American Journal of Transplantation最新文献

{"title":"The Case for Mandating ABO Genotyping to Prevent Catastrophic ABO-A Subgroup Errors.","authors":"Cathi Murphey,Matthias Kapturczak","doi":"10.1016/j.ajt.2025.07.2460","DOIUrl":"https://doi.org/10.1016/j.ajt.2025.07.2460","url":null,"abstract":"","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"6 1","pages":""},"PeriodicalIF":8.8,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144612796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to 'The Rochester Protocol for living donor liver transplantation of unresectable colorectal liver metastasis: A 5-year report on selection, approval, and outcomes' [American Journal of Transplantation 25 (2025) 780-792].","authors":"Matthew M Byrne,Mariana Chávez-Villa,Luis I Ruffolo,Anthony Loria,Yutaka Endo,Amber Niewiemski,Cristina Jimenez-Soto,Jennifer I Melaragno,Gopal A Ramaraju,Priya D Farooq,Richard F Dunne,Karen Pineda-Solis,Amit Nair,Mark Orloff,Koji Tomiyama,Roberto Hernandez-Alejandro","doi":"10.1016/j.ajt.2025.06.023","DOIUrl":"https://doi.org/10.1016/j.ajt.2025.06.023","url":null,"abstract":"","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"12 1","pages":""},"PeriodicalIF":8.8,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practical and ethical considerations in kidney paired donation and emerging liver paired exchange.","authors":"Neetika Garg,Joe Habbouche,Elisa J Gordon,AnnMarie Liapakis,Michelle T Jesse,Krista L Lentine","doi":"10.1016/j.ajt.2025.07.2459","DOIUrl":"https://doi.org/10.1016/j.ajt.2025.07.2459","url":null,"abstract":"Since the first kidney paired donation (KPD) transplant in the United States in 1999, the volume and scope of KPD has expanded substantially, accounting for nearly 20% of living donor kidney transplants in 2021-2022. Our review article discusses the practical and ethical issues specific to paired donor exchange that patients, transplant centers, and exchange programs commonly encounter. Access to paired donor exchange and education of candidates regarding the potential benefits, risks, and logistics of KPD are important considerations. Transplant centers and patients must consider practical issues including wait-times, allocation and matching strategies, assessment of organ quality, complex donors, cold ischemia time, and risks of broken chains. Protections available to donors from current KPD programs, the potential psychosocial effects, and the ethical concerns related to variable access and the proprietary nature of private exchange programs are also discussed. More detailed, timely data collection at a national level, and ability to merge national data with individual donor exchange registries will enable the analysis of the impact and outcomes of future trends in paired donation. KPD experience and key concepts may inform liver paired exchange, which has been employed internationally to expand living donor liver transplantation and is emerging in the United States.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"22 1","pages":""},"PeriodicalIF":8.8,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Human Development Index, Complication Reporting, and Failure-to-Rescue in Living Donor Liver Transplantation: Clarifying Critical Disparities.","authors":"Dimitri A Raptis,Michael Spiro,Marina Berenguer,Mohamed Rela","doi":"10.1016/j.ajt.2025.06.026","DOIUrl":"https://doi.org/10.1016/j.ajt.2025.06.026","url":null,"abstract":"","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"68 1","pages":""},"PeriodicalIF":8.8,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Current State of Simultaneous Heart Liver Transplantation in the United States.","authors":"Ahmad Anouti,Ali H Dakroub,Hussein Krayem,Lauren E Matevish,Hamza Dahshi,Sara Hassan,Arjmand R Mufti,Parsia A Vagefi,Maryjane Farr,Matthias Peltz,Lisa B VanWagner,Thomas G Cotter,William M Lee,Madhukar S Patel","doi":"10.1016/j.ajt.2025.07.001","DOIUrl":"https://doi.org/10.1016/j.ajt.2025.07.001","url":null,"abstract":"Simultaneous heart liver transplantation (SHLT) has expanded in recent years, bolstered by increases in congenital heart disease (CHD) indications and improvements in organ preservation. We performed a contemporary analysis of patients undergoing SHLT for CHD vs non-CHD, further exploring the impact of machine perfusion (MP). Patients undergoing SHLT between 2010-2024 were retrospectively identified using the UNOS database, assessing a primary outcome of patient survival and secondary outcome of MP utilization. 535 patients underwent SHLT, 224(41.9%) with CHD indication and 311(58.1%) non-CHD. CHD recipients had significantly lower one-(72.9% vs. 89.4%,p<0.01) and five-year survival (66.1% vs. 81.4%,p<0.01) compared to non-CHD recipients. CHD indication was independently associated with a two-fold increased mortality risk, compared to a non-CHD diagnosis (HR:2.31, 95%CI:[1.53,3.47]). Decision tree boosting demonstrated a 2.9% higher relative mortality likelihood after SHLT for recipients with CHD. From 2022-2024, SHLT MP utilization for CHD increased; among 111 patients, 18.0% received a MP liver, 8.1% a MP heart, and 10.8% MP heart and MP liver. In this analysis of modern SHLT cases, patients with CHD had suboptimal outcomes; several donor and recipient factors also impacted mortality. Awareness of these factors can guide pre-transplant optimization, donor/recipient matching, and strategic MP use to improve survival.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"13 1","pages":""},"PeriodicalIF":8.8,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144578682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STAR 2025 innate working group: the potential role of innate allorecognition in kidney allograft damage.","authors":"Olivier Thaunat,Fadi G Lakkis,Vasilis Kosmoliaptsis,Carrie Schinstock,Anat Tambur,Sebastiaan Heidt,Maarten Naesens","doi":"10.1016/j.ajt.2025.06.030","DOIUrl":"https://doi.org/10.1016/j.ajt.2025.06.030","url":null,"abstract":"In solid organ transplantation, the alloimmune response is traditionally attributed to the action of alloreactive T cells that recognize mismatched human leukocyte antigens (HLA), and by antibody formation and antibody-mediated rejection. However, recent evidence indicates that these paradigms of involvement of the adaptive immune system in organ transplant rejection don't explain all cases of graft inflammation, and that innate cell allorecognition plays a role. This review, conducted by the innate team of the Sensitization in Transplantation Assessment of Risk (STAR) workgroup, summarizes the concepts and empirical evidence supporting innate allorecognition. The focus is on NK cell activation via missing self and monocyte activation through SIRPα-CD47 pathway and SIRPα gene polymorphisms. A consensus definition of genetic missing self is proposed, necessitating both donor and recipient HLA class I genotyping, and evaluation of recipient inhibitory killer-cell immunoglobulin-like receptor (KIR) genotype. While in vitro studies and preclinical validations corroborate the potential of innate allorecognition concepts, further research is required to establish clinical utility. This article delineates future research directions to bridge the gap between theoretical promise and practical application in clinical transplantation.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"9 1","pages":""},"PeriodicalIF":8.8,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144578717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter in reference to \"Kidney graft directly implanted on endovascular stent in external iliac artery: a preliminary experience\".","authors":"Emilien Seizilles de Mazancourt,Xavier Matillon,Matthieu Arsicot","doi":"10.1016/j.ajt.2025.06.033","DOIUrl":"https://doi.org/10.1016/j.ajt.2025.06.033","url":null,"abstract":"","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"20 1","pages":""},"PeriodicalIF":8.8,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"West Nile Virus and Other Nationally Notifiable Arboviral Diseases - United States, 2023.","authors":"Marcus Pereira","doi":"10.1016/j.ajt.2025.06.032","DOIUrl":"https://doi.org/10.1016/j.ajt.2025.06.032","url":null,"abstract":"","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Malik and Patel.","authors":"Matthew M Byrne, Koji Tomiyama, Roberto Hernandez-Alejandro","doi":"10.1016/j.ajt.2025.06.031","DOIUrl":"https://doi.org/10.1016/j.ajt.2025.06.031","url":null,"abstract":"","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.9,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144566856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver transplantation for hepatitis D virus/hepatitis B virus coinfection in Italy: An intention-to-treat analysis of long-term outcomes","authors":"Roberta Angelico ,&nbsp;Silvia Trapani ,&nbsp;Tommaso Maria Manzia ,&nbsp;Ilaria Lenci ,&nbsp;Paolo Grossi ,&nbsp;Andrea Ricci ,&nbsp;Patrizia Burra ,&nbsp;Enzo Andorno ,&nbsp;Salvatore Agnes ,&nbsp;Sherrie Bhoori ,&nbsp;Umberto Baccarani ,&nbsp;Luca S. Belli ,&nbsp;Paola Carrai ,&nbsp;Lucio Caccamo ,&nbsp;Amedeo Carraro ,&nbsp;Matteo Cescon ,&nbsp;Michele Colledan ,&nbsp;Umberto Cillo ,&nbsp;Luciano De Carlis ,&nbsp;Nicola De Maria ,&nbsp;Mario Angelico","doi":"10.1016/j.ajt.2025.03.003","DOIUrl":"10.1016/j.ajt.2025.03.003","url":null,"abstract":"<div><div>Patients with hepatitis D virus (HDV)/hepatitis B virus (HBV)-related end-stage liver disease candidates for liver transplantation (LT) have traditionally been regarded as a special population, although their outcomes are controversial. An intention-to-treat (ITT) analysis of long-term outcomes of HDV/HBV-coinfected patients waitlisted for LT in Italy, between 2011 and 2020, was performed and compared with HBV-monoinfected LT candidates. Of 1731 HBV-infected LT candidates, 1237 (71.5%) had HBV monoinfection and 494 (28.5%) HDV/HBV coinfection. At listing, HDV/HBV-coinfected patients were significantly younger, listed mainly for decompensated cirrhosis, and with fewer hepatocellular carcinoma (HCC) cases; (26% vs 65.8%; <em>P</em> &lt;.0001) compared with HBV-monoinfected patients. HDV/HBV-coinfected patients showed better 5-year ITT survival (83.2%; 95% CI: 79.4%-83.4%, vs 71.6%; 95% CI: 68.8%-74.2%; <em>P</em> &lt; .0001). ITT-multivariable analysis identified the presence of HCC, advanced recipient age, and high model for end-stage liver disease-Na scores as mortality risk factors. Five years after LT, 99.1% of HDV/HBV-coinfected patients received oral nucleos(t)ide analogs, with immunoglobulins against antigen of the hepatitis B virus in 91.8% of cases. HBV and HDV viral recurrences were 1.1% and 0.2%, respectively, whereas recurrent or de novo HCC were 8.9% and 0.3%, respectively. In Italy, HDV/HBV-coinfected patients waitlisted for LT showed more favorable outcomes compared with HBV-monoinfected patients, both before and after LT. These excellent results, from the largest cohort reported so far, suggest that HDV/HBV-coinfected LT recipients do not represent a risky population and may be considered for simpler long-term antiviral prophylactic strategies.</div></div>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"25 7","pages":"Pages 1502-1514"},"PeriodicalIF":8.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143583999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}