Acta Ophthalmologica最新文献_第3页

Clinical characteristics and treatment outcomes of bilateral myopic macular neovascularization in high myopic patients. 高度近视患者双侧近视黄斑新生血管的临床特点及治疗效果。

IF 2.8 3区医学

Acta Ophthalmologica Pub Date : 2025-08-05 DOI: 10.1111/aos.17568

Soo Hyun Lim, Kunho Bae, Chang Ki Yoon, Eun Kyoung Lee, Kyu Hyung Park, Un Chul Park

{"title":"Clinical characteristics and treatment outcomes of bilateral myopic macular neovascularization in high myopic patients.","authors":"Soo Hyun Lim, Kunho Bae, Chang Ki Yoon, Eun Kyoung Lee, Kyu Hyung Park, Un Chul Park","doi":"10.1111/aos.17568","DOIUrl":"https://doi.org/10.1111/aos.17568","url":null,"abstract":"Purpose: To evaluate the clinical features and treatment outcomes of bilateral myopic macular neovascularization (mMNV).Methods: This single-centre retrospective study included patients with bilateral high myopia who were newly diagnosed with unilateral mMNV (first eye) between January 2008 and July 2020. Patients who presented with mMNV or macular atrophy suggestive of previous mMNV in the fellow eye (second eye) were excluded. Patients were classified into unilateral or bilateral groups based on mMNV development in the second eye during follow-up of >36 months.Results: Ninety-three patients were included with the mean age of 55.4 ± 13.1 years and 71 (76.3%) were female. The mean baseline spherical equivalent was -13.0 ± 5.5 diopters. Of total, 21 (22.6%) developed mMNV in the second eye during the mean follow-up period of 95.1 ± 38.9 months; the cumulative probabilities were 16.2% at 5 years and 28.9% at 10 years after the first eye mMNV development. The uninvolved second eyes of the unilateral group had shorter axial length (AL) and greater subfoveal choroidal thickness than the eyes with mMNV. The unilateral group showed a greater interocular difference in AL than the bilateral group (p < 0.001). The presence of lacquer cracks in the second eye was identified as a significant risk factor for the second eye mMNV development (HR = 5.64, 95% CI: 1.59-20.08, p = 0.008). In the bilateral group, the second eye showed less vision improvement after anti-VEGF treatment, but the final visual acuity and cumulative probability of fovea-involving mMNV-related chorioretinal atrophy did not differ between the eyes.Conclusions: Approximately 30% of bilateral high myopic patients with unilateral mMNV are estimated to develop mMNV in the second eye over a period of 10 years. The presence of lacquer cracks in the second eye was a significant risk factor. The first and second eyes showed comparable treatment outcomes.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SD-OCT-based biomarkers in predicting treatment outcomes of macular oedema secondary to retinal vein occlusion treated with anti-VEGF therapy. 基于sd - oct的生物标志物预测抗vegf治疗视网膜静脉闭塞继发黄斑水肿的治疗结果。

IF 2.8 3区医学

Acta Ophthalmologica Pub Date : 2025-08-04 DOI: 10.1111/aos.17574

Ken K Tsang, Vivian W K Hui, Christopher M K Pang, Ziqi Tang, Dawei Yang, Truong X Nguyen, Shaheeda Mohamed, Timothy Y Y Lai, Carol Y Cheung, Simon K H Szeto

{"title":"SD-OCT-based biomarkers in predicting treatment outcomes of macular oedema secondary to retinal vein occlusion treated with anti-VEGF therapy.","authors":"Ken K Tsang, Vivian W K Hui, Christopher M K Pang, Ziqi Tang, Dawei Yang, Truong X Nguyen, Shaheeda Mohamed, Timothy Y Y Lai, Carol Y Cheung, Simon K H Szeto","doi":"10.1111/aos.17574","DOIUrl":"https://doi.org/10.1111/aos.17574","url":null,"abstract":"Purpose: To investigate the role of spectral domain optical coherence tomography (SD-OCT)-based biomarkers in predicting treatment response of macular oedema (MO) secondary to retinal vein occlusion (RVO) to anti-vascular endothelial growth factor (VEGF) therapy.Methods: Retrospective cohort study including consecutive cases of RVO associated MO who received anti-VEGF injections between January 2020 and April 2021. LogMAR visual acuity (VA) at baseline, 12 and 24 months was correlated with a panel of SD-OCT-based biomarkers, including vitreomacular status, size of intra-retinal cysts (IRC), presence of disorganization of retinal inner layers (DRIL), hyper-reflective foci (HRF) in the retina, integrity of the external limiting membrane (ELM), ellipsoid zone (EZ), cone outer segment tip (COST) and presence of subretinal fluid (SRF).Results: One hundred and thirty eyes were included with 81 and 49 eyes in the BRVO and CRVO subgroup, respectively. In both subgroups, baseline disrupted EZ/ELM [BRVO: (β = 0.144 p = 0.008; β = 0.111 p = 0.014; β = 0.096 p = 0.042) and CRVO: (β = 0.316 p < 0.001; β = 0.336 p < 0.001; β = 0.327 p < 0.001)] were associated with worse VA from baseline through 24 months. In the BRVO subgroup, the presence of HRF (β = 0.209 p < 0.001) correlated with worse baseline VA. Improvement in DRIL extent [OR = 4.355 (1.109-17.094) p = 0.035; OR = 4.510 (1.707-11.917) p = 0.002] and EZ/ELM integrity [OR = 4.474 (1.783-11.223) p = 0.001; OR = 3.214 (1.414-7.305) p = 0.005] were associated with a higher likelihood of achieving at least a 5 letters gain at 12 and 24 months.Conclusion: A comprehensive system of SD-OCT-based features could predict functional outcomes of MO secondary to RVO with anti-VEGF therapy up to 24 months.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health-related quality of life of children with strabismus. 斜视儿童的健康相关生活质量。

IF 2.8 3区医学

Acta Ophthalmologica Pub Date : 2025-07-28 DOI: 10.1111/aos.17543

Lena Boulakh, Jonas L Isaksen, Christina Ellervik, Jørgen K Kanters, Helena Buch Hesgaard, Lisbeth Sandfeldt

{"title":"Health-related quality of life of children with strabismus.","authors":"Lena Boulakh, Jonas L Isaksen, Christina Ellervik, Jørgen K Kanters, Helena Buch Hesgaard, Lisbeth Sandfeldt","doi":"10.1111/aos.17543","DOIUrl":"https://doi.org/10.1111/aos.17543","url":null,"abstract":"Purpose: The agreement between children with strabismus and their parents on the health-related quality of life (HRQOL) of the child is unknown. Additionally, it is unknown if physical traits pre-dispose to a better outcome in HRQOL after strabismus surgery in children. This study aims to aid strabismus surgeons in deciding which children will improve HRQOL following strabismus surgery.Methods: We included 114 Danish children who underwent strabismus surgery for their strabismus and 29 controls without ophthalmologic manifestations. Each child and their parent answered questionnaires about the child's eye- and general health. We compared eye-specific, psychosocial and physical scores in children pre- and post-operatively with controls. We also investigated child-parent (proxy) agreement and whether sex, age and strabismus type were associated with improvement in HRQOL after surgery.Results: Children with strabismus scored themselves lower on eye-related HRQOL questions than their parents scored them (p = 0.01). Children with strabismus had similar improvements in HRQOL after surgery independent of age, sex, use of glasses and type of strabismus. Children with strabismus scored lower across all questionnaires on HRQOL even after surgery compared to controls (eye specific, p < 0.001; PedsQL psychosocial = 0.006).Conclusion: Strabismus surgery in children improved their quality of life regardless of sex, age, wearing glasses or strabismus type. The surgeon should be aware of potential discrepancies in perception of the HRQOL of the child, between the child and their parent when making their assessment.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal analysis of clinical characteristics associated with myopic retinoschisis. 近视眼视网膜裂临床特征的多模态分析。

IF 3 3区医学

Acta Ophthalmologica Pub Date : 2025-07-25 DOI: 10.1111/aos.17544

Jiaxin Tian, Yinghan Zhang, Kai Cao, Shanshan Huang, Ningli Wang, Yue Qi

{"title":"Multimodal analysis of clinical characteristics associated with myopic retinoschisis.","authors":"Jiaxin Tian, Yinghan Zhang, Kai Cao, Shanshan Huang, Ningli Wang, Yue Qi","doi":"10.1111/aos.17544","DOIUrl":"https://doi.org/10.1111/aos.17544","url":null,"abstract":"Purpose: To analyse the clinical characteristics and risk factors associated with myopic retinoschisis (MR) and its severity.Methods: In the case-control study, 200 highly myopic eyes with MR and 398 without MR were enrolled. All participants have recorded demographic characteristics and medical history. Axial length (AXL), epiretinal membranes (ERMs), vitreoretinal traction (VT), dome-shaped macula (DSM), macular outward scleral height (MOSH), and subfoveal CT were evaluated to describe ocular characteristics. Univariate analysis was used to analyse the differences in characteristics between the eyes with and without MR, as well as among the eyes exhibiting varying grades of MR. Following this, multivariate logistic regression was conducted to identify significant risk factors associated with MR and its severity.Results: In univariate analysis, the MR eyes had more keratorefractive surgeries, older age, longer AXL, greater MOSH, thinner subfoveal CT, higher rates of ERMs, VT as well as vertical DSM than the eyes without MR (all p < 0.05). Besides, there were significant differences in age, AXL, subfoveal CT, MOSH and rate of keratorefractive surgery, ERM as well as VT among different severities of MR (all p < 0.05). The further multivariate analysis revealed ERMs, VT, greater MOSH and subfoveal choroidal thinning were significantly associated with MR and its severity escalation (all p < 0.05), whereas a longer AXL was correlated with a decrease in MR severity (p = 0.018).Conclusions: ERMs, VT, higher MOSH and subfoveal choroidal thinning were significant risk factors for MR and its severity escalation, while axial elongation correlated with lower grades of MR.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reproducibility in the identification of retinal positions on serial fundus photographs: Theory and limitations. 在连续眼底照片视网膜位置识别的再现性：理论和局限性。

IF 3 3区医学

Acta Ophthalmologica Pub Date : 2025-07-24 DOI: 10.1111/aos.17566

Toke Bek, Giovanni Ometto

{"title":"Reproducibility in the identification of retinal positions on serial fundus photographs: Theory and limitations.","authors":"Toke Bek, Giovanni Ometto","doi":"10.1111/aos.17566","DOIUrl":"https://doi.org/10.1111/aos.17566","url":null,"abstract":"Background: Imaging of the retina is accompanied by distortions so that positions in fundus photographs cannot be linearly translated to positions in the retinal fundus. The purpose of this study was to describe an algorithm and evaluate its reproducibility in identifying points on the retina from their representation on serial fundus photographs.Methods: A mathematical formalism was derived to describe how the location of the fovea and the optic disc in fundus photographs, together with the centre-nodal point distance (d) and the curvature radius (r) of the eye, can be used to calculate spatial coordinates on the retina that correspond to given locations in the photograph. The effect of manual markings of the fovea and the optic disc as reference points was evaluated, and the formalism was tested on 105 photographs recorded with different image modalities and centring from 10 different patients.Results: Retinal locations could be identified in serial fundus photographs with a reproducibility of at least 50 μm when the centre-nodal point distance and the curvature radius were set to those in Gullstrand's standard eye. A main source of the variability was the manual identification of the fovea and optic disc used as reference points.Conclusions: The reproducibility in the identification of locations on the retina from serial fundus photographs depends on the accuracy in the definition of the fovea and optic disc used as reference points. This affects the potential for describing locations, distances, areas and changes in retinal lesions on serial photographs over time.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumour progression shows decrease in PD-L1 expression in matched metastases/primary uveal melanomas. 肿瘤进展显示匹配转移/原发性葡萄膜黑色素瘤中PD-L1表达降低。

IF 3 3区医学

Acta Ophthalmologica Pub Date : 2025-07-24 DOI: 10.1111/aos.17559

Maria Chiara Gelmi, Gulçin Gezgin, Ellen Kapiteijn, T H Khanh Vu, Martine J Jager, Robert M Verdijk

{"title":"Tumour progression shows decrease in PD-L1 expression in matched metastases/primary uveal melanomas.","authors":"Maria Chiara Gelmi, Gulçin Gezgin, Ellen Kapiteijn, T H Khanh Vu, Martine J Jager, Robert M Verdijk","doi":"10.1111/aos.17559","DOIUrl":"https://doi.org/10.1111/aos.17559","url":null,"abstract":"Purpose: Immune checkpoint inhibitors (ICI) have revolutionised the treatment of several malignancies. However, the results of ICI therapy remain unsatisfactory in metastatic uveal melanoma (UM). We analysed the expression of PD1, PD-L1, T-cell and macrophage markers in a set of matched primary and metastatic UM in an attempt to better understand the low effectiveness of ICI in metastatic UM.Methods: Thirty-two samples (19 metastases and 13 primary UM) were stained for PD-L1, PD1, CD3, CD4, CD8, CD68, CD163, HLA class I and BAP1. T-cell markers were scored quantitatively, while PD-L1, CD68, CD163 and BAP1 were scored semiquantitatively. The immunohistochemical (IHC) scores were compared between all primary and metastatic UM samples and between matched cases.Results: Both the general and the matched analyses revealed that the IHC scores for PD-L1 expression on tumour cells were lower in metastatic UM than in primary UM. Conversely, T-cell markers, including PD1, were significantly higher in UM metastases than primary UM, while macrophages did not show a difference. Metastases with a low HLA Class I expression lacked PD-L1 and PD1 expression. BAP-1 loss was associated with increased lymphocytic infiltration.Conclusions: While UM metastases had higher lymphocytic infiltrates than primary UM, PD-L1 showed a lower expression in metastases. We believe that the low effectiveness of ICI in the treatment of metastatic UM may be partly explained by the low PD-L1 expression. We propose that primary tumours may be more responsive to ICI therapy than metastases and could be targeted in a (neo)adjuvant setting for patients at high risk of developing metastases.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A brief history of keratoplasty. 角膜移植术简史。

IF 3 3区医学

Acta Ophthalmologica Pub Date : 2025-07-23 DOI: 10.1111/aos.17567

H Burkhard Dick, Ronald D Gerste, Sorcha Ní Dhubhghaill

{"title":"A brief history of keratoplasty.","authors":"H Burkhard Dick, Ronald D Gerste, Sorcha Ní Dhubhghaill","doi":"10.1111/aos.17567","DOIUrl":"https://doi.org/10.1111/aos.17567","url":null,"abstract":"The first successful corneal transplantation, performed by Eduard Zirm in 1905, marked a turning point in treating corneal blindness. This breakthrough was preceded by centuries of conceptual development, dating back to Galen's theoretical approach to corneal transparency restoration in ancient Rome. Erasmus Darwin later proposed corneal trephination in the 18th century, though without practical implementation. The 19th century saw a surge in experimental keratoplasty, with Karl Himley suggesting cross-species corneal transplants and Franz Reisinger coining the term 'keratoplasty'. Johann Dieffenbach and Samuel Bigger further explored transplantation in animal models. Arthur von Hippel's innovations in trephination laid the foundation for Zirm's success, who performed the first human-to-human corneal transplant using strict aseptic techniques. Subsequent advancements, including the establishment of eye banks, immunosuppressive therapies and modern lamellar keratoplasty techniques like DSAEK and DMEK, have significantly improved graft survival and visual outcomes. This historical perspective highlights the continuous evolution of corneal transplantation, underscoring the contributions of numerous pioneers whose innovations have shaped modern ophthalmology.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unilateral optic neuritis and thinning of retinal layers in the affected and unaffected eyes. 单侧视神经炎和视网膜层变薄的影响和未受影响的眼睛。

IF 3 3区医学

Acta Ophthalmologica Pub Date : 2025-07-22 DOI: 10.1111/aos.17552

Sanna Leinonen, Hanna-Mari Mäkelä, Chi Li, Leopold Schmetterer, Jacqueline Chua

{"title":"Unilateral optic neuritis and thinning of retinal layers in the affected and unaffected eyes.","authors":"Sanna Leinonen, Hanna-Mari Mäkelä, Chi Li, Leopold Schmetterer, Jacqueline Chua","doi":"10.1111/aos.17552","DOIUrl":"https://doi.org/10.1111/aos.17552","url":null,"abstract":"Purpose: Multiple sclerosis (MS)-related optic neuritis (ON) causes thinning of inner retinal layers. It remains unclear whether unilateral MSON also affects the unaffected contralateral eye. The purpose of this study was to compare macular retinal layer thicknesses in MS eyes with unilateral optic neuritis (MSON), their unaffected contralateral eyes and MS participants without a history of ON (MSnON).Methods: This cross-sectional screening study included 101 MSON and 106 MSnON participants. Retinal layer thicknesses were measured using optical coherence tomography scans at the standardized zones of the macula (central circle, inner ring and outer ring) and compared between the groups.Results: The unaffected contralateral non-ON eyes of MSON participants had thinner inner retinal layers including a thinner retinal nerve fibre layer (p values, 0.003-0.009), a thinner ganglion cell layer (p values, <0.001-0.006) and a thinner inner plexiform layer (p values, 0.004-0.012) compared to MS participants without a history of ON. Affected MSON eyes had thinner inner retinal layers compared to both unaffected fellow eyes and to MSnON participants (p < 0.001 for all comparisons). Additionally, in MSON eyes, the inner nuclear layer and outer retina were thicker at the inner and outer rings compared to contralateral eyes (p < 0.001 for all comparisons), but not when compared to the MSnON participants.Conclusion: We recommend bilateral examination, OCT imaging and follow-up for MS patients with unilateral acute ON to monitor also the contralateral eyes, which present with thinner inner retina layers than MSnON participants' eyes.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Secretory autophagy and epithelial-to-mesenchymal transition in cadaveric AMD samples: Novel pathways in disease progression. 尸体AMD样本的分泌性自噬和上皮到间质转化：疾病进展的新途径

IF 3 3区医学

Acta Ophthalmologica Pub Date : 2025-07-19 DOI: 10.1111/aos.17558

Iswariyaraja Sridevi Gurubaran, Ali Koskela, Hanna Heloterä, Kai Kaarniranta

引用次数: 0

Assessment of measurement repeatability by keratoconus severity using an OCT and Placido-based tomographer. 使用OCT和基于placido的断层扫描仪评估圆锥角膜严重程度测量的可重复性。

IF 3 3区医学

Acta Ophthalmologica Pub Date : 2025-07-17 DOI: 10.1111/aos.17557

Juan Arbelaez, Robert Herber, Jorge L Alio Del Barrio, Maria C Arbelaez, Paolo Vinciguerra, Frederik Raeiskup, Alex Gonzales, Riccardo Vinciguerra

{"title":"Assessment of measurement repeatability by keratoconus severity using an OCT and Placido-based tomographer.","authors":"Juan Arbelaez, Robert Herber, Jorge L Alio Del Barrio, Maria C Arbelaez, Paolo Vinciguerra, Frederik Raeiskup, Alex Gonzales, Riccardo Vinciguerra","doi":"10.1111/aos.17557","DOIUrl":"https://doi.org/10.1111/aos.17557","url":null,"abstract":"Purpose: Current criteria for assessing keratoconus progression rely heavily on Scheimpflug technology. However, this technology has demonstrated limitations in measurement repeatability, particularly in advanced keratoconus, and it applies a uniform standard across all disease stages. We aim to evaluate the repeatability of diagnostic indices for keratoconus screening using an anterior segment OCT coupled with Placido disc tomographer (MS-39) across different keratoconus stages to establish severity-based thresholds for progression.Design: Retrospective, multicentre cohort study.Methods: This retrospective study included 1103 eyes diagnosed with keratoconus, with three scans per eye acquired using the MS-39. The repeatability of curvature, elevation, and thickness indices was assessed using the coefficient of variation (CV%), confidence interval (CI), and coefficient of repeatability (CR). The study analysed the variability of these indices across different stages of keratoconus severity.Results: The MS-39 demonstrated high repeatability across most indices. Variability increased in advanced stages of keratoconus, particularly in posterior elevation and thickness parameters. For K flat and K steep, CR values remained below 1 D, with the highest CR for K flat being 0.53 up to a keratometry reading of 50 D, and for K steep being 0.74 up to a reading of 56 D. A thinnest point CR below 6 μm was observed for corneas up to 460 μm, while below 420 μm, the CR increased to 10.8 μm.Conclusion: OCT coupled with Placido disc tomographers offers an overall high repeatability of keratoconus diagnostic indices. Our findings allow us to establish new progression criteria tailored to the severity of the disease.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0