Acta Ophthalmologica最新文献

{"title":"Visual acuity, amblyopia and refractive error in preterm children with and without retinopathy of prematurity - Results from the Gutenberg Prematurity Study Young (GPSY).","authors":"Achim Fieß, Sandra Gißler, Alica Hartmann, Eva Mildenberger, Heike Elflein, Panagiotis Laspas, Christina Korb, Bernhard Stoffelns, Norbert Pfeiffer, Stephanie Grabitz, Alexander K Schuster","doi":"10.1111/aos.17515","DOIUrl":"https://doi.org/10.1111/aos.17515","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to assess visual outcomes in children born preterm, stratified by gestational age, hypo- and hypertrophy, and the presence of retinopathy of prematurity (ROP) and its treatment.</p><p><strong>Methods: </strong>This is a prospective observational cohort study (n = 949, 1889 eyes) assessing visual acuity, amblyopia, refractive error, and lens opacifications in a large sample of children born preterm and full-term aged 4-17 years. Covariates included gestational age, birth weight percentile, ROP status and treatment, maternal smoking, placental insufficiency, preeclampsia, breastfeeding, and perinatal adverse events with an adjustment for sex and age. Logistic regression analysis was conducted to evaluate associations.</p><p><strong>Results: </strong>Amblyopia prevalence was mainly associated with a gestational age ≤ 28 weeks (OR = 2.92, p = 0.03), placental insufficiency (OR = 3.84, p = 0.01), and ROP treatment (OR = 15.71, p ≤ 0.001). Distant corrected visual acuity (DCVA) in the better eye was significantly correlated with gestational age (ρ = -0.083; p = 0.01), birth weight (ρ = -0.096; p = 0.004), birth weight percentile (ρ = -0.064; p = 0.05), ROP (ρ = 0.13; p <0.001), ROP treatment (ρ = 0.21; p <0.001), and perinatal adverse events (ρ = 0.135; p <0.001). The spherical equivalent was associated only with ROP treatment [β = -2.91, p < 0.001]. Lens opacifications were significantly larger in the group treated for ROP (p ≤ 0.01).</p><p><strong>Conclusions: </strong>This study highlights that perinatal factors associated with prematurity affect visual acuity and refractive error as well as the development of amblyopia in children. Mainly, extreme prematurity ≤28 weeks as well as ROP and its treatment are the most important factors affecting visual development.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of retinal function and macular structure after 27G pars plana vitrectomy with minimal heads-up versus standard illumination in patients with idiopathic epiretinal membranes: A pilot randomized study.","authors":"Wojciech Lubiński, Tomasz Charabin, Karolina Podborączyńska-Jodko, Maciej Mularczyk, Ewelina Lachowicz-Gosławska","doi":"10.1111/aos.17526","DOIUrl":"https://doi.org/10.1111/aos.17526","url":null,"abstract":"<p><strong>Purpose: </strong>To analyse the clinical benefits of using the NGENUITY 3D Visualization System in vitreoretinal surgery with low levels of endoillumination, focusing on functional and structural retinal protection in patients with idiopathic epiretinal membranes (ERM).</p><p><strong>Design: </strong>Prospective, randomized, comparative study.</p><p><strong>Methods: </strong>Forty pseudophakic patients (29♀, 11♂; age 60-80 years) with ERM underwent 27G pars plana vitrectomy (PPV) and were randomly divided into two groups: Group I (20 eyes, 3D heads-up NGENUITY system, endoillumination 0.5 Lm) and Group II (20 eyes, standard microscope [Hi-R 900], endoillumination 3.2 Lm). Preoperative and 6-months postoperative evaluations included slit-lamp examination, intraocular pressure (IOP, Pascal tonometer), Distance Best Corrected Visual Acuity (DBCVA, logMAR), Central Subfoveal Thickness (CST), Retinal Nerve Fibre Layer Thickness (RNFL, OCT), Pattern ERG (PERG), multifocal ERG (mfERG), flash ERG (ERG, ISCEV standards), and retinal sensitivity (HFA macula test). Surgery time, xenon light exposure, ERM/ILM peeling time, fundus autofluorescence (FAF), metamorphopsia incidence, and intra-/postoperative adverse events were analysed. Results were statistically evaluated (p < 0.05).</p><p><strong>Results: </strong>Slit-lamp examination and IOP results were normal in both groups. DBCVA improved significantly (p = 0.005) in both groups but was better for Group I, albeit not statistically significant. CST and RNFL thickness decreased significantly in both groups (p = 0.01) and did not differ between them. In Group I, increased cone and ganglion cell function was registered, with PERG showing significantly higher increases in P50 and N95 wave amplitudes (p = 0.01) compared with Group II. In mfERG, an increase in P1-wave response density in Ring 1 (p = 0.01) was observed only in Group I. In ERG, Group I showed better rod (Ab, p = 0.04), cone (Aa, p = 0.03), and amacrine cell (scotopic OPS ∑A01 + A02 + A03, p = 0.02) function compared with Group II. Foveal threshold in the HFA macula test increased significantly only in Group I (p = 0.03). No significant differences were found in autofluorescence results, surgery times, xenon light exposure, or ERM and ILM peeling times between groups. Postoperatively, the frequency of absent or reduced severity of metamorphopsia was higher in Group I (71.4%) compared with Group II (61.5%). No intraoperative or postoperative adverse events occurred.</p><p><strong>Conclusion: </strong>Our preliminary results suggest that in patients with idiopathic ERM, 6 months after PPV using the NGENUITY 3D system with low levels of endoillumination, better retinal function was achieved compared with the standard PPV procedure, possibly due to reduced retinal phototoxicity. Further long-term studies are necessary to confirm that conclusion.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of a deep learning model for the automated detection and quantification of cystoid macular oedema on optical coherence tomography in patients with retinitis pigmentosa.","authors":"Hind Almushattat, Jonathan Hensman, Yasmine El Allali, Coen de Vente, Clara I Sánchez, Camiel J F Boon","doi":"10.1111/aos.17518","DOIUrl":"https://doi.org/10.1111/aos.17518","url":null,"abstract":"<p><strong>Purpose: </strong>Accurate assessment of cystoid macular oedema (CMO) in patients with retinitis pigmentosa (RP) on spectral-domain optical coherence tomography (SD-OCT) is crucial for tracking disease progression and may serve as a therapeutic endpoint. Manual CMO segmentation is labour-intensive and prone to variability, making artificial intelligence (AI) an appealing solution to improve accuracy and efficiency. This study aimed to validate a deep learning (DL) model for automated CMO detection and quantification on SD-OCT scans in patients with RP.</p><p><strong>Methods: </strong>A segmentation model based on the no-new-Unet (nnU-Net) architecture was trained on 112 OCT volumes from the RETOUCH dataset (70 for training, 42 for validation). The model was externally tested on 37 SD-OCT scans from RP patients, with annotations from three expert graders. Performance was assessed using the Dice similarity coefficient and intraclass correlation coefficient (ICC).</p><p><strong>Results: </strong>For randomly selected central B-scans, the model achieved a mean Dice score of 0.889 ± 0.002 standard deviation (SD), while observers scored 0.878 ± 0.007 SD. The ICC for the model was 0.945 ± 0.014 SD, compared to 0.979 ± 0.008 SD for observers. On manually chosen central B-scans, Dice scores were 0.936 ± 0.005 SD for the model and 0.946 ± 0.012 SD for observers, with ICC values of 0.964 ± 0.011 SD and 0.981 ± 0.011 SD, respectively.</p><p><strong>Conclusions: </strong>This DL model reliably segments CMO in RP, achieving performance comparable to human graders. It can enhance the efficiency and precision of CMO quantification, reducing variability in clinical practice and trials.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual acuity outcomes up to 12 years and risk factors for visual impairment in a national cohort of extremely preterm born children - The Extremely Preterm Infants in Sweden Study (EXPRESS).","authors":"Despoina Tsamadou, Karin Källén, Abbas Al-Hawasi, Ann Hellström, Gerd Holmström, Fatima Pedrosa-Domellöf, Kristina Tornqvist, Ulrika Kjellström, Lisa B Thorell, Lena Hellström-Westas, Andreas Ohlin, Ulrika Ådén, Kerstin Hellgren","doi":"10.1111/aos.17525","DOIUrl":"https://doi.org/10.1111/aos.17525","url":null,"abstract":"<p><strong>Purpose: </strong>The Extremely Preterm Infants in Sweden Study (EXPRESS) followed a national cohort of extremely preterm born (EPT, i.e. <27 weeks) children until 12 years of age. This study aimed to investigate the longitudinal development of visual acuity (VA) in children born EPT, explore the predictive value of early visual assessments, and evaluate risk factors for visual impairment at the age of 12 years.</p><p><strong>Methods: </strong>All 462 children born EPT in Sweden during April 2004-March 2007, and surviving to age 6.5 years, and full-term born matched controls were invited to participate in the 12-year follow-up. VA was assessed at 12 years and the results were compared with values at 2.5 and 6.5 years.</p><p><strong>Results: </strong>At age 12, 332 (72%) EPT survivors and 189 controls were examined. The mean VA in the EPT group was lower than in the control group (1.15, 95%CI [1.12-1.19] vs. 1.33, 95% CI [1.29-1.37]). Fifteen (4.5%) EPT had visual impairment. The examination at age 2.5 failed to identify most of them, while the examination at 6.5 could predict the final visual outcome at 12. Risk factors for visual impairment were low gestational age, moderate and severe intraventricular haemorrhage, treatment-requiring retinopathy of prematurity, cerebral palsy, and cognitive disability.</p><p><strong>Conclusion: </strong>In this national cohort, the VA outcome at age 12 was lower in children born EPT than full-term controls. As eye examination at 2.5 years did not reliably identify visual impairment, clinical risk factors should be considered in the screening of children born EPT to early identify the visually impaired.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progression and topographic subtypes of Terrien marginal degeneration.","authors":"Minna Ruutila, Pauliina Repo, Annamari T Immonen, Joni A Turunen, Marja-Liisa Lokki, A Inkeri Lokki, Jukka Moilanen, Kari Krootila, Tero T Kivelä","doi":"10.1111/aos.17524","DOIUrl":"https://doi.org/10.1111/aos.17524","url":null,"abstract":"<p><strong>Purpose: </strong>To report long-term outcomes and to search for immunological and genetic risk factors in Terrien marginal degeneration (TMD).</p><p><strong>Methods: </strong>Retrospective, in part prospective, hospital-based longitudinal follow-up study of 32 eyes of 16 Finnish patients from 2012 to 2023. Median follow-up was 7.3 years (range, 0.3-15.2). Symptoms, best corrected visual acuity, pattern in axial power map, astigmatism, corneal thickness, higher order irregularity, cavities, progression and human leukocyte antigen genes were analysed. In 13 blood samples, 483 corneal and inflammatory disease-related genes were analysed with exome sequencing.</p><p><strong>Results: </strong>The median age at first examination was 61 years (range, 13-89). Eleven (69%) patients were male, and 13 (81%) had bilateral disease. The median annual rate of progression of topographic astigmatism and new thinning was 0.03 D (range, -1.50 to 3.60) and 12.9 μm (range, -107.8 to 93.0), respectively; 0.15 D (range -1.50 to 1.17) and 21.6 μm (range, 1.3-93.0) in 6 (38%) patients with fast progression, and 0.02 D (range, -0.06 to 3.60) and 4.1 μm (range, -107.8 to 24.7) in 10 (72%) patients with slow progression. Topographic pattern, unilaterality, cavities, sectoral hyperaemia, poor response to medical treatment and new thinning after surgery were associated with fast progression. Thickness at maximal thinning fell below 450 μm only with fast progression. Five eyes changed the topographic pattern. Coexisting keratitis fugax hereditaria was found in one patient.</p><p><strong>Conclusions: </strong>A subtype of TMD progresses faster. The most sensitive indicators of progression were thinning and topographic astigmatism. No shared genetic cause for TMD was identified.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic diversity of Acanthamoeba and clinical outcome predictors in Danish patients with Acanthamoeba keratitis.","authors":"Sandra M Skovdal, Christen Rune Stensvold, Henrik Vedel Nielsen, Stine Elkjær Nielsen, Jesper Hjortdal, Anders Ivarsen","doi":"10.1111/aos.17527","DOIUrl":"https://doi.org/10.1111/aos.17527","url":null,"abstract":"<p><strong>Purpose: </strong>Acanthamoeba keratitis (AK) is a severe corneal infection with potential detrimental effects on visual outcome and quality of life, primarily affecting young contact lens wearers. We report Acanthamoeba genotypes, subtypes and clinical outcome from Danish patients with AK.</p><p><strong>Methods: </strong>Thirty-nine PCR-positive AK cases diagnosed and treated at Aarhus University Hospital, Denmark, from 2002 to 2022 were included. Corneal samples underwent next-generation sequencing (NGS) for Acanthamoeba genotyping. These data were compared with clinical data and results from PCR.</p><p><strong>Results: </strong>Acanthamoeba T4 was the most frequent genotype (n = 35), with four subtypes identified (T4A, T4B, T4D and T4G); three cases of the T3 genotype were observed. Three samples showed evidence of two distinct Acanthamoeba sequences. The median patient age was 35 years, genders were equally represented and the median time from symptom onset to diagnosis was 26 days. Ninety per cent had identifiable risk factors in addition to contact lens wear. Corticosteroid treatment prior to AK diagnosis, moderate-to-severe pain, male gender, older age, ring infiltration and infiltrate size >3 mm were associated with poor visual outcome. No significant correlation was found between Acanthamoeba genotype or subtype and clinical outcomes.</p><p><strong>Conclusion: </strong>We reveal the genetic diversity of Acanthamoeba involved in AK in Denmark. However, genotype or subtype did not predict clinical outcome. Further research is needed to clarify the role of specific genotypes and subtypes in disease progression and treatment response.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet and myopic macular degeneration in the Aier-SERI high myopia adult cohort study.","authors":"Kai-Xiong Cheong, Meible Chi, Wei Pan, Yu-Qi Lee, Yijia Zhang, Ziqi Hu, Hla Myint Htoon, Quan V Hoang, Mary Foong-Fong Chong, Weizhong Lan, Seang-Mei Saw, Ecosse L Lamoureux","doi":"10.1111/aos.17528","DOIUrl":"https://doi.org/10.1111/aos.17528","url":null,"abstract":"<p><strong>Purpose: </strong>We investigated relationships between two dietary composite scores and myopic macular degeneration (MMD) in a high myopia adult cohort, as there is a knowledge gap regarding the role of diet in MMD.</p><p><strong>Methods: </strong>This is a cross-sectional analysis of a population-based prospective cohort, the Aier-Singapore Eye Research Institute (SERI) high myopia cohort study of Chinese adults, in Changsha, central China. Systemic and ocular (including cycloplegic spherical equivalent [SE] and axial length [AL]) assessments were carried out. A self-administered food frequency questionnaire was used to assess the dietary intake. Dietary intake was categorised into 13 food groups (refined grains, whole grains, meat, fish, processed/unhealthy meat, plant-based protein, fruits, vegetables, fast food and savoury snacks, dairy products, desserts and sweet snacks, sugar-sweetened beverages, and alcohol). Using exploratory factor analysis, two dietary patterns (Dietary Pattern 1 [less healthy] and 2 [healthier]) were identified. Multivariable logistic regression analyses with Bonferroni corrections were performed to assess associations between diet and MMD.</p><p><strong>Results: </strong>Of 445 participants, 71 (16.0%) had MMD. The participants had an overall mean age of 42.3 ± 7.3 years, SE of -9.5 ± 4.3 dioptres (D) and AL of 27.3 ± 11.86 mm. In the multivariable analyses, none of the 13 food groups (p > 0.004 for all) or 2 dietary patterns (p > 0.05 for both) were associated with MMD, after adjusting for age, sex, education, SE and AL.</p><p><strong>Conclusion: </strong>We did not find associations between diet and MMD in a cohort of highly myopic adults. There is currently no dietary advice to prevent MMD. Larger and prospective studies conducted over multiple time points are required.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outsourced eye care in the Finnish capital region: Switching from fee-for-service to bundled payment model.","authors":"Susanna Moisander, Jukka Ari Olavi Moilanen, Hans Henrik Konstantin Backström, Olga Marjasova, Marko Juhani Myöhänen, Taina Pauliina Nykänen, Mikko Juhani Pietilä, Paulus Torkki","doi":"10.1111/aos.17523","DOIUrl":"https://doi.org/10.1111/aos.17523","url":null,"abstract":"<p><strong>Purpose: </strong>The demand for specialised eye care has quadrupled over the last two decades, driven by an aging population and the advent of new treatments. This surge has led to increased outsourcing by the Helsinki and Uusimaa Hospital District (HUS) Eye Hospital, initially relying on a fee-for-service model. This model, however, has been marked by excessive bureaucracy and transaction costs. Between 2019 and 2021, HUS Eye Hospital embarked on a comparative analysis of outsourcing models to identify the most cost-effective, efficient and suitable approach.</p><p><strong>Methods: </strong>After the review of literature and stakeholder interviews, three different outsourcing models were assessed: fee-for-service, capitation and bundled payment. The models were evaluated against each other and HUS insourcing using SWOT analysis, custom-made evaluation matrices and cost analysis.</p><p><strong>Results: </strong>The evaluation identified bundled payments as the most promising model for HUS eye care outsourcing. Under this model, patients diagnosed with or suspected of having eye diseases are referred to external service providers for a predetermined period, encompassing follow-up and treatment, with providers receiving a fixed payment for each assigned patient.</p><p><strong>Conclusion: </strong>Determining the optimal outsourcing model for HUS Eye Hospital was a complex process and necessitated the development of a new quality control system. The selection of bundled payment as the preferred method required an adaptation of it to the national requirements and legislation. While bundled payments have been successfully implemented in other medical specialties, their application in ophthalmology is novel, with forthcoming data from HUS Eye Hospital expected to shed further light on its effectiveness.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Jackknife and bootstrapping resampling techniques to evaluate the precision of lens formula constants.","authors":"Achim Langenbucher, Jascha Wendelstein, Alan Cayless, Thomas Olsen, Peter Hoffmann, Nóra Szentmáry","doi":"10.1111/aos.17522","DOIUrl":"https://doi.org/10.1111/aos.17522","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to develop a method for evaluating intraocular lens (IOL) formula constant uncertainties using two modern statistical techniques-jackknife and bootstrap resampling.</p><p><strong>Methods: </strong>Using two datasets (dataset 1: 888 eyes treated with the aberration correcting Hoya Vivinex IOL, dataset 2: 821 eyes with the spherical Alcon SA60AT/SN60AT IOL), formula constant uncertainties for the SRK/T (Aconst), Hoffer-Q (pACD), Holladay 1 (SF), simplified Haigis (a0) with preset a1/a2, Haigis (triplet a0/a1/a2), Castrop (triplet C/H/R) and Olsen formula (ACD) were evaluated. All input parameters were jackknife and bootstrap (N_B = 1000) resampled, and formula constants for each sample derived using nonlinear iterative optimisation techniques.</p><p><strong>Results: </strong>In single constant formulae where the constant acts directly on the effective lens position (Hoffer-Q, Holladay 1, simplified Haigis, Olsen), the formula constant in each case showed a standard deviation (SD) of about 0.01 with both jackknife and bootstrap sampling. The SRK/T Aconst showed a SD of about 0.018, and the Haigis and Castrop formulae with constant triplets showed large variations in the 3 constants (a0/a1/a2 about 0.036/0.005/0.002, C/H/R about 0.001/0.011/0.012). Direct formula reversion and solving for the formula constant yielded systematically larger SD values (Aconst/pACD,SF/a0/ACD = 0.586/0.395/0.403/0.324/0.304) with highly skewed distributions.</p><p><strong>Conclusion: </strong>The distributions of formula constants with relevant benchmarks such as SD or confidence intervals can be derived with jackknife and bootstrap resampling techniques, offering potential advantages over direct formula reversion which yields skewed distributions, making central metrics such as the formula constant distribution mean unsuitable for constant optimisation.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laser prophylaxis for retinal detachment in Stickler syndrome: A systematic review and meta-analysis.","authors":"David A Camp, Saaquib R Bakhsh, Ali Torkashvand, Nathan R Jensen, Ameay V Naravane, Peter J Belin, Polly A Quiram, Tsveta Ivanova, Thomas J Wubben, Cagri G Besirli, Brenda L Bohnsack, Michael J Shapiro, Michael P Blair, Amir R Hajrasouliha","doi":"10.1111/aos.17509","DOIUrl":"https://doi.org/10.1111/aos.17509","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effectiveness of laser prophylaxis in preventing retinal detachment (RD) in patients with Stickler syndrome.</p><p><strong>Methods: </strong>A literature search was performed to identify studies that compared RD rates between eyes that received laser prophylaxis and eyes that received no laser prophylaxis in patients with Stickler syndrome. Data sets from the included studies were pooled and analysed. Individual eyes that presented with RD and eyes without RD with <6 months of follow-up were excluded. The primary outcome was the rate of RD. The study was conducted in accordance with the PRISMA guideline 2020 for systematic reviews.</p><p><strong>Results: </strong>There were 6 articles included in the meta-analysis, including 400 eyes of 225 patients. RD rate was 6.6% (19 of 289) in eyes with laser compared to 36.0% (40 of 111) in eyes with no laser (p < 0.00001, chi-square) with a mean follow-up interval of 6.3 years for eyes with laser and 4.0 years for eyes with no laser. The pooled risk ratio for retinal detachment after laser prophylaxis was 0.23 (95% CI: 0.13-0.41).</p><p><strong>Conclusion: </strong>Prophylactic laser therapy was associated with a significantly lower risk of RD in patients with Stickler syndrome compared to no laser prophylaxis.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}