Acta Ophthalmologica最新文献

{"title":"Probability of myopic macular degeneration in dependence on axial length and age: The two-continent eye study.","authors":"Jost B Jonas, Rahul A Jonas, Mukharram M Bikbov, Gyulli M Kazakbaeva, Ellina M Iakupova, Ya Xing Wang, Vinay Nangia, Songhomitra Panda-Jonas","doi":"10.1111/aos.70241","DOIUrl":"https://doi.org/10.1111/aos.70241","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the probability of myopic macular degeneration (MMD).</p><p><strong>Methods: </strong>The project included four population-based investigations: Beijing Eye Study (BES) (n = 3325; age: 50+ years), Ural Eye and Medical Study (UEMS) (n = 5586 participants; age: 40+ years), Ural Very Old Study (UVOS) (n = 541;age: 85+ years) and Central India Eye and Medical Study (CIEMS) (n = 4467; age: 30+ years). MMD was defined according to the Meta-analysis for Pathologic Myopia Study Group. Based on binary regression analyses, probability equations were formulated.</p><p><strong>Results: </strong>The total study population (27 607 eyes; 14 108 individuals) was randomly divided in a ratio of 1:1 into a development subgroup for the probability score development and into a validation subgroup. In the validation subgroup, the probability assessment for MMD stage 2+ and 3+ had an area under the receiver operating characteristic curve of 0.996 and 0.998, respectively. Applying the probability equations, MMD stage 2+ probability for myope with an axial length of 28 and 30 mm increased from age 30 to 75 years from 55.0% to 88.1% and from 99.3% to 99.8%, respectively. MMD stage 3+ probability at an axial length of 28 and 30 mm increased from age 30 to 75 years from 8.3% to 57.5% and from 81.8% to 98.5%, respectively.</p><p><strong>Conclusions: </strong>The MMD probability assessment offers a rough estimate of the MMD probability at present and at older age, based on axial length and age. For an axial length of 28 and 30 mm, the probability of MMD stage 3+ at 75 years was 57.5% and 98.5%, respectively.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149134563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Focal ambient visual acuity stimulation improves vision in amblyopic children with stagnating BCVA—A retrospective study","authors":"Kai Januschowski,&nbsp;Abdullah Salim,&nbsp;Anna Thonet,&nbsp;Spyridon Dimopoulos,&nbsp;Henrike Julich-Haertel,&nbsp;Johann-Peter Engels,&nbsp;Norbert Schulz,&nbsp;Stéphanie Langefeld,&nbsp;Rudolf Siegel,&nbsp;Susanne Hopf","doi":"10.1111/aos.70137","DOIUrl":"10.1111/aos.70137","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>The aim of this study was to investigate whether amblyopic children with stagnating best-corrected visual acuity (BCVA) would benefit from an additional stimulation therapy—specifically focal ambient visual acuity stimulation (FAVAS) integrated into a computer game—compared to occlusion therapy alone.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective, multicentre study analysed clinical records of 227 children with amblyopia showing stagnation of visual acuity despite at least 90 days of occlusion therapy. Analyses were performed on an eye-based level. Eyes that had received FAVAS (Caterna Vision GmbH, Potsdam, Germany) alongside occlusion therapy were assigned to the FAVAS group, while eyes treated with occlusion therapy alone served as controls. Post hoc propensity score matching was applied. After matching, 105 patients (114 eyes; 57 eyes per group) remained for analysis. The primary endpoint was improvement in best corrected visual acuity (BCVA, logMAR); the secondary endpoint was change in stereo vision.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The FAVAS group showed a significant improvement in BCVA, with a mean gain of 0.15 logMAR (95% CI [0.11;0.18], <i>p</i> &lt; 0.001), compared to a non-significant improvement of 0.01 logMAR (95% CI [−0.02;0.04], <i>p</i> = 0.356) in the control group. No significant changes were observed in stereo vision in either group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The combination of occlusion therapy and FAVAS was superior to occlusion alone in amblyopic children with stagnating BCVA, yielding significant and clinically relevant improvements in visual acuity. These findings support the integration of digital stimulation therapy as an effective adjunct to conventional amblyopia treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>German Clinical Trials Register (DRKS): DRKS00030216.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":"104 7","pages":"811-817"},"PeriodicalIF":3.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aos.70137","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147669780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and associations of hyper-reflective bodies in the posterior vitreous: The Beijing eye study","authors":"Jost B. Jonas,&nbsp;Songhomitra Panda-Jonas,&nbsp;Rahul A. Jonas,&nbsp;Ya Xing Wang","doi":"10.1111/aos.70139","DOIUrl":"10.1111/aos.70139","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To assess prevalence and associations of intra-vitreal hyper-reflective bodies (vHRBs) in the posterior vitreous in a general population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Participants of the population-based Beijing Eye Study underwent systemic and ophthalmological examinations. We included into this study a randomly selected group of normal eyes without retinal diseases and a randomly selected group of eyes with age-related macular degeneration (AMD), polypoidal choroidal vasculopathy (PVC) or central serous choroidopathy (CSC). Using serial optical coherence tomography scans of the posterior fundus region, we searched for vHRBs in the posterior vitreous compartment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study consisted of 1347 eyes (age: 64.3 ± 9.8 years, range: 50–91 years; axial length: 23.04 ± 1.00 mm, range: 19.39–28.93 mm). vHRB were detected in 314/1347 eyes (23.3%; 95% confidence interval [CI]: 21.1, 25.6), that is, in 137 out of 447 normal eyes (28.9%; 95% CI: 24.8, 33.0), 110/458 eyes with early AMD (24.0%; 95% CI: 20.1, 27.9), 45/278 eyes with intermediate AMD (16.2%; 95% CI: 11.8, 20.5), 3/35 eyes with PCV (8.6%; 95% CI: 0.00, 18.3), and in 19/94 eyes with CSC (20.2%; 95% CI: 11.9, 28.5). In multivariable analysis, higher vHRB prevalence was associated with younger age (OR: 0.93; 95% CI: 0.91, 0.95; <i>p</i> &lt; 0.001), shorter axial length (OR: 0.69; 95% CI:0.56, 0.84; <i>p</i> &lt; 0.001), and lower stage of posterior vitreous detachment (OR: 0.53; 95% CI: 0.44, 0.64; <i>p</i> &lt; 0.001). It was independent of AMD stage (<i>p</i> = 0.87), and prevalence of PCV (<i>p</i> = 0.67) and CSC (<i>p</i> = 0.40). Higher amount of vHRBs (multivariable linear regression analysis) correlated with younger age (beta: −0.21; B: −0.02; 95% CI: −0.03, −0.02; <i>p</i> &lt; 0.001), shorter axial length (beta: −0.07; B: −0.09; 95% CI: −0.16, −0.02; <i>p</i> = 0.009) and lower stage of posterior vitreous detachment (beta: −0.15; B: −0.13; 95% CI: −0.19, −0.08; <i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>vHRBs were detected in one out of four normal eyes of individuals aged 50+ years, in dependence on younger age, shorter axial length and lower degree of posterior vitreous detachment. They were independent of a concurrence of AMD, PCV and CSC.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":"104 7","pages":"769-779"},"PeriodicalIF":3.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insulin usage and glaucoma treatment associated with the incidence of surgically treated vision-threatening epiretinal membrane: Evidence from an epidemiological study.","authors":"Sirpa Loukovaara, Jari Haukka","doi":"10.1111/aos.70256","DOIUrl":"https://doi.org/10.1111/aos.70256","url":null,"abstract":"<p><strong>Purpose: </strong>Multiple factors play a role in epiretinal membrane (ERM) formation and appear to affect the risk of ERM surgery. We explored whether the use of common systemic and topical medications is associated with ERM surgery in Finland.</p><p><strong>Methods: </strong>The main outcome variable was incidence of surgically treated vision-threatening epiretinal membrane (NOMESCO codes CKD91, 92, 94). The population-based historic cohort consisted of participants whose follow-up was started 2000. The main exposures of interest were Anatomical Therapeutic Chemical (ATC) codes: A10A (INSULINS AND ANALOGUES), A10B (BLOOD GLUCOSE-LOWERING DRUGS, excluding INSULINS), C10AA (HMG CoA reductase inhibitors) and S01 (OPHTHALMOLOGICALS) initiated during 2001-2010. We constructed a nested case-control (NCC) design with conditional logistic regression taking matching by sex and year of birth with calibre of 1 year into account and used NCC incident density sampling. Results are presented as odds ratios (OR) with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>Our cohort involved 2165 ERM cases undergoing surgery on any eye and 10 825 age-matched controls who did not undergo surgery (five for each case). In univariate analysis, the use of insulins and analogues (adjusted OR, 1.39 [95% CI, 1.24-1.56]) and blood glucose-lowering drugs (1.25, 1.02-1.53) were associated with an increased risk for ERM surgery. In multivariate analysis, the risk remained high in insulin users (1.67, 1.46-1.91) and in patients using any glaucoma medication (2.71, 2.30-3.19).</p><p><strong>Conclusions: </strong>Our study demonstrates registry-based associations between insulin use, glaucoma therapies and ERM surgery. These findings do not support a causal link.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult-onset Coats disease: A systematic review and meta-analysis of imaging biomarkers and targeted therapies","authors":"Catarina Francisco,&nbsp;Nisa Silva,&nbsp;Camiel J. F. Boon","doi":"10.1111/aos.70149","DOIUrl":"10.1111/aos.70149","url":null,"abstract":"<p>Coats disease diagnosed in adulthood is a rare idiopathic retinal telangiectatic vasculopathy that may differ in phenotype from childhood-diagnosed cases. This systematic review synthesizes current evidence to characterize its clinical spectrum, imaging features, treatment outcomes and underlying mechanisms, with a focus on immunovascular pathways. Following <i>Preferred Reporting Items for Systematic Reviews and Meta-Analyses</i> (PRISMA 2020) guidelines, PubMed, Scopus and Web of Science were searched through October 2025 for studies including patients ≥18 years with confirmed Coats disease. Clinical and imaging findings, treatment strategies and outcomes were extracted and narratively synthesized. When possible, random-effects meta-analysis was performed. Thirty-five studies comprising 240 patients (250 eyes) were included. Disease presentation was predominantly unilateral and diagnosed at Shields Stage 2 or 3. Laser photocoagulation and anti-vascular endothelial growth factor (VEGF) agents were the most frequently described therapies, with anatomical stabilization or regression of exudation reported in approximately half of treated eyes across heterogeneous studies, and better outcomes in earlier stages. Visual acuity was stabilized or improved in 57.1% of treated eyes, while recurrence occurred in 19.3%. Multimodal imaging consistently identified peripheral telangiectasia, lipid exudation and localized capillary nonperfusion. Aqueous cytokine profiling in small cohorts has reported elevated inflammatory mediators (e.g. interleukin [IL]-6 and IL-1β) in some adults, suggesting that inflammatory signalling may contribute to blood–retina barrier dysfunction and macular oedema alongside VEGF-related permeability. Current evidence supports Coats disease diagnosed in adulthood as a chronic telangiectatic retinal vasculopathy with frequent macular involvement. Therapeutic outcomes appear to favour individualized, imaging-guided combination strategies and prospective studies with standardized endpoints are needed to refine management.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":"104 7","pages":"e724-e744"},"PeriodicalIF":3.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aos.70149","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prechoroidal cleft in neovascular age-related macular degeneration (AMD): A narrative review of pathophysiology, clinical implications and prognosis","authors":"Clara Rizzo,&nbsp;Lorenzo Vannozzi,&nbsp;Marco Lupidi,&nbsp;Maria Cristina Savastano,&nbsp;Enrico Borrelli,&nbsp;Rodolfo Mastropasqua,&nbsp;Fabio Panini,&nbsp;Emanuele Crincoli,&nbsp;Francesco Faraldi,&nbsp;Gianni Virgili,&nbsp;Fabrizio Giansanti,&nbsp;Daniela Bacherini","doi":"10.1111/aos.70095","DOIUrl":"10.1111/aos.70095","url":null,"abstract":"<p>The prechoroidal cleft (PC) is a hyporeflective space visualized on optical coherence tomography (OCT), typically located within the pigment epithelial detachments (PEDs) in neovascular age-related macular degeneration (nAMD). Although its pathogenesis is not yet fully understood, proposed mechanisms include fluid accumulation secondary to macular neovascularization (MNV), contractile forces from fibrovascular tissue and chronic structural remodelling of the outer retinal layers. This narrative review synthesizes the current evidence regarding the imaging features, pathophysiological mechanisms, clinical relevance and prognostic implications of the PC in nAMD. The presence of a PC has been variably associated with MNV activity, poor visual outcomes, increased treatment burden and a higher risk of complications, such as retinal pigment epithelium (RPE) tears and submacular haemorrhage (SMH). However, emerging data suggest that the cleft may regress following sustained anti-VEGF therapy, implying a potential role as a marker of therapeutic response and anatomical improvement. Thus, the PC may serve as a dynamic biomarker of disease activity in nAMD patients. Nevertheless, its precise role in disease progression remains unclear, highlighting the need for further longitudinal and histopathological studies.</p>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":"104 7","pages":"e745-e756"},"PeriodicalIF":3.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147343206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal corneal thickness changes and their relation to ocular and systemic cardiovascular risk factors: Results from the Gutenberg Health Study","authors":"P. Wolfrum,&nbsp;A. M. Welzel,&nbsp;E. W. Böhm,&nbsp;J. Wasielica-Poslednik,&nbsp;P. S. Wild,&nbsp;I. Schmidtmann,&nbsp;J. Weinmann-Menke,&nbsp;M. E. Beutel,&nbsp;K. Geschke,&nbsp;K. J. Lackner,&nbsp;N. Pfeiffer,&nbsp;A. K. Schuster","doi":"10.1111/aos.70067","DOIUrl":"10.1111/aos.70067","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>This study aimed to evaluate 5-year longitudinal changes in both central and peripheral corneal thickness and to explore associations with ocular characteristics as well as systemic cardiovascular risk factors (CVRF).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The Gutenberg Health Study is a prospective population-based cohort study comprising 15 010 participants aged 35–74 years at baseline. Scheimpflug tomography (Pentacam, Oculus, Wetzlar, Germany) was performed during both the 5-year (2012–2017) and 10-year (2017–2022) follow-up examinations. Longitudinal changes in central corneal thickness (CCT) and in concentric rings at 2 mm (D2), 4 mm (D4), 6 mm (D6), 8 mm (D8) and 10 mm (D10) were evaluated in eyes with available measurements at both time points. Additionally, associations between changes in CCT and ocular characteristics as well as systemic CVRFs at the 5-year FU as well as its 5-year changes (Δ) were investigated by multivariable linear regression analyses using generalized estimating equations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>8755 eyes of 4857 participants were included and a significant reduction in CCT was observed across all age groups over 5 years. Peripheral corneal thickness remained stable over time. Multivariable analyses identified associations with a change in CCT and ocular characteristics including corneal diameter (B = −0.06, <i>p</i> &lt; 0.0001), axial length (B = 0.04, <i>p</i> &lt; 0.008), pseudophakia at the 5-year examination (B = −0.18, <i>p</i> &lt; 0.03) as well as systemic CVRF including age (B = −0.04, <i>p</i> &lt; 0.008), HbA1c (B = 0.03; <i>p</i> &lt; 0.040), ΔHbA1c (B = 0.05; <i>p</i> &lt; 0.001), ΔLDL (B = -0.03, <i>p</i> &lt; 0.047), ΔHDL (B = −0.05, <i>p</i> = 0.0006), ΔMAP (B = −0.04, <i>p</i> &lt; 0.01) and a continuous smoking status (B = 0.08, <i>p</i> &lt; 0.035).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>While observing a 5-year decline in CCT, peripheral corneal thickness remained relatively stable. We observed longitudinal associations between CCT changes and HbA1c, lipid profile, mean arterial pressure and smoking, suggesting that corneal thickness changes may be influenced by cardiovascular and metabolic health and thus may be taken into consideration in glaucoma risk stratification.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":"104 7","pages":"e777-e785"},"PeriodicalIF":3.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146083737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three hundred sixty-degree prophylactic laser retinopexy versus focal laser during rhegmatogenous retinal detachment repair: A systematic review and meta-analysis","authors":"Luke Yaldo,&nbsp;Albert Ting,&nbsp;Saif Pasha,&nbsp;Kyle Sporn,&nbsp;Abdelaziz Abdelaal,&nbsp;Joshua Ong","doi":"10.1111/aos.70127","DOIUrl":"10.1111/aos.70127","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To compare the anatomic, functional and safety outcomes of intra-operative 360-degree prophylactic laser retinopexy versus focal laser retinopexy during pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD) and to assess the certainty of evidence.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>PubMed, Web of Science and Scopus were searched on June 27, 2025. Randomized controlled trials and comparative observational studies evaluating 360-degree versus focal laser during PPV for RRD were included. Two reviewers independently extracted data and assessed risk of bias (ROB-2, NIH tools). Pooled analyses were conducted using random-effects models, and the certainty of evidence was graded using GRADE. The primary outcome was single-surgery anatomic success (SSAS). Secondary outcomes included best-corrected visual acuity (BCVA), intraocular pressure (IOP) and post-operative complications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirteen studies comprising 3639 eyes were included. Compared with focal laser, 360-degree laser achieved higher odds of SSAS (OR: 1.82; 95% CI, 1.40–2.39; <i>I</i>² = 0%; moderate-certainty). No differences were observed in final BCVA (MD = 0.06; 95% CI, −0.01 to 0.13; <i>I</i>² = 75.5%) or BCVA improvement (MD: –0.06; 95% CI, −0.22 to 0.11; <i>I</i>² = 0%). Rates of epiretinal membrane (OR = 1.11; 95% CI: 0.80–1.54, <i>I</i>² = 26.85%, moderate certainty), proliferative vitreoretinopathy (OR = 0.62; 95% CI: 0.36–1.08, <i>I</i>² = 0%, moderate certainty), cystoid macular oedema and macular hole were comparable between groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Adjunctive 360-degree laser retinopexy during PPV for RRD was associated with higher SSAS without a measurable increase in post-operative complications. However, no improvement in visual acuity outcomes was observed. Given the predominance of observational evidence, further well-designed randomized trials are warranted to clarify the magnitude of benefit.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":"104 7","pages":"731-741"},"PeriodicalIF":3.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aos.70127","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147621404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Tutopatch® assisted surgery for complex strabismus study: TASCS-study","authors":"Ires A. W. Verhees,&nbsp;Hinke Marijke Jellema,&nbsp;Anne-Marie E. L. Langenhorst,&nbsp;B. Jeroen Klevering,&nbsp;Laurentius J. van Rijn,&nbsp;Annabel L. W. Groot","doi":"10.1111/aos.70140","DOIUrl":"10.1111/aos.70140","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To investigate the efficacy of tendon elongation using bovine pericardium (Tutopatch®) in complex strabismus surgeries, with a specific focus on longer follow-up of postoperative outcomes and patient satisfaction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this pre-post cohort study, the records of all patients who underwent tendon elongation strabismus surgery with Tutopatch® at Radboudumc and Amsterdam UMC were retrospectively reviewed. Eligible patients were invited for a single prospective follow-up visit to assess long-term outcomes. Strabismus angle (success defined as ≤5.71° of orthotropia) and duction limitations (converted to a pseudo-quantitative scale ranging from 0 to 5) were evaluated preoperatively, 1 week postoperatively, 3 months postoperatively and at longer intervals where possible. Patient satisfaction was measured on a Visual Analogue Scale at the prospective follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sixty-nine participants (mean age 41.3 ± 18.4 years) were included. Fifty-one patients had childhood onset and eighteen patients had acquired onset of strabismus. Tutopatch® was predominantly used to correct the horizontal deviation. Long-term follow-up data (&gt;17.4 weeks) were available for 49 patients (71%), with a median follow-up of 124 weeks (range 19.9–431 weeks) and surgical success was achieved in 73% (near) and 60% (distance). Duction limitations significantly increased postoperatively, especially in exodeviations, but improved over time and seemed to have minimal impact on ocular alignment in primary position. Patient satisfaction was very high (median VAS 9.0), with only weak-to-moderate correlation with ocular alignment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Tutopatch® is a viable surgical option for tendon elongation in complex strabismus cases with favorable long-term ocular alignment, mild duction limitation and high patient satisfaction.</p>\u0000 </section>\u0000 </div>","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":"104 7","pages":"818-827"},"PeriodicalIF":3.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/aos.70140","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147696912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Memoriam: Professor Jan C. van Meurs","authors":"Dion Paridaens,&nbsp;Kai Kaarniranta,&nbsp;Line Kessel","doi":"10.1111/aos.70211","DOIUrl":"https://doi.org/10.1111/aos.70211","url":null,"abstract":"","PeriodicalId":6915,"journal":{"name":"Acta Ophthalmologica","volume":"104 7","pages":"834-835"},"PeriodicalIF":3.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149146642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}