Acta Ophthalmologica最新文献

{"title":"Analysis of glaucoma genes in Finnish patients with juvenile open-angle glaucoma","authors":"Perttu J. Liuska,&nbsp;Abdessallam Tadji,&nbsp;Pauliina Repo,&nbsp;Juho Hiltunen,&nbsp;Michael Backlund,&nbsp;Reetta-Stiina Järvinen,&nbsp;Eeva Ojanen,&nbsp;Anna Majander,&nbsp;Tero T. Kivelä,&nbsp;Mika Harju,&nbsp;Joni A. Turunen","doi":"10.1111/aos.15670","DOIUrl":"10.1111/aos.15670","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To identify germline variants in myocilin (<i>MYOC</i>) and other known monogenic glaucoma genes in Finnish patients with juvenile open-angle glaucoma (JOAG).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Finnish patients with JOAG treated between 2010 and 2018 at the Department of Ophthalmology, Helsinki University Hospital, Finland, were enrolled. We sequenced all exonic regions and flanking splice sites of <i>MYOC</i> for five patients and one healthy relative using Sanger sequencing. In 48 patients, we performed exome sequencing to identify variants also in 28 other glaucoma-related genes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fifty-three individuals with JOAG from 50 pedigrees, and one healthy relative, participated. The mean age at diagnosis was 30.8 years [SD 7.6; range 11 to 39]. Five probands had probably pathogenic variants in <i>MYOC</i>: c.1102C&gt;T p.(Gln368Ter), c.1109C&gt;T p.(Pro370Leu), c.1130C&gt;T p.(Thr377Met), c.1132G&gt;A p.(Asp378Asn) and c.1456C&gt;T p.(Leu486Phe). Four of these patients had a family history of dominantly inherited JOAG. The frequency of <i>MYOC</i> variants was 10% (5 of 50 families). One patient and his mother with JOAG had a novel loss-of-function variant in the <i>FOXC1</i> gene, c.366G&gt;A p.(Trp122Ter). A patient with sporadic JOAG had a homozygous likely pathogenic variant in the <i>LTBP2</i> gene, c.3938G&gt;A p.(Cys1313Tyr). The genetic variants explained 14% (7 out of 50 families; 95% CI, 6%–23%) of JOAG in our cohort.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The frequency of pathogenic variants in previously known glaucoma-associated genes is low in Finnish patients with JOAG. Because of the distinct genetic background of Finns, it might be possible to identify novel glaucoma genes through our JOAG series in the future.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":"101 7","pages":"797-806"},"PeriodicalIF":3.4,"publicationDate":"2023-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aos.15670","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9633818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of vision on generic health-related quality of life – A systematic review","authors":"Petri Purola,&nbsp;Seppo Koskinen,&nbsp;Hannu Uusitalo","doi":"10.1111/aos.15676","DOIUrl":"10.1111/aos.15676","url":null,"abstract":"<p>The aim of the study was to provide an overview on the relation between vision and generic health-related quality of life (HRQoL) in general populations worldwide. We conducted a systematic review to identify articles that have evaluated the relation of binocularly measured distance visual acuity (VA) and HRQoL in adults at population level around the world. Used search terms were related to visual acuity, vision loss, visual impairment and HRQoL. We identified 780 articles, of which 12 satisfied the eligibility criteria. The studies were conducted in the USA, Europe, Asia and Australia. Generic HRQoL was measured using EQ-5D, 15D, SF-36, SF-12 and/or WHOQoL. Nine studies reported a trend between decreasing VA and deteriorating HRQoL of at least some degree. Vision loss was mostly associated with dimensions related to physical health and capability, including self-care, mobility and usual activities. Mental dimensions – vitality and social functioning in particular – were also affected, although the results were inconsistent. Six studies compared the impact of different medical conditions on HRQoL, all of which reported that the impact of visual impairment was equal or stronger compared with other major medical conditions. In conclusion, generic HRQoL instruments are sensitive to detect the relation between vision and HRQoL, as they cover dimensions influenced by vision. Declining vision is associated with reduced functioning, which leads to dependence and isolation – both major factors in an individual's well-being. This phenomenon showed surprising similarity around the world and therefore emphasises the global burden of vision loss at both individual and societal level and encourages its prevention and treatment.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":"101 7","pages":"717-728"},"PeriodicalIF":3.4,"publicationDate":"2023-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aos.15676","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9257636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"This issue of Acta (April 2023)","authors":"","doi":"10.1111/aos.15665","DOIUrl":"10.1111/aos.15665","url":null,"abstract":"&lt;p&gt;The cover illustration demonstrates retinal racemose hemangioma arteriovenous malformations. This is published by Akter and Abousamra in the electronic part of this issue of ACTA.&lt;/p&gt;&lt;p&gt;Heikka and Jansonius in The Netherlands found that retinal nerve fibre layer thickness (RNFLT) and total retinal thickness (TRT)gave similar information on glaucoma progression, except in poor quality scans where TRT was better. OCT becomes less informative with glaucoma progression.&lt;/p&gt;&lt;p&gt;Pirinen et al in Finland suggest that intravitreal anti-VEGF treatment for neovascular AMD may accelerate glaucoma progression.&lt;/p&gt;&lt;p&gt;Dahlgren et al in Sweden found in a retrospective study that topical NSAID treatment was not associated with an increased efficacy of selective laser trabeculoplasty and may even reduce efficacy.&lt;/p&gt;&lt;p&gt;Ahmadi et al in Denmark found the prevalence of optic disc drusen to be elevated in patients diagnosed with normal tension glaucoma and these patients also had a low cup/disc ratio.&lt;/p&gt;&lt;p&gt;Kankainen and Harju in Finland describe a low incidence (0.2%) for endophthalmitis and blebitis after deep sclerectomy and trabeculectomy with routine use of Mitomycin C.&lt;/p&gt;&lt;p&gt;Bolek et al in Poland found ultrasound ciliary plasty to be an effective and well-tolerated method to reduce IOP in patients with refractory glaucoma.&lt;/p&gt;&lt;p&gt;Lee et al in Korea found preoperative peripapillary retinal nerve fibre layer and ganglion cell- inner plexiform layer thicknesses on OCT to be effective biomarkers for predicting visual outcomes after decompression of pituitary tumours.&lt;/p&gt;&lt;p&gt;Gärdin and Johansson in Sweden performed a retrospective study on postoperative anti-inflammatory treatment with NSAID in combination with steroids. The combination did not reduce need for unplanned postoperative visits or incidence of visually disturbing CME after cataract surgery compared with steroids alone.&lt;/p&gt;&lt;p&gt;Simons et al in The Netherlands found the cost-effectiveness of Descemet Membrane Endothelial Keratoplasty (DMEK) to be inferior to Ultrathin Descemet Stripping Automated Endothelial Keratoplasty (UT- DSAEK).&lt;/p&gt;&lt;p&gt;Dail et al in Germany compared retrospectively the effect of monotherapy with intravitreal ranibizumab, aflibercept and bevacizumab on retinal ganglion cell layer and retinal nerve fibre layer in patients with naïve neovascular age- related macular degeneration and found similar reduction in thickness with all 3 drugs.&lt;/p&gt;&lt;p&gt;Lehtonen et al in Finland studied prospectively the association between retinal parameters on OCT and motor and cognitive outcomes in very preterm babies. They describe associations between higher average peripapillary retinal nerve fibre layer thickness and better motor performance as well as higher ganglion cell layer volume and better cognitive performance.&lt;/p&gt;&lt;p&gt;Grzybowsky et al in Poland and USA recall the first successful planned extracapsular cataract extraction in 1752.&lt;/p&gt;&lt;p&gt;Badreldin et al in Denmark suggest identifying microorganisms in ker","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":"101 3","pages":"249-250"},"PeriodicalIF":3.4,"publicationDate":"2023-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aos.15665","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9264722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes of corneal biomechanics in children using orthokeratology and their roles in predicting axial length progression—A prospective 2-year study","authors":"Kaidi Xiang,&nbsp;Jun Chen,&nbsp;Wenchen Zhao,&nbsp;Zhuoting Zhu,&nbsp;Li Ding,&nbsp;Gabriella Bulloch,&nbsp;Linlin Du,&nbsp;Xun Xu,&nbsp;Mengjun Zhu,&nbsp;Xiangui He","doi":"10.1111/aos.15662","DOIUrl":"10.1111/aos.15662","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To determine how orthokeratology (ortho-k) affects corneal biomechanical properties in myopia control and whether corneal biomechanical parameters can predict clinical efficacy of ortho-k.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 125 children 7–15 years of age using ortho-k lenses were followed in this clinical practice and data of their right eyes were analysed. Corneal biomechanical parameters and most ocular biometry were measured at baseline, 1 week, and at 1, 3, 6, 12, 18 and 24 months. Axial length (AL) was collected every 6 months after baseline measurements.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>During the 2-year follow up, nine corneal biomechanical parameters, including deformation amplitude maximum (DA), varied between baseline and 1 week (<i>p</i> &lt; 0.05) and stabilized during the rest of wearing period (<i>p</i> &gt; 0.05). The mean AL increased from 25.02 ± 0.84 mm to 25.38 ± 0.81 mm and baseline DA strongly correlated with AL progression (Pearson <i>r</i> = 0.37). In the multiple regression models, baseline age, AL and DA were the independent factors for AL progression (<i>R</i>²: 0.7849, 0.2180 in low and moderate myopes). The area under the receiver operating characteristic curves using the three variables for predicting excessive AL progression (&gt;0.35 mm during 2 years) in low and moderate myopes was 0.902 and 0.698.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Corneal biomechanics firstly fluctuated before becoming stable with long-term ortho-k use. Corneal biomechanics was associated with AL progression in children wearing ortho-k lenses. DA combined with age and AL at baseline could predict AL progression in low myopes using ortho-k.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":"101 7","pages":"755-765"},"PeriodicalIF":3.4,"publicationDate":"2023-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aos.15662","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9161339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discussing depression in patients with visual impairment differs across countries: Validation of a prediction model in healthcare providers","authors":"Edine P. J. van Munster,&nbsp;Ruth M. A. van Nispen,&nbsp;Claire L. Nollett,&nbsp;Edith E. Holloway,&nbsp;Otto R. Maarsingh,&nbsp;Martijn W. Heymans,&nbsp;Hilde P. A. van der Aa","doi":"10.1111/aos.15663","DOIUrl":"10.1111/aos.15663","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Healthcare providers often experience difficulties in discussing depression with adults with visual impairment (VI), obstructing timely referral. The purpose of this study was to examine predictors of routine discussions of depression with adults with VI from the perspective of different healthcare providers from different countries.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Cross-sectional survey data from Welsh (<i>N</i> = 122), Australian (<i>N</i> = 94) and Dutch (<i>N</i> = 100) healthcare providers, that is eye care practitioners (ECPs) and low-vision care providers (LVCPs), were analysed. Multivariable logistic regression analysis was performed in the Welsh sample to determine predictors for discussing depression. Internal validation was conducted by using a bootstrap method, and the recalibrated model was externally validated in the Australian and Dutch sample.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Work experience in eye care services (OR 0.95; 95% confidence interval (CI) 0.92 to 0.99) and perceived barriers (OR 0.95; 95% CI 0.92 to 0.98) was found to predict discussing depression with patients. The area under the curve (AUC) of 0.73 reflected good discrimination of the model. The model showed a slightly better fit in the Australian sample (AUC = 0.77), but a poor fit in the Dutch sample.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The final prediction model was not generalizable to Dutch healthcare providers. They perceived less barriers in depression management than Welsh and Australian healthcare providers. This could be explained by differences in ECPs and LVCPs roles and responsibilities, increased attention on mental health and differences in organizing health care. Differences between healthcare providers' responsibilities and support needs should be taken into account while creating a facilitating environment to discuss depression.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":"101 7","pages":"766-774"},"PeriodicalIF":3.4,"publicationDate":"2023-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aos.15663","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9176260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Particle swarm optimisation strategies for IOL formula constant optimisation","authors":"Achim Langenbucher,&nbsp;Nóra Szentmáry,&nbsp;Alan Cayless,&nbsp;Jascha Wendelstein,&nbsp;Peter Hoffmann","doi":"10.1111/aos.15664","DOIUrl":"10.1111/aos.15664","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To investigate particle swarm optimisation (PSO) as a modern purely data driven non-linear iterative strategy for lens formula constant optimisation in intraocular lens power calculation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A PSO algorithm was implemented for optimising the root mean squared formula prediction error (rmsPE, defined as achieved refraction minus predicted refraction) for the Castrop formula in a dataset of <i>N</i> = 888 cataractous eyes with implantation of the Hoya Vivinex hydrophobic acrylic aspheric lens. The hyperparameters were set to inertia: 0.8, accelerations c1 = c2 = 0.1. The algorithm was initialised with <i>N</i>_P = 100 particles having random positions and velocities within the box constraints of the constant triplet parameter space C = 0.25 to 0.45, H = −0.25 to 0.25 and R = −0.25 to 0.25. The performance of the algorithm was compared to classical gradient-based Trust-Region-Reflective and Interior-Point algorithms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The PSO algorithm showed fast and stable convergence after 37 iterations. The rmsPE reduced systematically to 0.3440 diopters (D). With further iterations the scatter of the particle positions in the swarm decreased but without further reduction of rmsPE. The final constant triplet was C/H/R = 0.2982/0.2497/0.1435. The Trust-Region-Reflective/Interior-Point algorithms showed convergence after 27/17 iterations, respectively, resulting in formula constant triplets C/H/R = 0.2982/0.2496/0.1436 and 0.2982/0.2495/0.1436, both with the same rmsPE as the PSO algorithm (rmsPE = 0.3440 D).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The PSO appears to be a powerful adaptive nonlinear iteration algorithm for formula constant optimisation even in formulae with more than 1 constant. It acts independently of an analytical or numerical gradient and is in general able to search for the best solution even with multiple local minima of the target function.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":"101 7","pages":"775-782"},"PeriodicalIF":3.4,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aos.15664","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9509342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of lipid-lowering agent use and dry eye disease: A nationwide matched case–control study in Taiwan, 2002–2016","authors":"Li-Nien Chien,&nbsp;Yun-I Chou,&nbsp;Yuan-Jen Tsai,&nbsp;Li-Chin Sung,&nbsp;Hung-Yi Liu,&nbsp;Meng-Yin Lin,&nbsp;Tsung-Jen Wang,&nbsp;I-Chan Lin","doi":"10.1111/aos.15656","DOIUrl":"10.1111/aos.15656","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>The purpose of this study is to evaluate the association between lipid-lowering agent use and the risks of diagnosed dry eye disease (DED).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective, case–control study included 780 786 patients who received lipid-lowering agents in 2002–2016, of which 17 409 were newly diagnosed with DED during a ≥2-year follow-up period. These patients were matched 1:4 with control participants for age, sex, and comorbidities. Separate odds ratios (OR) were calculated for DED and each of statin and fibrate use.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Statin users had significantly higher odds of DED (adjusted OR = 1.12; 95% confidence interval (CI) = 1.08–1.16, <i>p</i> &lt; 0.0001) than nonusers. Fibrate users did not show higher odds of DED than nonusers (adjusted OR = 1.04; 95% CI = 0.99–1.10, <i>p</i> = 0.125). The lipophilic statin users did not show higher odds of DED compared with the hydrophilic statin users (adjusted OR = 0.99, 95% CI = 0.93–1.06, <i>p</i> = 0.729). Among statin users, the odds of DED did not differ significantly between patients receiving statin therapy for &gt;180 days vs. ≤90 days or patients receiving statin therapy for 91–180 days vs. ≤90 days (adjusted OR = 1.00, <i>p</i> = 0.922; adjusted OR = 0.94, <i>p</i> = 0.541, respectively). The odds of DED were not statistically different among patients receiving low-intensity, moderate-intensity, and high-intensity of statin therapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Patients receiving statin therapy had a higher DED risk than patients not receiving statin therapy. The type of statin, the duration, and the intensity of statin use were not significantly associated with DED risks. Further studies are required to identify the relevant factors related to DED risks with statin.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":"101 7","pages":"729-736"},"PeriodicalIF":3.4,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9141132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additional malignancies and mortality in uveal melanoma: A 20-year follow-up of a Norwegian patient cohort","authors":"Trude E. Robsahm,&nbsp;Ragnhild S. Falk,&nbsp;Nils A. Eide","doi":"10.1111/aos.15659","DOIUrl":"10.1111/aos.15659","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>The purpose of this study is to explore the frequency of additional primary malignancies in uveal melanoma (UM) patients and cause-specific mortality, to help guide surveillance strategies after UM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>All patients diagnosed with UM at Oslo University Hospital during 1990–2017 were eligible for inclusion. Linkage to the Cancer Registry of Norway obtained information on additional malignancies and cause of death throughout 2019. UM patients were categorized according to timing of additional malignancy (prior/simultaneously or after UM) or no additional cancer, and by UM stage at diagnosis. Age-adjusted mortality rates were presented per 1000 person-years with 95% confidence intervals (CI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study population included 960 UM patients: 77% were diagnosed in stage and I/II and 56% were men. Mean age at diagnosis was 63 years. Additional malignancies were observed in 152 patients prior/simultaneous to UM, and in 120 patients &gt;1 year after UM. Overall, mortality per 1000 person-years was 3.5 (95% CI 3.1–3.9) for UM and 3.0 (2.6–3.4) for other causes. Lowest UM mortality [1.3 (0.60–2.1)] was seen in patients with a second malignancy after UM, regardless of stage. Highest UM mortality was seen for UM patients in stage III/IV, both without [16.1 (13.2–19.1)] and with any additional malignancy [16.9 (6.6–27.3)].</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our results support that UM patients frequently have additional malignancies, both before and after UM. Low-UM mortality in patients with a primary malignancy after UM, might indicate less aggressive UM. The cumulative UM mortality flattens about 10 years after diagnosis and annual follow-up of patients for 10 years seems adequate.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":"101 6","pages":"696-704"},"PeriodicalIF":3.4,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9948940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of retinal optical coherence tomography in children with a newly diagnosed brain tumour","authors":"Myrthe A. Nuijts,&nbsp;Inge Stegeman,&nbsp;Giorgio L. Porro,&nbsp;Carlien A. M. Bennebroek,&nbsp;Tom van Seeters,&nbsp;Frank A. Proudlock,&nbsp;Antoinette Y. N. Schouten – van Meeteren,&nbsp;Saskia M. Imhof","doi":"10.1111/aos.15650","DOIUrl":"10.1111/aos.15650","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To estimate the diagnostic accuracy of circumpapillary retinal nerve fibre layer (RNFL) thickness and macular ganglion cell layer–inner plexiform layer (GCL-IPL) thickness measurements to discriminate an abnormal visual function (i.e. abnormal age-based visual acuity and/or visual field defect) in children with a newly diagnosed brain tumour.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cross-sectional analysis of a prospective longitudinal nationwide cohort study was conducted at four hospitals in the Netherlands, including the national referral centre for paediatric oncology. Patients aged 0–18 years with a newly diagnosed brain tumour and reliable visual acuity and/or visual field examination and optical coherence tomography were included. Diagnostic accuracy was evaluated with sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 115 patients included in the study (67 [58.3%] male; median age 10.6 years [range, 0.2–17.8 years]), reliable RNFL thickness and GCL-IPL thickness measurements were available in 92 patients (80.0%) and 84 patients (73.0%), respectively. The sensitivity for detecting an abnormal visual function was 74.5% for average RNFL thickness and 41.7% for average GCL-IPL thickness at a specificity of 44.5% and 82.9%, respectively. The PPV and NPV were 33.0% and 82.6% for the average RNFL thickness and 57.1% and 82.2% for the average GCL-IPL thickness.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>An abnormal visual function was discriminated correctly by using the average RNFL thickness in seven out of ten patients and by using the average GCL-IPL thickness in four out of ten patients. The relatively high NPVs signified that patients with normal average RNFL thickness and average GCL-IPL thickness measurements had a relative high certainty of a normal visual function.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":"101 6","pages":"658-669"},"PeriodicalIF":3.4,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aos.15650","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9948935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of residual amblyopia in adulthood and its association on educational outcome and quality of life in the Northern Finland Birth Cohort","authors":"M. Johanna Liinamaa,&nbsp;Ilmari L. Leiviskä,&nbsp;Ville O. Saarela","doi":"10.1111/aos.15660","DOIUrl":"10.1111/aos.15660","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>The purpose of the current study was to evaluate the prevalence of residual amblyopia in adults in a population screened and treated in childhood. We also wanted to evaluate the association of amblyopia on school success, level of education, and quality of life.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This is a follow-up study of 2708 subjects of the Northern Finland Birth Cohort. At the age of 46, the subjects took part in ophthalmic examinations, including the measurement of best-corrected visual acuity (BCVA) and refraction. Residual amblyopia was defined as BCVA 20/30 or less (logMAR ≥0.2) in one or both eyes or a two-line interocular visual acuity difference and absence of any pathological ocular factors. The quality of life was assessed with a 15D questionnaire, and educational outcome, school success, and episodic memory with a CANTAB-PAL (paired associates learning) test were evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The prevalence of amblyopia in the current adult population aged 46 years was 1.3% (<i>n</i> = 36). At 14 years, the amblyopia subjects had had significant differences in mean spherical equivalent between the amblyopic and fellow eye and strabismus more often than controls. No significant differences were observed in the CANTAB-PAL test or in educational outcome. However, amblyopia subjects had significant difficulties in the 15D questionnaire in terms of vision (54% vs. 34%, <i>p</i> = 0.01).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Due to screening and treatment in childhood, the number of adults with residual amblyopia was low. Despite minor visual impairment and discomfort, they cope very well in life in terms of educational outcome and quality of life.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":"101 7","pages":"747-754"},"PeriodicalIF":3.4,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aos.15660","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9492015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}