American Journal of Transplantation最新文献

Comment on Wisdom of the Crowd: Ensuring the Justness and Validity of Group Decision-Making in Solid Organ Transplant by Harper and colleagues. AJT Feb 2026. 《群体智慧：确保实体器官移植群体决策的公正性和有效性》（Harper等）评议。美国夏令时2026年2月。

IF 8.2 2区医学

American Journal of Transplantation Pub Date : 2026-05-07 DOI: 10.1016/j.ajt.2026.04.026

Aditya S Pawar

引用次数: 0

Corrigendum to "Molecular diagnosis of kidney allograft rejection based on the Banff Human Organ Transplant gene panel: A multicenter international study" [American Journal of Transplantation 25 (2025) 1631-1642]. “基于Banff人类器官移植基因面板的肾同种异体移植排斥反应的分子诊断：一项多中心国际研究”的更正[美国移植杂志25(2025)1631-1642]。

IF 8.2 2区医学

American Journal of Transplantation Pub Date : 2026-05-07 DOI: 10.1016/j.ajt.2026.01.012

Dina Zielinski, Valentin Goutaudier, Marta Sablik, Gillian Divard, Olivier Aubert, Alexis Piedrafita, Fariza Mezine, Jessy Dagobert, Anais Certain, Blaise Robin, Juliette Gueguen, Marion Rabant, Jean-Paul Duong van Huyen, Aurélie Sannier, Christine Randoux-Lebrun, Mehdi Maanaoui, Arnaud Lionet, Jean-Baptiste Gibier, Viviane Gnemmi, Moglie Le Quintrec, Bertrand Chauveau, Agathe Vermorel, Sophie Brouard, Magali Giral, Lionel Couzi, Oriol Bestard, Michelle Elias, Kevin Louis, Ivy A Rosales, R Neal Smith, Vanderlene L Kung, Dany Anglicheau, Christophe Legendre, Arnaud Del Bello, Edmund Huang, Benjamin Adam, Nassim Kamar, Robert B Colvin, Michael Mengel, Carmen Lefaucheur, Alexandre Loupy

引用次数: 0

De novo belatacept based immunosuppression is not associated with increased risk of invasive fungal infection in kidney transplant recipients. 在肾移植受者中，以贝拉他普为基础的免疫抑制与侵袭性真菌感染风险增加无关。

IF 8.2 2区医学

American Journal of Transplantation Pub Date : 2026-05-05 DOI: 10.1016/j.ajt.2026.04.029

Emily M Eichenberger, Geeta M Karadkhele, Payas Vasanth, Christian Larsen

{"title":"De novo belatacept based immunosuppression is not associated with increased risk of invasive fungal infection in kidney transplant recipients.","authors":"Emily M Eichenberger, Geeta M Karadkhele, Payas Vasanth, Christian Larsen","doi":"10.1016/j.ajt.2026.04.029","DOIUrl":"https://doi.org/10.1016/j.ajt.2026.04.029","url":null,"abstract":"The risk of invasive fungal infection (IFI) in kidney transplant recipients (KTR) receiving de novo belatacept-based immunosuppression remains incompletely understood. We conducted a single-center retrospective cohort study of adult KTR receiving de novo belatacept- or tacrolimus-based immunosuppression between 2016 -2025. Cumulative incidence of IFI was estimated using competing-risks methods with death as a competing event and compared using Gray's test. Associations between immunosuppression and IFI risk were evaluated using a cause-specific Cox model, with thymoglobulin and high dose steroids modeled as time-dependent covariates. A prespecified propensity score-matched cohort was analyzed to address selection bias. Associations between IFI and mortality were assessed using time-dependent Cox proportional hazards models. Among 2,729 KTR, 1,875 (68.7%) received belatacept and 854 (31.3%) tacrolimus. The one-year cumulative incidence of IFI was 1.4% in belatacept-treated patients vs 1.8% in tacrolimus-treated patients (P=0.47). Belatacept compared to tacrolimus was not associated with IFI (hazard ratio [HR] 0.87, 95% CI 0.54, 1.39). IFI was associated with mortality (HR 5.03, 95% CI 3.12, 8.09). Similar results were observed in the propensity score-matched cohort. De novo belatacept-based immunosuppression does not confer increased risk of IFI, and routine antifungal prophylaxis may not be necessary.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

XVIIth Banff Conference on Allograft Pathology: The Banff Workshop Heart Report on Microvascular Inflammatory Burden in Heart Transplantation and the Impact of Molecular and Non-Invasive Diagnostic Tools. 第xviii届班夫同种异体移植病理会议：班夫研讨会心脏报告：心脏移植中的微血管炎症负担以及分子和非侵入性诊断工具的影响。

IF 8.2 2区医学

American Journal of Transplantation Pub Date : 2026-05-02 DOI: 10.1016/j.ajt.2026.04.024

Marny Fedrigo, Benjamin A Adam, Annalisa Angelini, Gerald J Berry, Guillaume Coutance, Jean-Paul Duong-Van-Huyen, Elena Osto, Elaine F Reed, Francesco Tona, Dylan V Miller

{"title":"XVIIth Banff Conference on Allograft Pathology: The Banff Workshop Heart Report on Microvascular Inflammatory Burden in Heart Transplantation and the Impact of Molecular and Non-Invasive Diagnostic Tools.","authors":"Marny Fedrigo, Benjamin A Adam, Annalisa Angelini, Gerald J Berry, Guillaume Coutance, Jean-Paul Duong-Van-Huyen, Elena Osto, Elaine F Reed, Francesco Tona, Dylan V Miller","doi":"10.1016/j.ajt.2026.04.024","DOIUrl":"https://doi.org/10.1016/j.ajt.2026.04.024","url":null,"abstract":"The XVIIth Banff Conference on Allograft Pathology, held in Paris in 2024 in collaboration with the Paris Institute for Transplantation and Organ Regeneration (PITOR) of Université de Paris Cité, convened the heart transplant (HTx) working group to discuss two main topics: (a) the microvascular inflammatory burden on endomyocardial biopsy (EMB), with a focus on new advancements in inflammation-endothelium interactions within the allograft; and (b) the impact of molecular and non-invasive diagnostic tools in rejection monitoring. The discussions addressed the implications of molecular pathology performed on formalin-fixed paraffin-embedded tissue in the context of the inflammatory burden on EMBs, and explored the emerging characteristics of the endothelium in the microvasculature and its relationship with alloantibodies. The integration of tissue and blood molecular analyses has enhanced the reliability and accuracy of EMB interpretation by pathologists, while highlighting the complexity of inflammatory mechanisms occurring in the allograft. The high negative predictive value of non-invasive biomarkers and novel imaging modalities suggests their potential applicability in clinical practice and their capacity to modify follow-up strategies in heart transplant recipients.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Normothermic regional perfusion in kidney transplants with donors after controlled circulatory death: Functional benefits and safety in older recipients. 控制性循环死亡后供体肾移植的常温局部灌注：老年受者的功能益处和安全性

IF 8.2 2区医学

American Journal of Transplantation Pub Date : 2026-05-02 DOI: 10.1016/j.ajt.2026.04.027

Néstor Toapanta, Jordi Comas, Fritz Diekmann, Edoardo Melilli, María José Pérez-Saez, Anna Vila, Carme Facundo, Emma Arcos, Jaume Tort, Alberto Sandiumenge, Francesc Moreso, Oriol Bestard

{"title":"Normothermic regional perfusion in kidney transplants with donors after controlled circulatory death: Functional benefits and safety in older recipients.","authors":"Néstor Toapanta, Jordi Comas, Fritz Diekmann, Edoardo Melilli, María José Pérez-Saez, Anna Vila, Carme Facundo, Emma Arcos, Jaume Tort, Alberto Sandiumenge, Francesc Moreso, Oriol Bestard","doi":"10.1016/j.ajt.2026.04.027","DOIUrl":"https://doi.org/10.1016/j.ajt.2026.04.027","url":null,"abstract":"Normothermic regional perfusion (NRP) is increasingly used in controlled donation after circulatory death (cDCD) to mitigate ischemia-reperfusion injury. While NRP reduces delayed graft function (DGF), its impact on long-term outcomes, particularly in elderly recipients, remains uncertain. We retrospectively analyzed first kidney transplants from cDCD donors in a national registry (2015-2023). Outcomes after NRP were compared to rapid recovery (RR) using 1:1 propensity-score matching based on donor/recipient age, comorbidities, and transplant year. A predefined subcohort analysis focused on recipients aged ≥65 years. Endpoints included DGF, hospital stay, renal function, and 5-year graft and patient survival. Among 1,414 transplants, 1,153 were eligible and 410 matched pairs were analyzed. DGF and median hospital stay were significantly lower with NRP than with RR (19% vs 34%; OR for RR vs NRP 2.87; 95% CI 2.1-4.0; p<0.001, and 11 vs 13 days; difference -2.0 days; 95% CI -3.6 to -0.4; p=0.012, respectively). No significant differences were observed in eGFR trajectories or 5-year overall graft survival (p=0.896), death-censored graft survival (p=0.666), and patient survival (p=0.981). Results were consistent in recipients ≥65 years. In this large real-world cDCD cohort, NRP improved early post-transplant outcomes without influencing mid-term graft or patient survival.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tensor-Based Integration of Time-Series Measurements Reveals Relationships Between Underlying Disease, Early Injury, and CD4+ Polarization in Liver Transplantation. 基于张量的时间序列测量积分揭示了肝移植中潜在疾病、早期损伤和CD4+极化之间的关系。

IF 8.2 2区医学

American Journal of Transplantation Pub Date : 2026-05-02 DOI: 10.1016/j.ajt.2026.04.025

Jackson L Chin, Zhixin Cyrillus Tan, Rebecca A Sosa, Ying Zheng, David W Gjertson, Alexander Hoffmann, Fady M Kaldas, Yuan Zhai, Jerzy W Kupiec-Weglinski, Elaine F Reed, Aaron S Meyer

{"title":"Tensor-Based Integration of Time-Series Measurements Reveals Relationships Between Underlying Disease, Early Injury, and CD4+ Polarization in Liver Transplantation.","authors":"Jackson L Chin, Zhixin Cyrillus Tan, Rebecca A Sosa, Ying Zheng, David W Gjertson, Alexander Hoffmann, Fady M Kaldas, Yuan Zhai, Jerzy W Kupiec-Weglinski, Elaine F Reed, Aaron S Meyer","doi":"10.1016/j.ajt.2026.04.025","DOIUrl":"https://doi.org/10.1016/j.ajt.2026.04.025","url":null,"abstract":"A lack of integrative analyses in liver transplantation (LT) limits understanding of relationships between immunological signatures, time, and recipient/donor health factors in LT. In this exploratory study, we collected cytokine and liver function test (LFT) measurements from LT donors and recipients at multiple pre- and post-operative timepoints. We developed a tensor-based factorization method to reduce these measurements to four components that manifested across cytokines, LFTs, and time. These components associated pre-operative immune signatures with immune signatures up to a month post-operation. Integration of allograft survival into this factorization reduced these four components to two associated with five-year allograft survival. These signatures suggested that pronounced CD4+ polarization associated with impaired growth factor expression and increased allograft loss risk. Donor and recipient age modulated this CD4+ polarization. These findings provide insights into the immunological signatures of LT, identifying potential therapeutic avenues for future validation.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-anastomotic biliary strictures after cDCD liver transplantation with normothermic regional perfusion- An IDEAL-Stage 4 study with a prospective radiological follow-up. 正常区域灌注的cDCD肝移植术后非吻合口胆道狭窄-一项理想4期研究和前瞻性放射学随访。

IF 8.2 2区医学

American Journal of Transplantation Pub Date : 2026-05-02 DOI: 10.1016/j.ajt.2026.04.028

Emma Mulet, Xavier Muller, Natacha Boulanger, Guillaume Rossignol, Fanny Lebossé, Domitille Erard, Teresa Antonini, Marie Charlotte Delignette, Alice Blet, Céline Guichon, Pierre Jacquenod, Angello Della Corte, Agnès Rode, Kayvan Mohkam, Jean-Yves Mabrut

{"title":"Non-anastomotic biliary strictures after cDCD liver transplantation with normothermic regional perfusion- An IDEAL-Stage 4 study with a prospective radiological follow-up.","authors":"Emma Mulet, Xavier Muller, Natacha Boulanger, Guillaume Rossignol, Fanny Lebossé, Domitille Erard, Teresa Antonini, Marie Charlotte Delignette, Alice Blet, Céline Guichon, Pierre Jacquenod, Angello Della Corte, Agnès Rode, Kayvan Mohkam, Jean-Yves Mabrut","doi":"10.1016/j.ajt.2026.04.028","DOIUrl":"https://doi.org/10.1016/j.ajt.2026.04.028","url":null,"abstract":"Retrospective studies showed a reduction of non-anastomotic strictures (NAS) after cDCD liver transplantation using normothermic regional perfusion (NRP). In the absence of an RCT, a systematic radiological follow-up of recipients is warranted to validate these findings. This single-center retrospective study (01/2015-01/2024) includes all consecutive cDCD liver transplantations performed after A-NRP at a single center. Recipients were included in a prospective radiological follow-up protocol with magnetic resonance cholangiopancreatography (MRCP) to identify NAS, which were defined as strictures of intra- or extra-hepatic bile ducts in the absence of arterial thrombosis. Seventy-one NRP cDCD LTs were included in the study of which 66 (93%) underwent a follow-up MRCP after a median of 180 days. We diagnosed 1 asymptomatic radiological NAS (1.4%) with minor severity (grade E) not requiring treatment. The rate of symptomatic anastomotic biliary complications was 30% (n=21). After a median follow-up of 39 months, we recorded no graft loss related to biliary complications. One- and 5-year graft and recipient survival rates were 94.4% and 85.9%, and 95.8% and 84.6% respectively. This single center 10-year experience with A-NRP for cDCD LT and a prospective MRCP follow-up of recipients shows <2% of NAS with no graft loss related to biliary complications.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AJT Catalyst: Expanding voices, accelerating science. AJT Catalyst：扩大声音，加速科学发展。

IF 8.2 2区医学

American Journal of Transplantation Pub Date : 2026-05-01 DOI: 10.1016/j.ajt.2026.03.012

James Gardner, Sandy Feng

引用次数: 0

The ASTS and AJT at 25 years: where we have been and where we will go. ast和AJT的25年：我们走过的路和我们将走向的路。

IF 8.2 2区医学

American Journal of Transplantation Pub Date : 2026-05-01 DOI: 10.1016/j.ajt.2026.03.031

Julie K Heimbach, Ginny L Bumgardner, Debra L Sudan, Elizabeth A Pomfret, James F Markmann

引用次数: 0

Circulating T cell specific extracellular vesicles as biomarkers of acute cellular rejection after lung transplantation. 循环T细胞特异性细胞外囊泡作为肺移植后急性细胞排斥反应的生物标志物。

IF 8.2 2区医学

American Journal of Transplantation Pub Date : 2026-04-28 DOI: 10.1016/j.ajt.2026.04.021

Laxminarayana Korutla, Katsutaka Mineura, Nicole DeMarais, Charles R Liu, Vincent Burke, Yun Zhu Bai, Andreas Habertheuer, Irbaz Hameed, Yuriko Terada, Sriharsha Talapaneni, Shinichi Kawana, Jon H Ritter, Daniel Kreisel, Prashanth Vallabhajosyula

{"title":"Circulating T cell specific extracellular vesicles as biomarkers of acute cellular rejection after lung transplantation.","authors":"Laxminarayana Korutla, Katsutaka Mineura, Nicole DeMarais, Charles R Liu, Vincent Burke, Yun Zhu Bai, Andreas Habertheuer, Irbaz Hameed, Yuriko Terada, Sriharsha Talapaneni, Shinichi Kawana, Jon H Ritter, Daniel Kreisel, Prashanth Vallabhajosyula","doi":"10.1016/j.ajt.2026.04.021","DOIUrl":"https://doi.org/10.1016/j.ajt.2026.04.021","url":null,"abstract":"There is a critical need for development of non-invasive biomarkers of acute cellular rejection (ACR) in lung transplantation. We hypothesized that ACR induces changes in small extracellular vesicle (sEV) secretory output of T cells into the peripheral circulation, thereby providing a noninvasive method of diagnosis. First, we investigated this hypothesis in a mouse lung transplant model. In line with dense infiltration of lung allograft by T cells during ACR, peripheral blood total T cell and CD8+ T cell counts, as well as, T cell sEV RNA cargoes (Cd3, Cd8, Ifng, Tcrb, and microRNA (Mir)21a) were significantly upregulated in mice receiving allogeneic compared to syngeneic lungs at the postoperative day 7 time point. Second, translating these findings to clinical lung transplantation, we analyzed circulating T cell sEV RNA cargoes with time-matched surveillance transbronchial allograft biopsies in 20 patients. In eight patients with >A1 ACR, eight candidate RNA biomarkers (CD8, TCR, IFNG, HLA-DRA, CD38, MIR21, MIRLET7I, MIR101) were significantly upregulated compared to 12 patients without ACR. Collectively, these findings support further investigation of T cell sEVs as a novel biomarker for ACR diagnosis in lung transplantation.","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":" ","pages":""},"PeriodicalIF":8.2,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147808869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0