, with a mean of 18.9 (SD = 10.2) months following the first eye. Mean VA in first and second eye was 56.3 (SD = 19.3)/74.1 (SD = 9.9) letters at the time of second eye development, and 51.1 (SD = 22.5)/73.6 (SD = 8.9) letters after 24-months. Mean composite NEI-VFQ-25 score was 81.4 (SD = 14.6) and 79.1 (SD = 17.2) at these time points.</p><p><strong>Conclusions: </strong>Long-term VRQoL remains stable in unilateral treated nAMD. However, a clinically meaningful reduction in VRQoL occurs following development and treatment in the second eye which does not recover. It is important to offer appropriate support when the first and then second eye develop nAMD.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":"e803-e809"},"PeriodicalIF":3.0,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The additional yield of screening for open-angle glaucoma in a population with high prevalence of pseudoexfoliation: The Thessaloniki Eye Study.","authors":"Dimitrios A Giannoulis, Anne L Coleman, Masao Roy Wilson, Alon Harris, Evangelia Papakonstantinou, Panagiota Ntonti, Fei Yu, Vassilis Kilintzis, Anna-Bettina Haidich, Theofanis Pappas, Eleftherios Anastasopoulos, Iordanis Vagiakis, Anastasia Raptou, Grigoria Tzoanou, Fotis Topouzis","doi":"10.1111/aos.70215","DOIUrl":"10.1111/aos.70215","url":null,"abstract":"<p><strong>Purpose: </strong>To identify incident open-angle glaucoma (OAG) cases detected through regular ophthalmic care and from screening in a population-based cohort and study the additional yield of screening in a population with high prevalence of pseudoexfoliation (PEX).</p><p><strong>Methods: </strong>Longitudinal, population-based study in Thessaloniki, Greece. Among eligible subjects, 1092 were examined at the follow-up stage. Previously undiagnosed glaucoma was defined as the absence of prior self-reported glaucoma or ocular hypertension or prior medical/surgical treatment. Glaucoma severity was assessed using the Hodapp-Parrish-Anderson criteria.</p><p><strong>Results: </strong>The population at risk, after excluding glaucoma patients diagnosed at baseline, consisted of 1042 participants. Forty-six subjects developed incident OAG and 27 of them (58.7%, 95% CI: 43.5-71.7) were undiagnosed at follow-up visit, corresponding to a 2.6% (95% CI: 1.6-3.6) 12-year incidence rate of undiagnosed OAG. After stratification, the incidence of undiagnosed OAG was 1.8% in non-PEX subjects (14 of 772) and 4.8% in PEX subjects (13 of 270). Glaucoma stage did not differ significantly between previously diagnosed and undiagnosed cases (p = 0.46 for better eye and p = 0.72 for worse eye). Among undiagnosed cases, 7 had moderate or worse visual field loss in both eyes, and 17 in at least one eye.</p><p><strong>Conclusions: </strong>The overall rate of undiagnosed incident OAG in this population-based cohort was substantial. A screening programme could have detected a significant number of glaucoma cases. The high rates of undiagnosed glaucoma among PEX subjects could suggest a higher additional yield of screening in this group. More studies are needed to evaluate the cost-effectiveness of screening in populations with high PEX prevalence.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":"e786-e792"},"PeriodicalIF":3.0,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the 'TWO-ROP' algorithm in a tertiary Care Centre in Greece.","authors":"Stella Moutzouri, Celine Chaaya, Francisco Altamirano, Srujay Pandiri, Sandra Hoyek, Marfy Abousifein, Arthur Brant, Demetrios G Vavvas, Asimina Mataftsi, Nimesh A Patel","doi":"10.1111/aos.70053","DOIUrl":"10.1111/aos.70053","url":null,"abstract":"<p><strong>Purpose: </strong>The TWO-ROP algorithm is a modified screening protocol based on US data for low-risk infants that limits screening to a single outpatient exam at 38 or 40 weeks to reduce the retinopathy of prematurity (ROP) screening burden without compromising safety. The aim of this study was to validate the algorithm on an external data set outside the United States.</p><p><strong>Methods: </strong>This is a retrospective study of premature infants screened for ROP at a tertiary centre in Greece. Infants with higher birth weight (BW) and greater gestational age (GA) were included and stratified into three groups: group 1 (BW < 1500 g, GA ≥ 32 weeks), group 2 (BW ≥ 1500 g, GA < 32 weeks) and group 3 (BW ≥ 1500 g, GA ≥ 32 weeks). The rate of ROP and type 1 ROP were evaluated.</p><p><strong>Results: </strong>Five hundred and fifty-three of the 1251 infants (44.2%) met the inclusion criteria. Groups 1, 2 and 3 had 139 (25.1%), 283 (51.2%) and 131 (23.7%) patients. Fourteen patients (2.5%) had ROP, including 7 in group 1, 7in group 2 and 0 in group 3 (p < 0.001). No patient met the criteria for type 1 ROP. No cases of treatment warranted ROP (TW-ROP) were observed in the cohort, indicating no missed cases under the TWO-ROP algorithm. When applying the algorithm, 14.3%-14.9% (mean 14.6%) of ROP examinations were saved.</p><p><strong>Conclusion: </strong>The TWO-ROP algorithm can reduce examinations while ensuring safety in Greece when using the local screening guidelines. This is the first ex-US validation and supports the potential for risk-stratified screening globally to optimize resources while maintaining safety.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":"e841-e845"},"PeriodicalIF":3.0,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145666736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}