Acta Ophthalmologica最新文献_第3页

Epidemiology and burden of mild/moderate versus high myopia in Germany: A claims data analysis. 德国轻度/中度与高度近视的流行病学和负担：一项索赔数据分析。

IF 2.8 3区医学

Acta Ophthalmologica Pub Date : 2025-09-08 DOI: 10.1111/aos.17589

Tarcyane Barata Garcia, Nils Kossack, Marc Pignot, Mohammed Dagher, Alexander K Schuster, Kun Shi-van Wielink

{"title":"Epidemiology and burden of mild/moderate versus high myopia in Germany: A claims data analysis.","authors":"Tarcyane Barata Garcia, Nils Kossack, Marc Pignot, Mohammed Dagher, Alexander K Schuster, Kun Shi-van Wielink","doi":"10.1111/aos.17589","DOIUrl":"https://doi.org/10.1111/aos.17589","url":null,"abstract":"Purpose: This study aimed to investigate the prevalence, healthcare resource utilization (HCRU) and associated costs of myopia in Germany, comparing mild/moderate and high myopia across various age groups using real-world data.Methods: A retrospective cross-sectional study was conducted using data from the WIG2 benchmark database. Patients with a diagnosis of myopia (ICD-10-GM H52.1) were categorized into mild/moderate or high myopia. The study population was stratified into preschool (0-5 years), primary school (6-9 years), secondary school (10-17 years), adult (18-59 years), elderly (60-75 years) and very old (>75 years) age groups. Prevalence trends were evaluated across paediatric and adolescent subpopulations. Propensity score matching was applied to balance group differences. HCRU and associated costs were analysed for each cohort.Results: Between 2018 and 2022, mild/moderate myopia consistently exhibited higher prevalence across all age groups compared to high myopia. Prevalence of both myopia types increased significantly with age, particularly in females, with mild/moderate myopia reaching 19.86% (95% CI 19.08-20.66) at age 17, compared to 14.00% (95% CI 13.37-14.67) in males. In 2022, individuals with high myopia had significantly higher ophthalmic HCRU and associated costs compared to those with mild/moderate myopia. The economic burden was notably higher in older age groups, with increased hospitalizations and outpatient visits. High myopia incurred higher costs across all age groups, with the largest difference in the very old cohort (€234.20).Conclusion: This study highlights the significant clinical and economic burden of high myopia in Germany. Targeted interventions are needed to manage myopia progression and reduce healthcare costs, particularly in ageing individuals.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world outcomes of aflibercept 8 mg in patients previously treated for neovascular age-related macular degeneration. 阿非利赛普8mg治疗新生血管性老年性黄斑变性患者的实际疗效。

IF 2.8 3区医学

Acta Ophthalmologica Pub Date : 2025-09-08 DOI: 10.1111/aos.17590

Imadeddin Abu Ishkheidem, Esra Inci, Martin Breimer, Sofia Töyrä Silfverswärd, Madeleine Zetterberg, Marita Andersson Grönlund

{"title":"Real-world outcomes of aflibercept 8 mg in patients previously treated for neovascular age-related macular degeneration.","authors":"Imadeddin Abu Ishkheidem, Esra Inci, Martin Breimer, Sofia Töyrä Silfverswärd, Madeleine Zetterberg, Marita Andersson Grönlund","doi":"10.1111/aos.17590","DOIUrl":"https://doi.org/10.1111/aos.17590","url":null,"abstract":"Purpose: To evaluate visual, anatomical and safety outcomes of aflibercept 8 mg in previously treated patients with neovascular age-related macular degeneration (nAMD).Methods: This retrospective study included nAMD patients switched to aflibercept 8 mg from prior anti-VEGF therapies at Sahlgrenska University Hospital between February 2024 and February 2025. Data on best-corrected visual acuity (BCVA), central retinal thickness (CRT), pigment epithelial detachment (PED) height, fluid status, treatment intervals, time to fluid recurrence and adverse events were collected.Results: 181 eyes (167 patients; mean age 80.4 ± 8.5 years; 67.7% female) were included, with a median follow-up of 12.9 weeks (range 4.1-48.1). A total of 415 injections were administered (mean 2.1 ± 1.5 per eye). BCVA remained stable (baseline 0.46 ± 0.31 logMAR; post-treatment 0.47 ± 0.37 logMAR; p = 0.18). CRT decreased significantly (-19.5 ± 47.2 μm; p < 0.001), as did PED height (-37.4 ± 68.4 μm; p < 0.001). Intraretinal fluid prevalence decreased from 34.3% to 19.3% (p < 0.001) and subretinal fluid from 53.0% to 33.7% (p < 0.001). The median maximal dry interval achieved was nine weeks, and analysis of interval extension showed a statistically significant mean increase of 1.27 ± 4.24 weeks overall (p = 0.0009), particularly in eyes dry at baseline. The median time to fluid recurrence among those with reactivation was ten weeks. Higher baseline CRT predicted greater CRT reduction (-44.1 μm per 100 μm increase; p < 0.001) but shorter dry intervals. Safety was favourable, with one case (0.6% per eye; 0.2% per injection) of mild anterior uveitis and no cases of intraocular pressure elevation.Conclusions: Switching to aflibercept 8 mg led to stable vision, significant anatomical improvements, extended treatment intervals and a favourable short-term safety profile. Longer follow-up is warranted.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Congenital aniridia: European COST action ANIRIDIA-NET guidelines for diagnosis, management and care. 先天性无虹膜：欧洲成本行动无虹膜网诊断，管理和护理指南。

IF 2.8 3区医学

Acta Ophthalmologica Pub Date : 2025-09-02 DOI: 10.1111/aos.17587

Davide Romano, Vito Romano, Alejandra Daruich, Giulio Ferrari, Matthieu Robert, Francesco Semeraro, Neil Lagali, Dominique Bremond-Gignac

{"title":"Congenital aniridia: European COST action ANIRIDIA-NET guidelines for diagnosis, management and care.","authors":"Davide Romano, Vito Romano, Alejandra Daruich, Giulio Ferrari, Matthieu Robert, Francesco Semeraro, Neil Lagali, Dominique Bremond-Gignac","doi":"10.1111/aos.17587","DOIUrl":"https://doi.org/10.1111/aos.17587","url":null,"abstract":"Congenital aniridia is a rare ocular disorder affecting the majority of eye structures and can be associated with systemic manifestations. The main visible phenotypic characteristic is the partial or complete absence of the iris; however, foveal hypoplasia is a more frequent and reliable clinical sign. Other ocular comorbidities are associated with the disease, such as cataract, keratopathy and optic nerve hypoplasia. Mutation in the PAX6 gene is the most common cause of congenital aniridia, but other causative mutations exist. The main ocular symptoms experienced by those with congenital aniridia are photophobia, glare, low visual acuity, dryness/irritation of the ocular surface and nystagmus. Management and follow-up of patients with congenital aniridia can be challenging due to the lack of effective therapeutic options and the complexity of ocular manifestations and outcomes. These guidelines for the diagnosis, management and care of congenital aniridia have been developed at the European level, thanks to ANIRIDIA-NET, based on a review of the scientific literature on clinical and molecular characterization, therapeutic options as well as non-medical approaches.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A model for de novo pigmentation of amelanotic retinal pigment epithelial cells. 无色素变性视网膜色素上皮细胞新生色素沉着模型。

IF 2.8 3区医学

Acta Ophthalmologica Pub Date : 2025-09-02 DOI: 10.1111/aos.17572

Santosh Gupta, Lyubomyr Lytvynchuk, Taras Ardan, Hana Studenovska, Georgina Faura, Lars Eide, Ljubo Znaor, Slaven Erceg, Knut Stieger, Jan Motlik, Goran Petrovski

{"title":"A model for de novo pigmentation of amelanotic retinal pigment epithelial cells.","authors":"Santosh Gupta, Lyubomyr Lytvynchuk, Taras Ardan, Hana Studenovska, Georgina Faura, Lars Eide, Ljubo Znaor, Slaven Erceg, Knut Stieger, Jan Motlik, Goran Petrovski","doi":"10.1111/aos.17572","DOIUrl":"https://doi.org/10.1111/aos.17572","url":null,"abstract":"Purpose: Retinal Pigment Epithelial (RPE) cells perform critical functions in the visual cycle. Their melanin pigmentation, which is organized into specialized compartments - melanosomes, is highly critical for proper vision. A chemical method to induce pigmentation in a non-pigmented model of ARPE-19 cells was applied using L-DOPA as a repurposed drug from the current treatment of Parkinson's disease.Methods: L-DOPA was optimized for its toxic effect on ARPE-19 cells along with pigmentation development. Gene expression and immunocytochemistry confirmed upregulation of melanogenesis-related genes and proteins. Melanosomes were characterized by TEM.Results: We found 1000 μM L-DOPA to induce pigmentation of ARPE-19 cells by Day 3, and achieve full pigmentation by Day 5. By Day 5, L-DOPA at 1000 μM induced mitochondrial and nuclear DNA damage. However, the gene expression of RPE-specific markers (tyrosinase, TYRP1, CRALBP, PEDF) was significantly different in L-DOPA-treated ARPE-19 cells compared to non-treated ones. Positive expression for Tyrosinase enzyme was confirmed by ICC on both Day 3 and Day 5 of L-DOPA treatment. Transmission electron microscopy showed the de novo melanosome formation with ultrastructural features of various stages of maturity (Stage I to IV), apical-basal polarity and melanosome localization on the apical side of the L-DOPA-treated ARPE-19 cells.Conclusion: Our study showed that L-DOPA treatment could induce de novo melanosome formation in amelanotic RPEs. We propose a newer approach of developing an ex vivo model for de novo pigmentation of RPE cells with cell-specific modification and culture condition optimization.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nationwide trends in macular hole, epiretinal membrane and floaters surgery, 2010-2023. 2010-2023年全国黄斑孔、视网膜前膜和飞蚊手术趋势。

IF 2.8 3区医学

Acta Ophthalmologica Pub Date : 2025-09-01 DOI: 10.1111/aos.17585

Birgitte Romme Nielsen, Martin Nissen Hermann, Jakob Grauslund, Morten la Cour, Mark Alberti

{"title":"Nationwide trends in macular hole, epiretinal membrane and floaters surgery, 2010-2023.","authors":"Birgitte Romme Nielsen, Martin Nissen Hermann, Jakob Grauslund, Morten la Cour, Mark Alberti","doi":"10.1111/aos.17585","DOIUrl":"https://doi.org/10.1111/aos.17585","url":null,"abstract":"Purpose: To examine the incidence of pars plana vitrectomy (PPV) for full-thickness macular hole (FTMH), epiretinal membrane (ERM) and floaters over time and across regions in Denmark.Methods: This nationwide registry-based study included all patients undergoing PPV for FTMH, ERM, or floaters in Denmark from 2010 to 2023. Crude and age-standardized incidence rates were calculated using Poisson regression, stratified by sex, age, region and year.Results: Among 11 693 patients undergoing PPV, the median age was 71 years (IQR, 66-76) and 83% (9744/11 693) were pseudophakic at surgery. Overall incidence rates per 100 000 person-years were 5.7 (95% CI, 5.5-5.8) for FTMH, 7.1 (6.9-7.2) for ERM, and 1.8 (1.7-1.9) for floaters. FTMH surgery was more common in females across all ages, while ERM and floater surgeries were more frequent in males aged ≥60 years. From 2010-2012 to 2021-2023, the incidence increased for FTMH and ERM, while floater surgery declined in females and remained stable in males. Regional variation was observed for all indications, most notably for ERM.Conclusion: The incidence of PPV for both FTMH and ERM rose significantly from 2010 to 2023. The regional variation in FTMH may indicate undertreatment, while differences in ERM and floater surgeries reflect the absence of standardized guidelines for ERM and floater surgery, underscoring the need for national guidelines to ensure equitable ophthalmic care.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of angle kappa and multifocal intraocular lenses and their effect on visual outcomes. 角度kappa和多焦人工晶状体及其对视力的影响。

IF 2.8 3区医学

Acta Ophthalmologica Pub Date : 2025-08-30 DOI: 10.1111/aos.17561

Thomas Kohnen, Viswanathan Ramasubramanian, Rajaraman Suryakumar

{"title":"A review of angle kappa and multifocal intraocular lenses and their effect on visual outcomes.","authors":"Thomas Kohnen, Viswanathan Ramasubramanian, Rajaraman Suryakumar","doi":"10.1111/aos.17561","DOIUrl":"https://doi.org/10.1111/aos.17561","url":null,"abstract":"Although most patients are satisfied with their vision after multifocal intraocular lens (IOL) implantation, dissatisfaction has been reported for various reasons, including poor visual outcomes and visual disturbances. Many published reports hypothesise that preoperative angle kappa may be an associated factor in patient dissatisfaction. Therefore, there is considerable interest in understanding the connection between preoperative angle kappa and visual outcome after multifocal IOL implantation. This narrative review presents clinical data on angle kappa and its relationship to visual outcomes, visual quality, IOL position and visual disturbances after cataract surgery and multifocal IOL implantation. Although recent advances improved objective measurement of angle kappa, inconsistencies in reporting angle kappa make comparison across studies and patient populations difficult. The consensus among multiple studies was that angle kappa did not influence visual and refractive outcomes following multifocal IOL surgery. However, there were conflicting reports on the correlation between angle kappa and subjective visual quality and patient-reported visual disturbances. Differences in study design, patient characteristics and multifocal IOL characteristics may explain these discrepancies. IOL orientation, tilt and decentration may be affected by angle kappa and likely contribute to some visual disturbances. Additional modelling studies using multifocal IOLs and ocular biometry could improve our understanding of the relationship between angle kappa and IOL alignment. Accurate assessment of preoperative angle kappa in patients with cataracts is important for successful outcomes and patient satisfaction.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The state of your journal: Acta Ophthalmologica in 2024. 你的期刊现状：2024年《眼科学报》。

IF 2.8 3区医学

Acta Ophthalmologica Pub Date : 2025-08-27 DOI: 10.1111/aos.17584

Kai Kaarniranta, Einar Stefánsson

引用次数: 0

Threat to fixation and vision-related quality of life in patients with open-angle glaucoma. 对开角型青光眼患者固定及视力相关生活质量的威胁。

IF 2.8 3区医学

Acta Ophthalmologica Pub Date : 2025-08-26 DOI: 10.1111/aos.17586

Charlotte Almer, Dorothea Peters

{"title":"Threat to fixation and vision-related quality of life in patients with open-angle glaucoma.","authors":"Charlotte Almer, Dorothea Peters","doi":"10.1111/aos.17586","DOIUrl":"https://doi.org/10.1111/aos.17586","url":null,"abstract":"Purpose: We aimed to investigate the association between overlapping threat to fixation (TTF) and vision-related quality of life (VRQoL) in patients with manifest open-angle glaucoma (OAG).Methods: Overall, 316 patients with manifest OAG were recruited from the glaucoma outpatient department of Skåne University Hospital, Malmö, Sweden, between April and December 2018. VRQoL was assessed using the Swedish version of the National Eye Institute Visual Function Questionnaire-25 (VFQ-25). The results were analysed using Rasch analysis. Overlapping TTF was defined as glaucomatous visual field loss (VFL) involving at least one of the four most central points, depressed at p < 1% on the total deviation probability map of Humphrey visual fields, and present at corresponding points in both eyes. The relationship between VRQoL and overlapping TTF was examined using linear regression analysis.Results: In univariable linear regression analysis, overlapping TTF was significantly associated with VRQoL scores on the Visual Functioning Scale (VFS) and Socioemotional Scale (SES). However, this correlation was not significant in multivariable linear regression analysis after adjusting for potentially confounding factors (all p > 0.05). Integrated visual field mean deviation (IVF-MD) and best-corrected visual acuity in the better and worse eyes were significantly correlated with Rasch-calibrated VFQ-25 scores. Collectively, these factors accounted for 37% and 34% of the variance in VFS and SES scores, respectively.Conclusion: Overlapping TTF was not an independent predictor of VRQoL after controlling for VFL severity. By contrast, IVF-MD emerged as the most significant predictor of VRQoL.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metastatic potential of small posterior uveal melanomas. 小葡萄膜后黑素瘤的转移潜力。

IF 2.8 3区医学

Acta Ophthalmologica Pub Date : 2025-08-21 DOI: 10.1111/aos.17582

Gustav Stålhammar, Helen Kalirai, Sarah E Coupland, Salvatore Grisanti, Svenja Rebecca Sonntag, Ayseguel Tura, Antonio Eleuteri, Rumana N Hussain, Heinrich Heimann, Hannah Coudé Adam

{"title":"Metastatic potential of small posterior uveal melanomas.","authors":"Gustav Stålhammar, Helen Kalirai, Sarah E Coupland, Salvatore Grisanti, Svenja Rebecca Sonntag, Ayseguel Tura, Antonio Eleuteri, Rumana N Hussain, Heinrich Heimann, Hannah Coudé Adam","doi":"10.1111/aos.17582","DOIUrl":"https://doi.org/10.1111/aos.17582","url":null,"abstract":"Purpose: To investigate the prevalence of aggressive traits in small posterior uveal melanomas (UM).Methods: This retrospective, multicentre cohort study included 804 patients with small posterior UM (≤9 mm in largest basal diameter, ≤3 mm in thickness) from centres in the UK, Germany, and Sweden. Chromosomal aberrations, cytomorphology, nuclear BAP1 expression and circulating tumour cells (CTC) were analysed.Results: Markers of poor prognosis, including monosomy 3, 8q gain, loss of BAP1 expression, and the presence of CTC, were detected in tumours as small as 3-4 mm in diameter and 1-1.5 mm in thickness. In the cytogenetically analysed subset, monosomy 3 was observed in 23% (41/175), 8q gain in 32% (23/72) and 6q aberrations in 13% (9/71); loss of nuclear BAP1 was seen in 22% (19/88); and CTC were detected in 50% (22/44). There was a strong association between tumour size and the number of clinical risk factors for lesion growth, such as subretinal fluid, orange pigment and acoustic hollowness on ultrasound, whereas these clinical features did not correlate with markers for poor prognosis. Monosomy of chromosome 3, gain of 8q, loss of 1p, gain or loss of 6q, gain or loss of 8p, loss of BAP1 expression, and cytomorphology were associated with worse survival.Conclusion: Aggressive traits are common in small UM, including those <10 mm3 in volume. Clinical risk factors traditionally used for assessing nevus growth appear more closely related to lesion size than metastatic potential. These findings underscore the importance of identifying novel clinical markers for metastatic risk.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The efficacy and safety of dichoptic therapy in comparison to patching in children with amblyopia: A systematic review and meta-analysis. 弱视儿童复视治疗与补片治疗的疗效和安全性：一项系统回顾和荟萃分析。

IF 2.8 3区医学

Acta Ophthalmologica Pub Date : 2025-08-19 DOI: 10.1111/aos.17583

Mumen H Halabi, Bashaer Aldhahwani

{"title":"The efficacy and safety of dichoptic therapy in comparison to patching in children with amblyopia: A systematic review and meta-analysis.","authors":"Mumen H Halabi, Bashaer Aldhahwani","doi":"10.1111/aos.17583","DOIUrl":"10.1111/aos.17583","url":null,"abstract":"Amblyopia is the leading cause of monocular vision loss in children. Standard treatment begins with refractive correction, followed by interventions to stimulate the amblyopic eye. Dichoptic therapy (DT) and patching therapy (PT) are commonly used but differ in mechanism. This systematic review and meta-analysis compares their efficacy, compliance and safety in paediatric amblyopia. A comprehensive search of PubMed, Scopus, Web of Science and Embase was conducted for randomized controlled trials (RCTs) comparing DT and PT in children with amblyopia. Methodological quality was assessed using the Cochrane Risk of Bias tool. Pooled data were analysed using a random-effects model, reported as mean differences (MD) or risk ratios (RR) with 95% confidence intervals (CIs). Twelve RCTs involving 1034 children were included. No significant differences were observed between DT and PT in visual acuity (MD = -0.01, 95% CI [-0.05, 0.03], p = 0.54; I2 = 85%), stereoacuity (MD = 0.01, 95% CI [-0.07, 0.08], p = 0.84; I2 = 17%), compliance (RR = 0.91, 95% CI [0.71, 1.18], p = 0.49; I2 = 85%) or adverse events (RR = 1.46, 95% CI [0.53, 4.04], p = 0.46; I2 = 54%). DT and PT show comparable outcomes in visual acuity, stereoacuity, compliance and safety based on pooled data. However, these findings may not apply to all amblyopia types, particularly strabismic amblyopia, where binocular function is often absent. Future studies should include subtype-specific analyses to better define the roles of each treatment.","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0