Pregnancy as a risk factor for central serous chorioretinopathy: A systematic review and meta-analysis.

IF 2.8 3区医学 Q1 OPHTHALMOLOGY

Acta Ophthalmologica Pub Date : 2025-09-30 DOI:10.1111/aos.70013

Nathalie Skovgaard Eriksen, Zainab Fakhril-Din, Riccardo Fasana, Rodrigo Anguita, Elon H C van Dijk, Lorenzo Ferro Desideri, Jakob Grauslund, Michael Stormly Hansen, Oliver Niels Klefter, Armin Motaabbed, Line Petersen, Prithvi Ramtohul, Mehmet Cem Sabaner, Osman Savran, Miklos Schneider, Yousif Subhi

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引用次数: 0

Abstract

Purpose: Pregnancy induces significant changes in the body, including increased peripheral and choroidal blood perfusion and an increased systemic corticosteroid level. Here, we systematically reviewed the evidence on pregnancy as a risk factor for developing central serous chorioretinopathy (CSC) and conducted a meta-analysis to obtain a summary estimate.

Methods: We searched 12 literature databases on 16 February 2025 for epidemiological studies, which evaluated the potential association between pregnancy and CSC. All eligible studies were included for a qualitative review and a meta-analysis. The meta-analysis was made using the random-effects model on the odds ratio (OR) of the association between pregnancy and CSC.

Results: Four studies were eligible for our review. Of the 2766 individuals (1345 patients with CSC, 1391 controls) in these studies, females constituted 26%-64% of study populations in individual studies. The calculated summary estimate of pregnancy as a risk factor for CSC was OR 5.51 (95% CI: 2.12-14.30, p = 0.00046). Heterogeneity statistics suggested minimal to no heterogeneity (Cochran's Q = 0.72; I² = 0%), the funnel plot was symmetrical and the sensitivity analysis suggested robustness of the estimates.

Conclusion: Pregnancy appears to be a significant risk factor for CSC.

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妊娠是中枢性浆液性脉络膜视网膜病变的危险因素：一项系统回顾和荟萃分析。

目的：妊娠引起机体的显著变化，包括外周血和脉络膜血灌注增加和全身皮质类固醇水平增加。在这里，我们系统地回顾了妊娠是发生中心性浆液性脉络膜视网膜病变（CSC）的危险因素的证据，并进行了荟萃分析以获得总结估计。方法：我们于2025年2月16日检索了12个文献数据库进行流行病学研究，评估妊娠与CSC之间的潜在关联。所有符合条件的研究纳入定性评价和荟萃分析。采用随机效应模型对妊娠与CSC相关的优势比（OR）进行meta分析。结果：有4项研究符合我们的综述。在这些研究中的2766名个体（1345名CSC患者，1391名对照）中，女性占个体研究研究人群的26%-64%。妊娠作为CSC危险因素的计算总值为OR 5.51 （95% CI: 2.12-14.30, p = 0.00046）。异质性统计表明，异质性极小或无异质性（Cochran’s Q = 0.72; I2 = 0%），漏斗图对称，敏感性分析表明，估计具有稳健性。结论：妊娠是CSC的重要危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Ophthalmologica 医学-眼科学

CiteScore

7.60

自引率

5.90%

发文量

433

审稿时长

6 months

期刊介绍： Acta Ophthalmologica is published on behalf of the Acta Ophthalmologica Scandinavica Foundation and is the official scientific publication of the following societies: The Danish Ophthalmological Society, The Finnish Ophthalmological Society, The Icelandic Ophthalmological Society, The Norwegian Ophthalmological Society and The Swedish Ophthalmological Society, and also the European Association for Vision and Eye Research (EVER). Acta Ophthalmologica publishes clinical and experimental original articles, reviews, editorials, educational photo essays (Diagnosis and Therapy in Ophthalmology), case reports and case series, letters to the editor and doctoral theses.