Acta Ophthalmologica最新文献

{"title":"Development of subfoveal nodule in Coats' disease: Prevalence, stages, prognosis, and treatment.","authors":"Murat Yüksel, Şengül Özdek, Ece Özdemir Zeydanli, H Tuba Atalay, H Baran Özdemir, C Murat Hasanreisoglu, I Gokhan Gurelik","doi":"10.1111/aos.70055","DOIUrl":"10.1111/aos.70055","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the prevalence, developmental stages, and factors affecting the progression of subfoveal nodules (SFN) in Coats' disease.</p><p><strong>Methods: </strong>A retrospective review of medical records and multimodal images was conducted for patients with Stage 2A-3A Coats' disease in a tertiary university setting. SFN development was classified into five stages: Stage 0 - macular exudation without subfoveal hard exudate; Stage 1 - subfoveal exudation; Stage 2 - consolidation of exudation; Stage 3- vascularization of SFN; Stage 4 - scarring and subfoveal fibrotic nodule. Factors influencing the formation and progression of SFN were analysed.</p><p><strong>Results: </strong>The study included 44 eyes of 43 patients, with a mean age of 6.9 ± 4.1 years and a mean follow-up of 33 months. SFN prevalence was 48% initially and 91% at final follow-up. No differences were noted in baseline demographics or clinical characteristics across SFN stages. Patients developing SFN earlier than 9 months were significantly younger than those developing in a longer period (>9 months) (5.9 ± 2.7 vs. 8.9 ± 3.6, p = 0.037), and the mean number of intravitreal (IV) anti-VEGF/steroid injections applied per year was lower in the latter group (3.69 ± 1.29 vs. 1.12 ± 1.21, p = 0.001). The risk of early SFN development was 2.4 times higher in patients under 7 years and four times higher in those receiving three or fewer IV anti-VEGF/steroid injections per year.</p><p><strong>Conclusion: </strong>The prevalence of SFN (91%) in this study was found to be higher compared with the literature. More frequent anti-VEGF/steroid injections, compared with conventional treatment, may slow the progression of SFN.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":"e858-e867"},"PeriodicalIF":3.0,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145699581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence of glaucoma intervention studies to World Glaucoma Association guidelines.","authors":"Andrea Servillo, Carlo Alberto Cutolo, Chiara Viganò, Paolo Forte, Riccardo Manocchio, Gus Gazzard, Luca Rossetti, Michele Iester, Francesco Oddone, Gianni Virgili, Stefano De Cillà, Alessandro Rabiolo","doi":"10.1111/aos.70070","DOIUrl":"10.1111/aos.70070","url":null,"abstract":"<p><strong>Objective: </strong>To assess the adherence of glaucoma surgical and laser studies to WGA guidelines for reporting glaucoma surgery studies, analyse trends in adherence over time and explore associations between adherence and study characteristics.</p><p><strong>Methods: </strong>Systematic review (PROSPERO:CRD42023394477) of glaucoma surgical and laser studies published between 2010 and 2023 in PubMed/MEDLINE and EMBASE. Eligible studies included RCTs, non-randomized comparative and prospective observational designs (>100 eyes). Two reviewers independently extracted data across five domains: Methodology, Definition of success, Ethics, Postoperative complications and Statistical reporting. Temporal trends and associations with study features were analysed using linear regression.</p><p><strong>Results: </strong>Two hundred and fifty-six studies were included, 75% of which were published in Q1-Q3 journals. Mean overall adherence was 47% ± 9.2%. Domain-level adherence was highest in Ethics (61% ± 20%), followed by Postoperative complications (50% ± 22%), Statistical reporting (48% ± 18%), Methodology (44% ± 12%) and Definition of success (30% ± 13%). No significant differences (p > 0.06) were observed in overall adherence for studies from Europe, Asia, Oceania or the Middle East. Studies involving cataract surgery for angle-closure disease (est. = -10% [-19%, -2.2%], p = 0.014) and laser trabeculoplasty (est. = -7.1% [-11%, -3.5%], p < 0.001) had lower adherence compared with trabeculectomy, while MIGS studies showed no difference (p = 0.45). Visual field progression was reported in only 3% of studies, while various anatomical outcomes (e.g. bleb morphology) were reported in 0%-24% of studies.</p><p><strong>Conclusion: </strong>Current literature shows poor adherence to WGA guidelines across both traditional and newer glaucoma surgeries, reflecting inadequate reporting and outdated recommendations. Evidence-based updates, broader consensus and stronger implementation are needed to ensure standardized and meaningful reporting.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":"e793-e802"},"PeriodicalIF":3.0,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146103373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring fundus-controlled mesopic and scotopic perimetry in inherited retinal disease.","authors":"Laura J Taylor, Amandeep S Josan, Daniel A O Adeyoju, Isabella Farrance, Robert E MacLaren","doi":"10.1111/aos.70142","DOIUrl":"10.1111/aos.70142","url":null,"abstract":"<p><strong>Purpose: </strong>Microperimetry is increasingly used as an outcome measure in clinical trials for retinal disease. This study compares mesopic and scotopic microperimetry in a heterogeneous cohort of patients with inherited retinal disease to assess their suitability as clinical trial outcome measures and to determine the most appropriate testing modality.</p><p><strong>Methods: </strong>Participants completed mesopic and scotopic microperimetry (S-MAIA) after 20 min of dark adaptation, as part of the Visual Function in Retinal Degeneration study (ISRCTN24016133). Testing was performed on both eyes (right first) without formal pupil dilation. Reliability and sensitivity performance were explored. A subset of participants (n = 23 patients and n = 16 controls) underwent repeat scotopic testing for repeatability analyses.</p><p><strong>Results: </strong>Twenty-nine participants with inherited retinal disease and 40 healthy control participants completed microperimetry testing. Mesopic microperimetry in patients and in healthy controls showed good reliability and sensitivity performance. Scotopic microperimetry in patient participants was limited by poor test reliability, reflected by a high number of test exclusions from reliability screening, and significant floor effects in measured sensitivity. In addition, scotopic microperimetry showed no greater improvement in sensitivity or specificity than mesopic microperimetry. Repeatability analyses were limited by the small sample size following elimination of unreliable tests.</p><p><strong>Conclusion: </strong>Mesopic microperimetry is recommended as a stable and reliable outcome measure. Scotopic microperimetry appears to be limited by poor reliability and floor effects in patients with inherited retinal disease. The utility of scotopic microperimetry in patients with very early disease presentation, who present with highly preserved central vision (i.e. highly preserved mesopic microperimetry), remains unexplored.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":"e832-e840"},"PeriodicalIF":3.0,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13651910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early high-dose aflibercept 8 mg clinical outcomes in wet age-related macular degeneration patients resistant to aflibercept 2 mg or faricimab.","authors":"Pinja Sutinen, Idan Hecht, Raimo Tuuminen","doi":"10.1111/aos.70213","DOIUrl":"10.1111/aos.70213","url":null,"abstract":"","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":"e885-e887"},"PeriodicalIF":3.0,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13651925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repeatability of interpolated corneal tomography maps in healthy and keratoconus corneas before and after crosslinking.","authors":"Anneli Fredriksson, Jad Hayek, Anders Behndig","doi":"10.1111/aos.70245","DOIUrl":"https://doi.org/10.1111/aos.70245","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the repeatability of interpolated Pentacam HR elevation, densitometry and anterior chamber depth (ACD) map data before and after customized corneal crosslinking (CXL) in keratoconus (KC) and healthy eyes with low-grade myopia (MY), including effects of KC severity.</p><p><strong>Methods: </strong>Participants with progressive KC or stable MY treated with CXL were included from prospective studies. Eyes lacking complete 6- and 12-month follow-up or acceptable quality Pentacam HR examinations were excluded. Repeatability was assessed descriptively and using linear mixed-effects models (LMMs) across groups and visits. KC severity analyses used baseline maximum keratometry (K_max), both continuously and categorically (KC high/low).</p><p><strong>Results: </strong>Ninety-five right eyes (36 KC, 59 MY) were included. Variability was generally low and greater in KC only in central elevation (anterior, p < 0.001; posterior, p = 0.001; LMM). Nevertheless, model-based limits for absolute differences between measurements, termed repeatability limits (RLs), did not exceed 1.66 μm (maximum visit-specific descriptive RL: 2.55 μm). Descriptive comparisons indicated greater KC variability overall, mixed 6-month changes and smaller group differences at 12 months, but LMMs showed no significant post-CXL repeatability changes. Selected parameters showed 4%-8% greater variability per 1-D increase in K_max, and several elevation parameters and central ACD were more variable in KC high than KC low.</p><p><strong>Conclusion: </strong>Interpolated Pentacam HR maps were highly repeatable, with no significant post-CXL change. Variability appeared more strongly related to KC severity than diagnosis or visit. Subsequent derivation may contribute additional variability to conventional Pentacam parameters, particularly in more advanced KC.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of visual impairment and rehabilitation measures in adults-Data from the Swedish Quality Registry for Rehabilitation in Visual Impairment.","authors":"Ulrika Kjellström, Kristina Tornqvist, Katarina Baudin, Malin Regardt, Marion Schroeder","doi":"10.1111/aos.70258","DOIUrl":"https://doi.org/10.1111/aos.70258","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the Swedish Quality Registry for Rehabilitation in Visual Impairment (SKRS) and present rehabilitation measures and underlying diagnoses of visual impairment and blindness in adults in Sweden.</p><p><strong>Methods: </strong>The study includes data from the SKRS collected between January 2016 and December 2025 for patients aged ≥20 years who received rehabilitation services from low vision centres in Sweden. The degree and underlying causes of visual impairment, as well as rehabilitation interventions, were analysed.</p><p><strong>Results: </strong>In 2025, SKRS recorded 12 622 registrations for 11 810 unique patients, with women accounting for 62%. The median waiting time from referral to first visit was 37 days. Most patients had a moderate visual impairment. In 2025, age-related macular degeneration (AMD) represented the most common diagnosis (50.2%), followed by glaucoma (18.3%), blindness of unspecified cause/visual impairment (5.9%), retinal diseases (5%), diabetic retinopathy (2.8%) and optic nerve diseases (2.2%). The most frequently registered procedure codes were in the group of assistive technology with 30.3%, followed by investigative procedures with 26.1% and follow-up with 19.9%. The proportion of International Classification of Functioning, Disability and Health based instruments had increased significantly; from 0.04% in 2016 to 72.5% in 2025. The proportion of individual rehabilitation plans had risen by 18.6% since the start of the COVID-19 pandemic-from 53.2% in 2020 to 71.8% in 2025.</p><p><strong>Conclusion: </strong>SKRS provides representative data on rehabilitation measures and associated diagnoses among adults with visual impairments in Sweden. The data confirm that AMD and glaucoma are the most common causes and highlight inequalities in access to visual rehabilitation.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149214885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of therapeutic penetrating keratoplasty and deep anterior lamellar keratoplasty in acanthamoeba keratitis: A systematic review and meta-analysis.","authors":"Gábor Tóth, Junbo Wang, Shanhe Liu, Shuailin Li, Szilárd Váncsa, Mátyás Paczkó, Tamás Kói, Péter Hegyi, Nóra Szentmáry","doi":"10.1111/aos.70257","DOIUrl":"https://doi.org/10.1111/aos.70257","url":null,"abstract":"<p><p>While acanthamoeba keratitis (AK) is a sight-threatening corneal infection, a thorough comparison of the outcomes of therapeutic penetrating keratoplasty (PK) and therapeutic deep anterior lamellar keratoplasty (DALK) is lacking. We aimed to compare clinical outcomes of PK and DALK in AK. The study was preregistered in the PROSPERO database (CRD420251233705). A comprehensive search of Embase, MEDLINE, and the Cochrane Central Register of Controlled Trials (CENTRAL) was conducted through 11 November 2025. Eligible studies reported outcomes after PK or DALK in patients with AK, specifically graft survival, best spectacle-corrected visual acuity (BSCVA) and postoperative complications. Of the 1257 studies screened, 28 studies comprising 478 eyes with AK were included in the meta-analysis. Individual participant data (IPD) were available from 11 studies. The pooled graft survival rate was significantly higher after DALK (0.90, 95% CI 0.48-0.99) than after PK (0.63, 95% CI 0.54-0.71) (p = 0.025). No significant difference was observed in either BSCVA improvement between PK (-1.00, 95% CI -1.36 to -0.64) and DALK (-1.29, 95% CI -2.30 to -0.28) (p = 0.314), or in postoperative BSCVA between PK (0.97, 95% CI 0.68 to 1.25) and DALK (0.86, 95% CI -0.02 to 1.74) (p = 0.739). Postoperative complications did not differ significantly between the two procedures (all p ≥ 0.91). DALK may provide superior graft survival compared with PK in AK, while visual and postoperative outcomes appear comparable between the two procedures. Within the observed follow-up periods, treatment delay alone was not clearly associated with visual outcomes after PK.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in glaucoma diagnosis and medical management in Germany: A nationwide claims data analysis over 10 years.","authors":"Somar M Hasan, Leonore Bovy, Maike Below, Kerstin Klimke, Alexander K Schuster, Jan Darius Unterlauft, Carl Erb, Argyrios Chronopoulos, Robert P Finger","doi":"10.1111/aos.70261","DOIUrl":"https://doi.org/10.1111/aos.70261","url":null,"abstract":"<p><strong>Purpose: </strong>Analysing longitudinal trends in recorded diagnosis and medical management of glaucoma in Germany over a 10-year period.</p><p><strong>Methods: </strong>A retrospective cohort study using nationwide outpatient claims and prescription data from the German statutory health insurance system. Patients with documented glaucoma or glaucoma suspect (ICD-10 H40.*) between 2014 and 2023 were included. Analyses assessed annual diagnosed glaucoma patients, demographic characteristics, proportions of medically treated patients and prescribing patterns of glaucoma medications. Trends in medication classes and number of active ingredients per patient were evaluated.</p><p><strong>Results: </strong>In 2014, 2 065 065 glaucoma patients were registered. Documented patient numbers increased until 2019, reaching 2 129 673 and subsequently declined after the pandemic year to 2 025 226 in 2023. Mean patient age increased from 71.0 to 72.4 years. The proportion of medically treated patients increased from 68% to 71.5% across all glaucoma subtypes, except for primary open-angle glaucoma, where it remained stable (86.2%-86.1%) and primary angle-closure glaucoma, where it decreased (68.7%-65.6%). Among treated patients, monotherapy declined from 54.8% to 46.8%, while the proportion on two medications increased from 30.7% to 33.7%, three medications from 10.3% to 12.3%, four medications from 3.2% to 4.9% and 5 or more from 1.0% to 1.9%. Among patients receiving multiple agents, fixed-combinations increased from 75.7% to 80.5%. Prescribing patterns shifted towards greater use of prostaglandin analogues and reduced use of beta-blockers.</p><p><strong>Conclusion: </strong>After increasing until 2019, the number of documented glaucoma patients in Germany declined despite an ageing population. Concurrently, treatment strategies shifted towards intensified medical therapy with greater use of multiple medications and fixed combinations, particularly prostaglandin-based regimens.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nearly doubled incidence of surgically treated primary rhegmatogenous retinal detachment in Southern Sweden, 2011-2025.","authors":"Pernilla Rosenquist, Joakim Thylefors","doi":"10.1111/aos.70250","DOIUrl":"https://doi.org/10.1111/aos.70250","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the incidence of surgically treated primary rhegmatogenous retinal detachment (RRD) in Southern Sweden between 2011 and 2025, and to examine whether demographic change or risk factor trends account for any change in incidence.</p><p><strong>Methods: </strong>This retrospective, population-based study included all surgically treated primary RRD cases in Southern Sweden between 1 January 2011 and 31 December 2025. Crude and age- and sex-standardised incidence rates were calculated per 100 000 person-years using population data from Statistics Sweden. Cataract surgery data were obtained from the Swedish National Cataract Registry.</p><p><strong>Results: </strong>A total of 6916 surgically treated primary RRD cases were identified. Annual incidence increased from 15.8 to 29.5 cases per 100 000 person-years between 2011 and 2025, an 86.7% increase. Peak incidence of 30.4 per 100 000 person-years was seen in both 2019 and 2024. The increase persisted after age- and sex-standardisation. Mean age at surgery was 62 years and 68.3% occurred in men. Cataract surgery rate increased by 56.2% between 2011 and 2024. The proportion of pseudophakic RRD rose from 37.7% during 2011-2013 to 55.4% in 2023-2025.</p><p><strong>Conclusion: </strong>The RRD incidence in Southern Sweden nearly doubled over the past 15 years, reaching levels among the highest reported worldwide. The increase persisted after standardisation, indicating that population ageing and sex distribution do not account for it. The concurrent rise in cataract surgery and in the proportion of pseudophakic RRD is notable, but these population-level observations cannot establish a causal link between the rise in RRD and the cataract surgery rate.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149190562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of implantable collamer lens on biometric measurements and intraocular lens power calculation formulas.","authors":"Wan-Ping Zhang, Yong-Zheng Qu, An-Peng Pan, An-Song Li, Jing-Feng Zhao, Zi-Yue Li, Lin-Hua Chen, Jun Hu, A-Yong Yu","doi":"10.1111/aos.70259","DOIUrl":"https://doi.org/10.1111/aos.70259","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effect of the implantable collamer lens (ICL) on biometric measurements and intraocular lens (IOL) power calculation formulas.</p><p><strong>Methods: </strong>This prospective theoretical study included 92 eyes undergoing ICL surgery. Preoperative and 1-year postoperative biometric parameters, including axial length (AL), keratometry (K), anterior-chamber depth (ACD), lens thickness (LT), central corneal thickness (CCT) and corneal diameter (CD), were measured using IOLMaster 700. Nine formula types (10 variants) were evaluated: Barrett Universal II (BU II; BU II^a, IOLMaster 700-based; BU II^b, online calculator), Cooke K6, EVO, Hill-RBF, Hoffer QST, Holladay 1, Kane, Pearl-DGS and SRK/T. Primary outcomes were the difference in predicted spherical equivalent before and after ICL implantation (Δ-pSEQ) and the percentage of eyes within specified Δ-pSEQ ranges.</p><p><strong>Results: </strong>For all eyes (n = 92), significant post-ICL changes included increased AL, steep K (K2), LT, CCT (+0.02 mm, +0.08 D, +0.26 mm, +0.003 mm; p = 0.031, 0.021, <0.001, 0.008) and decreased ACD (-0.28 mm, p < 0.001). ACD segmentation errors occurred in 34.78% of eyes, associated with low vault (optimal cut-off, 0.491 mm; AUC = 0.921). Eyes were grouped by segmentation accuracy (correct, n = 60; incorrect, n = 32). All Δ-pSEQ values were within ±0.50 D; between-subgroup differences in Δ-pSEQ ranges were not significant (p > 0.05). The highest proportions within ±0.25 D were SRK/T (86% overall, 94% incorrect group) and BU II^a (85% correct group); EVO had the lowest (71%-72%).</p><p><strong>Conclusion: </strong>ICL implantation alters biometric measurements and theoretically predicted Δ-pSEQ; although these changes are statistically significant, their clinical significance is negligible. While incorrect ACD segmentation is common, it is unlikely to substantially affect the theoretical calculation results.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}