Exploring ocular fundus morphology in relation to growth in adolescents born moderate-to-late preterm.

IF 2.8 3区医学 Q1 OPHTHALMOLOGY

Acta Ophthalmologica Pub Date : 2025-10-03 DOI:10.1111/aos.70011

Alexandra Lind, Sara Ali, Titus Ovik, Zoran Popovic, Eva Aring, Jovanna Dahlgren, Marita Andersson Grönlund

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引用次数: 0

Abstract

Purpose: To study ocular fundus morphology and its relation to growth in adolescents born moderate-to-late preterm (MLP) and full term.

Methods: This prospective and population-based cohort study included 50 MLP adolescents (26 girls, mean age 16.5 years) and 50 full-term controls (30 girls, mean age 16.7 years). Optical coherence tomography measurements were studied in relation to gestational age, auxological data, insulin-like growth factor-I (IGF-I) and IGF-binding protein 3 (IGFBP-3).

Results: The MLP group showed an increased central macular retinal thickness (MRT) compared with controls in right eye (RE) (249.7 ± 21.0 vs. 239.9 ± 16.4 μm, p = 0.019). Moreover, the MLP group showed a thinner total peripapillary retinal nerve fibre layer (ppRNFL) thickness in RE (104.3 ± 8.5 vs. 109.1 ± 8.3, p = 0.0011). Nasal ppRNFL thickness was thinner in both RE (79.4 ± 13.2 vs. 85.0 ± 10.8, p = 0.0012) and left eye (LE) (77.0 ± 13.8 vs. 81.7 ± 13.4, p = 0.025) compared with controls. A weak association between total ppRNFL thickness and IGF-I levels was found (RE, r = 0.28, p = 0.032; LE, r = 0.27, p = 0.048), as well as between central MRT and a ratio between IGF-I and IGFBP-3 levels (RE, r = 0.30, p = 0.022). Additionally, there was a correlation between optic cup/disc area ratio and birth weight (RE: r = -0.44, p = 0.0006; LE: r = -0.30, p = 0.026).

Conclusion: The present study suggests that growth and MLP birth may impact ocular fundus morphology. The MLP adolescents were shown to have thinner ppRNFL thickness and greater MRT, compared with full-term controls. Furthermore, a weak association between these structures and growth factors was found. In addition, the current study proposes that birth weight may impact optic disc parameters.

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探讨中度至晚期早产青少年眼底形态与生长的关系。

目的：研究中晚期早产儿和足月青少年的眼底形态及其与生长发育的关系。方法：这项前瞻性和基于人群的队列研究包括50名MLP青少年（26名女孩，平均年龄16.5岁）和50名足月对照（30名女孩，平均年龄16.7岁）。研究了光学相干断层扫描测量与胎龄、生理数据、胰岛素样生长因子- i （IGF-I）和胰岛素样生长因子结合蛋白3 （IGFBP-3）的关系。结果：与对照组相比，MLP组右眼中央黄斑视网膜厚度（MRT）增加（249.7±21.0 μm vs. 239.9±16.4 μm, p = 0.019）。此外，MLP组视网膜乳头周围神经纤维层（ppRNFL）总厚度更薄（104.3±8.5∶109.1±8.3,p = 0.0011）。鼻部ppRNFL厚度在RE组（79.4±13.2比85.0±10.8,p = 0.0012）和LE组（77.0±13.8比81.7±13.4,p = 0.025）较对照组均较薄。发现ppRNFL总厚度与IGF-I水平之间存在弱相关性（RE, r = 0.28, p = 0.032； LE, r = 0.27, p = 0.048），中心MRT与IGF-I和IGFBP-3水平之比之间存在弱相关性（RE, r = 0.30, p = 0.022）。视神经杯/视神经盘面积比与出生体重有相关性（RE: r = -0.44, p = 0.0006; LE: r = -0.30, p = 0.026）。结论：生长发育和MLP出生可能影响眼底形态。与足月对照组相比，MLP青少年的ppRNFL厚度更薄，MRT更高。此外，发现这些结构与生长因子之间存在弱关联。此外，目前的研究提出，出生体重可能会影响视盘参数。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Ophthalmologica 医学-眼科学

CiteScore

7.60

自引率

5.90%

发文量

433

审稿时长

6 months

期刊介绍： Acta Ophthalmologica is published on behalf of the Acta Ophthalmologica Scandinavica Foundation and is the official scientific publication of the following societies: The Danish Ophthalmological Society, The Finnish Ophthalmological Society, The Icelandic Ophthalmological Society, The Norwegian Ophthalmological Society and The Swedish Ophthalmological Society, and also the European Association for Vision and Eye Research (EVER). Acta Ophthalmologica publishes clinical and experimental original articles, reviews, editorials, educational photo essays (Diagnosis and Therapy in Ophthalmology), case reports and case series, letters to the editor and doctoral theses.