American Journal of Transplantation最新文献

Long-term outcomes of induction immunosuppression for kidney transplant recipients with HIV who have average immunologic risk: An inverse probability treatment weighting analysis 免疫风险一般的 HIV 肾移植受者接受诱导免疫抑制的长期疗效：反概率治疗加权分析。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-04-01 DOI: 10.1016/j.ajt.2024.11.004

Rasha El Rifai , Kaushik Bhunia , Lauren Fontana , Kurtis J. Swanson , Scott Jackson , Byron H. Smith , Samy M. Riad

{"title":"Long-term outcomes of induction immunosuppression for kidney transplant recipients with HIV who have average immunologic risk: An inverse probability treatment weighting analysis","authors":"Rasha El Rifai , Kaushik Bhunia , Lauren Fontana , Kurtis J. Swanson , Scott Jackson , Byron H. Smith , Samy M. Riad","doi":"10.1016/j.ajt.2024.11.004","DOIUrl":"10.1016/j.ajt.2024.11.004","url":null,"abstract":"<div><div>We analyzed the Scientific Registry of Transplant Recipients (2004-2022) for primary kidney transplant recipients with HIV who had average immunologic risk and were discharged on tacrolimus/mycophenolate mofetil (with or without corticosteroids). Recipients were grouped by induction type: rabbit antithymocyte globulin (r-ATG, n = 688) and human interleukin-2 receptor antagonist (IL2Ra, n = 467). Kaplan-Meier curves were generated to examine recipient and graft survival by induction type. We used mixed Cox proportional hazard models to determine associations between induction type and outcomes of interest, with adjustments for recipient and donor factors and transplant center as a random effect. Regression with propensity score weighting reduced selection bias from nonrandom induction allocation. The unadjusted 10-year survival rate was 57% for those receiving r-ATG and 64% for those receiving IL2Ra (<em>P</em> < .001). Adjusted risk of death was significantly lower for IL2Ra induction than r-ATG induction with Cox multivariable (hazard ratio, 0.65; 95% CI, 0.47-0.91; <em>P</em> = .01) and inverse probability treatment weighting (hazard ratio, 0.38; 95% CI, 0.29-0.50; <em>P</em> < .01) models. Death-censored kidney graft survival did not differ by induction type in either model. The 1-year rejection rate was 10.1% and 11.6% for r-ATG and IL2Ra recipients, respectively (<em>P</em> = .52). Overall, IL2Ra conferred better long-term survival than r-ATG without increased risk of graft loss.</div></div>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"25 4","pages":"Pages 756-766"},"PeriodicalIF":8.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142613044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The concept of immunothrombosis in pancreas transplantation 胰腺移植中免疫血栓的概念。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-04-01 DOI: 10.1016/j.ajt.2024.11.025

Christophe Masset , Nicolas Drillaud , Catherine Ternisien , Nicolas Degauque , Nathalie Gerard , Sarah Bruneau , Julien Branchereau , Gilles Blancho , Benoit Mesnard , Sophie Brouard , Magali Giral , Diego Cantarovich , Jacques Dantal

{"title":"The concept of immunothrombosis in pancreas transplantation","authors":"Christophe Masset , Nicolas Drillaud , Catherine Ternisien , Nicolas Degauque , Nathalie Gerard , Sarah Bruneau , Julien Branchereau , Gilles Blancho , Benoit Mesnard , Sophie Brouard , Magali Giral , Diego Cantarovich , Jacques Dantal","doi":"10.1016/j.ajt.2024.11.025","DOIUrl":"10.1016/j.ajt.2024.11.025","url":null,"abstract":"<div><div>Early failure of a pancreatic allograft due to complete thrombosis has an incidence of approximately 10% and is the main cause of comorbidity in pancreas transplantation. Although several risk factors have been identified, the exact mechanisms leading to this serious complication are still unclear. In this review, we define the roles of the individual components involved during sterile <em>immunothrombosis</em>—namely endothelial cells, platelets, and innate immune cells. Further, we review the published evidence linking the main risk factors for pancreatic thrombosis to cellular activation and vascular modifications. We also explore the unique features of the pancreas itself: the vessel endothelium, specific vascularization, and relationship to other organs—notably the spleen and adipose tissue. Finally, we summarize the therapeutic possibilities for the prevention of pancreatic thrombosis depending on the different mechanisms such as anticoagulation, anti-inflammatory molecules, endothelium protectors, antagonism of damage-associated molecular patterns, and use of machine perfusion.</div></div>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"25 4","pages":"Pages 650-668"},"PeriodicalIF":8.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes to MMWR: Implications for PHD and the transplant community

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-04-01 DOI: 10.1016/j.ajt.2025.02.011

Marcus R. Pereira, Emily A. Blumberg

引用次数: 0

Delivery of butyrate to the lower gut by polymeric micelles prolongs survival of distal skin allografts 通过聚合物胶束向下肠道输送丁酸盐可延长远端皮肤异体移植的存活时间。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-04-01 DOI: 10.1016/j.ajt.2024.11.018

Martin Sepulveda , Montserrat Kwan , Luqiu Chen , Alexandra Cassano , Shijie Cao , Ruyi Wang , Anna J. Slezak , Jeffrey A. Hubbell , Cathryn R. Nagler , Maria-Luisa Alegre

{"title":"Delivery of butyrate to the lower gut by polymeric micelles prolongs survival of distal skin allografts","authors":"Martin Sepulveda , Montserrat Kwan , Luqiu Chen , Alexandra Cassano , Shijie Cao , Ruyi Wang , Anna J. Slezak , Jeffrey A. Hubbell , Cathryn R. Nagler , Maria-Luisa Alegre","doi":"10.1016/j.ajt.2024.11.018","DOIUrl":"10.1016/j.ajt.2024.11.018","url":null,"abstract":"<div><div>The microbiota composition is known to influence the kinetics of graft rejection, but many questions remain as to whether/how microbiota-derived metabolites affect graft outcome. We investigated the effects of the short-chain fatty acid butyrate, a product of dietary fiber fermentation. Sustained intragastric administration of a micelle-based formulation of butyrate (butyrate micelle [ButM]) that releases its cargo in the lower gastrointestinal tract elevated cecal butyrate content and significantly prolonged minor-mismatched and major-mismatched skin allograft survival in mice. While ButM did not influence regulatory T cells or the adaptive alloimmune responses we tested, it modulated the myeloid cell compartment. At steady state, ButM treatment reduced the number of circulating Ly6C<sup>hi</sup>CD11b<sup>+</sup> monocytes and other myeloid cells in secondary lymphoid organs and skin, altered their expression of genes involved in mitochondrial metabolism and key inflammatory processes, and reduced their ability to produce TNFa, likely via an indirect mechanism. ButM treatment also reduced numbers of graft-infiltrating monocytes but not T cells. Consistent with its critical effect on myeloid cells, ButM’s extension of graft survival depended on the presence of CCR2<sup>+</sup> cells. These findings imply that cecal ButM improves distal allograft outcomes by quantitatively and qualitatively modulating myeloid cells, thereby inhibiting the innate immune cell-mediated effector phase of alloimmunity.</div></div>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"25 4","pages":"Pages 695-705"},"PeriodicalIF":8.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Continuous donor-recipient age-matching in the Eurotransplant region: Outcomes, parameters and prediction 连续供体-受体年龄匹配在欧洲移植地区：结果，参数和预测。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-04-01 DOI: 10.1016/j.ajt.2025.01.011

Maarten Coemans , Maarten Naesens

引用次数: 0

Prognostic implications of lung cancers incidentally identified on explant: A joint study of the Scientific Registry of Transplant Recipients and the National Cancer Database 移植时偶然发现的肺癌的预后影响：移植受者科学登记处和国家癌症数据库的联合研究。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-04-01 DOI: 10.1016/j.ajt.2024.11.014

Ryan James Rebernick , Juan Diaz Martinez , Marc De Perrot , Marcelo Cypel , Shaf Keshavjee , Rishindra Mamidi Reddy , Elliot Wakeam

{"title":"Prognostic implications of lung cancers incidentally identified on explant: A joint study of the Scientific Registry of Transplant Recipients and the National Cancer Database","authors":"Ryan James Rebernick , Juan Diaz Martinez , Marc De Perrot , Marcelo Cypel , Shaf Keshavjee , Rishindra Mamidi Reddy , Elliot Wakeam","doi":"10.1016/j.ajt.2024.11.014","DOIUrl":"10.1016/j.ajt.2024.11.014","url":null,"abstract":"<div><div>The implications of a lung malignancy in a lung transplant recipient are poorly understood. Here, we linked national transplant and cancer databases to determine how lung cancer impacted prognosis in lung transplant recipients with incidentally explanted lung cancers (IELCs). Records from the Scientific Registry of Transplant Recipients and National Cancer Database were linked to identify 186 patients who received a lung transplant and were subsequently diagnosed with lung cancer. These patients were determined to have IELC and were compared with control patients who received a lung transplant but were not diagnosed with IELC. Of the 186 patients, 144 had non-small cell lung cancer (NSCLC), 6 had small cell lung cancer, and 36 had neuroendocrine cancer. Patients with stage I/II NSCLC or any stage neuroendocrine cancer had overall survival and cancer-related mortality rates comparable with those of controls. Conversely, patients with stage III/IV NSCLC had worse overall survival, higher rates of cancer-related mortality, and infrequently received cancer-specific nonoperative treatment. Taken together, stage I/II NSCLC and neuroendocrine cancers should be reconsidered as an absolute contraindication to transplant. Conversely, patients with stage III/IV NSCLC had worse outcomes, and strategies are needed to increase the use of adjuvant therapy.</div></div>","PeriodicalId":123,"journal":{"name":"American Journal of Transplantation","volume":"25 4","pages":"Pages 814-824"},"PeriodicalIF":8.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-04-01 DOI: 10.1016/j.ajt.2024.11.034

Isabelle Dominique V. Tomacruz , Tomoki Tsukahara , Beatrice P. Concepcion, Michelle A. Josephson

引用次数: 0

Long-term outcomes at 5 years posttransplant in imlifidase-desensitized kidney transplant patients imlifidase脱敏肾移植患者移植后5年的长期预后。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-04-01 DOI: 10.1016/j.ajt.2024.11.029

Stanley C. Jordan, Angela Q. Maldonado, Bonnie E. Lonze, Kristoffer Sjöholm, Anna Lagergren, Robert A. Montgomery, Anna Runström, Niraj M. Desai, Christophe Legendre, Torbjörn Lundgren, Bengt von Zur Mühlen, Ashley A. Vo, Jan Tollemar, Paola Lefèvre, Tomas Lorant

引用次数: 0

Synthetic Notch-receptor-driven suppressor cells deliver targeted immune modulation and protect transplanted human islets

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-04-01 DOI: 10.1016/j.ajt.2025.02.016

Han S. Yin, Im-Hong Sun, James M. Gardner

引用次数: 0

Finding actionable information in the universe of data 在数据宇宙中寻找可操作的信息。

IF 8.9 2区医学

American Journal of Transplantation Pub Date : 2025-04-01 DOI: 10.1016/j.ajt.2025.01.004

Jennifer Gagnon , Lisa M. McElroy

引用次数: 0