Acta Ophthalmologica最新文献_第9页

RE: Camp DA, Bakhsh SR, Torkashvand A, et al. Laser prophylaxis for retinal detachment in Stickler syndrome: A systematic review and meta-analysis. Acta Ophthalmologica. 2025 May 15. doi: 10.1111/aos.17509. Epub ahead of print. PMID: 40370211. RE: Camp DA, Bakhsh SR， Torkashvand A等。激光预防Stickler综合征视网膜脱离：系统回顾和荟萃分析。眼科学报。2025年5月15日。doi: 10.1111 / aos.17509。打印前Epub。PMID: 40370211。

IF 2.8 3区医学

Acta Ophthalmologica Pub Date : 2026-02-12 DOI: 10.1111/aos.70079

Robert E Morris, Ferenc Kuhn, Matthew R West, Matthew H Oltmanns, Cary R Baxter

引用次数: 0

Long-term follow-up of chronic central serous chorioretinopathy patients receiving oral eplerenone and half-dose photodynamic therapy in the SPECTRA trial: SPECTRA trial report No. 4. 长期随访慢性中枢性浆液性脉络膜视网膜病变患者接受口服依普利酮和半剂量光动力治疗的SPECTRA试验：SPECTRA试验报告4号。

IF 2.8 3区医学

Acta Ophthalmologica Pub Date : 2026-02-11 DOI: 10.1111/aos.70106

Helena M A Feenstra, Issam El Mansori, Thomas J van Rijssen, Roula Tsonaka, Roselie M H Diederen, Carel B Hoyng, Reinier O Schlingemann, Camiel J F Boon, Elon H C van Dijk

{"title":"Long-term follow-up of chronic central serous chorioretinopathy patients receiving oral eplerenone and half-dose photodynamic therapy in the SPECTRA trial: SPECTRA trial report No. 4.","authors":"Helena M A Feenstra, Issam El Mansori, Thomas J van Rijssen, Roula Tsonaka, Roselie M H Diederen, Carel B Hoyng, Reinier O Schlingemann, Camiel J F Boon, Elon H C van Dijk","doi":"10.1111/aos.70106","DOIUrl":"https://doi.org/10.1111/aos.70106","url":null,"abstract":"Purpose: Assessing the 24-month treatment outcome of half-dose photodynamic therapy (PDT) or oral eplerenone in chronic central serous chorioretinopathy (cCSC).Methods: Multicentre randomized clinical trial included cCSC patients from the SPECTRA trial who were randomized to receive half-dose PDT or oral eplerenone. Outcomes were evaluated at 24 months, including the primary outcome measure of complete resolution of subretinal fluid (SRF) on optical coherence tomography (OCT) and the secondary outcome measures best-corrected visual acuity (BCVA), retinal and foveal sensitivity on microperimetry and the National Eye Institute Visual Functioning Questionnaire 25 (NEI-VFQ25) score.Results: At baseline, 107 patients were included, of which 80 patients attended the final visit at 24 months: 40 had been randomized to primary treatment with half-dose PDT and 40 to eplerenone. In the eplerenone group, as many as 36/40 (90%) needed crossover treatment at 3 months with half-dose PDT due to persistent SRF, compared to 8/40 (20%) in the half-dose PDT group. At the final visit, complete SRF resolution was observed in 32/40 (80%) who were primarily treated with half-dose PDT and in 35/40 (88%) who received primary eplerenone treatment (p = 0.609). There were no significant differences in terms of BCVA, foveal sensitivity, retinal sensitivity and NEI-VFQ25 score.Conclusions: This study provides evidence for the long-term efficacy of half-dose PDT in resolving SRF and improving functional outcomes in cCSC. Even when patients initially received eplerenone treatment that did not result in complete SRF resolution, crossover treatment with half-dose PDT led to similar (long-term) group outcomes compared to half-dose PDT as initial treatment.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146163400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astigmatic changes after Descemet membrane endothelial keratoplasty (DMEK) in decompensated penetrating keratoplasty grafts. 失代偿性穿透性角膜移植术（DMEK）后角膜散光的改变。

IF 2.8 3区医学

Acta Ophthalmologica Pub Date : 2026-02-11 DOI: 10.1111/aos.70081

Florian Thomas Steinberg, Jithmi Weliwitage, Marie von Berg, Silvia Schrittenlocher, Simona Schlereth, Claus Cursiefen, Björn Bachmann

{"title":"Astigmatic changes after Descemet membrane endothelial keratoplasty (DMEK) in decompensated penetrating keratoplasty grafts.","authors":"Florian Thomas Steinberg, Jithmi Weliwitage, Marie von Berg, Silvia Schrittenlocher, Simona Schlereth, Claus Cursiefen, Björn Bachmann","doi":"10.1111/aos.70081","DOIUrl":"https://doi.org/10.1111/aos.70081","url":null,"abstract":"Purpose: To evaluate the surgery-induced changes of astigmatism after Descemet membrane endothelial keratoplasty (DMEK) in eyes with failed previous penetrating keratoplasty (PK).Design: Retrospective, interventional cohort study based on prospective DMEK database.Methods: Evaluation of 15 eyes after DMEK surgery for endothelial decompensation after PK. Astigmatic changes before decompensation and after DMEK surgery were compared using anterior and posterior keratometry and True Net Power (TNP) in corneal tomography (Pentacam, Oculus). The differences in magnitude of astigmatism and axis of steep meridian were calculated by algebraic and vectorial methods, and significant differences to specified thresholds were determined by the non-parametric Wilcoxon rank test.Results: Surgically induced changes (SIC) in magnitude of astigmatism at anterior surface, posterior surface and TNP were -1.4dpt ± 3.7, -0.2dpt ± 0.8 and -1.3dpt ± 3.9, respectively. No significant changes in astigmatism and axis difference by algebraic method in comparison with a hypothetical median of 0dpt and 10° were observed. Calculation of astigmatism difference by vectorial method showed a significant deviation in anterior surface (observed median = 4.4dpt, p < 0.001), posterior surface (observed median 1.0dpt, p = 0.012) and TNP (observed median = 3.6dpt, p < 0.001).Conclusion: Even if no significant change in magnitude and axis of astigmatism to acceptable thresholds could be shown after DMEK in failed PK using the algebraic method, there is a significant and relevant change in magnitude of astigmatism using the vectorial calculation. Based on these results, caution is advised when using toric intraocular lenses in PK eyes, as astigmatic change is expected when performing DMEK on eyes with failed PK.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146155654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between central serous chorioretinopathy and personality types: A systematic review and meta-analysis. 中枢性浆液性脉络膜视网膜病变与人格类型的关系：一项系统回顾和荟萃分析。

IF 2.8 3区医学

Acta Ophthalmologica Pub Date : 2026-02-11 DOI: 10.1111/aos.70097

Emil Ørnberg, Victor Bruun, Younes Subhi, Rodrigo Anguita, Lasse J Cehofski, Lorenzo Ferro Desideri, Elon H C van Dijk, Michael S Hansen, Oliver N Klefter, Danson V Muttuvelu, Line Petersen, M Cem Sabaner, Miklos Schneider, M Orkun Sevik, Yousif Subhi

{"title":"Association between central serous chorioretinopathy and personality types: A systematic review and meta-analysis.","authors":"Emil Ørnberg, Victor Bruun, Younes Subhi, Rodrigo Anguita, Lasse J Cehofski, Lorenzo Ferro Desideri, Elon H C van Dijk, Michael S Hansen, Oliver N Klefter, Danson V Muttuvelu, Line Petersen, M Cem Sabaner, Miklos Schneider, M Orkun Sevik, Yousif Subhi","doi":"10.1111/aos.70097","DOIUrl":"https://doi.org/10.1111/aos.70097","url":null,"abstract":"In this study, we systematically review and synthesize the evidence on the association between central serous chorioretinopathy (CSC) and personality types, and quantify the relationship between Type A behaviour and CSC. We systematically searched 12 literature databases on 5 October 2025 for studies in which personality types were evaluated in patients with CSC. Data extraction and risk-of-bias assessment followed standardized protocols. Studies were reviewed qualitatively. Random-effects meta-analysis was performed for the association between Type A behaviour and CSC. Twelve studies of 2176 participants (949 patients with CSC, 1227 controls) were included. Across studies, patients with CSC exhibited personality profiles marked by time urgency, competitiveness, emotional tension and maladaptive affect regulation, including higher neuroticism-anxiety, aggression-hostility and alexithymia scores. A significant association was found between Type A behaviour and CSC (pooled OR 3.43; 95% CI 1.94-6.07; p = 0.00002) in the four studies that evaluated this relationship. Sensitivity analysis confirmed robustness of the association. In conclusion, certain personality traits, particularly Type A behaviour, are associated with CSC. The relationship between personality and CSC appears biologically plausible given the role of stress-related hypothalamic-pituitary-adrenal axis activation and elevated cortisol levels, both recognized in CSC pathophysiology. However, complex biopsychosocial interactions without a direct causal pathway may also be the case. Understanding psychological predispositions may contribute to a more comprehensive view of CSC risk and care. Further longitudinal and mechanistic studies are warranted.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146155646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-physician delivered intravitreal injection service: A systematic review of safety, implementation, training and patient experience. 非医师提供的玻璃体内注射服务：安全性、实施、培训和患者经验的系统回顾。

IF 2.8 3区医学

Acta Ophthalmologica Pub Date : 2026-02-11 DOI: 10.1111/aos.70104

Trang Truong Laursen, Haris Bralic, Jakob Grauslund, Yousif Subhi, Lonny Stokholm

{"title":"Non-physician delivered intravitreal injection service: A systematic review of safety, implementation, training and patient experience.","authors":"Trang Truong Laursen, Haris Bralic, Jakob Grauslund, Yousif Subhi, Lonny Stokholm","doi":"10.1111/aos.70104","DOIUrl":"https://doi.org/10.1111/aos.70104","url":null,"abstract":"The global demand for intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy continues to rise, straining ophthalmic capacity worldwide. Task shifting from physicians to trained non-physician healthcare professionals has emerged as a potential strategy to expand service delivery. This systematic review summarizes current evidence on the safety, implementation, training and patient experiences associated with non-physician-delivered intravitreal injection services. We systematically searched 13 scientific literature databases for studies of anti-VEGF injections performed by non-physicians. Data were extracted on safety outcomes, implementation, training, supervision and patient-reported experience. Results from individual studies were qualitatively reviewed according to these four organizational themes. Sixteen studies comprising 100 150 injections were included, primarily from the United Kingdom and Scandinavia. All injectors completed structured training under an ophthalmologist's supervision. Complication rates were very low, including 0.015%-0.07% for endophthalmitis which were comparable to physician-led benchmarks. Implementation of non-physician-delivered intravitreal injection services increased clinical capacity by 25%-85%, reduced waiting times and costs, and maintained safety and efficiency. Patients reported high satisfaction, confidence and acceptance of non-physician-delivered injections. Non-physician-delivered intravitreal injection services are safe, feasible and well accepted when supported by structured training and robust governance frameworks. This task-shifting model offers a scalable solution to meet growing global demand for anti-VEGF therapy. Standardized international training and certification frameworks may further enhance safety and sustainability.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146155685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relearning Bradford Hill through our final patient in the Tenecteplase in Central Retinal Artery Occlusion Study. 重新学习布拉德福德希尔通过我们的最后一个病人在Tenecteplase视网膜中央动脉闭塞研究。

IF 2.8 3区医学

Acta Ophthalmologica Pub Date : 2026-02-11 DOI: 10.1111/aos.70107

Øystein Kalsnes Jørstad, Stephen James Ryan, Morten Carstens Moe, Anne Hege Aamodt

引用次数: 0

Rapid corneal endothelial cell loss following PreserFlo MicroShunt implantation. PreserFlo MicroShunt植入后角膜内皮细胞快速丢失。

IF 2.8 3区医学

Acta Ophthalmologica Pub Date : 2026-02-10 DOI: 10.1111/aos.70096

Suzu Deie, Kikuno Hirose, Taro Baba, Naoki Okada, Kana Tokumo, Atsuhiko Fukuto, Tai-Ichiro Chikama, Hirokazu Sakaguchi, Kazuyuki Hirooka

引用次数: 0

Outer nuclear layer hyperreflectivity as an optical coherence tomography finding in Danon disease. Danon病的外核层高反射率光学相干断层扫描发现。

IF 2.8 3区医学

Acta Ophthalmologica Pub Date : 2026-02-10 DOI: 10.1111/aos.70098

Maria Emfietzoglou, Gustavo Sakuno, Sandra Hoyek, Daniel M Vu, Jason Comander, John B Miller, Srinivas R Sadda, Nimesh A Patel, Demetrios G Vavvas

{"title":"Outer nuclear layer hyperreflectivity as an optical coherence tomography finding in Danon disease.","authors":"Maria Emfietzoglou, Gustavo Sakuno, Sandra Hoyek, Daniel M Vu, Jason Comander, John B Miller, Srinivas R Sadda, Nimesh A Patel, Demetrios G Vavvas","doi":"10.1111/aos.70098","DOIUrl":"https://doi.org/10.1111/aos.70098","url":null,"abstract":"Purpose: To describe an optical coherence tomography (OCT) finding that is highly prevalent in Danon disease.Methods: Retrospective observational case series at a single centre, combined with a systematic literature review of PubMed and EMBASE for genetically confirmed Danon disease patients with available macular OCT images. Fifty-two macular OCT scans from 29 genetically confirmed Danon disease patients (5 from our institution; 24 from 11 published studies) were included. For each patient, a single foveal-centred macular OCT scan per eye was selected for analysis. Two independent reviewers assessed images for the presence of outer nuclear layer (ONL) hyperreflectivity, with discrepancies resolved by consensus.Results: Evidence of ONL hyperreflectivity appeared in 39 macular scans (75%). Of the 13 scans without this finding (25%), 10 scans (19%) showed macular atrophy (including bull's-eye maculopathy cases) or cystoid macular oedema that obscured evaluation of outer retinal layers at the fovea, and two scans (4%) used colour-encoded OCT that prevented reliable evaluation of the ONL. In only one scan (2%), ONL hyperreflectivity was absent despite preserved foveal architecture and adequate image quality.Conclusion: ONL hyperreflectivity is a highly prevalent OCT finding in Danon disease, most evident in young patients without advanced outer retinal atrophy. This feature may serve as a non-invasive finding of early retinal involvement. Longitudinal studies are warranted to confirm its prognostic value.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146148704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visual outcome after vitrectomy for small idiopathic macular hole: Results from the Small idiopathic MAcuLar hoLe (SMALL) study. 小特发性黄斑孔玻璃体切除术后的视力结果：来自小特发性黄斑孔（small）研究的结果。

IF 2.8 3区医学

Acta Ophthalmologica Pub Date : 2026-02-10 DOI: 10.1111/aos.70077

Matteo Fallico, Paolo Caselgrandi, Paola Marolo, Guglielmo Parisi, Enrico Borrelli, Luca Ceroni, Michele Reibaldi

{"title":"Visual outcome after vitrectomy for small idiopathic macular hole: Results from the Small idiopathic MAcuLar hoLe (SMALL) study.","authors":"Matteo Fallico, Paolo Caselgrandi, Paola Marolo, Guglielmo Parisi, Enrico Borrelli, Luca Ceroni, Michele Reibaldi","doi":"10.1111/aos.70077","DOIUrl":"https://doi.org/10.1111/aos.70077","url":null,"abstract":"Purpose: To investigate visual outcomes after surgery for small idiopathic full-thickness macular holes (FTMHs) exploring associated clinical variables.Methods: Multicentre, retrospective study including eyes with FTMH ≤250 μm treated with anatomically successful vitrectomy with a 12-month follow-up. The primary outcome was the incidence rate of normal vision outcome, defined as a postoperative best-corrected visual acuity (BCVA) ≤0.1 logMAR and to explore clinical variables associated with it. Rates of suboptimal visual outcome (final BCVA >0.3 logMAR) and intermediate visual outcome (final BCVA >0.1 and ≤0.3 logMAR) were considered as secondary outcomes along with associated clinical variables.Results: Of 539 included eyes, 219 eyes (40.6%) achieved a normal vision outcome. An intermediate visual outcome was shown in 205 eyes (38%) and a suboptimal visual outcome in 115 eyes (21.3%). Vitrectomy with conventional internal limiting membrane (ILM) peeling was performed in 308 eyes (57%), while an inverted flap technique was used in 193 eyes (36%). Thirty-eight eyes (7%) underwent vitrectomy without ILM peeling. Clinical variables associated with normal vision were a better preoperative BCVA and conventional ILM peeling. No ILM peeling vitrectomy proved to be a factor associated with normal vision. Inverted flap technique and a worse preoperative BCVA were associated with suboptimal visual outcome.Conclusion: Surgical treatment of small FTMHs has to be recommended since an excellent final visual outcome has been shown in 40% of cases. Vitrectomy with conventional ILM peeling should be considered the treatment of choice, while the inverted flap technique would not be advisable. Further studies are needed to confirm the role of vitrectomy without ILM peeling.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146148791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroeconomics and myopia prevention: A framework for public health intervention. 神经经济学与近视预防：公共卫生干预的框架。

IF 2.8 3区医学

Acta Ophthalmologica Pub Date : 2026-02-10 DOI: 10.1111/aos.70100

Dan-Lin Li, Ting-Han Guo, Andrzej Grzybowski, Chen-Wei Pan

{"title":"Neuroeconomics and myopia prevention: A framework for public health intervention.","authors":"Dan-Lin Li, Ting-Han Guo, Andrzej Grzybowski, Chen-Wei Pan","doi":"10.1111/aos.70100","DOIUrl":"https://doi.org/10.1111/aos.70100","url":null,"abstract":"Aims to outline the application of neuroeconomics in paediatric myopia prevention, offering a framework for designing public health interventions that target decision-making mechanisms such as intertemporal choice, social preferences and neurohormonal regulation. We synthesized theories and empirical evidence from neuroeconomics, psychology and neuroscience. Multimodal approaches-including behavioural tasks (e.g. delay discounting, Ultimatum Game), functional near-infrared spectroscopy (fNIRS), pupillometry and salivary assays-were used to evaluate how interventions influence neurocognitive processes. Neuroeconomic research reveals that myopia-related behaviours involve neural competition between impulsive and regulatory systems, temporal discounting of future rewards and modulation by social norms and neurohormones (e.g. dopamine, oxytocin). Intervention strategies incorporating immediate incentives, social normative feedback, environmental nudges and reduced cognitive effort show potential in promoting outdoor time and behaviour change. Neuroeconomics provides a novel framework for myopia prevention by targeting neural computation mechanisms. Future research should focus on cross-cultural and developmental validation while addressing ethical and implementation challenges to advance precise and equitable public health strategies.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146148701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0