Acta Ophthalmologica最新文献

{"title":"Patient-reported outcome measures after non-diffractive extended range of field IOL implantation: PureSee versus Vivity","authors":"Kyungmin Koh,&nbsp;Raimo Tuuminen,&nbsp;Dong Gyu Na,&nbsp;Sohee Jeon","doi":"10.1111/aos.70076","DOIUrl":"10.1111/aos.70076","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To perform a head-to-head comparison of two extended range of field intraocular lenses (IOLs) for their patient-reported outcome measures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Setting</h3>\u0000 \u0000 <p>Keye Eye Hospital, Seoul, Korea.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Clinical cohort study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Eighty-five emmetropic bilaterally operated patients (PureSee [<i>N</i> = 34] vs. AcrySof Vivity [<i>N</i> = 51]) were compared for their visual outcomes, dysphotopsia (scale 0–100), and spectacle-independent visual function index (VF)-14 questionnaire scores at the 6-month timepoint.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Baseline patient and ophthalmic variables were comparable between the groups. Acrysof Vivity provided better uncorrected near (0.21 ± 0.10 vs. 0.28 ± 0.07 LogMAR units, <i>p</i> &lt; 0.001) and intermediate visual acuities (0.08 ± 0.09 vs. 0.22 ± 0.08 LogMAR units, <i>p</i> &lt; 0.001) compared with PureSee. In contrast, contrast sensitivities in photopic (1.57 ± 0.14 vs. 1.45 ± 0.17 LogCWeber, <i>p</i> = 0.024) and mesopic conditions (1.30 ± 0.12 vs. 1.19 ± 0.17 LogCWeber, <i>p</i> = 0.025) were greater for PureSee than Acrysof Vivity. PureSee was associated with overall mean dysphotopsia scores (1.3 ± 3.2 vs. 5.8 ± 9.3, <i>p</i> = 0.009) significantly less than for Acrysof Vivity. Spectacle-independent VF-14 scores for visual acuities at near, specifically reading small print (76.0 ± 20.0 vs. 65.9 ± 22.4, <i>p</i> = 0.046), newspaper or a book (94.8 ± 11.5 vs. 80.3 ± 19.5, <i>p</i> &lt; 0.001), and large-print or numbers on a telephone (88.0 ± 15.4 vs. 79.5 ± 18.2, <i>p</i> = 0.030) were significantly greater for Acrysof Vivity than PureSee, whereas overall mean spectacle-independent VF-14 scores remained statistically non-significant for the two IOLs (92.6 ± 5.7 vs. 89.3 ± 9.7, respectively; <i>p</i> = 0.115).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Acrysof Vivity was associated with greater spectacle-independent near visual acuity and visual function for reading, while PureSee outperformed in photopic and mesopic contrast sensitivities, glare, starburst, and overall dysphotopsia. Based on these pros and cons, optimal extended range of field IOL selection should be aligned with the individual's needs and concerns.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":"104 6","pages":"649-655"},"PeriodicalIF":3.0,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146091724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal vessel oxygen saturation is affected in multiple sclerosis and optic neuritis","authors":"Anna Bryndis Einarsdottir,&nbsp;Sveinn Hakon Hardarson,&nbsp;Thomas Lee Torp,&nbsp;Zsolt Illes,&nbsp;Helle Hvilsted Nielsen,&nbsp;Jakob Grauslund","doi":"10.1111/aos.70121","DOIUrl":"10.1111/aos.70121","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Structural and metabolic changes in the retina may serve as biomarkers in central nervous system disease. Optical coherence tomography studies have shown structural changes in the retina of patients with multiple sclerosis (MS). We aimed to find whether retinal oxygen levels are affected in MS patients and/or eyes with optic neuritis when compared with healthy subjects or unaffected fellow eyes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We compared oxygen saturation in retinal blood vessels in MS patients and healthy controls. Oxygen saturation of haemoglobin was measured in retinal blood vessels with a spectrophotometric non-invasive retinal oximeter. Twenty-nine patients with MS, of whom 12 had a history of optic neuritis, were examined. Data were compared between the affected and non-affected optic neuritis eyes and 29 healthy individuals in a case-control study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Retinal vessel oxygen saturation was significantly increased in MS patients compared with healthy controls. Arteriolar saturation was 96.2% ± 3.6% in the MS cohort (mean ± SD, <i>n</i> = 29) and 93.8% ± 3.7% (<i>n</i> = 29, <i>p</i> = 0.017) in the healthy cohort. Venular saturation was 64.2% ± 5.0% in the MS cohort (<i>n</i> = 29) and 59.3% ± 6.0% (<i>n</i> = 29, <i>p</i> = 0.001) in the healthy cohort. Oxygen saturation in retinal venules in MS patients was higher in eyes with known optic neuritis (65.1% ± 4.1%; mean ± SD, <i>n</i> = 10) than in unaffected fellow eyes (62.3% ± 6.3%, <i>p</i> = 0.049).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The results suggest that retinal oxygen metabolism is affected in MS patients and optic neuritis. Non-invasive retinal oxygen imaging may be an objective biomarker in MS and optic neuritis and useful in the study of its pathophysiology. Further studies are needed to confirm and expand these findings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":"104 6","pages":"700-704"},"PeriodicalIF":3.0,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Memoriam: The life and legacy of Prof. Dr. Barbara Käsmann-Kellner","authors":"Rasha Sameer Moustafa","doi":"10.1111/aos.70057","DOIUrl":"https://doi.org/10.1111/aos.70057","url":null,"abstract":"","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":"104 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aos.70057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148704519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy of Nd:YAG laser peripheral iridotomy and surgical iridectomy in modulating perioperative subclinical inflammation after DMEK","authors":"Matteo Airaldi,&nbsp;Riccardo Chiorrini,&nbsp;Sabrina Vaccaro,&nbsp;Vittorio Cannistrà,&nbsp;Giacomo Beschi,&nbsp;Antonio Moramarco,&nbsp;Luigi Fontana,&nbsp;Eliana Forbice,&nbsp;Giuseppe Nascimbeni,&nbsp;Francesco Semeraro,&nbsp;Vito Romano","doi":"10.1111/aos.70068","DOIUrl":"10.1111/aos.70068","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To compare the effect of preoperative Nd:YAG laser peripheral iridotomy (PI) and intraoperative surgical iridectomy on subclinical inflammation before and after Descemet membrane endothelial keratoplasty (DMEK), using validated anterior segment optical coherence tomography (AS-OCT) inflammatory biomarkers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Among 132 eyes eligible for analysis, this matched cohort study included 40 eyes (20 per group) undergoing DMEK for Fuchs endothelial dystrophy or pseudophakic bullous keratopathy. Patients received either a preoperative laser PI or intraoperative surgical iridectomy. Eyes were matched according to gender, age, presence of preoperative posterior stromal ripples, baseline visual acuity and corneal thickness. Pre- and post-operative inflammation was quantified using AS-OCT measured aqueous-to-air relative intensity (ARI) and anterior chamber (AC) cell reflectivity. Post-operative trends in subclinical inflammation were compared using generalized additive models (GAM). Visual, pachymetric and endothelial outcomes, as well as post-operative complications, were compared.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The laser PI group showed greater baseline ARI (<i>p</i> &lt; 0.001) consistent with higher preoperative subclinical inflammation, while surgical iridectomy eyes exhibited greater cell counts after DMEK and at final follow-up (both <i>p</i> = 0.05). Post-operative inflammatory spikes resolved by 6–8 weeks, with faster normalization and lower peak values in the laser PI group. Visual acuity improvement, central corneal thickness reduction, endothelial cell loss and complication rates were comparable.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Preoperative laser PI was associated with lower early post-operative subclinical inflammation compared with intraoperative surgical iridectomy, without compromising visual or endothelial outcomes. These findings suggest that a less invasive PI approach may mitigate early post-operative immune activation, promoting smoother AC homeostasis after DMEK.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":"104 6","pages":"656-665"},"PeriodicalIF":3.0,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146058526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of systemic long-term medications for the development of age-related macular degeneration","authors":"Hanna Heloterä,&nbsp;Reijo Sund,&nbsp;Toni Rikkonen,&nbsp;Kai Kaarniranta","doi":"10.1111/aos.70113","DOIUrl":"10.1111/aos.70113","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Age-related macular degeneration (AMD) is a leading cause of central vision loss in the elderly; however, the systemic factors that modulate its incidence and progression remain unclear. We sought to determine whether long-term use of systemic medications, including diabetes and antithrombotic medications, corticosteroids and immunosuppressants, is associated with the development of AMD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The data included a pooled cohort of two follow-up studies: the Kuopio Osteoporosis Risk Factor and Prevention Study and the Kuopio Fall Prevention Study. A total of 16 518 women born between 1932 and 1946 living in eastern Finland were followed up between 1993 and 2021. The long-term medication use was indicated as ≥5 years of regular purchase of drugs. Incidence for AMD was analysed per long-term medication group, but also during the 5 years period in age matched groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We observed increased odds for AMD among long-term users of systemic corticosteroids (HR 1.348, <i>p</i> &lt; 0.001), immunosuppressants (HR 1.623, <i>p</i> = 0.004) and antithrombotic (HR 1.145, <i>p</i> = 0.042) medication. However, results with antithrombotic medications were not as consistent as with corticosteroids and immunosuppressants. Interestingly, the mean age at diagnosis of AMD was later among antithrombotic medication users compared to the control group (77.9 vs. 76.1, respectively, <i>p</i> &lt; 0.001) and earlier among patients using other diabetes medications than metformin (75.3 vs. 77.1, <i>p</i> = 0.026).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>People with long-term corticosteroid and immunosuppressant use are at greater risk for developing AMD. Further research on systemic components behind corticosteroid and immunosuppressant use, modulating AMD progression, is warranted.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":"104 6","pages":"674-681"},"PeriodicalIF":3.0,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aos.70113","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147363845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"16S/18S metabarcoding versus culture for aetiological assessment in infectious keratitis: A prospective paired-sample study.","authors":"Sandra M Skovdal, Christen Rune Stensvold, Henrik Vedel Nielsen, Stine Elkjær Nielsen, Jesper Hjortdal, Lise Kristensen, Anders Ivarsen","doi":"10.1111/aos.70218","DOIUrl":"https://doi.org/10.1111/aos.70218","url":null,"abstract":"<p><strong>Purpose: </strong>Infectious keratitis (IK) is a vision-threatening condition with diverse microbial aetiologies, yet conventional culture-based diagnostics often have limited sensitivity. We investigated whether 16S/18S rRNA amplicon-based next-generation sequencing (NGS) can enhance aetiological assessment when used alongside standard microbiological methods.</p><p><strong>Methods: </strong>In this prospective paired-sample study, 57 patients with IK underwent corneal sampling with conventional culture, PCR (HSV/VZV and Acanthamoeba) and 16S/18S metabarcoding. Microbiological findings were interpreted in a structured workflow incorporating clinical correlation and comparison with samples from the contralateral healthy eye.</p><p><strong>Results: </strong>Excluding entirely viral cases, NGS did not significantly increase the overall diagnostic outcome compared with culture and PCR alone (n = 53, 42% vs. 51%, p = 0.27) but improved the combined diagnostic yield (n = 53) to 58%. NGS identified clinically relevant pathogens in 39% of cases, including four cases not detected by culture, whereas culture identified nine cases missed by NGS. Concordance between methods was observed in 55% of positive cases. NGS on samples from the contralateral eye aided interpretation of NGS data in over 25% of cases by distinguishing commensal background from likely pathogens. Although microbiological findings led to treatment modification in 16% of cases, these were all in cases diagnosed by conventional methods.</p><p><strong>Conclusion: </strong>Based on our findings, 16S/18S metabarcoding may be useful as a targeted supplementary test in atypical, refractory or culture-negative IK cases where conventional sampling is compromised. Findings should be interpreted alongside conventional microbiology, clinical findings and preferably contralateral-eye sampling.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148676474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of prior glaucoma surgery on graft survival after DMEK: A large retrospective cohort study.","authors":"Tamara Bilic, Peter Szurman, Warda Darwisch, Dominik Weber, André M Trouvain, Clara E Englisch, Berthold Seitz, Annekatrin Rickmann","doi":"10.1111/aos.70214","DOIUrl":"https://doi.org/10.1111/aos.70214","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate outcomes in glaucoma eyes (G) compared with non-glaucoma eyes (NG) after Descemet membrane endothelial keratoplasty (DMEK), with a particular focus on the role of prior glaucoma surgery.</p><p><strong>Methods: </strong>In this retrospective cohort study, 2538 eyes undergoing DMEK were analysed, including 241 glaucoma eyes (G) and 2297 non-glaucoma eyes (NG). Outcomes included visual acuity, intraocular pressure, endothelial cell loss, rebubbling rate, repeat DMEK, and graft survival. Subgroup analyses were performed comparing treated glaucoma eyes (MG) with surgically treated glaucoma eyes (SG).</p><p><strong>Results: </strong>G eyes showed worse outcomes compared with NG eyes, including higher endothelial cell loss, increased repeat DMEK rates (14% vs. 6%, p < 0.001), and reduced graft survival (5-year survival 85.2% vs. 92.1%, p < 0.001). Within G eyes, SG eyes demonstrated poorer graft survival than MG eyes (HR 2.32, p = 0.020). The highest risk was observed in eyes with multiple prior glaucoma procedures.</p><p><strong>Conclusion: </strong>Glaucoma eyes (G) had worse DMEK outcomes than non-glaucoma eyes (NG), particularly among surgically treated glaucoma eyes (SG). SG eyes were more strongly associated with endothelial cell loss, repeat DMEK, and graft failure than medically treated glaucoma eyes (MG). These findings may help guide risk stratification and patient counselling, although residual confounding and differences in glaucoma severity cannot be excluded.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148668093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term follow-up of chronic central serous chorioretinopathy patients receiving oral eplerenone and half-dose photodynamic therapy in the SPECTRA trial: SPECTRA trial report No. 4.","authors":"Helena M A Feenstra, Issam El Mansori, Thomas J van Rijssen, Roula Tsonaka, Roselie M H Diederen, Carel B Hoyng, Reinier O Schlingemann, Camiel J F Boon, Elon H C van Dijk","doi":"10.1111/aos.70106","DOIUrl":"10.1111/aos.70106","url":null,"abstract":"<p><strong>Purpose: </strong>Assessing the 24-month treatment outcome of half-dose photodynamic therapy (PDT) or oral eplerenone in chronic central serous chorioretinopathy (cCSC).</p><p><strong>Methods: </strong>Multicentre randomized clinical trial included cCSC patients from the SPECTRA trial who were randomized to receive half-dose PDT or oral eplerenone. Outcomes were evaluated at 24 months, including the primary outcome measure of complete resolution of subretinal fluid (SRF) on optical coherence tomography (OCT) and the secondary outcome measures best-corrected visual acuity (BCVA), retinal and foveal sensitivity on microperimetry and the National Eye Institute Visual Functioning Questionnaire 25 (NEI-VFQ25) score.</p><p><strong>Results: </strong>At baseline, 107 patients were included, of which 80 patients attended the final visit at 24 months: 40 had been randomized to primary treatment with half-dose PDT and 40 to eplerenone. In the eplerenone group, as many as 36/40 (90%) needed crossover treatment at 3 months with half-dose PDT due to persistent SRF, compared to 8/40 (20%) in the half-dose PDT group. At the final visit, complete SRF resolution was observed in 32/40 (80%) who were primarily treated with half-dose PDT and in 35/40 (88%) who received primary eplerenone treatment (p = 0.609). There were no significant differences in terms of BCVA, foveal sensitivity, retinal sensitivity and NEI-VFQ25 score.</p><p><strong>Conclusions: </strong>This study provides evidence for the long-term efficacy of half-dose PDT in resolving SRF and improving functional outcomes in cCSC. Even when patients initially received eplerenone treatment that did not result in complete SRF resolution, crossover treatment with half-dose PDT led to similar (long-term) group outcomes compared to half-dose PDT as initial treatment.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":"e565-e577"},"PeriodicalIF":3.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13353556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146163400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in choroidal and retinal thickness 6 months before and during 18 months of orthokeratology lens treatment in myopic children.","authors":"P O Hansen, F Møller, T M Jakobsen","doi":"10.1111/aos.70084","DOIUrl":"10.1111/aos.70084","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate changes in choroidal and retinal thickness before and during myopia control treatment with orthokeratology lenses (OKL) in myopic children.</p><p><strong>Methods: </strong>This was a sub-study of CONTROL and CONTROL2 studies. The present study was a 2-year, prospective, single-group interventional study consisting of a 6-month pre-treatment observation period followed by 18-month OKL treatment. Choroidal and retinal thicknesses were measured using a 3D macula scan with swept-source optical coherence tomography. All thickness measures were corrected for magnification using the Imagenet6 software. Axial length was measured using Lenstar LS900 and corrected for change in central corneal thickness. Data were collected at three pre-treatment visits and seven post-treatment visits (from Day 3 up to 18 months).</p><p><strong>Results: </strong>The 20 study participants had a mean age of 11.2 ± 1.9 years, median cycloplegic spherical equivalent refractive error of -2.58 diopters (range - 4.75 to -1.00) and mean axial length of 24.56 ± 0.63 mm. During the pre-treatment period, there was a statistically significant decrease in retinal thickness of -1.44 μm (p = 0.038, SE 0.70, 95% CI -2.82 to -0.08), but a significant increase was seen after initiation of OKL treatment. Thickness peaked at 2.54 μm (p < 0.001, SE 0.72, 95% CI 1.13 to 3.95) at the 6-month follow-up. We observed a tendency for the choroidal thickness to decrease during the pre-treatment period (-5.96 μm, p = 0.12, SE 3.78, 95% CI -13.37 to 1.46) and then a statistically significant increase after treatment initiation with a peak of 11.95 μm after 1 month of treatment (p = 0.003, SE 4.08, 95% CI 3.94 to 19.96). Short-term change in choroidal thickness after treatment initiation did not correlate with change in overall eye length defined as subfoveal choroidal thickness plus axial length adjusted for post-treatment change in central corneal thickness. For each individual participant, the choroidal thickness and retinal thickness were highly positively correlated at each visit throughout the study (p < 0.001, 95% CI 0.69 to 2.09, linear mixed model).</p><p><strong>Conclusion: </strong>Treatment with OKL increased both retinal and choroidal thickness in myopic children. Short-term change in choroidal thickness was not a predictor for growth of the overall eye length. Further studies of the presumed structural changes in the choroid and the retina are warranted.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":"e578-e589"},"PeriodicalIF":3.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13353577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146058467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astigmatic changes after Descemet membrane endothelial keratoplasty (DMEK) in decompensated penetrating keratoplasty grafts.","authors":"Florian Thomas Steinberg, Jithmi Weliwitage, Marie von Berg, Silvia Schrittenlocher, Simona Schlereth, Claus Cursiefen, Björn Bachmann","doi":"10.1111/aos.70081","DOIUrl":"10.1111/aos.70081","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the surgery-induced changes of astigmatism after Descemet membrane endothelial keratoplasty (DMEK) in eyes with failed previous penetrating keratoplasty (PK).</p><p><strong>Design: </strong>Retrospective, interventional cohort study based on prospective DMEK database.</p><p><strong>Methods: </strong>Evaluation of 15 eyes after DMEK surgery for endothelial decompensation after PK. Astigmatic changes before decompensation and after DMEK surgery were compared using anterior and posterior keratometry and True Net Power (TNP) in corneal tomography (Pentacam, Oculus). The differences in magnitude of astigmatism and axis of steep meridian were calculated by algebraic and vectorial methods, and significant differences to specified thresholds were determined by the non-parametric Wilcoxon rank test.</p><p><strong>Results: </strong>Surgically induced changes (SIC) in magnitude of astigmatism at anterior surface, posterior surface and TNP were -1.4dpt ± 3.7, -0.2dpt ± 0.8 and -1.3dpt ± 3.9, respectively. No significant changes in astigmatism and axis difference by algebraic method in comparison with a hypothetical median of 0dpt and 10° were observed. Calculation of astigmatism difference by vectorial method showed a significant deviation in anterior surface (observed median = 4.4dpt, p < 0.001), posterior surface (observed median 1.0dpt, p = 0.012) and TNP (observed median = 3.6dpt, p < 0.001).</p><p><strong>Conclusion: </strong>Even if no significant change in magnitude and axis of astigmatism to acceptable thresholds could be shown after DMEK in failed PK using the algebraic method, there is a significant and relevant change in magnitude of astigmatism using the vectorial calculation. Based on these results, caution is advised when using toric intraocular lenses in PK eyes, as astigmatic change is expected when performing DMEK on eyes with failed PK.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":"e516-e529"},"PeriodicalIF":3.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13353707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146155654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}